Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

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October 1, 2019

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

Nature Immunology, ISSN: 15292916 15292908

Nathan W. Zammit; Owen M. Siggs; Paul Gray; Keisuke Horikawa; David B. Langley; Stacey N. Walters; Stephen R. Daley; Claudia Loetsch; Joanna Warren; Jin Yan Yap; Daniele Cultrone; Amanda Russell; Elisabeth K. Malle; Jeanette E. Villanueva; Mark J. Cowley; Velimir Gayevskiy; Marcel E. Dinger; Robert Brink; David Zahra; Geeta Chaudhri; Gunasegaran Karupiah; Belinda Whittle; Carla Roots; Edward M. Bertram; Michiko Yamada; Yogesh Jeelall; Anselm Enders; Benjamin E. Clifton; Peter D. Mabbitt; Colin J. Jackson; Susan R. Watson; Craig N. Jenne; Lewis L. Lanier; Tim Wiltshire; Matthew H Spitzer; Garry P. Nolan; Frank Schmitz; Alan Aderem; Benjamin T. Porebski; Ashley M. Buckle; Derek W. Abbott; John B. Ziegler; Maria E. Craig; Paul Benitez-Aguirre; Juliana Teo; Stuart G. Tangye; Cecile King; Melanie Wong; Murray P. Cox; Wilson Phung; Jia Tang; Wendy N. Sandoval; Ingrid E. Wertz; Daniel Christ; Christopher C. Goodnow; Shane T. Grey

October 1, 2019

Using the Healthy Days Measure to Assess Factors Associated with Poor Health-Related Quality of Life for Patients with Metastatic Breast, Lung, or Colorectal Cancer Enrolled in a Medicare Advantage Health Plan

Population Health Management, ISSN: 19427905 19427891

Adrianne Casebeer; Dana Drzayich Antol; Sari Hopson; Raya Khoury; Andrew Renda; Aparna R. Parikh; Alisha Stein; Todd Michael; Stephen Stemkowski; Mikele M. Bunce

October 1, 2019

MetagenomeFeatures: An R package for working with 16S rRNA reference databases and marker-gene survey feature data

Bioinformatics, ISSN: 14602059 13674803

Nathan D. Olson; Nidhi Shah; Jayaram Kancherla; Justin Wagner; Joseph N. Paulson; Hector Corrada Bravo

October 1, 2019

ErbB3 and IGF1R signaling are required for Nrf2-dependent growth in Keap1-mutant lung cancer

Cancer Research, ISSN: 15387445 00085472

Steffan Vartanian; James Lee; Christiaan N. Klijn; Florian Gnad; Maria Bagniewska; Gabriele Schaefer; Donglu Zhang; Jenille Tan; Sara A. Watson; Liling Liu; Chen; Yuxin Liang; Colin K. Watanabe; Trinna L. Cuellar; David Kan; Ryan J. Hartmaier; Ted Lau; Michael Costa; Scott E. Martin; Mark Merchant; Benjamin Haley; David Stokoe

October 1, 2019

Rapid development of glaucoma via ITV nonselective ANGPT 1/2 antibody: A potential role for ANGPT/Tie2 signaling in primate aqueous humor outflow

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Evan A Thackaberry; Yi Zhou; Christina L. Zuch de Zafra; Fuh; Chingwei V. Lee; Sarah Sanowar; John B.B. Ridgway; Aija Kusi; Cindy A. Farman; Helen Booler; Daniel Sheinson; Carol A. Rasmussen; Paul Miller; Eric Wakshull; Minhong Yan; Vlad Bantseev

October 1, 2019

Real-World Clinical and Economic Outcomes and the Role of Bevacizumab in Patients With Non-Small-Cell Lung Cancer With Liver Metastases

Journal of Oncology Practice, ISSN: 1935469X

Wong; Ning Wu; Erru Yang; Jessica Davies; Young Kwang Chae

October 1, 2019

Correction to: Cardiovascular Risks, Bleeding Risks, and Clinical Events from 3 Phase III Trials of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis (Advances in Therapy, (2019), 36, 10, (2910-2926), 10.1007/s12325-019-01052-y)

Advances in Therapy, ISSN: 18658652 0741238X

Marilyn K Glassberg; Steven D Nathan; Chin-Yu Lin; Elizabeth A. Morgenthien; John L. Stauffer; Willis Chou; Paul W. Noble

