Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

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February 14, 2019

Trastuzumab emtansine for residual invasive HER2-positive breast cancer

New England Journal of Medicine, ISSN: 15334406 00284793

Gunter Von Minckwitz; Chiun-Sheng Huang; Max Mano; Sibylle Loibl; Eleftherios P. Mamounas; Untch; Norman Wolmark; Priya Rastogi; Andreas Schneeweiss; Andres Redondo; Hans H. Fischer; William Jacot; Alison K. Conlin; Claudia Arce-Salinas; Irene L. Wapnir; Christian Jackisch; Michael P. DiGiovanna; Peter A. Fasching; John Crown; Pia Wülfing; Zhimin Shao; Elena Rota Caremoli; Haiyan Wu; Lisa H. Lam; David Tesarowski; Melanie Smitt; Hannah Douthwaite; Stina M. Singel; Charles E. Geyer Jr.

February 11, 2019

Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy

Cancer Cell, ISSN: 18783686 15356108

Tuba N. Gide; Camelia Quek; Alexander M. Menzies; Annie T. Tasker; Ping Shang; Jeff Holst; Jason Madore; Su Yin Lim; Rebecca Velickovic; Matthew Wongchenko; Yibing Yan; Serigne Lo; Matteo S. Carlino; Alexander Guminski; Robyn P.M. Saw; Angel Pang; Helen M. McGuire; Umaimainthan Palendira; John F. Thompson; Helen Rizos; Ines Pires da Silva; Marcel Batten; Richard A. Scolyer; Georgina V. Long; James S. Wilmott

February 11, 2019

Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease

Acta Neuropathologica, ISSN: 14320533 00016322

Claudia Cicognola; Gunnar Brinkmalm; Jessica Wahlgren; Erik Portelius; Johan Gobom; Nicholas C. Cullen; Oskar Hansson; Lucilla Parnetti; Radu Constantinescu; Kristin R. Wildsmith; Hsu-Hsin Chen; Thomas G. Beach; Tammaryn Lashley; Henrik Zetterberg; Kaj Blennow; Kina Höglund

February 7, 2019

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

Cell, ISSN: 10974172 00928674

Hui Xu; Tianbo Li; Alexis Rohou; Christopher P. Arthur; Foteini Tzakoniati; Evera Wong; Alberto Estevez; Christine Kugel; Yvonne Franke; Jun Chen; Claudio Ciferri; David Hackos; Christopher M. Koth; Jian Payandeh

February 5, 2019

Multi-arm PEG-maleimide conjugation intermediate characterization and hydrolysis study by a selective HPLC method

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Jennifer Wang; Samuel H. Yang; Kelly Zhang

February 5, 2019

Enabling genome-wide association testing with multiple diseases and no healthy controls

Gene, ISSN: 18790038 03781119

Jennifer A. Tom; Diana Chang; Arthur Wuster; Kiran Mukhyala; Karen T. Cuenco; Amy Cowgill; Jan Vogel; Jens Reeder; Brian L. Yaspan; Julie Hunkapiller; Matthew J. Brauer; Timothy W. Behrens; William F. Forrest; Tushar Bhangale

February 5, 2019

Population pharmacokinetic and covariate analyses of intravenous trastuzumab (Herceptin ® ), a HER2-targeted monoclonal antibody, in patients with a variety of solid tumors

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Angelica Quartino; Hanbin Li; Whitney P. Kirschbrown; Ranvir Mangat; D. Russell Wada; Amit Garg; Jin Y. Jin; Bert L. Lum

February 5, 2019

Supercritical fluid chromatography-tandem mass spectrometry for high throughput bioanalysis of small molecules in drug discovery

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Xiaolin Zhang; Xiao Ding; Jianshuang Wang; Brian J. Dean

