Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 3551 - 3600 OF 15612 RESULTS

Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in nonsmall cell lung cancer
PLoS ONE, ISSN: 19326203
Willemijn S.M.E. Theelen; Thomas Kuilman; Katja Schulze; Wei Zou; Oscar Krijgsman; Dennis D.G.C. Peters; Sten Cornelissen; Kim Monkhorst; Pranamee Sarma; Teiko Sumiyoshi; Lukas Amler; Stefan M. Willems; Johannes L.G. Blaauwgeers; Carel Jm van Noesel; Daniel S. Peeper; Michel Van Den Heuvel; Marcin Kowanetz
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Determination of a no observable effect level for endotoxin following a single intravitreal administration to cynomolgus monkeys
Journal of Ocular Pharmacology and Therapeutics, ISSN: 15577732 10807683
Vlad Bantseev; Paul Miller; T. Michael Nork; Carol A. Rasmussen; Aija McKenzie; Brian J. Christian; Helen Booler; Evan A Thackaberry
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Hippo Pathway in Cancer: Aberrant Regulation and Therapeutic Opportunities
Trends in Cancer, ISSN: 24058033
Philamer C. Calses; James J. Crawford; Jennie R. Lill; Anwesha Dey
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A novel depurination methodology to assess DNA alkylation of chloro-bis-seco-cyclopropylbenzoindoles allowed for comparison of minor-groove reactivity S
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Shuai Wang; Buyun Chen; Peter Dragovich; Thomas H. Pillow; Leanna Staben; Jun Guo; Dian Su; Chenghong Zhang; Sudheer Bobba; Yong Ma; Jianshuang Wang; Dewakar Sangaraju; Binqing Wei; Gail L. Phillips; Cyrus Khojasteh; Donglu Zhang
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Health-related quality of life and health status in persons with haemophilia A with inhibitors: A prospective, multicentre, non-interventional study (NIS)
Haemophilia, ISSN: 13652516 13518216
Johnny N. Mahlangu; Johannes Oldenburg; Michael U. Callaghan; Midori Shima; Mancuso; Peter C. Trask; Michael Recht; Claudia Garcia; Renchi Yang; Michaela Lehle; Harrison Macharia; Elina Asikanius; Gallia Levy; Kruse-Jarres; Sylvia von Mackensen
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Atezolizumab plus bevacizumab and chemotherapy in non-small-cell lung cancer (IMpower150): key subgroup analyses of patients with EGFR mutations or baseline liver metastases in a randomised, open-label phase 3 trial
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Martin Reck; Tony Mok; Makoto Nishio; Jotte; Federico Cappuzzo; Orlandi; Daniil Stroyakovskiy; Nogami; Rodriguez-Abreu; Moro-Sibilot; Thomas; Fabrice Barlesi; Finley; Lee; Coleman; Deng; Marcin Kowanetz; Geetha Shankar; Wei Lin; Mark A. Socinski
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Polatuzumab vedotin or pinatuzumab vedotin plus rituximab in patients with relapsed or refractory non-Hodgkin lymphoma: final results from a phase 2 randomised study (ROMULUS)
The Lancet Haematology, ISSN: 23523026
Morschhauser; Ian W. Flinn; Ranjana H. Advani; Laurie H. Sehn; Catherine S. Diefenbach; Kathryn S. Kolibaba; Oliver W. Press; Gilles Salles; Herve Tilly; Chen; Sarit E. Assouline; Bruce D. Cheson; Dreyling; Anton Hagenbeek; Pier Luigi Zinzani; Surai Jones; Ji Cheng; Dan Lu; Elicia M. Penuel; Jamie Hirata; Michael Wenger; Yu-Waye Chu; Jeff P. Sharman
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Opportunities and challenges using artificial intelligence in ADME/Tox
Nature Materials, ISSN: 14764660 14761122
Barun Bhhatarai; W. Patrick Walters; Cornelis E. Hop; Guido Lanza; Sean Ekins
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Synthetic Antigen Gels as Practical Controls for Standardized and Quantitative Immunohistochemistry
Journal of Histochemistry and Cytochemistry, ISSN: 15515044 00221554
Kathy Hötzel; Charles Havnar; Hai Ngu; Sandra Rost; Scot D. Liu; Linda Rangell; Franklin V. Peale Jr.
