Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 2951 - 3000 OF 15612 RESULTS

Understanding commercial cell culture process performance variation through advanced data analytics
BioPharm International, ISSN: 19391862 1542166X
Jun Luo; Sid Kundu; Yiming Peng; Jesse Bergevin
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Ex vivo myelination and remyelination in cerebellar slice cultures as a quantitative model for developmental and disease-relevant manipulations
Journal of Visualized Experiments, ISSN: 1940087X
Kimberle Shen; Tracy J. Yuen
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Super-enhancer acquisition drives oncogene expression in triple negative breast cancer
PLoS ONE, ISSN: 19326203
Ryan Raisner; Russell Bainer; Peter M. Haverty; Kelli L. Benedetti; Karen Gascoigne
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Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts
Nature Methods, ISSN: 15491676 15491277
Naeimeh Atabaki-Pasdar; Mattias Ohlsson; Ana Vinuela; Francesca Frau; Hugo Pomares-Millan; Mark Haid; Angus G. Jones; E. Louise Thomas; Robert W. Koivula; Azra Kurbasic; Pascal M. Mutie; Hugo Fitipaldi; Juan Fernandez; Adem Y. Dawed; Giuseppe N. Giordano; Ian M. Forgie; Timothy J. McDonald; Femke Rutters; Henna Cederberg; Elizaveta Chabanova; Matilda Dale; Federico De Masi; Cecilia Engel Thomas; Kristine H. Allin; Tue H. Hansen; Alison Heggie; Mun-Gwan Hong; Petra J M Elders; Gwen Kennedy; Tarja Kokkola; Helle Krogh Pedersen; Anubha Mahajan; Donna McEvoy; Francois Pattou; Violeta Raverdy; Ragna S. Häussler; Sapna Sharma; Henrik S. Thomsen; Jagadish Vangipurapu; Henrik Vestergaard; Leen M. T Hart; Jerzy Adamski; Petra B. Musholt; Søren Brage; Søren Brunak; Emmanouil T. Dermitzakis; Gary Frost; Torben Hansen; Markku Laakso; Oluf Pedersen; Martin Ridderstråle; Hartmut Ruetten; Andrew T. Hattersley; Mark Walker; Joline Beulens; Andrea Mari; Jochen M. Schwenk; Ramneek Gupta; Mark I. McCarthy; Ewan Pearson; Jimmy D. Bell; Imre Pavo; Paul W. Franks
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Anti-VEGF treatment enhances CD8+T-cell antitumor activity by amplifying hypoxia
Cancer immunology research, ISSN: 23266074 23266066
Patricia De Almeida; Judy Mak; Genevive Hernandez; Rajiv Jesudason; Aurelie Herault; Vincent Javinal; Jovencio Borneo; Kim; Kevin B. Walsh
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IRE1α disruption in triple-negative breast cancer cooperates with antiangiogenic therapy by reversing ER stress adaptation and remodeling the tumor microenvironment
Cancer Research, ISSN: 15387445 00085472
Jonathan M. Harnoss; Adrien Le Thomas; Mike Reichelt; Ofer Guttman; Thomas D Wu; Scot A. Marsters; Anna Shemorry; David Lawrence; David Kan; Ehud Segal; Mark Merchant; Klara Totpal; Lisa Crocker; Kathryn Mesh; Monika Dohse; Margaret Solon; Zora Modrusan; Joachim Rudolph; Koeppen; Peter Walter; Avi Ashkenazi
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CD96 functions as a co-stimulatory receptor to enhance CD8+ T cell activation and effector responses
European Journal of Immunology, ISSN: 15214141 00142980
Eugene Y. Chiang; Patricia De Almeida; Denise De Almeida Nagata; Kristin Harden Bowles; Xiangnan Du; Avantika S. Chitre; Karl L. Banta; Youngsu Kwon; Brent Mckenzie; Stephanie Mittman; Rafael Cubas; Keith R. Anderson; Søren Warming; Jane L. Grogan
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Patient-Reported Outcomes from the Phase III Randomized IMmotion151 Trial: Atezolizumab þ Bevacizumab versus Sunitinib in Treatment-Naïve Metastatic Renal Cell Carcinoma
Clinical Cancer Research, ISSN: 15573265 10780432
Michael B. Atkins; Brian I Rini; Robert J. Motzer; Thomas Powles; David McDermott; Cristina Suárez; Sergio Bracarda; Walter M. Stadler; Frede Donskov; Howard Gurney; Stephane Oudard; Motohide Uemura; Elaine T. Lam; Carsten Grüllich; Quach; Susheela Carroll; Beiying Ding; Qian Zhu; Elisabeth Piault-Louis; Christina Schiff; Bernard Escudier
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Atezolizumab with or without bevacizumab in unresectable hepatocellular carcinoma (GO30140): an open-label, multicentre, phase 1b study
