Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 3151 - 3200 OF 15612 RESULTS

January 15, 2020

Phase Ia study of anti-NAPI2B antibody–drug conjugate lifastuzumab vedotin DNIB0600A in patients with non–small cell lung cancer and platinum-resistant ovarian cancer

Clinical Cancer Research, ISSN: 15573265 10780432

David E. Gerber; Jeffery R. Infante; Michael S. Gordon; Sarah B. Goldberg; Miguel Martín; Enriqueta Felip; Maria Martinez Garcia; Joan H. Schiller; David Spigel; Julie Cordova; Valerie Westcott; Wang; David S. Shames; Younjeong Choi; Robert S. Kahn; Randall Dere; Divya Samineni; Jian Xu; Kedan Lin; Katie Wood; Stephanie Royer-Joo; Lemahieu; Schuth; Vaze; Daniel Maslyar; Eric W. Humke; Howard A. Burris

January 14, 2020

GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models

Cell Reports, ISSN: 22111247

Jesse E. Hanson; Keran Ma; Justin Elstrott; Martin Weber; Sandrine Saillet; Abdullah S. Khan; Jeffrey Simms; Benjamin Liu; Thomas A. Kim; Gui-Qiu Yu; Yelin Chen; Tzu-Ming Wang; Zhiyu Jiang; Bianca M. Liederer; Gauri Deshmukh; Hilda Solanoy; Connie Chan; Benjamin D. Sellers; Matthew Volgraf; Jacob B. Schwarz; David Hackos; Robby M. Weimer; Morgan Sheng; T. Michael Gill; Kimberly Scearce-Levie; Jorge J. Palop

January 9, 2020

Log D Contributions of Substituents Commonly Used in Medicinal Chemistry

ACS Medicinal Chemistry Letters, ISSN: 19485875

Matthew L. Landry; James J. Crawford

January 9, 2020

A brief history of human disease genetics

Nature, ISSN: 14764687 00280836

Melina Claussnitzer; Judy H. Cho; Rory Collins; Nancy J. Cox; Emmanouil T. Dermitzakis; Matthew E. Hurles; Sekar Kathiresan; Eimear E. Kenny; Cecilia M. Lindgren; Daniel G. MacArthur; Kathryn N. North; Sharon E. Plon; Heidi L. Rehm; Neil Risch; Charles Rotimi; Jay Shendure; Nicole Soranzo; Mark I. McCarthy

January 7, 2020

Probing the Impact of the Knob-into-Hole Mutations on the Structure and Function of a Therapeutic Antibody

Analytical Chemistry, ISSN: 15206882 00032700

Peilu Liu; Xuan Gao; Victor Lundin; Catherine Shi; Yilma T. Adem; Kevin Lin; Guoying Jiang; Kao; Feng Yang; David A. Michels; Alan G. Marshall; Hui-Min Zhang

January 7, 2020

Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity

ChemMedChem, ISSN: 18607187 18607179

Thomas H. Pillow; Pragya Adhikari; Robert A. Blake; Jinhua Chen; Geoffrey Del Rosario; Gauri Deshmukh; Isabel Figueroa; Karen Gascoigne; Amrita Kamath; Susan Kaufman; Tracy L. Kleinheinz; Katherine R. Kozak; Brandon Latifi; Douglas Leipold; Chun Sing Li; Ruina Li; Melinda M. Mulvihill; Aimee O'Donohue; Rebecca K. Rowntree; Jack D. Sadowsky; John Wai; Xinxin Wang; Cong Wu; Zijin Xu; Hui Yao; Shang-Fan Yu; Donglu Zhang; Richard Zang; Hongyan Zhang; Hao Zhou; Xiaoyu Zhu; Peter Dragovich

January 5, 2020

Assessing the utility of in vitro microtubule assays for studying mechanisms of peripheral neuropathy with the microtubule inhibitor class of cancer chemotherapy

Chemico-Biological Interactions, ISSN: 18727786 00092797

Genualdi; Stuart C. Feinstein; Wilson; Jordan; Nicola J. Stagg

January 3, 2020

Dual photoredox/nickel-catalyzed conversion of aryl halides to aryl aminooxetanes: Computational evidence for a substrate-dependent switch in mechanism

ACS Catalysis, ISSN: 21555435

Kavoos Kolahdouzan; Ryan Khalaf; Jessica M. Grandner; Yongsheng Chen; Jack A. Terrett; Malcolm P. Huestis