February 1, 2019

MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage

Nature Metabolism, ISSN: 25225812

Pedro Sousa-Victor; Joana Neves; Wendy Cedron-Craft; P. Britten Ventura; Chen-Yu Liao; Rebeccah Riley; Ilya Soifer; Nicholas Van Bruggen; Ganesh Kolumam; Saul A. Villeda; Deepak A. Lamba; Heinrich Jasper

February 1, 2019

Correction: Rheumatoid arthritis-interstitial lung disease in the United States: Prevalence, incidence, and healthcare costs and mortality (Journal of Rheumatology (2018))

Journal of Rheumatology, ISSN: 14992752 0315162X

Karina Raimundo; Joshua J. Solomon; Amy L. Olson; Amanda M. Kong; Ashley L. Cole; Aryeh Fischer; Jeffrey J. Swigris

February 1, 2019

Comparative Effectiveness of Non-cisplatin First-line Therapies for Metastatic Urothelial Carcinoma: Phase 2 IMvigor210 Study Versus US Patients Treated in the Veterans Health Administration

European Urology Oncology, ISSN: 25889311

Nancy Vander Velde; Annie Guérin; Raluca Ionescu-Ittu; Sherry Shi; Eric Q. Wu; Shih Wen Lin; Ling-I Hsu; Kai-Uwe Saum; Sabine de Ducla; Jingjing Wang; Shi Li; AnnChristine Thåström; Shuqian Liu; Lizheng Shi; John T. Leppert

February 1, 2019

Correlation of cytomegalovirus (CMV) disease severity and mortality with CMV viral burden in CMV-seropositive donor and CMV-seronegative solid organ transplant recipients

Open Forum Infectious Diseases, ISSN: 23288957

Jacqueline McBride; Daniel Sheinson; Jenny Jiang; Nicholas Lewin-Koh; Barbara G. Werner; Jennifer K.L. Chow; Xiaoning Wu; Jorge A. Tavel; David R. Snydman

February 1, 2019

Evaluation of polysaccharide-based chiral stationary phases in modern SFC-MS/MS for enantioselective bioanalysis

Bioanalysis, ISSN: 17576199 17576180

Liuxi Chen; Brian J. Dean; Xiaorong Liang

February 1, 2019

MYOD1 functions as a clock amplifier as well as a critical co-factor for downstream circadian gene expression in muscle

eLife, ISSN: 2050084X

Brian A. Hodge; Xiping Zhang; Miguel A. Gutierrez-Monreal; Yi Cao; David W. Hammers; Zizhen Yao; Christopher A. Wolff; Ping Du; Denise Kemler; Andrew R. Judge; Karyn A. Esser

February 1, 2019

Phase I study of the anti-FcRH5 antibody-drug conjugate DFRF4539A in relapsed or refractory multiple myeloma

Blood Cancer Journal, ISSN: 20445385

A. Keith Stewart; Amrita Y. Krishnan; Seema Singhal; Ralph V. Boccia; Manish R. Patel; Ruben Niesvizky; Chanan-Khan; Sikander Ailawadhi; Jochen Brumm; Kirsten E. Mundt; Kyu Hong; Jacqueline McBride; Quyen Shon-Nguyen; Yuanyuan Xiao; Vanitha Ramakrishnan; Andrew G. Polson; Divya Samineni; Douglas Leipold; Eric W. Humke; James Scott McClellan; Jesus G. Berdeja

February 1, 2019

Targeting IL-10 family cytokines for the treatment of human diseases

Cold Spring Harbor Perspectives in Biology, ISSN: 19430264

Xiaoting Wang; Kit Wong; Wenjun Ouyang; Sascha Rutz

February 1, 2019

Fixed duration of venetoclax-rituximab in relapsed/refractory chronic lymphocytic leukemia eradicates minimal residual disease and prolongs survival: Post-treatment follow-up of the Murano phase III study

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Kater; John F. Seymour; Hillmen; Barbara Eichhorst; Anton W. Langerak; Carolyn J. Owen; Maria Verdugo; Jenny Q. Wu; Elizabeth A. Punnoose; Yanwen Jiang; Jue Wang; Michelle Boyer; Kathryn Humphrey; Mehrdad Mobasher; Thomas J. Kipps