The Lancet Oncology, ISSN: 14745488 14702045
Michael S Lee; Chih-Hung Hsu; Stein; Wendy Verret; Stephen P. Hack; Spahn; Bo Liu; Heba Abdullah; Wang; Lee; Bang; Bendell; Chao; J-S Chen; Chung; S. Lindsey Davis; Dev; Edward J. Gane; George R. Blumenschein; Aiwu Ruth He; Hochster; C-H Hsu; Masafumi Ikeda; Lee; Lee; Mahipal; Manji; Morimoto; Kazushi Numata; Pishvaian; Shukui Qin; Ryan; Ryoo; Sasahira; Stein; John H. Strickler; Niall C. Tebbutt
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Physiologically-Based Pharmacokinetic Model-Informed Drug Development for Fenebrutinib: Understanding Complex Drug-Drug Interactions
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Yuan Chen; Fang Ma; Nicholas Steven Jones; Yoshida; Po-Chang Chiang; Matthew Durk; Matthew Wright; Jin Yan Jin; Leslie Chinn
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Genomic Analysis of Circulating Tumor Cells at the Single-Cell Level
Journal of Molecular Diagnostics, ISSN: 19437811 15251578
Shan Lu; Chia-Jung Chang; Yinghui Guan; Edith Szafer-Glusman; Elizabeth A. Punnoose; An Do; Becky Suttmann; Ross Gagnon; Angel Rodriguez; Mark Landers; Jill M. Spoerke; Lackner; Wenzhong Xiao; Wang
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Novel Homodimer Metabolites of GDC-0994 via Cytochrome P450–Catalyzed Radical Coupling
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Jessica M. Grandner; Sudheer Bobba; Yanzhou Liu; Paul Beroza; Donglu Zhang; Shuguang Ma
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Publisher Correction: Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial (Nature Medicine, (2019), 25, 11, (1706-1714), 10.1038/s41591-019-0628-7)
Nature Medicine, ISSN: 1546170X 10788956
Thomas Powles; Mark Kockx; Alejo Rodriguez-Vida; Ignacio Durán; Simon J. Crabb; Michiel S Van Der Heijden; Bernadett Szabados; Albert Font Pous; Gwenaëlle Gravis; Urbano Anido Herranz; Andrew Protheroe; Alain Ravaud; Denis Maillet; Maria Jose Mendez; Cristina Suárez; Mark Linch; Aaron Prendergast; Pieter-Jan van Dam; Diana Stanoeva; Sofie Daelemans; Sanjeev Mariathasan; Joy S. Tea; Kelly Mousa; Romain Banchereau; Daniel Castellano
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Caroline A. Evans, Phillip C. Wright, Josselin Noirel (Eds.): Mass spectrometry of proteins: methods and protocols
Analytical and Bioanalytical Chemistry, ISSN: 16182650
David Arnott
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Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook
Cancer Treatment Reviews, ISSN: 15321967 03057372
Josep Garcia; Herbert Hurwitz; Alan Sandler; David W. Miles; Robert L. Coleman; Regula Deurloo; Olivier L. Chinot
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Data on charge separation of bispecific and mispaired IgGs using native charge-variant mass spectrometry
Data in Brief, ISSN: 23523409
Wilson Phung; Guanghui Han; Stéphanie G.I. Polderdijk; Michael Dillon; Whitney Shatz; Peter S. Liu; Bingchuan Wei; Pawankumar Suresh; David Fischer; Christoph Spiess; Aaron O. Bailey; Paul J. Carter; Jennie R. Lill; Wendy N. Sandoval
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Strategies to Reduce Reconstitution Time of Lyophilized Biotherapeutics
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Jacob Luoma; Fred Lim
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Flow Function of Pharmaceutical Powders at Low-Stress Conditions Can Be Inferred Using a Simple Flow-Through-Orifice Device
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Xingcheng Zhou; Ewa Nauka; Ajit S. Narang; Chen Mao
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NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly
Journal of Hepatology, ISSN: 16000641 01688278
Feng He; Laura Antonucci; Shinichiro Yamachika; Zechuan Zhang; Koji Taniguchi; Atsushi Umemura; Georgia Hatzivassiliou; Merone Roose-Girma; Miguel Reina-Campos; Angeles Duran; Maria T. Diaz-Meco; Jorge Moscat; Beicheng Sun; Michael Karin