January 2, 2020

Exposure–response analysis of venetoclax in combination with rituximab in patients with relapsed or refractory chronic lymphocytic leukemia: pooled results from a phase 1b study and the phase 3 MURANO study

Leukemia and Lymphoma, ISSN: 10292403 10428194

Rong Deng; Leonid Gibiansky; Tong Lu; Xiaobin Li; Dan Lu; Chunze Li; Sandhya Girish; Jue Wang; Michelle Boyer; Noopur Shankar; Kathryn Humphrey; Kevin J. Freise; Ahmed Hamed Salem; John F. Seymour; Kater; Dale Miles

January 2, 2020

Cost-effectiveness of omalizumab for the treatment of moderate-to-severe uncontrolled allergic asthma in the United States

Current Medical Research and Opinion, ISSN: 14734877 03007995

Patrick W. Sullivan; Qianyi Li; S. Pinar Bilir; Joseph Dang; Abhishek Kavati; Ming Yang; Yamina Rajput

January 1, 2020

The Role of Futility Analyses in Alzheimer’s Disease Clinical Trials

Journal of Prevention of Alzheimer's Disease, ISSN: 24260266 22745807

Rachelle S. Doody

January 1, 2020

Combined vaccination with NY-ESO-1 protein, poly-ICLC, and montanide improves humoral and cellular immune responses in patients with high-risk melanoma

Cancer immunology research, ISSN: 23266074 23266066

Anna Pavlick; Ana B. Blazquez; Marcia Meseck; Michael Lattanzi; Patrick A. Ott; Thomas U. Marron; Rose Marie Holman; John Mandeli; Andres M. Salazar; Christopher B. McClain; Gustavo Gimenez; Sreekumar Balan; Sacha Gnjatic; Rachel L. Sabado; Nina Bhardwaj

January 1, 2020

Importance of drying in small molecule drug product development

Drying Technologies for Biotechnology and Pharmaceutical Applications,

Paroma Chakravarty; Karthik Nagapudi

January 1, 2020

Sensitive detection of therapeutic efficacy with the etdrs diabetic retinopathy severity scale

Clinical Ophthalmology, ISSN: 11775483 11775467

Jiameng Zhang; Erich C. Strauss

January 1, 2020

Single-molecule nanopore sequencing reveals extreme target copy number heterogeneity in arylomycin-resistant mutants

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Hany S. Girgis; Cory D. DuPai; Jessica Lund; Janina Reeder; Joseph Guillory; Durinck; Yuxin Liang; Joshua S. Kaminker; Peter A. Smith; Elizabeth Skippington

January 1, 2020

Five-year patterns of diabetic retinopathy progression in us clinical practice

Clinical Ophthalmology, ISSN: 11775483 11775467

Andrew A. Moshfeghi; Vincent Garmo; Daniel Sheinson; Avanti Ghanekar; Ibrahim Abbass

January 1, 2020

Comment on 'Implication of baseline levels and early changes of C-reactive protein for subsequent clinical outcomes of patients with rheumatoid arthritis treated with tocilizumab'

Annals of the Rheumatic Diseases, ISSN: 14682060 00034967

Attila Pethoe-Schramm; Jenny Devenport; William Reiss

January 1, 2020

Long-Term Stability of Anti-Vascular Endothelial Growth Factor (a-VEGF) Biologics Under Physiologically Relevant Conditions and Its Impact on the Development of Long-Acting Delivery Systems

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Debby P. Chang; Shalini Burra; Eric S. Day; Joyce Chan; Laetitia Comps-Agrar; Thierry Nivaggioli; Karthikan Rajagopal

January 1, 2020

Circulating tumor DNA and biomarker analyse from the lotus randomized trial of first-line ipatasertib and paclitaxel for metastatic triple-negative breast cancer

JCO Precision Oncology, ISSN: 24734284

Matthew Wongchenko; Sung-Bae Kim; Saura; Oliveira; Doron Lipson; Mark Kennedy; Mandy Greene; Virginia Breese; Aruna Mani; Xu; Rebecca Dent

January 1, 2020

Development of deep learning models to predict best-corrected visual acuity from optical coherence tomography

Translational Vision Science and Technology, ISSN: 21642591

Michael G. Kawczynski; Thomas Bengtsson; Jian Dai; J. Jill Hopkins; Simon S. Gao; Jeffrey R. Willis

January 1, 2020

Association of baseline systemic corticosteroid use with overall survival and time to next treatment in patients receiving immune checkpoint inhibitor therapy in real-world US oncology practice for advanced non-small cell lung cancer, melanoma, or urothelial carcinoma