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Microperimetry for geographic atrophy secondary to age-related macular degeneration
Survey of Ophthalmology, ISSN: 18793304 00396257
Karl G. Csaky; Praveen J. Patel; Yasir J. Sepah; David G. Birch; Diana V. Do; Michael S. Ip; Robyn H. Guymer; Chi D. Luu; Shamika Gune; Hugh Lin; Daniela Ferrara
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A novel method for determining antibody-dependent cellular phagocytosis
Journal of Immunological Methods, ISSN: 18727905 00221759
Lynn Kamen; Srividya Myneni; Chris Langsdorf; Elviza Kho; Benjamin A. Ordonia; Tara Thakurta; Kai Zheng; An Song; Shan Chung
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Interfacial Stress in the Development of Biologics: Fundamental Understanding, Current Practice, and Future Perspective
AAPS Journal, ISSN: 15507416
Jinjiang Li; Mary E. Krause; Xiaodong Chen; Yuan Cheng; Weiguo Dai; John J. Hill; Min Huang; Susan Jordan; Daniel P. LaCasse; Linda O. Narhi; Evgenyi Shalaev; Ian C. Shieh; Justin C. Thomas; Raymond Tu; Songyan Zheng; Lily Zhu
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Ocrelizumab efficacy in subgroups of patients with relapsing multiple sclerosis
Journal of Neurology, ISSN: 14321459 03405354
Benjamin Turner; Bruce A. C. Cree; Ludwig Kappos; Montalban; Caroline Papeix; Wolinsky; Regine Buffels; Damian Fiore; Hideki Garren; Jian Han; Stephen L. Hauser
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Development of a kinetic antibody-dependent cellular cytotoxicity assay
Journal of Immunological Methods, ISSN: 18727905 00221759
Lynn Kamen; Tara Thakurta; Srividya Myneni; Kai Zheng; Shan Chung
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Ocrelizumab infusion experience in patients with relapsing and primary progressive multiple sclerosis: Results from the phase 3 randomized OPERA I, OPERA II, and ORATORIO studies
Multiple Sclerosis and Related Disorders, ISSN: 22110356 22110348
Lori Mayer; Ludwig Kappos; Michael K. Racke; Rammohan; Traboulsee; Stephen L. Hauser; Laura Julian; Harold Köndgen; Carrie Li; Julie Napieralski; Hanzhe Zheng; Wolinsky
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A prospective observational safety study of patients with BRAF V 600 -mutated unresectable or metastatic melanoma treated with vemurafenib (Zelboraf Safety Study)
British Journal of Dermatology, ISSN: 13652133 00070963
Pippa G. Corrie; Terheyden; ten Tije; Herbst; Jansen; Marples; Debus; Marconcini; Blasinska-Morawiec; Freivogel; Munson; Grant R. Goodman; Jessie Hsu; Natalia Sadetsky; Dawn Colburn; Piotr Rutkowski
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Quantitative X-Ray Microcomputed Tomography Assessment of Internal Tablet Defects
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Edward Yost; Pascal Chalus; Shawn Zhang; Stefanie Peter; Ajit S. Narang
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Durability of Diabetic Retinopathy Improvement with As-Needed Ranibizumab: Open-Label Extension of RIDE and RISE Studies
Ophthalmology, ISSN: 15494713 01616420
Jennifer K. Sun; Pin-Wen Wang; Sarah Taylor; Zdenka Haskova
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Quantitative neuroimaging measures of myelin in the healthy brain and in multiple sclerosis
Human Brain Mapping, ISSN: 10970193 10659471
Jonathan O'Muircheartaigh; Irene Vavasour; Emil Ljungberg; David K. B. Li; Alexander Rauscher; Victoria Levesque; Hideki Garren; David Clayton; Roger Tam; Traboulsee; Shannon Kolind
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Development of a Subcutaneous Fixed-Dose Combination of Pertuzumab and Trastuzumab: Results From the Phase Ib Dose-Finding Study
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Whitney P. Kirschbrown; Chris J. Wynne; Kagedal; Russell D. Wada; Hanbin Li; Wang; Ihsan Nijem; Tanja Badovinac-Crnjevic; Helena Gasser; Sarah Heeson; Jennifer Eng-Wong; Amit Garg