February 1, 2019

TET2-dependent hydroxymethylome plasticity reduces melanoma initiation and progression

Cancer Research, ISSN: 15387445 00085472

Elise Bonvin; Enrico Radaelli; Martin Bizet; Flavie Luciani; Emilie Calonne; Pascale Putmans; David Nittner; Nitesh Kumar Singh; Sara F. Santagostino; Valerie Petit; Lionel Larue; Jean-Christophe Marine; François Fuks

February 1, 2019

Randomized phase II study evaluating AKT blockade with ipatasertib, in combination with abiraterone, in patients with metastatic prostate cancer with and without PTEN loss

Clinical Cancer Research, ISSN: 15573265 10780432

De Bono; Ugo De Giorgi; Daniel Nava Rodrigues; Christophe Massard; Sergio Bracarda; Albert Font; Jose Angel Arranz Arija; Kent Shih; George Daniel Radavoi; Xu; Wai Y. Chan; Han Ma; Steven Gendreau; Ruth Riisnaes; Premal Patel; Daniel Maslyar; Viorel Jinga

February 1, 2019

Real-world use of bevacizumab in metastatic colorectal, metastatic breast, advanced ovarian and cervical cancer:A systematic literature review

Future Oncology, ISSN: 17448301 14796694

Sherif Raouf; Gianfilippo Bertelli; Agnes Ograbek; Polly Field; Irwin Tran

February 1, 2019

Second-line and subsequent therapy and outcomes for follicular lymphoma in the United States: data from the observational National LymphoCare Study

British Journal of Haematology, ISSN: 13652141 00071048

Brian K. Link; Bann-Mo Day; Zhou; Zelenetz; Keith Dawson; James R. Cerhan; Christopher R. Flowers; Jonathan W. Friedberg

February 1, 2019

TomahaqCompanion: A Tool for the Creation and Analysis of Isobaric Label Based Multiplexed Targeted Assays

Journal of Proteome Research, ISSN: 15353907 15353893

Christopher M. Rose; Brian K. Erickson; Devin K. Schweppe; Rosa Viner; Jae Choi; John Rogers; Ryan Bomgarden; Steven P. Gygi; Donald S. Kirkpatrick

February 1, 2019

Multiethnic genome-wide association study of diabetic retinopathy using liability threshold modeling of duration of diabetes and glycemic control

Diabetes, ISSN: 1939327X 00121797

Samuela Pollack; Robert P. Igo; Richard A. Jensen; Mark Christiansen; Xiaohui Li; Ching-Yu Cheng; Maggie C. Y. Ng; Albert V Smith; Elizabeth Rossin; Ayellet V. Segrè; Samaneh Davoudi; Gavin S. Tan; Yii-Der Ida Chen; Jane Z. Kuo; Latchezar M. Dimitrov; Lynn K. Stanwyck; Weihua Meng; S. Mohsen Hosseini; Minako Imamura; Darryl Nousome; Jihye Kim; Yang Hai; Yucheng Jia; Jeeyun Ahn; Aaron Leong; Kaanan Shah; Kyu Hyung Park; Xiuqing Guo; Eli Ipp; Kent D. Taylor; Sharon G. Adler; John R. Sedor; Barry I. Freedman; I-Te Lee; Wayne H.-H. Sheu; Michiaki Kubo; Atsushi Takahashi; Samy Hadjadj; Michel Marre; David-Alexandre Trégouët; Roberta Mckean-Cowdin; Rohit Varma; Mark I. McCarthy; Leif Groop; Emma Ahlqvist; Valeriya Lyssenko; Elisabet Agardh; Andrew Morris; Alex S F Doney; Helen M. Colhoun; Iiro Toppila; Niina Sandholm; Per-Henrik Groop; Shiro Maeda; Craig L. Hanis; Alan Penman; Ching J. Chen; Heather Hancock; Paul Mitchell; Jamie E. Craig; Emily Y. Chew; Andrew D. Paterson; Michael A. Grassi; Colin Palmer; Donald W. Bowden; Brian L. Yaspan; David Siscovick; Mary Frances Cotch; Jie Jin Wang; Kathryn P. Burdon; Andrew K. Wong; Barbara E.K. Klein; Ronald Klein; Jerome I. Rotter; Sudha K. Iyengar; Alkes L. Price; Lucia Sobrin