OncoImmunology, ISSN: 2162402X 21624011

Alexandra Drakaki; Preet K. Dhillon; Heather A. Wakelee; Chui; Jinjoo Shim; Matthew Kent; Viraj Degaonkar; Tien Hoang; Virginia McNally; Patricia Luhn; Ralf Gutzmer

January 1, 2020

microbiomeDASim: Simulating longitudinal differential abundance for microbiome data

F1000Research, ISSN: 1759796X 20461402

Jennifer A. Tom; Joseph N. Paulson; Justin Williams; Hector Corrada Bravo

January 1, 2020

Targeted IgMs agonize ocular targets with extended vitreal exposure

mAbs, ISSN: 19420870 19420862

Chen; Maciej Paluch; Julie A. Zorn; Sharmila Rajan; Brandon Leonard; Alberto Estevez; John Brady; Chiu; Wilson Phung; Amin Famili; Minhong Yan; Claudio Ciferri; Marissa L. Matsumoto; Greg A. Lazar; Susan R. Crowell; Hass; Nick Agard

January 1, 2020

Using artificial intelligence for improving stroke diagnosis in emergency departments: a practical framework

Therapeutic Advances in Neurological Disorders, ISSN: 17562864 17562856

Vida Abedi; Ayesha Khan; Durgesh Chaudhary; Debdipto Misra; Venkatesh Avula; Dhruv Mathrawala; Chadd Kraus; Kyle A. Marshall; Nayan Chaudhary; Xiao Li; Clemens M. Schirmer; Fabien Scalzo; Jiang Li; Ramin Zand

January 1, 2020

Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity

mAbs, ISSN: 19420870 19420862

Yue Sun; Alberto Estevez; Tilman Schlothauer; Aaron T. Wecksler

January 1, 2020

Safety, Tolerability, and Pharmacokinetics of Crenezumab in Patients with Mild-to-Moderate Alzheimer's Disease Treated with Escalating Doses for up to 133 Weeks

Journal of Alzheimer's Disease, ISSN: 18758908 13872877

Heather Guthrie; Lawrence S. Honig; Helen Lin; Kaycee M. Sink; Kathleen Blondeau; Angelica Quartino; Michael J. Dolton; Montserrat Carrasco-Triguero; Qinshu Lian; Tobias Bittner; David Clayton; Jillian Smith; Ostrowitzki

January 1, 2020

Recent progress in roll compaction process development for pharmaceutical solid dosage form manufacture

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Ariel Muliadi; Alamelu Banda; Chen Mao

January 1, 2020

Transient receptor potential ankyrin 1 (TRPA1) antagonists: a patent review (2015–2019)

Expert Opinion on Therapeutic Patents, ISSN: 17447674 13543776

Huifen Chen; Jack A. Terrett

January 1, 2020

Modeling colorectal cancer progression through orthotopic implantation of organoids

Methods in Molecular Biology, ISSN: 19406029 10643745

Felipe de Sousa e Melo; Jonathan M. Harnoss; Noelyn Kljavin; Ryan Scott; Catherine Sohn; Kevin G. Leong; Frederic J. De Sauvage

