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Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4001 - 4050 OF 15612 RESULTS

Therapeutic interleukin-6 blockade reverses transforming growth factor-beta pathway activation in dermal fibroblasts: Insights from the faSScinate clinical trial in systemic sclerosis
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Christopher P. Denton; Voon H Ong; Shiwen Xu; Haiyin Chen-Harris; Zora Modrusan; Robert Lafyatis; Dinesh Khanna; Angelika Jahreis; Jeffrey N. Siegel; Thierry Sornasse
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A Pharmacometric Approach to Substitute for a Conventional Dose-Finding Study in Rare Diseases: Example of Phase III Dose Selection for Emicizumab in Hemophilia A
Clinical Pharmacokinetics, ISSN: 11791926 03125963
Koichiro Yoneyama; Christophe Schmitt; Naoki Kotani; Gallia Levy; Ryu Kasai; Satofumi Iida; Midori Shima; Takehiko Kawanishi
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Analytical Validation of a Hybrid Capture–Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA
Journal of Molecular Diagnostics, ISSN: 19437811 15251578
Travis Clark; Jon H. Chung; Mark Kennedy; Jason D. Hughes; Niru Chennagiri; Daniel S. Lieber; Bernard Fendler; Lauren Young; Mandy Zhao; Michael Coyne; Virginia Breese; Geneva Young; Amy Donahue; Dean Pavlick; Alyssa Tsiros; Timothy Brennan; Shan Zhong; Tariq Mughal; Mark Bailey; Jie He; Steven Roels; Garrett M Frampton; Jill M. Spoerke; Steven Gendreau; Lackner; Erica Schleifman; Peters; Jeffrey S. Ross; Siraj M. Ali; Vincent A. Miller; Jeffrey P. Gregg; Phillip J. Stephens; Allison Welsh; Geoff A. Otto; Doron Lipson
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Development of a mass spectrometry-based tryptophan 2, 3-dioxygenase assay using liver cytosol from multiple species
Analytical Biochemistry, ISSN: 10960309 00032697
Jing Wang; Ryan Takahashi; Kevin Dement; Amy Gustafson; Jane R. Kenny; Simon Wong; Zhengyin Yan
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The Border of Macular Atrophy in Age-Related Macular Degeneration: A Clinicopathologic Correlation
American Journal of Ophthalmology, ISSN: 18791891 00029394
Rosa Dolz-Marco; Chandrakumar Balaratnasingam; Jeffrey D. Messinger; Miaoling Li; Daniela Ferrara; K. Bailey Freund; Christine A. Curcio
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Emicizumab prophylaxis in patients who have hemophilia a without inhibitors
New England Journal of Medicine, ISSN: 15334406 00284793
Johnny N. Mahlangu; Johannes Oldenburg; Paz-Priel; Claude Negrier; Markus Niggli; Mancuso; Christophe Schmitt; Jiménez-Yuste; Kempton; Dhalluin; Michael U. Callaghan; Bujan; Midori Shima; Adamkewicz; Elina Asikanius; Gallia Levy; Kruse-Jarres
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An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor
Cell, ISSN: 10974172 00928674
Nadia Martinez-Martin; Jessica Marcandalli; Christine S. Huang; Christopher P. Arthur; Michela Perotti; Mathilde Foglierini; Hoangdung Ho; Annie M. Dosey; Stephanie K. Shriver; Jian Payandeh; Alexander Leitner; Antonio Lanzavecchia; Laurent Perez; Claudio Ciferri
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Gut-selective integrin-targeted therapies for inflammatory bowel disease
Journal of Crohn's and Colitis, ISSN: 18764479 18739946
Christopher A. Lamb; Sharon O'Byrne; Mary E. Keir; Eugene C. Butcher
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Kinase domain dimerization drives RIPK3-dependent necroptosis
Science Signaling, ISSN: 19379145 19450877
Saravanan Raju; Daniel M. Whalen; Meron Mengistu; Carter J. Swanson; John Quinn; Taylor; Webster; Kim Newton; Andrey S. Shaw
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Development of an Efficient Manufacturing Process for Reversible Bruton's Tyrosine Kinase Inhibitor GDC-0853