October 1, 2019

Scientific and Regulatory Policy Committee Points to Consider*: The Toxicologic Pathologist’s Role in the 3Rs

Toxicologic Pathology, ISSN: 15331601 01926233

Renee R. Hukkanen; Noel Dybdal; Niraj K. Tripathi; Patricia V. Turner; Sean P. Troth

October 1, 2019

Optimizing venetoclax dose in combination with low intensive therapies in elderly patients with newly diagnosed acute myeloid leukemia: An exposure-response analysis

Hematological Oncology, ISSN: 10991069 02780232

Suresh K. Agarwal; Sathej Gopalakrishnan; Sven Mensing; Jalaja Potluri; John Hayslip; Whitney P. Kirschbrown; Anna Friedel; Rajeev M. Menon; Ahmed Hamed Salem

October 1, 2019

Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging

PLoS ONE, ISSN: 19326203

Chenguang Zhou; Hao Cai; Amos Baruch; Nicholas Lewin-Koh; Meng Yang; Fengxun Guo; Deming Xu; Rong Deng; Wouter L. W. Hazenbos; Amrita Kamath

October 1, 2019

Clinically meaningful visual improvements and predictors of early vision gains with ranibizumab for diabetic macular oedema

BMJ Open Ophthalmology, ISSN: 23973269

Lawrence S. Morse; Linda Yau; Lisa Tuomi

October 1, 2019

Cardiovascular Risks, Bleeding Risks, and Clinical Events from 3 Phase III Trials of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

Advances in Therapy, ISSN: 18658652 0741238X

Marilyn K Glassberg; Steven D Nathan; Chin-Yu Lin; Elizabeth A. Morgenthien; John L. Stauffer; Willis Chou; Paul W. Noble

October 1, 2019

Development of an IL-6 point-of-care assay: Utility for real-time monitoring and management of cytokine release syndrome and sepsis

Bioanalysis, ISSN: 17576199 17576180

Saloumeh Kadkhodayan Fischer; Kathi Williams; Ling Wang; Emmanuel Capio; Mikhail Briman

September 20, 2019

Improved Synthesis of the Nav1.7 Inhibitor GDC-0276 via a Highly Regioselective SNAr Reaction

Organic Process Research and Development, ISSN: 1520586X 10836160

Andreas Stumpf; Zhigang Cheng; Danial Beaudry; Remy Angelaud; Francis Gosselin

September 20, 2019

CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions

Frontiers in Immunology, ISSN: 16643224

Courtney Easley-Neal; Oded Foreman; Neeraj Sharma; Ali A. Zarrin; Robby M. Weimer

September 15, 2019

Dynamics of Bone Cell Interactions and Differential Responses to PTH and Antibody-Based Therapies

Bulletin of Mathematical Biology, ISSN: 15229602 00928240

Vincent Lemaire; David R. Cox

September 13, 2019

A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals

Microbiome, ISSN: 20492618

Petar Scepanovic; Flavia Hodel; Stanislas Mondot; Valentin Partula; Allyson L. Byrd; Christian Hammer; Cécile Alanio; Jacob Bergstedt; Etienne Patin; Mathilde Touvier; Olivier Lantz; Matthew L. Albert; Darragh Duffy; Lluis Quintana-Murci; Jacques Fellay

September 13, 2019

Solution structure and flexibility of the condensin HEAT-repeat subunit Ycg1

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Karen Manalastas-Cantos; Marc Kschonsak; Christian H. Haering; Dmitri Svergun

September 12, 2019

Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1)

ACS Medicinal Chemistry Letters, ISSN: 19485875

Jianwen A. Feng; Patrick Lee; Moulay Hicham Alaoui; Kathy Barrett; Georgette M. Castanedo; Robert Godemann; Paul A. McEwan; Xiaolu Wang; Ping Wu; Yamin Zhang; Seth F. Harris; Steven T. Staben

September 12, 2019

Late-differentiated effector neoantigen-specific CD8+ T cells are enriched in peripheral blood of non-small cell lung carcinoma patients responding to atezolizumab treatment

Journal for ImmunoTherapy of Cancer, ISSN: 20511426

Michael Fehlings; Suchit Jhunjhunwala; Marcin Kowanetz; William E. O'Gorman; Priti Hegde; Hermi Sumatoh; Boon Heng Lee; Alessandra Nardin; Etienne Becht; Susan Flynn; Ballinger; Evan W. Newell; Mahesh Yadav