January 1, 2020

What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

Human Brain Mapping, ISSN: 10970193 10659471

Christopher R. K. Ching; Derrek P. Hibar; Tiril P. Gurholt; Abraham Nunes; Sophia I. Thomopoulos; Christoph Abé; Ingrid Agartz; Rachel M. Brouwer; Dara M. Cannon; Sonja M C de Zwarte; Lisa T. Eyler; Pauline Favre; Tomas Hajek; Unn K. Haukvik; Josselin Houenou; Mikael Landén; Tristram A. Lett; Colm McDonald; Leila Nabulsi; Yash Patel; Melissa E. Pauling; Tomas Paus; Joaquim Radua; Marcio G. Soeiro-de-Souza; Giulia Tronchin; Neeltje E. M. Van Haren; Eduard Vieta; Henrik Walter; Ling-Li Zeng; Martin Alda; Jorge Almeida; Dag Alnæs; Silvia Alonso-Lana; Cara Altimus; Michael Bauer; Bernhard T. Baune; Carrie E. Bearden; Marcella Bellani; Francesco Benedetti; Michael Berk; Amy C. Bilderbeck; Hilary P. Blumberg; Erlend Bøen; Irene Bollettini; Caterina del Mar Bonnin; Paolo Brambilla; Erick J. Canales-Rodríguez; Xavier Caseras; Orwa Dandash; Udo Dannlowski; Giuseppe Delvecchio; Ana M. Díaz-Zuluaga; Danai Dima; Édouard Duchesnay; Torbjørn Elvsåshagen; Scott C. Fears; Sophia Frangou; Janice M. Fullerton; David C. Glahn; Jose M. Goikolea; Melissa J. Green; Dominik Grotegerd; Oliver Gruber; Bartholomeus C. M. Haarman; Chantal Henry; Fleur M. Howells; Victoria Ives-Deliperi; Andreas Jansen; Tilo T.J. Kircher; Christian Knöchel; Bernd Krämer; Beny Lafer; Carlos López-Jaramillo; Rodrigo Machado-Vieira; Bradley J. MacIntosh; Elisa M. T. Melloni; Philip B. Mitchell; Igor Nenadic; Fabiano Nery; Allison C. Nugent; Viola Oertel; Roel A. Ophoff; Miho Ota; Bronwyn J. Overs; Daniel L. Pham; Mary L. Phillips; Julian A. Pineda-Zapata; Sara Poletti; Mircea Polosan; Edith Pomarol-Clotet; Arnaud Pouchon; Yann Quidé; Maria M. Rive; Gloria Roberts; Henricus G. Ruhe; Raymond Salvador; Salvador Sarró; Theodore D. Satterthwaite; Aart H. Schene; Kang Sim; Jair C. Soares; Michael Stäblein; Dan J. Stein; Christian K. Tamnes; Georgios V. Thomaidis; Cristian Vargas Upegui; Dick J. Veltman; Michèle Wessa; Lars T. Westlye; Heather C. Whalley; Daniel H. Wolf; Mon-Ju Wu; Lakshmi N. Yatham; Carlos A. Zarate; Paul M. Thompson; Ole A. Andreassen

January 1, 2020

Mechanistic modeling of soluble Aβ dynamics and target engagement in the brain by anti-Aβ mAbs in Alzheimer’s disease

Current Alzheimer Research, ISSN: 18755828 15672050

Gregory Z. Ferl; Reina N. Fuji; Jasvinder K. Atwal; Tony Sun; Ramanujan; Angelica Quartino

January 1, 2020

Predictors of early diabetic retinopathy regression with ranibizumab in the ride and rise clinical trials

Clinical Ophthalmology, ISSN: 11775483 11775467

Michael Singer; Mimi Liu; Patricio G. Schlottmann; Arshad M. Khanani; Miranda Hemphill; Lauren Hill; Lisa Tuomi; Zdenka Haskova

January 1, 2020

Diabetic population-based model to estimate impact of ranibizumab on diabetic retinopathy severity in patients with diabetic macular edema

Clinical Ophthalmology, ISSN: 11775483 11775467

Rohit Varma; Neil M. Bressler; Quan V. Doan; Ivan J. Suñer; Mark Danese; Chantal M. Dolan; Abraham Lee; Jason S. Ehrlich; Yamina Rajput

January 1, 2020

Chapter 11: Particles in Biopharmaceuticals: Causes, Characterization, and Strategy

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Steven Messick; Miguel Saggu; Anacelia Ríos Quiroz

January 1, 2020

Chapter 24: Considerations and Challenges When Filling High-Concentration Monoclonal Antibody Formulations into Prefilled Syringes

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Wendy Shieu; Maa

January 1, 2020

Chapter 4: Production Strategies and Challenges with IgG-Based Bispecific Ab Formats

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Chen Gu; Diego Ellerman

January 1, 2020

Chapter 15: Drug Product Formulation Development and Formulation Robustness Criteria for a mAb in a Pre-filled Syringe

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Alavattam Sreedhara; Gregory Downing; Karen Rutherford

January 1, 2020

Impact of genetic and nongenetic factors on body mass index and waist-hip ratio change in HIV-infected individuals initiating antiretroviral therapy

Open Forum Infectious Diseases, ISSN: 23288957

Catalina Barceló; Monia Guidi; Christian W. Thorball; Christian Hammer; Aziz Chaouch; Sebastian Haubitz; Bernasconi; Thierry Buclin; Philip E. Tarr; Chantal Csajka; Anagnostopoulos; Battegay; Bernasconi; Böni; Braun; Bucher; Alexandra Calmy; Cavassini; Ciuffi; Dollenmaier; Egger; Elzi; Fehr; Jacques Fellay; Hansjakob Furrer; Fux; Günthard; Haerry; Barbara Hasse; Hirsch; Hoffmann; Hösli; Huber; Christian Kahlert; Kaiser; Keiser; Klimkait; Kouyos; Kovari; Ledergerber; Martinetti; Martinez de Tejada; Marzolini; Metzner; Müller; Nicca; Paioni; Pantaleo; Perreau; Rauch; Rudin; Alexandra U. Scherrer; Schmid; Speck; Stöckle; Tarr; Trkola; Vernazza; Wandeler; Weber; Yerly