February 1, 2019

A phase II, randomised study of mFOLFOX6 with or without the Akt inhibitor ipatasertib in patients with locally advanced or metastatic gastric or gastroesophageal junction cancer

European Journal of Cancer, ISSN: 18790852 09598049

Bang; Yoon-Koo Kang; Ng; Hyun Cheol Chung; Zev A. Wainberg; Steven Gendreau; Wai Y. Chan; Xu; Daniel Maslyar; Raymond D. Meng; Chau; Jaffer A. Ajani

February 1, 2019

Atezolizumab in patients with advanced non-small cell lung cancer and history of asymptomatic, treated brain metastases: Exploratory analyses of the phase III OAK study

Lung Cancer, ISSN: 18728332 01695002

Shirish M. Gadgeel; Rimas V. Lukas; Jerome H Goldschmidt; Paul Conkling; Keunchil Park; Diego L Cortinovis; Filippo De Marinis; Achim Rittmeyer; Jyoti D. Patel; Joachim Von Pawel; Carol E. O'Hear; Catherine Lai; Hu; Ballinger; Alan Sandler; Mayank Gandhi; Louis Fehrenbacher

February 1, 2019

Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Heleen Scheerens; Ashley Smith; Olga Li; Lee Honigberg; Harris; Gabriële Holtappels; Claus Bachert

February 1, 2019

Ribonucleoprotein Transfection for CRISPR/Cas9-Mediated Gene Knockout in Primary T Cells

Current Protocols in Immunology, ISSN: 1934368X 19343671

Soyoung A. Oh; Akiko Seki; Sascha Rutz

February 1, 2019

Impact of Method of Preparation of Amorphous Solid Dispersions on Mechanical Properties: Comparison of Coprecipitation and Spray Drying

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Hao Helen Hou; Aniruddha Rajesh; Keyur Pandya; Joseph W. Lubach; Ariel Muliadi; Edward Yost; Wei Jia; Karthik Nagapudi

February 1, 2019

A PK/PD Analysis of Circulating Biomarkers and Their Relationship to Tumor Response in Atezolizumab-Treated non-small Cell Lung Cancer Patients

Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236

Ida Netterberg; Chi-Chung Li; Luciana L. Molinero; Nageshwar Budha; Siddharth Sukumaran; Mark Stroh; E. Niclas Jonsson; Lena E. Friberg

February 1, 2019

Previously reported placebo-response-associated variants do not predict patient outcomes in inflammatory disease Phase III trial placebo arms

Genes and Immunity, ISSN: 14765470 14664879

Asher Haug-Baltzell; Tushar Bhangale; Diana Chang; Amy Dressen; Brian L. Yaspan; Ward Ortmann; Matthew J. Brauer; Julie Hunkapiller; Jens Reeder; Kiran Mukhyala; Karen T. Cuenco; Jennifer A. Tom; Amy Cowgill; Jan Vogel; William F. Forrest; Timothy W. Behrens; Robert R. Graham; Arthur Wuster

February 1, 2019

Development of a PD-L1 Complementary Diagnostic Immunohistochemistry Assay (SP142) for Atezolizumab