September 12, 2019

Lead Optimization Yields High Affinity Frizzled 7-Targeting Peptides That Modulate Clostridium difficile Toxin B Pathogenicity in Epithelial Cells

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Simon Hansen; Aaron H Nile; Shrenik C. Mehta; Jakob Fuhrmann; Rami N. Hannoush

September 12, 2019

Lead Optimization Yields High Affinity Frizzled 7-Targeting Peptides That Modulate Clostridium difficile Toxin B Pathogenicity in Epithelial Cells

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Simon Hansen; Aaron H Nile; Shrenik Mehta; Jakob Fuhrmann; Rami N. Hannoush

September 10, 2019

Identification of an acetonitrile addition impurity formed during peptide disulfide bond reduction using dithiothreitol and Tris(2-carboxyethyl)phosphine

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Eileen X. Zhao; Frederic St-Jean; Sarah J. Robinson; Lauren E. Sirois; Jackson D. Pellett; Mohammad Al-Sayah

September 10, 2019

Correlations between surface composition and aerosolization of jet-milled dry powder inhaler formulations with pharmaceutical lubricants

International Journal of Pharmaceutics, ISSN: 18733476 03785173

Sharad Mangal; Heejun Park; Reham Nour; Nivedita Shetty; Alex Cavallaro; Dmitry Zemlyanov; Kyrre Thalberg; Vibha Puri; Mark Nicholas; Ajit S. Narang; Qi (Tony) Zhou

September 10, 2019

Control of Intestinal Cell Fate by Dynamic Mitotic Spindle Repositioning Influences Epithelial Homeostasis and Longevity

Cell Reports, ISSN: 22111247

Daniel Jun-Kit Hu; Heinrich Jasper

September 6, 2019

Establishment of neurofilament light chain Simoa assay in cerebrospinal fluid and blood

Bioanalysis, ISSN: 17576199 17576180

Robert Hendricks; Baker; Jochen Brumm; Teresa Davancaze; Chris Harp; Ann E. Herman; H-Christian von Büdingen; Michael J. Townsend; Saloumeh Kadkhodayan Fischer

September 4, 2019

CD3 bispecific antibody-induced cytokine release is dispensable for cytotoxic T cell activity

Science Translational Medicine, ISSN: 19466242 19466234

Ji Li; Robert Piskol; Ryan Ybarra; Ying-Jiun J. Chen; Jason Li; Dionysos S. Slaga; Maria Hristopoulos; Robyn Clark; Zora Modrusan; Klara Totpal; Melissa Junttila; Teemu T. Junttila

September 4, 2019

Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer

Frontiers in Immunology, ISSN: 16643224

Wei Yu Lin; Daqi Xu; Cary D. Austin; Patrick Caplazi; Kate Senger; Yonglian Sun; Surinc Er Jeet; Judy Young; Donnie Delarosa; Eric Suto; Zhiyu Huang; Juan Zhang; Donghong Yan; Cesar A. Corzo; Kai H. Barck; Sharmila Rajan; Looney; Vineela D. Gandham; Justin Lesch; Wei-Ching Liang; Elaine Mai; Hai Ngu; Navneet Ratti; Yongmei Chen; Misner; Tori Lin; Dimitry Danilenko; Paula Katavolos; Estelle Doudemont; Hirdesh Uppal; Jeffrey Eastham; Judy Mak; Patricia De Almeida; Katherine Bao; Azadeh Hadadianpour; Mary E. Keir; Richard A. D. Carano; Laurie Diehl; Min Xu; Yan Wu; Robby M. Weimer; Jason Devoss; Wyne P. Lee; Mercedesz Balazs; Kevin B. Walsh; Kathila R. Alatsis; Flavius Martin; Ali A. Zarrin