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Scientific Regulatory Policy Committee Points to Consider*: Nuisance Factors, Block Effects, and Batch Effects in Nonclinical Safety Assessment Studies
Toxicologic Pathology, ISSN: 15331601 01926233
A. Eric Schultze; Bindu Bennet; Jessica Caverly Rae; Alan Y. Chiang; Kendall S. Frazier; Paula Katavolos; LuAnn McKinney; Daniel J. Patrick; Niraj K. Tripathi
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Monitoring protein communities and their responses to therapeutics
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Hanna G. Budayeva; Donald S. Kirkpatrick
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Natural History of Geographic Atrophy Secondary to Age-Related Macular Degeneration: Results from the Prospective Proxima A and B Clinical Trials
Ophthalmology, ISSN: 15494713 01616420
Nancy M. Holekamp; Charles C. Wykoff; Steffen Schmitz-Valckenberg; Jordi Monés; Eric H. Souied; Hugh Lin; Melvin D. Rabena; Ronald A. Cantrell; Erin C. Henry; Fan Tang; Balakumar Swaminathan; Jillian Martin; Daniela Ferrara; Giovanni Staurenghi
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Determinants of lung function improvement with omalizumab in adults with allergic asthma
Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198
Nicola A. Hanania; Ratko Djukanovic; Liam G. Heaney; Ming Yang; Bongin Yoo; Ahmar Iqbal; Noelle M. Griffin; Bradley E. Chipps
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RIP1 kinase activity is critical for skin inflammation but not for viral propagation
Journal of Leukocyte Biology, ISSN: 19383673 07415400
Webster; Youngsu C. Kwon; Summer Park; Hua Zhang; Nick Corr; Nina Ljumanovic; Adedeji; Eugene Varfolomeev; Tatiana Goncharov; Jessica Preston; Sara F. Santagostino; Snahel Patel; Min Xu; Jonathan M. Maher; Brent Mckenzie; Domagoj Vucic
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Phase I study of the anti-endothelin B receptor antibody-drug conjugate DEDN6526A in patients with metastatic or unresectable cutaneous, mucosal, or uveal melanoma
Investigational New Drugs, ISSN: 15730646 01676997
Shahneen Sandhu; Catriona McNeil; Patricia M. LoRusso; Manish R. Patel; Omar Kabbarah; Chunze Li; Sandra Sanabria; W. Michael Flanagan; Ru-Fang Yeh; Flavia Brunstein; Denise Nazzal; Rodney Hicks; Lemahieu; Raymond D. Meng; Omid Hamid; Jeffery R. Infante
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Atezolizumab with or without bevacizumab in unresectable hepatocellular carcinoma (GO30140): an open-label, multicentre, phase 1b study
The Lancet Oncology, ISSN: 14745488 14702045
Michael S Lee; Chih-Hung Hsu; Stein; Wendy Verret; Stephen P. Hack; Spahn; Bo Liu; Heba Abdullah; Wang; Aiwu Ruth He; Lee; Bang; Bendell; Chao; J-S Chen; Chung; S. Lindsey Davis; Dev; Edward J. Gane; George R. Blumenschein; Aiwu Ruth He; Hochster; C-H Hsu; Masafumi Ikeda; Lee; Lee; Mahipal; Manji; Morimoto; Kazushi Numata; Pishvaian; Shukui Qin; Ryan; Ryoo; Sasahira; Stein; John H. Strickler; Niall C. Tebbutt
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Safety and patient-reported outcomes of atezolizumab plus chemotherapy with or without bevacizumab versus bevacizumab plus chemotherapy in non-small-cell lung cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Martin Reck; Wehler; Orlandi; Nogami; Carlo Barone; Moro-Sibilot; Shtivelband; Jose Luis González Larriba; Jeffrey Rothenstein; Martin Früh; Wei Yu; Deng; Coleman; Geetha Shankar; Hina Patel; Kelsch; Lee; Elisabeth Piault; Mark A. Socinski
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The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells
Science Signaling, ISSN: 19379145 19450877
Cesar A. Corzo; Eugene Varfolomeev; A F. Setiadi; Ross Francis; Sha Klabunde; Kate Senger; Swathi Sujatha-Bhaskar; Joy Drobnick; Steven Do; Eric Suto; Zhiyu Huang; Jeffrey Eastham-Anderson; Arna Katewa; Jodie Pang; Melanie Domeyer; Christopher Dela Cruz; Andres Paler Martinez; Vivian W. C. Lau; Azadeh Hadadianpour; Vladimir Ramirez-Carrozi; Yonglian Sun; Katherine Bao; Daqi Xu; Emily Hunley; Hans D. Brightbill; Søren Warming; Merone Roose-Girma; Alfred Wong; Lucinda Tam; Claire Emson; James J. Crawford; Wendy B. Young; Rajita Pappu; Brent Mckenzie; Vida Asghari; Domagoj Vucic; Jason A. Hackney; Cary D. Austin; Wyne P. Lee; Annemarie N. Lekkerkerker; Nico Ghilardi; Marian C. Bryan; James R. Kiefer; Michael J. Townsend; Ali A. Zarrin