Organic Process Research and Development, ISSN: 1520586X 10836160
Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Qingping Tian; Danial Beaudry; Jessica L. Defreese; Alec Fettes; Philippe James; David Linder; Sushant Malhotra; Chong Han; Remy Angelaud; Francis Gosselin
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Extracellular vesicles in DLBCL provide abundant clues to aberrant transcriptional programming and genomic alterations
Blood, ISSN: 15280020 00064971
Sarah C. Rutherford; Angela A. Fachel; Sheng Li; Seema Sawh; Ashlesha Muley; Jennifer Ishii; Ashish Saxena; Pilar M. Dominguez; Eloisi Caldas Lopes; Xabier Agirre; Nyasha Chambwe; Fabian Correa; Yanwen Jiang; Kristy L. Richards; Doron Betel; Rita Shaknovich
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Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate
Molecular Cell, ISSN: 10974164 10972765
Tsun-Kai Chang; David Lawrence; Min Lu; Jenille Tan; Jonathan M. Harnoss; Scot A. Marsters; Peter S. Liu; Wendy N. Sandoval; Scott E. Martin; Avi Ashkenazi
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ERK Mutations and amplification confer resistance to ERK-inhibitor therapy
Clinical Cancer Research, ISSN: 15573265 10780432
Bijay S. Jaiswal; Durinck; Eric Stawiski; Jianping Yin; Weiru Wang; Eva Lin; John Moffat; Scott E. Martin; Zora Modrusan; Somasekar Seshagiri
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Facile quantitation of free thiols in a recombinant monoclonal antibody by reversed-phase high performance liquid chromatography with hydrophobicity-tailored thiol derivatization
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Leslie Welch; Xiao Dong; Daniel Hewitt; Michelle Irwin; Luke McCarty; Christina Tsai; Tomasz K. Baginski
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Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation
Cell Reports, ISSN: 22111247
Ryan Raisner; Samir Kharbanda; Lingyan Jin; Edwin Jeng; Emily Chan; Mark Merchant; Matthias Peter; Russell Bainer; Tommy K. Cheung; David Arnott; E. Megan Flynn; F. Anthony Romero; Steven Magnuson; Karen Gascoigne
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Reply to J.J. Tao et al
Journal of Clinical Oncology, ISSN: 15277755 0732183X
John Hainsworth; Funda Meric-Bernstam; Charles Swanton; Herbert Hurwitz; David Spigel; Christopher J. Sweeney; Howard A. Burris; Ron Bose; Bongin Yoo; Alisha Stein; Beattie; Razelle Kurzrock
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Scaffold-Hopping Approach to Discover Potent, Selective, and Efficacious Inhibitors of NF-ΰB Inducing Kinase
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Nicole Blaquiere; Georgette M. Castanedo; Jason D. Burch; Leonid M. Berezhkovskiy; Hans D. Brightbill; Suzanne Brown; Connie Chan; Po-Chang Chiang; James J. Crawford; Teresa Dong; Peter W. Fan; Jianwen A. Feng; Nico Ghilardi; Robert Godemann; Emily Gogol; Alice Grabbe; Alison J. Hole; Baihua Hu; Sarah G. Hymowitz; Moulay Hicham Alaoui Ismaili; Hoa Le; Patrick Lee; Wyne P. Lee; Xingyu Lin; Ning Liu; Paul A. McEwan; Brent Mckenzie; Hernani L. Silvestre; Eric Suto; Swathi Sujatha-Bhaskar; Guosheng Wu; Lawren C. Wu; Yamin Zhang; Zoe Zhong; Steven T. Staben
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The Effect of Low Ionic Strength on Diffusion and Viscosity of Monoclonal Antibodies
Molecular Pharmaceutics, ISSN: 15438392 15438384
Mariya Pindrus; Steven J. Shire; Sandeep Yadav; Devendra S. Kalonia
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Novel markers to track oxidative polysorbate degradation in pharmaceutical formulations
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Sanket Dahotre; Anthony Tomlinson; Baiwei Lin; Sandeep Yadav