September 4, 2019

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

Science Advances, ISSN: 23752548

Alexessander Couto Alves; N. Maneka G. De Silva; Ville Karhunen; Ulla Sovio; Shikta Das; Rob Taal; Nicole M. Warrington; Alexandra M. Lewin; Marika Kaakinen; Diana L. Cousminer; Elisabeth Thiering; Nicholas J. Timpson; Tom A. Bond; Estelle Lowry; Christopher D. Brown; Xavier Estivill; Virpi Lindi; Jonathan P. Bradfield; Frank Geller; Doug Speed; Lachlan Coin; Marie Loh; Sheila J. Barton; Lawrence J. Beilin; Hans Bisgaard; Klaus Bønnelykke; Rohia Alili; Ida J. Hatoum; Katharina Schramm; Rufus Cartwright; Marie-Aline Charles; Vincenzo Salerno; Karine Clément; Annique A.J. Claringbould; Cornelia M. Van Duijn; Elena Moltchanova; Johan G. Eriksson; Cathy Elks; Bjarke Feenstra; Claudia Flexeder; Stephen Franks; Timothy M. Frayling; Rachel M. Freathy; Paul Elliott; Elisabeth Widén; Hakon Hakonarson; Andrew T. Hattersley; Alina Rodriguez; Marco Banterle; Joachim Heinrich; Barbara Heude; John W. Holloway; Albert Hofman; Elina Hyppönen; Hazel Inskip; Lee M. Kaplan; Åsa Hedman; Esa Läärä; Holger Prokisch; Harald Grallert; Timo A. Lakka; Debbie A. Lawlor; Mads Melbye; Tarunveer S. Ahluwalia; Marcella Marinelli; Iona Y Millwood; Lyle J. Palmer; Craig E. Pennell; John R. Perry; Susan M. Ring; Markku J. Savolainen; Fernando Rivadeneira; Marie Standl; Jordi Sunyer; Carla M.T. Tiesler; Clive Holmes; William Schierding; O'Justin M. Sullivan; Inga Prokopenko; Karl-Heinz Herzig; George Davey Smith; Paul O'Reilly; Janine F. Felix; Jessica L. Buxton; Alexandra I. F. Blakemore; Ken K. Ong; Vincent W.V. Jaddoe; Struan F.A. Grant; Sylvain Sebert; Mark I. McCarthy; Marjo-Riitta Järvelin

September 4, 2019

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

Science Advances, ISSN: 23752548

Alexessander Couto Alves; N. Maneka G. De Silva; Ville Karhunen; Ulla Sovio; Shikta Das; Rob Taal; Nicole M. Warrington; Alexandra M. Lewin; Marika Kaakinen; Diana L. Cousminer; Elisabeth Thiering; Nicholas J. Timpson; Tom A. Bond; Estelle Lowry; Christopher D. Brown; Xavier Estivill; Virpi Lindi; Jonathan P. Bradfield; Frank Geller; Doug Speed; Lachlan Coin; Marie Loh; Sheila J. Barton; Lawrence J. Beilin; Hans Bisgaard; Klaus Bønnelykke; Rohia Alili; Ida J. Hatoum; Katharina Schramm; Rufus Cartwright; Marie-Aline Charles; Vincenzo Salerno; Karine Clément; Annique A.J. Claringbould; Cornelia M. Van Duijn; Elena Moltchanova; Johan G. Eriksson; Cathy Elks; Bjarke Feenstra; Claudia Flexeder; Stephen Franks; Timothy M. Frayling; Rachel M. Freathy; Paul Elliott; Elisabeth Widén; Hakon Hakonarson; Andrew T. Hattersley; Alina Rodriguez; Marco Banterle; Joachim Heinrich; Barbara Heude; John W. Holloway; Albert Hofman; Elina Hyppönen; Hazel Inskip; Lee M. Kaplan; Åsa Hedman; Esa Läärä; Holger Prokisch; Harald Grallert; Timo A. Lakka; Debbie A. Lawlor; Mads Melbye; Tarunveer S. Ahluwalia; Marcella Marinelli; Iona Y Millwood; Lyle J. Palmer; Craig E. Pennell; John R. Perry; Susan M. Ring; Markku J. Savolainen; Fernando Rivadeneira; Marie Standl; Jordi Sunyer; Carla M.T. Tiesler; André G. Uitterlinden; William Schierding; O'Justin M. Sullivan; Inga Prokopenko; Karl-Heinz Herzig; George Davey Smith; Paul O'Reilly; Janine F. Felix; Jessica L. Buxton; Alexandra I. F. Blakemore; Ken K. Ong; Vincent W.V. Jaddoe; Struan F.A. Grant; Sylvain Sebert; Mark I. McCarthy; Marjo-Riitta Järvelin

September 2, 2019

Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor

Xenobiotica, ISSN: 13665928 00498254

Bianca M. Liederer; Jonathan Cheong; Kang-Jye Chou; Peter Dragovich; Hoa Le; Xiaorong Liang; Justin Ly; Sophie Mukadam; Jason Oeh; Deepak Sampath; Leslie Wang; Susan C. Wong

