Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 2851 - 2900 OF 15612 RESULTS

Elevated Serum Amino Acids Induce a Subpopulation of Alpha Cells to Initiate Pancreatic Neuroendocrine Tumor Formation
Cell Reports Medicine, ISSN: 26663791
Derek K. Smith; Lance Kates; Durinck; Nisha Patel; Eric Stawiski; Noelyn Kljavin; Oded Foreman; Bence Sipos; Mark J. Solloway; Bernard B. Allan; Andrew S. Peterson
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Structure of the essential inner membrane lipopolysaccharide–PbgA complex
Nature, ISSN: 14764687 00280836
Thomas Clairfeuille; Kerry R. Buchholz; Qingling Li; Erik Verschueren; Peter S. Liu; Dewakar Sangaraju; Summer Park; Cameron Noland; Kelly M. Storek; Nicholas N. Nickerson; Lynn Martin; Trisha Dela Vega; Anh Miu; Janina Reeder; Maria Ruiz-Gonzalez; Danielle L. Swem; Guanghui Han; Daniel P. DePonte; Mark S. Hunter; Cornelius Gati; Sheerin Shahidi-Latham; Min Xu; Nicholas J. Skelton; Benjamin D. Sellers; Elizabeth Skippington; Wendy N. Sandoval; Emily J. Hanan; Jian Payandeh; Steven T. Rutherford
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Insulin degrading enzyme (IDE) expressed by Chinese hamster ovary (CHO) cells is responsible for degradation of insulin in culture media
Journal of Biotechnology, ISSN: 18734863 01681656
Salina Louie; Jayanthi Lakkyreddy; Brian M. Castellano; Benjamin Haley; Anh Nguyen Dang; Cynthia Lam; Danming Tang; Steven E. Lang; Snedecor; Shahram Misaghi
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Nanolipoprotein Particles as a Delivery Platform for Fab Based Therapeutics
Bioconjugate Chemistry, ISSN: 15204812 10431802
Martine Darwish; Whitney Shatz; Brandon Leonard; Kelly M. Loyet; Kathy Barrett; Janice L. Wong; Hong Li; Ryan Abraham; May Lin; Yvonne Franke; Christine Tam; Kyle Mortara; Inna Zilberleyb; Craig D. Blanchette
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Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity
ACS Medicinal Chemistry Letters, ISSN: 19485875
James J. Crawford; Wendy Lee; Adam R. Johnson; Kelly Delatorre; Jacob Z. Chen; Eigenbrot; Julia Heidmann; Satoko Kakiuchi-Kiyota; Arna Katewa; James R. Kiefer; Lichuan Liu; Joseph W. Lubach; Misner; Hans E. Purkey; Karin Reif; Jennifer Vogt; Harvey Wong; Christine Yu; Wendy B. Young
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Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Nicole Blaquiere; Elisia Villemure; Steven T. Staben
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STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells
EMBO Molecular Medicine, ISSN: 17574684 17574676
Sascha Kahlfuss; Ulrike Kaufmann; Axel R Concepcion; Lucile Noyer; Dimitrius Raphael; Martin Vaeth; Jun Yang; Priya Pancholi; Mate Maus; James Muller; Lina Kozhaya; Alireza Khodadadi-Jamayran; Zhengxi Sun; Patrick Shaw; Derya Unutmaz; Peter B Stathopulos; Cori Feist; Scott B Cameron; Stuart E Turvey; Stefan Feske
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Impact of initial treatment and prognostic factors on postprogression survival in BRAF-mutated metastatic melanoma treated with dacarbazine or vemurafenib ± cobimetinib: A pooled analysis of four clinical trials
Journal of Translational Medicine, ISSN: 14795876
Paolo A. Ascierto; Antoni Ribas; James Larkin; McArthur; Karl Lewis; Axel Hauschild; Keith Flaherty; Edward McKenna; Qian Zhu; Yong Mun; Brigitte Dréno
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Method screening strategies of stereoisomers of compounds with multiple chiral centers and a single chiral center
Journal of Chromatography A, ISSN: 18733778 00219673
Jessica Lin; Charlotte Tsang; Raymond Lieu; Kelly Zhang
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Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis
JCI insight, ISSN: 23793708