Applied Immunohistochemistry and Molecular Morphology, ISSN: 15334058 15412016

Bharathi Vennapusa; Brian Baker; Marcin Kowanetz; Jennifer Boone; Ina Menzl; Jean-Marie Bruey; Gregg D. Fine; Sanjeev Mariathasan; Ian McCaffery; Mocci; Sandra Rost; Dustin Smith; Eslie Dennis; Szu-Yu Tang; Bita Damadzadeh; Espen Walker; Priti Hegde; Williams; Koeppen; Zachary Boyd

February 1, 2019

Clinicopathologic Correlation of Aneurysmal Type 1 Neovascularization in Age-Related Macular Degeneration

Kidney International Reports, ISSN: 24686530

Miaoling Li; Rosa Dolz-Marco; Jeffrey D. Messinger; Kenneth R. Sloan; Daniela Ferrara; Christine A. Curcio; K. Bailey Freund

January 25, 2019

Multiple-gene targeting and mismatch tolerance can confound analysis of genome-wide pooled CRISPR screens

Genome Biology, ISSN: 1474760X 14747596

Jean-Philippe Fortin; Jenille Tan; Karen Gascoigne; Peter M. Haverty; William F. Forrest; Michael Costa; Scott E. Martin

January 24, 2019

Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (Na V ) 1.7 with Potent Analgesic Activity

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Shaoyi Sun; Qi Jia; Alla Zenova; Michael S. Wilson; Sultan Chowdhury; Thilo Focken; Jun Li; Shannon M. Decker; Michael Grimwood; Jean-Christophe Andrez; Ivan Hemeon; Tao Sheng; Chien-An Chen; Andrew D. White; David Hackos; Lunbin Deng; Girish Bankar; Kuldip Khakh; Elaine Chang; Rainbow Kwan; Sophia Lin; Karen Nelkenbrecher; Benjamin D. Sellers; Antonio G. DiPasquale; Jae H. Chang; Jodie Pang; Luis E. Sojo; Andrea Lindgren; Matthew Waldbrook; Zhiwei Xie; Clint Young; Johnson; C. Lee Robinette; Charles J. Cohen; Brian S. Safina; Daniel P. Sutherlin; Daniel F. Ortwine; Christoph Dehnhardt

January 21, 2019

CCNE1 amplification is associated with poor prognosis in patients with triple negative breast cancer

BMC Cancer, ISSN: 14712407

Zi-Ming Zhao; Susan E. Yost; Katherine E. Hutchinson; Sierra Min Li; Yate-Ching Yuan; Javad Noorbakhsh; Zheng Liu; Charles Warden; Johnson; Xiwei Wu; Jeffrey H. Chuang; Yuan Yuan

January 18, 2019

Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp 3 -sp 2 Suzuki Coupling of a Benzyl Carbonate

Organic Process Research and Development, ISSN: 1520586X 10836160

Lauren E. Sirois; Matthew M. Zhao; Ngiap-Kie Lim; Mark S. Bednarz; Bryce A. Harrison; Wenxue Wu

January 16, 2019

Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies

Bioconjugate Chemistry, ISSN: 15204812 10431802

Nicholas Vance; Neelie Zacharias; Ultsch; Guangmin Li; Aimee Fourie; Peter S. Liu; Julien Lafrance-Vanasse; James A. Ernst; Wendy N. Sandoval; Katherine R. Kozak; Gail L. Phillips; Weiru Wang; Jack D. Sadowsky

January 14, 2019

Study of a Competing Hydrodefluorination Reaction during the Directed ortho-Lithiation/Borylation of 2-Fluorobenzaldehyde

Organometallics, ISSN: 15206041 02767333

Frederic St-Jean; Katarzyna A. Piechowicz; Lauren E. Sirois; Remy Angelaud; Francis Gosselin

January 14, 2019

Directed Cp Rh III -Catalyzed Fluorosulfonylvinylation of Arenes

Organometallics, ISSN: 15206041 02767333

Gqwetha Ncube; Malcolm P. Huestis

January 11, 2019

Fatty acid recognition in the Frizzled receptor family

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Aaron H Nile; Rami N. Hannoush