September 1, 2019

Cost of Disease Progression in Patients with Metastatic Breast, Lung, and Colorectal Cancer

Oncologist, ISSN: 1549490X 10837159

Carolina Reyes; Nicole M. Engel-Nitz; Stacey Dacosta Byfield; Arliene Ravelo; Sarika Ogale; Tim Bancroft; Amy Anderson; May Chen; Matthew Matasar

September 1, 2019

Cost of Disease Progression in Patients with Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia, and Non-Hodgkin's Lymphoma

Oncologist, ISSN: 1549490X 10837159

Carolina Reyes; Nicole M. Engel-Nitz; Stacey Dacosta Byfield; Arliene Ravelo; Sarika Ogale; Tim Bancroft; Amy Anderson; May Chen; Matthew Matasar

September 1, 2019

Rituximab dosing in hematological malignancies: an old question, revisited

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Peter N. Morcos; Axel Boehnke; Nancy Valente; Donald E. Mager

September 1, 2019

Long-term safety and effectiveness of tocilizumab in patients with rheumatoid arthritis and inadequate responses to csDMARDs and/or TNF inhibitors: an open-label study close to clinical practice

Clinical Rheumatology, ISSN: 14349949 07703198

Vivian P. Bykerk; Ostor; José Alvaro-Gracia; Karel Pavelka; José Andrés Román Ivorra; Michael T. Nurmohamed; Yves Luder; Paris N. M. Sidiropoulos; Jenny Devenport; Jean Sibilia

September 1, 2019

A Rapid High-Sensitivity Reversed–Phase Ultra High Performance Liquid Chromatography Mass Spectrometry Method for Assessing Polysorbate 20 Degradation in Protein Therapeutics

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Ying Cheng; Mark Hu; Camellia Zamiri; Toshiro Carcelen; Barthélemy Demeule; Anthony Tomlinson; Jie Gu; Yinges Yigzaw; Matt S. Kalo; X. Christopher Yu

September 1, 2019

Impact of omalizumab on patient-reported outcomes in chronic idiopathic urticaria: Results from a randomized study (XTEND-CIU)

Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198

Thomas B. Casale; Thomas R. Murphy; Michael Holden; Yamina Rajput; Bongin Yoo; Jonathan A. Bernstein

September 1, 2019

Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data

Clinical and Translational Science, ISSN: 17528062 17528054

Chunze Li; Cindy Zhang; Rong Deng; Douglas Leipold; Dongwei Li; Brandon Latifi; Yuying Gao; Crystal Zhang; Zao Li; Dale Miles; Shang-Chiung Chen; Divya Samineni; Wang; Priya Agarwal; Dan Lu; Saileta Prabhu; Sandhya Girish; Amrita Kamath

September 1, 2019

Pharmacokinetic and exposure–response analysis of pertuzumab in patients with HER2-positive metastatic gastric or gastroesophageal junction cancer

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Whitney P. Kirschbrown; Wang; Ihsan Nijem; Atsushi Ohtsu; Paulo M. Hoff; Manish A. Shah; Lin Shen; Yoon-Koo Kang; Maria Alsina; Sandhya Girish; Amit Garg

September 1, 2019

Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel NaV1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy Volunteers

Clinical Drug Investigation, ISSN: 11791918 11732563

Michael E. Rothenberg; Tagen; Jae H. Chang; Janel Boyce-Rustay; Michel Friesenhahn; David Hackos; Avis Hains; Daniel P. Sutherlin; Michael Ward; William Cho

September 1, 2019

Safety analysis of rFVIIa with emicizumab dosing in congenital hemophilia A with inhibitors: Experience from the HAVEN clinical program

Journal of Thrombosis and Haemostasis, ISSN: 15387836 15387933

Gallia Levy; Elina Asikanius; Peter Kuebler; Soraya Benchikh El Fegoun; Sille Esbjerg; Stephanie Seremetis

September 1, 2019

Cross-sectional associations between [18F]GTP1 tau PET and cognition in Alzheimer's disease

Neurobiology of Aging, ISSN: 15581497 01974580

Edmond Teng; Michael Ward; Paul T. Manser; Sandra M. Sanabria-Bohorquez; Rebecca D. Ray; Kristin R. Wildsmith; Suzanne Baker; Geoffrey A. Kerchner; Robby M. Weimer