Kasia Owczarczyk; Matthew Cascino; Cecile Holweg; Tew; Ward Ortmann; Timothy W. Behrens; Thomas Schindler; Langford; William St.Clair; Peter A. Merkel; Spiera; Seo; Cees Kallenberg; Specks; Noha Lim; John H. Stone; Paul Brunetta; Marco Prunotto
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Immunoaffinity LC-MS/MS is more suitable than ELISA to quantify a PEGylated molecule in cynomolgus monkey serum
Bioanalysis, ISSN: 17576199 17576180
Yanqiu Liu; Luna Liu; Nancy Yu; Lu Dai; Cinzia Stella; Vincent Chang; Surinder Kaur; Keyang Xu; Eric Wakshull
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Point-of-care and utility in clinical trials: Making quicker decisions to transform patient care and drug development
Bioanalysis, ISSN: 17576199 17576180
Saloumeh Kadkhodayan Fischer
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Regions of conformational flexibility in the proprotein convertase PCSK9 and design of antagonists for LDL cholesterol lowering
Biochemical Society Transactions, ISSN: 14708752 03005127
Daniel Kirchhofer; Burdick; Nicholas J. Skelton; Yingnan Zhang; Ultsch
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Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Filip Roudnicky; Jitao David Zhang; Bo Kyoung Kim; Nikhil J. Pandya; Yanjun Lan; Lisa Sach-Peltason; Heloise Ragelle; Pamela Strassburger; Sabine Gruener; Mirjana Lazendic; Sabine Uhles; Franco Revelant; Oliv Eidam; Gregor Sturm; Verena Kueppers; Klaus Christensen; Leonard D. Goldstein; Manuel Tzouros; Balazs Banfai; Zora Modrusan; Martin Graf; Christoph Patsch; Mark Burcin; Claas A. Meyer; Peter D. Westenskow; Chad A. Cowan
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Disease Monitoring Using Post-induction Circulating Tumor DNA Analysis following First-Line Therapy in Patients with Metastatic Colorectal Cancer
Clinical Cancer Research, ISSN: 15573265 10780432
Xiaoju Max Ma; Bendell; Herbert Hurwitz; Christine Ju; John J. Lee; Alex Lovejoy; Christoph Mancao; Alan Nicholas; Richard Price; Nicolas Sommer; Nalin Tikoo; Lijing Yao; Stephanie J. Yaung; John F. Palma
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EVALUATION OF SURGICAL FACTORS AFFECTING VITREOUS HEMORRHAGE FOLLOWING PORT DELIVERY SYSTEM WITH RANIBIZUMAB IMPLANT INSERTION IN A MINIPIG MODEL
Retina, ISSN: 15392864 0275004X
Vlad Bantseev; Chris Schuetz; Helen Booler; Joshua Horvath; Kristof Hovaten; Signe Erickson; Ellison Bentley; T. Michael Nork; William R. Freeman; Jay M. Stewart; Giulio Barteselli
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Regulation of cell death and immunity by xiap
Cold Spring Harbor Perspectives in Biology, ISSN: 19430264
Philipp J. Jost; Domagoj Vucic
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NADPH-independent inactivation of CYP2B6 and NADPH-dependent inactivation of CYP3A4/5 by PBD: Potential implication for assessing covalent modulators for time-dependent inhibition
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Mika Kosaka; Donglu Zhang; Simon Wong; Zhengyin Yan
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Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism
Nature Structural and Molecular Biology, ISSN: 15459985 15459993
Byung-Gil Lee; Fabian Merkel; Matteo Allegretti; Markus Hassler; Christopher Cawood; Léa Lecomte; Francis J. O’Reilly; Ludwig R. Sinn; Pilar Gutierrez-Escribano; Marc Kschonsak; Sol Bravo; Takanori Nakane; Juri Rappsilber; Luis Aragon; Martin Beck; Jan Löwe; Christian H. Haering
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In Situ-Forming Glucose-Responsive Hydrogel from Hyaluronic Acid Modified with a Boronic Acid Derivative
Macromolecular Chemistry and Physics, ISSN: 15213935 10221352
Emily Holz; Karthikan Rajagopal
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RAS-targeted therapies: is the undruggable drugged?