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Safety and efficacy of vismodegib in relapsed/refractory acute myeloid leukaemia: results of a phase Ib trial
British Journal of Haematology, ISSN: 13652141 00071048
Dale Bixby; Richard Noppeney; Tara L. Lin; Jorge E. Cortes; Jürgen Krauter; Karen Yee; Bruno C. Medeiros; Alwin Krämer; Sarit E. Assouline; Walter Fiedler; Natalie Dimier; Brian Simmons; Todd Riehl; Dawn Colburn
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Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Steven J. McKerrall; Nguyen; Kwong Wah Lai; Philippe Bergeron; Lunbin Deng; Antonio G. DiPasquale; Jae H. Chang; Jun Chen; Tania Chernov-Rogan; David Hackos; Jonathan M. Maher; Daniel F. Ortwine; Jodie Pang; Jian Payandeh; William R. Proctor; Shannon D. Shields; Jennifer Vogt; Pengfei Ji; Wenfeng Liu; Elisa Ballini; Lilia Schumann; Glauco Tarozzo; Girish Bankar; Sultan Chowdhury; Abid Hasan; Johnson; Kuldip Khakh; Sophia Lin; Charles J. Cohen; Christoph Dehnhardt; Brian S. Safina; Daniel P. Sutherlin
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A prognostic model of persistent bacteremia and mortality in complicated staphylococcus aureus bloodstream infection
Clinical Infectious Diseases, ISSN: 15376591 10584838
Alessander O. Guimaraes; Yi Cao; Kyu Hong; Oleg Mayba; Melicent Peck; Johnny Gutierrez; Felicia Ruffin; Montserrat Carrasco-Triguero; Jason Dinoso; Angelo Clemenzi-Allen; Catherine A. Koss; Stacey A. Maskarinec; Chambers; Vance G. Fowler; Amos Baruch; Carrie M. Rosenberger
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Convergent Synthesis of PI3K Inhibitor GDC-0908 Featuring Palladium-Catalyzed Direct C-H Arylation toward Dihydrobenzothienooxepines
Journal of Organic Chemistry, ISSN: 15206904 00223263
Haiming Zhang; Beryl X. Li; Brian Wong; Andreas Stumpf; C. Gregory Sowell; Francis Gosselin
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Correction to: Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: Final update of the pivotal ERIVANCE BCC study (BMC Cancer. (2017) 17 (332) DOI: 10.1186/s12885-017-3286-5)
BMC Cancer, ISSN: 14712407
Aleksandar Sekulic; Michael R. Migden; Nicole Basset-Seguin; Claus Garbe; Anja Gesierich; Christopher D. Lao; Chris Miller; Laurent Mortier; Dedee F. Murrell; Omid Hamid; Jorge F. Quevedo; Jeannie Hou; Edward McKenna; Natalie Dimier; Sarah Williams; Dirk Schadendorf; Axel Hauschild
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BcGST-an interactive bias-correction method to identify over-represented gene-sets in boutique arrays
Bioinformatics, ISSN: 14602059 13674803
Kevin Y.X. Wang; Alexander M. Menzies; Ines Pires da Silva; James S. Wilmott; Yibing Yan; Matthew Wongchenko; Richard F. Kefford; Richard A. Scolyer; Georgina V. Long; Garth Tarr; Samuel Mueller; Yang
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Central nervous system metastasis in patients with HER2-positive metastatic breast cancer: Patient characteristics, treatment, and survival from systhers
Clinical Cancer Research, ISSN: 15573265 10780432
Sara A. Hurvitz; O'Shaughnessy; Ginny Mason; Denise A. Yardley; Mohammad Jahanzeb; Adam Brufsky; Hope S. Rugo; Sandra M. Swain; Peter A. Kaufman; Debasish Tripathy; Laura Chu; Haocheng Li; Vincent Antao; Melody A. Cobleigh
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Human growth hormone
Pharmaceutical Biotechnology: Fundamentals and Applications,
Dao; Barbara M. Lippe; Mike Laird; Ingrid Beierle
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Recombinant human deoxyribonuclease I
Pharmaceutical Biotechnology: Fundamentals and Applications,
Lazarus; Wagener
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Monoclonal antibodies: From structure to therapeutic application
Pharmaceutical Biotechnology: Fundamentals and Applications,