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The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues
Frontiers in Cell and Developmental Biology, ISSN: 2296634X
Webster; Domagoj Vucic
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It Takes Two to Regenerate: Optimizing Custom Wnt Surrogates
Cell Chemical Biology, ISSN: 24519448 24519456
Simon Hansen; Rami N. Hannoush
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Characterizing and Quantitating Therapeutic Tethered Multimeric Antibody Degradation Using Affinity Capture Mass Spectrometry
Analytical Chemistry, ISSN: 15206882 00032700
Wenjing Li; Neha Srikumar; William F. Forrest; Diego Ellerman; Chen Gu; Robert Tchelepi; Greg A. Lazar; Yichin Liu; John C. Tran
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Predictive in Vitro Vitreous and Serum Models and Methods to Assess Thiol-Related Quality Attributes in Protein Therapeutics
Analytical Chemistry, ISSN: 15206882 00032700
Y. Diana Liu; Yan Chen; George Tsui; Bingchuan Wei; Feng Yang; Christopher Yu; Christopher Cornell
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Atezolizumab with or without chemotherapy in metastatic urothelial cancer (IMvigor130): a multicentre, randomised, placebo-controlled phase 3 trial
The Lancet, ISSN: 1474547X 01406736
Matthew D. Galsky; Jose Angel Arranz Arija; Aristotelis Bamias; Ian Davis; Maria De Santis; Eiji Kikuchi; Xavier Garcia-del-Muro; Ugo De Giorgi; Marina Mencinger; Kouji Izumi; Stefano Panni; Mahmut Gumus; Mustafa Özgüroğlu; Arash Rezazadeh Kalebasty; Se Hoon Park; Boris Alekseev; Fabio A Schutz; Jian-Ri Li; Dingwei Ye; Nicholas J. Vogelzang; Sandrine Bernhard; Darren Tayama; Sanjeev Mariathasan; Almut Mecke; AnnChristine Thåström; Enrique Grande
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Safety, Clinical Activity, and Biological Correlates of Response in Patients with Metastatic Melanoma: Results from a Phase I Trial of Atezolizumab—Response
Clinical Cancer Research, ISSN: 15573265 10780432
Omid Hamid; Rene Bruno; Marcella Fassò; Carol E. O'Hear; Benjamin Wu
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Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma
New England Journal of Medicine, ISSN: 15334406 00284793
Richard S. Finn; Shukui Qin; Masafumi Ikeda; Peter R. Galle; Michel Ducreux; Tae-You Kim; Masatoshi Kudo; Valeriy Breder; Philippe Merle; Ahmed Kaseb; Daneng Li; Wendy Verret; D-Z Xu; Sairy Hernandez; Juan Liu; Chen Huang; Sohail Mulla; Wang; Ho Yeong Lim; Zhu; Ann-Lii Cheng
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Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma
New England Journal of Medicine, ISSN: 15334406 00284793
Richard S. Finn; Shukui Qin; Masafumi Ikeda; Peter R. Galle; Michel Ducreux; Tae-You Kim; Masatoshi Kudo; Valeriy Breder; Philippe Merle; Ahmed Kaseb; Daneng Li; Wendy Verret; D-Z Xu; Sairy Hernandez; Juan Liu; Chen Huang; Sohail Mulla; Wang; Ho Yeong Lim; Andrew X. Zhu; Ann-Lii Cheng
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Dexamethasone premedication suppresses vaccine-induced immune responses against cancer
OncoImmunology, ISSN: 21624011
Mathias Vormehr; Sophie M. Lehar; Lena M. Kranz; Siri Tahtinen; Yoko Oei; Vincent Javinal; Lélia Delamarre; Kerstin C. Walzer; Mustafa Diken; Sebastian Kreiter; Ira Mellman; Ugur Sahin; Jill Schartner; Özlem Türeci
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Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Irene Tom; Victoria Pham; Kenneth J. Katschke Jr.; Wei Li; Wei-Ching Liang; Johnny Gutierrez; Andrew Ah Young; Isabel Figueroa; Shadi Toghi Eshghi; Ching Wei V. Lee; Jitendra Kanodia; Scott J. Snipas; Guy S. Salvesen; Phillip Lai; Lee Honigberg; Menno Van Lookeren Campagne; Daniel Kirchhofer; Amos Baruch; Jennie R. Lill