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Amanda R. Moore; Scott C. Rosenberg; Frank McCormick; Shiva Malek
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Evaluating the Pharmacokinetics and Systemic Effects of a Permeability Enhancer Sodium N-[8-(2-hydroxybenzoyl)amino] Caprylate in Rats
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Po-Chang Chiang; Gauri Deshmukh; Jia Liu; Karthik Nagapudi; Jacob Z. Chen; Nicole R. Valle; Ruina Li; Emile G. Plise; Matthew Durk
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Tumor Segmentation and Feature Extraction from Whole-Body FDG-PET/CT Using Cascaded 2D and 3D Convolutional Neural Networks
Journal of Digital Imaging, ISSN: 1618727X 08971889
Skander Jemaa; Jill Fredrickson; Richard A. D. Carano; Tina Nielsen; De Crespigny; Thomas Bengtsson
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Timing of Peak Vision Gains in Patients with Neovascular Age-Related Macular Degeneration Treated with Ranibizumab
Ophthalmology Retina, ISSN: 24686530
Rahul N. Khurana; Louis K. Chang; Bann-Mo Day; Avanti Ghanekar; Ivaylo Stoilov
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Atezolizumab in Combination With Carboplatin and Nab-Paclitaxel in Advanced Squamous NSCLC (IMpower131): Results From a Randomized Phase III Trial
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Jotte; Federico Cappuzzo; Ihor Vynnychenko; Daniil Stroyakovskiy; Rodriguez-Abreu; Maen Hussein; Ross A. Soo; Henry J Conter; Kozuki; Kuan-Chieh Huang; Graupner; Sun; Tien Hoang; Helen Jessop; Mark L. McCleland; Ballinger; Alan Sandler; Mark A. Socinski
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A Review on Mixing-Induced Protein Particle Formation: The Puzzle of Bottom-Mounted Mixers
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Benson Gikanga; Maa
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Proprotein convertase 7 (PCSK7) reduces apoA-V levels
FEBS Journal, ISSN: 17424658 1742464X
Yahya Ashraf; Stéphanie Duval; Vatsal Sachan; Rachid Essalmani; Delia Susan-Resiga; Anna Roubtsova; Josée Hamelin; Gerhardy; Daniel Kirchhofer; Vincent S. Tagliabracci; Annik Prat; Robert Scott Kiss; Nabil G. Seidah
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Atezolizumab in Combination With Carboplatin and Nab-Paclitaxel in Advanced Squamous NSCLC (IMpower131): Results From a Randomized Phase III Trial
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Jotte; Federico Cappuzzo; Ihor Vynnychenko; Daniil Stroyakovskiy; Rodriguez-Abreu; Maen Hussein; Ross A. Soo; Henry J Conter; Kozuki; Kuan-Chieh Huang; Graupner; Shawn Sun; Tien Hoang; Helen Jessop; Mark L. McCleland; Ballinger; Alan Sandler; Mark A. Socinski
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The Immunoglobulin Superfamily Receptome Defines Cancer-Relevant Networks Associated with Clinical Outcome
Cell, ISSN: 10974172 00928674
Erik Verschueren; Bushra Husain; Kobe Yuen; Yi Sun; Sairupa Paduchuri; Yasin Senbabaoglu; Isabelle Lehoux; Tia A. Arena; Blair Wilson; Steve Lianoglou; Corey Bakalarski; Yvonne Franke; Pamela Chan; Athena W. Wong; Lino C. Gonzalez Jr.; Sanjeev Mariathasan; Shannon J. Turley; Jennie R. Lill; Nadia Martinez-Martin
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Strategies to Mitigate the Bioactivation of Aryl Amines
Chemical Research in Toxicology, ISSN: 15205010 0893228X
Chenghong Zhang; James J. Crawford; Matthew L. Landry; Huifen Chen; Jane R. Kenny; S. Cyrus Khojasteh; Wendy Lee; Shuguang Ma; Wendy B. Young
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Cross-Pharma Collaboration on the Development and Evaluation of a New Mid-Scale Preparative Supercritical Fluid Chromatography Instrument