January 1, 2020

MAP4K4 negatively regulates CD8 T cell-mediated antitumor and antiviral immunity

Science immunology, ISSN: 24709468

Emel Esen; Ismail Sergin; Rajiv Jesudason; Patricia Himmels; Webster; Hua Zhang; Min Xu; Robert Piskol; Erin McNamara; Stephen Gould; Aude-Hélène Capietto; Lélia Delamarre; Kevin B. Walsh; Weilan Ye

January 1, 2020

Visual Function Decline Resulting from Geographic Atrophy: Results from the Chroma and Spectri Phase 3 Trials

Ophthalmology Retina, ISSN: 24686530

Jeffrey S. Heier; Dante Joseph Pieramici; Usha Chakravarthy; Sunil Patel; Sunil Gupta; Andrew Lotery; Eleonora M. Lad; David Silverman; Erin C. Henry; Majid Anderesi; Elizabeth Tschosik; Sarah Gray; Daniela Ferrara; Robyn H. Guymer

January 1, 2020

MicrobiomeDASim: Simulating longitudinal differential abundance for microbiome data

F1000Research, ISSN: 1759796X 20461402

Justin Williams; Hector Corrada Bravo; Jennifer A. Tom; Joseph N. Paulson

January 1, 2020

Risk stratification biomarkers for Staphylococcus aureus bacteraemia

Clinical and Translational Immunology, ISSN: 20500068

Yi Cao; Alessander O. Guimaraes; Melicent Peck; Oleg Mayba; Felicia Ruffin; Kyu Hong; Montserrat Carrasco-Triguero; Vance G. Fowler; Stacey A. Maskarinec; Carrie M. Rosenberger

January 1, 2020

A comparison of hepato-cellular in vitro platforms to study CYP3A4 induction

PLoS ONE, ISSN: 19326203

Beyza Bulutoglu; Camilo Rey-Bedón; Safak Mert; Lipeng Tian; Yoon-Young Jang; Martin L. Yarmush; Berk Usta

January 1, 2020

Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress

eLife, ISSN: 2050084X

Mable Lam; Scot A. Marsters; Avi Ashkenazi; Peter Walter

January 1, 2020

Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals

eLife, ISSN: 2050084X

Agata Wesolowska-Andersen; Grace Zhuo Yu; Vibe Nylander; Fernando Abaitua; Matthias Thurner; Jason M. Torres; Anubha Mahajan; Anna L. Gloyn; Mark I. McCarthy

January 1, 2020

Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires

mAbs, ISSN: 19420870 19420862

Yi-Chun Hsiao; Ying-Jiun J. Chen; Leonard D. Goldstein; Jia Wu; Zhonghua Lin; Kellen Schneider; Subhra Chaudhuri; Aju Antony; Kanika Bajaj Pahuja; Zora Modrusan; Dhaya Seshasayee; Somasekar Seshagiri; Isidro Hötzel

January 1, 2020

Intestinal Stem Cell Aging: Origins and Interventions

Annual Review of Physiology, ISSN: 15451585 00664278

Heinrich Jasper

January 1, 2020

Improved translation of stability for conjugated antibodies using an in vitro whole blood assay

mAbs, ISSN: 19420870 19420862

Aimee Fourie-O’Donohue; Phillip Chu; Josefa Dela Cruz Chuh; Robert Tchelepi; Siao Ping Tsai; John C. Tran; William S. Sawyer; Dian Su; Carl Ng; Keyang Xu; Shang-Fan Yu; Thomas H. Pillow; Jack D. Sadowsky; Peter Dragovich; Yichin Liu; Katherine R. Kozak

January 1, 2020

Survey of Customers Requesting Medical Information: Preferences and Information Needs of Patients and Health Care Professionals to Support Treatment Decisions

Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790

Stacey M. Fung; Cheryl Sud; Matt Suchodolski

January 1, 2020

In Vitro Assays for Assessing Potential Adverse Effects of Cancer Immunotherapeutics

Methods in Pharmacology and Toxicology, ISSN: 19406053 15572153

Jinze Li; Mayur S. Mitra; Gautham K. Rao

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