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High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
William S. Sawyer; Neha Srikumar; Joe Carver; Phillip Chu; Amy Shen; Ankai Xu; Ambrose Jon Williams; Christoph Spiess; Cong Wu; Yichin Liu; John C. Tran
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Cancer neoantigens and immunogenicity: mutation position matters
Molecular and Cellular Oncology, ISSN: 23723556
Aude-Hélène Capietto; Suchit Jhunjhunwala; Lélia Delamarre
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Beyond type 2 cytokines in asthma - new insights from old clinical trials
Expert Opinion on Therapeutic Targets, ISSN: 17447631 14728222
David F. Choy; Joseph R. Arron
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ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway
Autophagy, ISSN: 15548635 15548627
Zhiqiang Deng; Junghyun Lim; Qian Wang; Kerry Purtell; Shuai Wu; Gloria M. Palomo; Haiyan Tan; Giovanni Manfredi; Yanxiang Zhao; Junmin Peng; Bo Hu; Shi Chen; Zhenyu Yue
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Dose modification of subcutaneous tocilizumab in patients with rheumatoid arthritis
American Health and Drug Benefits, ISSN: 19422970 19422962
Jennie Best; Ibrahim Abbass; Lenore Tominna; William Reiss
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Reconstitution reveals two paths of force transmission through the kinetochore
eLife, ISSN: 2050084X
Grace Hamilton; Luke A. Helgeson; Cameron Noland; Charles L. Asbury; Yoana Dimitrova; Trisha N. Davis
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The genomic landscape of metastatic breast cancer: Insights from 11,000 tumors
PLoS ONE, ISSN: 19326203
Jacob Rinaldi; Ethan S. Sokol; Ryan J. Hartmaier; Sally E. Trabucco; Garrett M Frampton; Michael E. Goldberg; Lee A. Albacker; Anneleen Daemen; Gerard Manning
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High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade
Nature Medicine, ISSN: 1546170X 10788956
Kobe Yuen; L-F Liu; Vinita Gupta; Shravan Madireddi; Shilpa Keerthivasan; Congfen Li; Deepali Rishipathak; P. Mickey Williams; Edward E. Kadel III; Koeppen; Ying-Jiun Chen; Zora Modrusan; Jane L. Grogan; Romain Banchereau; Ning Leng; AnnChristine Thåström; Xiaodong Shen; Kenji Hashimoto; Darren Tayama; Michiel S Van Der Heijden; Jonathan E. Rosenberg; David McDermott; Thomas Powles; Priti Hegde; Mahrukh Huseni; Sanjeev Mariathasan
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IMbrave 050: A Phase III trial of atezolizumab plus bevacizumab in high-risk hepatocellular carcinoma after curative resection or ablation
Future Oncology, ISSN: 17448301 14796694
Stephen P. Hack; Spahn; Minshan Chen; Ann-Lii Cheng; Ahmed Kaseb; Masatoshi Kudo; Han Chu Lee; Adam Yopp; Pierce Chow; Shukui Qin
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Characterization of antineovascularization activity and ocular pharmacokinetics of phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor GNE-947
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Xingrong Liu; Xiaorong Liang; Jennifer Lecouter; Savita Ubhayakar; Jacob Z. Chen; Jay Cheng; Tom Lee; Joseph W. Lubach; Jim Nonomiya; Sheerin Shahidi-Latham; Cristine Quiason; Eric G. Solon; Matthew Wright; Cornelis E. Hop; Timothy P. Heffron
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Absolute Bioavailability of Vemurafenib in Patients With BRAFV600 Mutation–Positive Malignancies
Clinical Pharmacology in Drug Development, ISSN: 21607648 2160763X
Weijiang Zhang; Dawn Colburn; Brian Simmons; Zsuzsanna Papai; Enric Bertran; Simone Schadt; Christophe Husser; Harper Forbes; Dieter Roethlisberger; Thomas Hartung
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A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys
Toxicological Sciences, ISSN: 10960929 10966080
Mayur S. Mitra; Karla Lancaster; Adedeji; Gopinath S. Palanisamy; Rutwij A. Dave; Fiona Zhong; Matthew S. Holdren; Shannon J. Turley; Wei-Ching Liang; Yan Wu; Y. Gloria Meng; Jean-Michel Vernes; Melissa Schutten
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