Organic Process Research and Development, ISSN: 1520586X 10836160
Mirlinda Biba; Mengling Wong; Anne Akin; Eric T. Manning; Lisa Schaffter; Larry Miller; Yingru Zhang; William P. Farrell; Jimmy O. Dasilva; Lisa Nogle; Benjamin Hritzko; Frank Riley; Robert P. Depianta; Kevin Barry; Donghong A. Gao; Eric Seest; Meenakshi Goel; Loanne Chung; James Paulson; Heewon Lee; Douglas B. Moore; Shuping Dong; William Leister; Nobumitsu Fukushima; Andy Sasaki; Timothy Lee; Takayuki Iriki; Masayuki Nishimura; Masami Tomita; Michiaki Owa; Katsuhiro Tanaka; Tomohiro Shagawa; Thomas J. Moran; Takeshi Bamba; Christopher J. Welch
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Immunization associated with primary tumor growth leads to rejection of commonly used syngeneic tumors upon tumor rechallenge
Journal for ImmunoTherapy of Cancer, ISSN: 20511426
Bruno Alicke; Klara Totpal; Jill Schartner; Amy M. Berkley; Sophie M. Lehar; Aude-Hélène Capietto; Rafael Cubas; Stephen Gould
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Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non–small cell lung cancer: Analysis of over 8000 cases
Cancer, ISSN: 10970142 0008543X
Philip C. Mack; Kimberly C. Banks; Carin R. Espenschied; Rebekah A. Burich; Oliver A. Zill; Christine E. Lee; Jonathan W. Riess; Stefanie Mortimer; Talasaz; Richard Lanman; David R. Gandara
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Immunity to commensal skin fungi promotes psoriasiform skin inflammation
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Charlotte Hurabielle; Verena M. Link; Nicolas Bouladoux; Seong-Ji Han; E. Dean Merrill; Yaima L. Lightfoot; Nickie Seto; Christopher K E Bleck; Margery Smelkinson; Oliver J. Harrison; Jonathan L. Linehan; Samira Tamoutounour; Michail S. Lionakis; Mariana J. Kaplan; Saeko Nakajima; Yasmine Belkaid
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Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition
Stem Cell Reports, ISSN: 22136711
Natacha Bohin; Theresa M. Keeley; Alexis J. Carulli; Emily M. Walker; Elizabeth A. Carlson; Jie Gao; Iannis Aifantis; Christian W. Siebel; Michael W. Rajala; Martin G. Myers; Jennifer C. Jones; Constance D. Brindley; Peter J. Dempsey; Linda C. Samuelson
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Functional Genomics for Cancer Drug Target Discovery
Cancer Cell, ISSN: 18783686 15356108
Benjamin Haley; Filip Roudnicky
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Automated, Generic Reagent and Ultratargeted 2D-LC-MS/MS Enabling Quantification of Biotherapeutics and Soluble Targets down to pg/mL Range in Serum
Analytical Chemistry, ISSN: 15206882 00032700
Jintang He; Lingyao Meng; Jane Ruppel; Jie Yang; Surinder Kaur; Keyang Xu
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Characterization of Polysorbate Ester Fractions and Implications in Protein Drug Product Stability
Molecular Pharmaceutics, ISSN: 15438392 15438384
Anthony Tomlinson; Isidro E. Zarraga; Barthélemy Demeule
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Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of crispr-cas9
Journal of Experimental Medicine, ISSN: 15409538 00221007
Emily C. Freund; Jaclyn Y. Lock; Jaehak Oh; Timurs Maculins; Lélia Delamarre; Christopher J. Bohlen; Benjamin Haley; Aditya Murthy
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The Statistical Filter Approach to Constrained Optimization
Technometrics, ISSN: 15372723 00401706
Tony Pourmohamad; Herbert K. H. Lee
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Cost of cystectomy-related complications in patients with bladder cancer in the United States