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Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease
Nephrology Dialysis Transplantation, ISSN: 14602385 09310509
Irfana Soomro; Ying Sun; Zhai Li; Lonnette Diggs; Georgia Hatzivassiliou; Ajit G. Thomas; Rana Rais; Slusher; Stefan Somlo; Edward Y. Skolnik
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Comments on assays used to measure VEGF in the presence of anti-VEGF therapeutics
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Eric Wakshull; Robert L. Avery; Mauricio Maia
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Validation of a plasma-based comprehensive cancer genotyping assay utilizing orthogonal tissue- and plasma-based methodologies
Clinical Cancer Research, ISSN: 15573265 10780432
Justin I. Odegaard; John J. Vincent; Stefanie Mortimer; James V. Vowles; Bryan C. Ulrich; Kimberly C. Banks; Stephen R. Fairclough; Oliver A. Zill; Marcin Sikora; Reza Mokhtari; Diana Abdueva; Rebecca J. Nagy; Christine E. Lee; Lesli A. Kiedrowski; Cloud P. Paweletz; Helmy Eltoukhy; Richard Lanman; Darya I. Chudova; Talasaz
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Prevention of Fatal C3 Glomerulopathy by Recombinant Complement Receptor of the Ig Superfamily
Journal of the American Society of Nephrology, ISSN: 15333450 10466673
Xiaoxu Wang; Menno Van Lookeren Campagne; Kenneth J. Katschke Jr.; Damodar Gullipalli; Takashi Miwa; Yoshiyasu Ueda; Yuan Wang; Matthew Palmer; Guolan Xing; Wen-Chao Song
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Sustained Response Following Discontinuation of Methotrexate in Patients With Rheumatoid Arthritis Treated With Subcutaneous Tocilizumab: Results From a Randomized, Controlled Trial
Arthritis and Rheumatology, ISSN: 23265205 23265191
Joel M. Kremer; William F. Rigby; Nora G. Singer; Christine Birchwood; Darcy Gill; William Reiss; Jinglan Pei; Margaret Michalska
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Updated Efficacy Analysis Including Secondary Population Results for OAK: A Randomized Phase III Study of Atezolizumab versus Docetaxel in Patients with Previously Treated Advanced Non–Small Cell Lung Cancer
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Louis Fehrenbacher; Joachim Von Pawel; Keunchil Park; Achim Rittmeyer; David R. Gandara; Santiago Ponce Aix; Ji-Youn Han; Shirish M. Gadgeel; Toyoaki Hida; Diego L Cortinovis; Manuel Cobo; Dariusz M Kowalski; Filippo De Marinis; Mayank Gandhi; Bradford Danner; Christina Matheny; Marcin Kowanetz; Pei He; Federico Felizzi; Hina Patel; Alan Sandler; Ballinger; Fabrice Barlesi
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Effect of pirfenidone on gastric emptying in a rat model
Pulmonary Pharmacology and Therapeutics, ISSN: 15229629 10945539
Lin Pan; Thomas R. Gelzleichter; Yuan Chen; Cindy Burg; Susan L. Limb; Linda Nguyen
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Prognostic and predictive biomarkers for patients with idiopathic pulmonary fibrosis treated with pirfenidone: post-hoc assessment of the CAPACITY and ASCEND trials
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Margaret Neighbors; Christopher R. Cabanski; Thirumalai R. Ramalingam; X Rebecca Sheng; Tew; Chunyan Gu; Guiquan Jia; Kun Peng; Jill M. Ray; Brett Ley; Paul J. Wolters; Harold R. Collard; Joseph R. Arron
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Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress
Cell Death and Differentiation, ISSN: 14765403 13509047
Mable Lam; David Lawrence; Avi Ashkenazi; Peter Walter
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Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Digoxin in Patients With BRAFV600 Mutation–Positive Metastatic Malignancy