January 9, 2019

Regio- and Enantioselective Iridium-Catalyzed Amination of Racemic Branched Alkyl-Substituted Allylic Acetates with Primary and Secondary Aromatic and Heteroaromatic Amines

Journal of the American Chemical Society, ISSN: 15205126 00027863

Seung Wook Kim; Leyah A. Schwartz; Jason R. Zbieg; Craig E. Stivala; Michael J. Krische

January 8, 2019

Why Computed Protein Folding Landscapes Are Sensitive to the Water Model

Journal of Chemical Theory and Computation, ISSN: 15499626 15499618

Ramu Anandakrishnan; Saeed Izadi; Alexey V. Onufriev

January 8, 2019

Baseline characteristics associated with early visual acuity gains after ranibizumab treatment for retinal vein occlusion

BMC Ophthalmology, ISSN: 14712415

W. Lloyd Clark; Mimi Liu; John Kitchens; Pin-Wen Wang; Zdenka Haskova

January 7, 2019

A phase I, randomized, observer-blinded, single and multiple ascending-dose study to investigate the safety, pharmacokinetics, and immunogenicity of BITS7201A, a bispecific antibody targeting IL-13 and IL-17, in healthy volunteers 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology

BMC Pulmonary Medicine, ISSN: 14712466

Tracy Staton; Kun Peng; Ryan Owen; David F. Choy; Christopher R. Cabanski; Alice Fong; Flavia Brunstein; Kathila R. Alatsis; Hubert Chen

January 7, 2019

In Situ Characterization of the Microstructural Evolution of Biopharmaceutical Solid-State Formulations with Implications for Protein Stability

Molecular Pharmaceutics, ISSN: 15438392 15438384

Stijn H.S. Koshari; Purnendu K. Nayak; Shalini Burra; Isidro E. Zarraga; Karthikan Rajagopal; Yun Liu; Norman J. Wagner; Abraham M. Lenhoff

January 7, 2019

Trehalose Limits Fragment Antibody Aggregation and Influences Charge Variant Formation in Spray-Dried Formulations at Elevated Temperatures

Molecular Pharmaceutics, ISSN: 15438392 15438384

Karthikan Rajagopal; Debby P. Chang; Purnendu K. Nayak; Saeed Izadi; Thomas W. Patapoff; Jennifer Zhang; Robert F. Kelley; Alavattam Sreedhara

January 7, 2019

In Vivo Stability Profiles of Anti-factor D Molecules Support Long-Acting Delivery Approaches

Molecular Pharmaceutics, ISSN: 15438392 15438384

Kelly M. Loyet; Hass; Wendy N. Sandoval; Ashley Morando; Peter S. Liu; Whitney Shatz; Leslie Dickmann; Margaret Kenrick; Jeremy Good; Teresa Davancaze; Alyssa M. Morimoto; Robert F. Kelley; Justin M. Scheer

January 5, 2019

Seeking universal detectors for analytical characterizations

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Kelly Zhang; Kenji L. Kurita; Venkatramani; David J. Russell

January 4, 2019

Macrolactamization Approaches to Arylomycin Antibiotics Core

Organic Letters, ISSN: 15237052 15237060

Ngiap-Kie Lim; Xin Linghu; Nicholas Wong; Haiming Zhang; C. Gregory Sowell; Francis Gosselin

January 4, 2019

Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury

Science, ISSN: 10959203 00368075

Oliver J. Harrison; Jonathan L. Linehan; Han-Yu Shih; Nicolas Bouladoux; Seong-Ji Han; Margery Smelkinson; Shurjo K. Sen; Allyson L. Byrd; Michel Enamorado; Chen Yao; Samira Tamoutounour; Francois Van Laethem; Charlotte Hurabielle; Nicholas Collins; Andrea Paun; Rosalba Salcedo; John J. O'Shea; Yasmine Belkaid

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