September 1, 2019

[18F]GTP1 (Genentech Tau Probe 1), a radioligand for detecting neurofibrillary tangle tau pathology in Alzheimer’s disease

European Journal of Nuclear Medicine and Molecular Imaging, ISSN: 16197089 16197070

Sandra M. Sanabria-Bohorquez; Jan Marik; Annie Ogasawara; Jeff N. Tinianow; Herman S. Gill; Olivier Barret; Gilles D. Tamagnan; David Alagille; Gai Ayalon; Paul T. Manser; Thomas Bengtsson; Michael Ward; Simon P. Williams; Geoffrey A. Kerchner; John P. Seibyl; Ken Marek; Robby M. Weimer

September 1, 2019

Immune profiles in primary squamous cell carcinoma of the head and neck

Oral Oncology, ISSN: 18790593 13688375

Vassiliki Saloura; Evgeny Izumchenko; Zhixiang Zuo; Bao; Michael Korzinkin; Ivan Ozerov; Alex Zhavoronkov; Sidransky; Atul Bedi; Mohammad O. Hoque; Koeppen; Michaela K. Keck; Arun Khattri; London; Nikita Kotlov; Fatima; Theodore Vougiouklakis; Yusuke Nakamura; Mark Lingen; Nishant Agrawal; Peter A. Savage; Stephen Kron; Justin Kline; Marcin Kowanetz; Tanguy Y. Seiwert

September 1, 2019

Correction to: Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel NaV1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy Volunteers (Clinical Drug Investigation, (2019), 39, 9, (873-887), 10.1007/s40261-019-00807-3)

Clinical Drug Investigation, ISSN: 11791918 11732563

Michael E. Rothenberg; Tagen; Jae H. Chang; Janel Boyce-Rustay; Michel Friesenhahn; David Hackos; Avis Hains; Daniel P. Sutherlin; Michael Ward; William Cho

September 1, 2019

Relocation of study participants for rare and ultra-rare disease trials: Ethics and operations

Contemporary Clinical Trials, ISSN: 15592030 15517144

Luke Gelinas; Brian Crawford; Ariella Kelman; Barbara E. Bierer

September 1, 2019

Neoadjuvant letrozole plus taselisib versus letrozole plus placebo in postmenopausal women with oestrogen receptor-positive, HER2-negative, early-stage breast cancer (LORELEI): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

The Lancet Oncology, ISSN: 14745488 14702045

Saura; Dominik Hlauschek; Oliveira; Zardavas; Jallitsch-Halper; Lorena de la Peña; Nuciforo; Alberto Ballestrero; Dubsky; Janine M Lombard; Peter Vuylsteke; Carlos A Castaneda; Colleoni; Giuliano Santos Borges; Eva Ciruelos; Monica Fornier; Katalin Boer; Aditya Bardia; Wilson; Thomas J. Stout; Jerry Y. Hsu; Yi Shi; Martine Piccart; Michael Gnant; Baselga; Evandro De Azambuja

September 1, 2019

Recommendations for the Design of Clinical Drug–Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically-Based Pharmacokinetic Model

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Yuan Chen; Tamara D. Cabalu; Ernesto Callegari; Heidi J. Einolf; Lichuan Liu; Neil Parrott; Peters; Edgar Schuck; Pradeep Sharma; Helen Tracey; Vijay V. Upreti; Ming Zheng; Andy Z.X. Zhu; Stephen D. Hall

September 1, 2019

Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236

Bhagwat Prasad; Brahim Achour; Per Artursson; Cornelis E. Hop; Yurong Lai; Philip C. Smith; Jill Barber; Jacek R. Wiśniewski; Spellman; Yasuo Uchida; Michael A. Zientek; Jashvant D. Unadkat; Amin Rostami-Hodjegan

September 1, 2019

An Nfil3–Zeb2–Id2 pathway imposes Irf8 enhancer switching during cDC1 development

Nature Immunology, ISSN: 15292916 15292908

Prachi Bagadia; Xiao Huang; Tian-Tian Liu; Vivek Durai; Gary E. Grajales-Reyes; Maximilian Nitschke; Zora Modrusan; Jeffrey M. Granja; Ansuman T. Satpathy; Carlos G. Briseño; Marco Gargaro; Arifumi Iwata; Sunkyung Kim; Howard Y. Chang; Andrey S. Shaw; Theresa L. Murphy; Kenneth M. Murphy

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