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Weijiang Zhang; Christine McIntyre; Melissa Kuhn; Harper Forbes; Kim; Jeeyun Lee; Lev Demidov; Dawn Colburn
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Corrigendum to ‘Effects of RG7652, a Monoclonal Antibody Against PCSK9, on Low-Density Lipoprotein Cholesterol (LDL-C), LDL-C Subfractions, and Inflammatory Biomarkers in Patients at High Risk of or with Established Coronary Heart Disease (From the Phase 2 EQUATOR Study)’ (The American Journal of Cardiology (2017) 119(10) (1576–1583), (S0002914917302060) (10.1016/j.amjcard.2017.02.020))
American Journal of Cardiology, ISSN: 18791913 00029149
Amos Baruch; Mosesova; John Davis; Nageshwar Budha; Alexandr Vilimovskij; Robert S. Kahn; Kun Peng; Kyra J. Cowan; Laura Pascasio Harris; Thomas R. Gelzleichter; Josh Lehrer; John C. Davis; Whittemore G. Tingley
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Alteplase for the treatment of acute ischemic stroke in patients with low National Institutes of Health Stroke Scale and not clearly disabling deficits (Potential of rtPA for Ischemic Strokes with Mild Symptoms PRISMS): Rationale and design
International Journal of Stroke, ISSN: 17474949 17474930
Sharon D. Yeatts; Joseph P. Broderick; Anjan Chatterjee; Edward C Jauch; Steven R. Levine; Jose G Romano; Jeffrey L. Saver; Achala Vagal; Barbara Purdon; Jenny Devenport; Pooja Khatri
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Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Amy Dressen; Abbas Alexander; Christopher R. Cabanski; Janina Reeder; Thirumalai R. Ramalingam; Margaret Neighbors; Tushar Bhangale; Matthew J. Brauer; Julie Hunkapiller; Jens Reeder; Kiran Mukhyala; Karen T. Cuenco; Jennifer A. Tom; Amy Cowgill; Jan Vogel; William F. Forrest; Harold R. Collard; Paul J. Wolters; Jonathan A Kropski; Lisa H Lancaster; Timothy S. Blackwell; Joseph R. Arron; Brian L. Yaspan
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Characterization and survival of patients with metastatic basal cell carcinoma in the Department of Veterans Affairs: a retrospective electronic health record review
Archives of Dermatological Research, ISSN: 1432069X 03403696
Vanessa W. Stevens; David D. Stenehjem; Olga V. Patterson; Kamauu; Yeun Mi Yim; Rob Morlock; Scott L. Duvall
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Phase I study of the anti-α5β1 monoclonal antibody MINT1526A with or without bevacizumab in patients with advanced solid tumors
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Colin D. Weekes; Lee Rosen; Anna Capasso; Kit Man Wong; Weilan Ye; Maria Anderson; Bruce Mccall; Jill Fredrickson; Eric Wakshull; Stephen M. Eppler; Quyen Shon-Nguyen; Rupal Desai; Mahrukh Huseni; Priti Hegde; Tony Pourmohamad; Ina Rhee; Alberto Bessudo
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Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Navpreet Kaur; Ajit S. Narang; Arvind Kumar Bansal
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Adsorption of polysorbate 20 and proteins on hydrophobic polystyrene surfaces studied by neutron reflectometry
Colloids and Surfaces B: Biointerfaces, ISSN: 18734367 09277765
Zhenhuan Zhang; Sara Orski; Ann Marie Woys; Guangcui Yuan; Isidro E. Zarraga; Norman J. Wagner; Yun Liu
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Considerations for the Use of Polysorbates in Biopharmaceuticals
Pharmaceutical Research, ISSN: 1573904X 07248741
Michael T. Jones; Hanns-Christian Mahler; Sandeep Yadav; Dilbir Bindra; Vincent Corvari; R. Matthew Fesinmeyer; Kapil Gupta; Alexander M. Harmon; Kenneth D. Hinds; Atanas Koulov; Wei Liu; Kevin Maloney; John Wang; Ping Y. Yeh; Satish K. Singh
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In vitro assessment of chemotherapy-induced neuronal toxicity