Rong Deng; C. Andrew Boswell; Wendy Putnam; Meina Tao Tang; Amit Garg; Chunze Li; Shan Chung; Sandhya Girish
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General Purpose Water Model Can Improve Atomistic Simulations of Intrinsically Disordered Proteins
Journal of Chemical Theory and Computation, ISSN: 15499626 15499618
Parviz Seifpanahi Shabane; Saeed Izadi; Alexey V. Onufriev
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Autophagy Regulation of Metabolism Is Required for CD8 + T Cell Anti-tumor Immunity
Cell Reports, ISSN: 22111247
Devorkin; Nils Pavey; Gillian Carleton; Alexandra Comber; Cally Ho; Junghyun Lim; Erin McNamara; Haochu Huang; Kim; Lauren G. Zacharias; Noboru Mizushima; Tatsuya Saitoh; Shizuo Akira; Wayne Beckham; Alireza Lorzadeh; Michelle Moksa; Qi Cao; Aditya Murthy; Martin Hirst; DeBerardinis; Julian J. Lum
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RALying Regeneration through Wnt Internalization in Stem Cells
Cell Stem Cell, ISSN: 18759777 19345909
Helen Tauc; Heinrich Jasper
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Regulation of Tumor-Associated Myeloid Cell Activity by CBP/EP300 Bromodomain Modulation of H3K27 Acetylation
Cell Reports, ISSN: 22111247
Denise De Almeida Nagata; Eugene Y. Chiang; Suchit Jhunjhunwala; Patrick Caplazi; Vidhyalakshmi Arumugam; Zora Modrusan; Emily Chan; Mark Merchant; Lingyan Jin; David Arnott; F. Anthony Romero; Steven Magnuson; Karen Gascoigne; Jane L. Grogan
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Single-institution retrospective review of patients with recurrent glioblastoma treated with bevacizumab in clinical practice
Health Science Reports, ISSN: 23988835
Annick Desjardins; James E. Herndon; Frances McSherry; Arliene Ravelo; Eric S. Lipp; Patrick Healy; Katherine B. Peters; John H. Sampson; Dina Randazzo; Nicolas Sommer; Allan H. Friedman; Henry S. Friedman
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IMpower030: Phase III study evaluating neoadjuvant treatment of resectable stage II-IIIB non-small cell lung cancer (NSCLC) with atezolizumab (atezo) + chemotherapy
Annals of Oncology, ISSN: 15698041
Solange Peters; Kim; Benjamin Solomon; David R. Gandara; Rafal Dziadziuszko; Brunelli; Marina C. Garassino; Martin Reck; Wang; To; Sun; Barbara Gitlitz; Alan Sandler; Naiyer A. Rizvi
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Prognostic power of pathogen cell-free DNA in staphylococcus aureus bacteremia
Open Forum Infectious Diseases, ISSN: 23288957
Alessander O. Guimaraes; Johnny Gutierrez; Stacey A. Maskarinec; Yi Cao; Kyu Hong; Felicia Ruffin; Montserrat Carrasco-Triguero; Melicent Peck; Vance G. Fowler; Amos Baruch; Carrie M. Rosenberger
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Sustained circulating bacterial deoxyribonucleic acid is associated with complicated staphylococcus aureus bacteremia
Open Forum Infectious Diseases, ISSN: 23288957
Johnny Gutierrez; Alessander O. Guimaraes; Nicholas Lewin-Koh; Aklile Berhanu; Min Xu; Yi Cao; Janice Kim; Donghong Yan; Joanna K. Chang; Jason Dinoso; Catherine A. Koss; Angelo Clemenzi-Allen; Chambers; Melicent Peck; Amos Baruch; Carrie M. Rosenberger
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A rapid derivatization based LC-MS/MS method for quantitation of short chain fatty acids in human plasma and urine
Bioanalysis, ISSN: 17576199 17576180
Allan Jaochico; Dewakar Sangaraju; Sheerin Shahidi-Latham
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Incidence and risk of glucocorticoid-associated adverse effects in patients with rheumatoid arthritis
Arthritis Care and Research, ISSN: 21514658 2151464X
Jessica C. Wilson; Khaled Sarsour; Sara Gale; Attila Pethö-Schramm; Susan S. Jick; Christoph R. Meier
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Anti-PD-L1 treatment results in functional remodeling of the macrophage compartment