Current Medical Research and Opinion, ISSN: 14734877 03007995
Elisabetta Malangone-Monaco; Kathleen Wilson; Diakun; Darren Tayama; Sacha Satram; Sarika Ogale
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Recognizing atrophy and mixed-type neovascularization in age-related macular degeneration via clinicopathologic correlation
Translational Vision Science and Technology, ISSN: 21642591
Ling Chen; Miaoling Li; Jeffrey D. Messinger; Daniela Ferrara; Christine A. Curcio; K. Bailey Freund
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Determining the Clearance of Degraded Protein via a Monoclonal Antibody Purification Process in Support of Cleaning Carryover Limits in Multiproduct Facilities
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124
Pao Lin Che; Alison P. Bailey; Chi Yan J Tam; Melissa Alvarez; Adeyma Arroyo
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Industry One-Voice-of-Quality (1VQ) Solutions: Effective Management of Post-Approval Changes in the Pharmaceutical Quality System (PQS)-through Enhanced Science and Risk-Based Approaches
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124
Emma Ramnarine; Anders Vinther; Kimberly Bruhin; Christina Tovar; Marcello Colao
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An in vitro quantitative systems pharmacology approach for deconvolving mechanisms of drug-induced, multilineage cytopenias
PLoS Computational Biology, ISSN: 15537358 1553734X
Jennifer L. Wilson; Dan Lu; Nick Corr; Aaron Fullerton; James Lu
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Response in patients with BIRC3-mutated relapsed/refractory chronic lymphocytic leukemia treated with fixed-duration venetoclax and rituximab
Haematologica, ISSN: 15928721 03906078
Kater; Yanwen Jiang; Brenda Chyla; John F. Seymour
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Optimizing Hydroxyl Radical Footprinting Analysis of Biotherapeutics Using Internal Standard Dosimetry
Journal of the American Society for Mass Spectrometry, ISSN: 18791123
Natalie K. Garcia; Alavattam Sreedhara; Galahad Deperalta; Aaron T. Wecksler
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Multiparametric MR-PET imaging predicts pharmacokinetics and clinical response to GDC-0084 in patients with recurrent high-grade glioma
Clinical Cancer Research, ISSN: 15573265 10780432
Benjamin M. Ellingson; Jingwen Yao; Catalina Raymond; David A. Nathanson; Ararat Chakhoyan; Jeremy Simpson; James S. Garner; Alan G. Olivero; Lars Mueller; Jordi Rodon; Elizabeth Gerstner; Timothy F. Cloughesy; Patrick Y. Wen
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Tumor fusion burden as a hallmark of immune infiltration in prostate cancer
Cancer immunology research, ISSN: 23266074 23266066
Marie-Claire Wagle; Joseph Castillo; Shrividhya Srinivasan; Thomas Holcomb; Kobe Yuen; Edward E. Kadel III; Sanjeev Mariathasan; Daniel L Halligan; Adrian R. Carr; Max Bylesjo; Paul R. McAdam; Sarah Lynagh; Koen M. Marien; Mark Kockx; Yannick Waumans; Shih-Min A. Huang; Lackner; Zineb Mounir
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A phase 2 randomized, double-blind, placebo-controlled trial of MHAA4549A, a monoclonal antibody, plus oseltamivir in patients hospitalized with severe influenza a virus infection
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Jeremy Lim; Anna C. Nilsson; Michael Silverman; Nimer Assy; Priya Kulkarni; Jacqueline McBride; Rong Deng; Chloe Li; Xiaoying Yang; Allen Nguyen; Priscilla Horn; Mauricio Maia; Aide Castro; Melicent Peck; Joshua Galanter; Tom W. Chu; Elizabeth Newton; Jorge A. Tavel
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