Cancer Research, ISSN: 15387445 00085472
Huizhong Xiong; Stephanie Mittman; Ryan Rodriguez; Marina Moskalenko; Patricia Pacheco-Sanchez; Yagai Yang; Dorothee Nickles; Rafael Cubas
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The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification
PLoS ONE, ISSN: 19326203
Mona Abed; Erik Verschueren; Hanna G. Budayeva; Peter S. Liu; Donald S. Kirkpatrick; Rohit Reja; Sarah K. Kummerfeld; Webster; Sarah Gierke; Mike Reichelt; Keith R. Anderson; Robert J. Newman; Merone Roose-Girma; Zora Modrusan; Hazal Pektas; Emin Maltepe; Kim Newton; Vishva M. Dixit
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Low-pass whole-genome sequencing of circulating cell-free DNA demonstrates dynamic changes in genomic copy number in a squamous lung cancer clinical cohort
Clinical Cancer Research, ISSN: 15573265 10780432
Xiaoji Chen; Ching-Wei Chang; Jill M. Spoerke; Kathryn E. Yoh; Vidushi Kapoor; Charles Baudo; Junko Aimi; Mamie Yu; May M. Y. Liang-Chu; Rebecca Suttmann; Huw; Steven Gendreau; Cummings; Lackner
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Activation of naïve CD4 + T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 + T cells
Nature Immunology, ISSN: 15292916 15292908
Jason P. Twohig; Ana Cardus Figueras; Robert Andrews; Florian Wiede; Benjamin C. Cossins; Alicia Derrac Soria; Myles J. Lewis; Michael J. Townsend; David Millrine; Jasmine Li; David G. Hill; Javier Uceda Fernandez; Xiao Liu; Barbara Szomolay; Christopher J. Pepper; Philip R. Taylor; Costantino Pitzalis; Tony Tiganis; Nigel Williams; Gareth W. Jones; Simon A. Jones
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Structurally-defined deubiquitinase inhibitors provide opportunities to investigate disease mechanisms
Drug Discovery Today: Technologies, ISSN: 17406749
Ingrid E. Wertz; Jeremy Murray
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A comparison of total and plasma membrane abundance of transporters in suspended, plated, sandwich-cultured human hepatocytes versus human liver tissue using quantitative targeted proteomics and cell surface biotinylation S
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Vineet Kumar; Laurent Salphati; Cornelis E. Hop; Guangqing Xiao; Yurong Lai; Anita Mathias; Xiaoyan Chu; W. Griffith Humphreys; Mingxiang Liao; Scott Heyward; Jashvant D. Unadkat
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Exposure–Response-Based Product Profile–Driven Clinical Utility Index for Ipatasertib Dose Selection in Prostate Cancer
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Rui Zhu; Bill Poland; Russell D. Wada; Qi Liu; Luna Musib; Daniel Maslyar; Eunpi Cho; Wei Yu; Han Ma; Jin Yan Jin; Nageshwar Budha
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Cost-Effectiveness Analysis of Pertuzumab With Trastuzumab and Chemotherapy Compared to Trastuzumab and Chemotherapy in the Adjuvant Treatment of HER2-Positive Breast Cancer in the United States
Value in Health, ISSN: 15244733 10983015
Louis P. Garrison Jr.; Joseph B. Babigumira; Clément Tournier; Hans-Peter Goertz; Solomon J. Lubinga; Edith A. Perez
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Efficacy of Pirfenidone in the Context of Multiple Disease Progression Events in Patients With Idiopathic Pulmonary Fibrosis
Chest, ISSN: 19313543 00123692
Steven D Nathan; Ulrich Costabel; Ian Glaspole; Marilyn K Glassberg; Lisa H Lancaster; David J. Lederer; Carlos A Pereira; Benjamin L. Trzaskoma; Elizabeth A. Morgenthien; Susan L. Limb; Athol Wells
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New tools for pathology: a user's review of a highly multiplexed method for in situ analysis of protein and RNA expression in tissue
Journal of Pathology, ISSN: 10969896 00223417
Jérémie Decalf; Matthew L. Albert; James Ziai
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