Toxicology in Vitro, ISSN: 18793177 08872333
Chelsea Snyder; Lanlan Yu; Tin Ngo; Daniel Sheinson; Yuda Zhu; Min Tseng; Misner; Karin Staflin
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LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis
Science, ISSN: 10959203 00368075
Poffenberger; Metcalfe-Roach; Aguilar; Chen; Hsu; Wong; Johnson; Flynn; Samborska; Ma; Gravel; Tonelli; Devorkin; Kim; Hall; Izreig; Loginicheva; Beauchemin; Siegel; Maxim N. Artyomov; Julian J. Lum; Zogopoulos; Blagih; Jones
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Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines
Genome Medicine, ISSN: 1756994X
Petar Scepanovic; Cécile Alanio; Christian Hammer; Flavia Hodel; Jacob Bergstedt; Etienne Patin; Christian W. Thorball; Nimisha Chaturvedi; Bruno Charbit; Laurent Abel; Lluis Quintana-Murci; Darragh Duffy; Matthew L. Albert; Jacques Fellay; Andres Alcover; Hugues Aschard; Philippe Bousso; Pierre Bruhns; Ana Cumano; Caroline Demangel; Ludovic Deriano; James P. Di Santo; Françoise Dromer; Gérard Eberl; Jost Enninga; Odile Gelpi; Ivo Gomperts-Boneca; Milena Hasan; Claude Leclerc; Hugo Mouquet; Sandra Pellegrini; Lars Rogge; Anavaj Sakuntabhai; Olivier Schwartz; Benno Schwikowski; Spencer Shorte; Frédéric Tangy; Marie-Noëlle Ungeheuer; Kalla Astrom; Serge Hercberg; Mathilde Touvier; Olivier Lantz; Vassili Soumelis; Stanislas Pol; Antonio Rausell; Eric Tartour; Antoine Toubert
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Serum periostin levels following small bone fractures, long bone fractures and joint replacements: An observational study
Allergy, Asthma and Clinical Immunology, ISSN: 17101492 17101484
Rachel Varughese; Ruth Semprini; Claire Munro; James Fingleton; Cécile T.J. Holweg; Mark Weatherall; Beasley; Irene Braithwaite
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Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation
eLife, ISSN: 2050084X
Ryan Ferrao; Heidi J. A. Wallweber; Patrick J. Lupardus
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Hydroamination versus Allylic Amination in Iridium-Catalyzed Reactions of Allylic Acetates with Amines: 1,3-Aminoalcohols via Ester-Directed Regioselectivity
Journal of the American Chemical Society, ISSN: 15205126 00027863
Seung Wook Kim; Thomas Wurm; Gilmar A. Brito; Woo-Ok Jung; Jason R. Zbieg; Craig E. Stivala; Michael J. Krische
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FRET Reagent Reveals the Intracellular Processing of Peptide-Linked Antibody-Drug Conjugates
Bioconjugate Chemistry, ISSN: 15204812 10431802
Byoung-Chul Lee; Cecile Chalouni; Sophia Doll; Nalle; Martine Darwish; Siao Ping Tsai; Katherine R. Kozak; Geoffrey Del Rosario; Shang-Fan Yu; Hans Erickson; Richard L. Vandlen
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A model of overall survival predicts treatment outcomes with atezolizumab versus chemotherapy in non–small cell lung cancer based on early tumor kinetics
Clinical Cancer Research, ISSN: 15573265 10780432
Laurent Claret; Jin Y. Jin; Charles Ferte; Helen Winter; Sandhya Girish; Mark Stroh; Pei He; Ballinger; Alan Sandler; Amita Joshi; Achim Rittmeyer; David R. Gandara; Jean-Charles Soria; Rene Bruno
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Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing
JCI insight, ISSN: 23793708
Omar H. Maarouf; Mayuko Uehara; Vivek Kasinath; Zhabiz Solhjou; Naima Banouni; Baharak Bahmani; Liwei Jiang; Osman A. Yilmam; Indira Guleria; Scott B. Lovitch; Jane L. Grogan; Paolo Fiorina; Peter T. Sage; Jonathan S. Bromberg; Martina M. McGrath; Reza Abdi
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Palladium-Catalyzed Site-Selective Amidation of Dichloroazines
Organic Letters, ISSN: 15237052 15237060
Ian S. Young; Anna-Lena Glass; Theresa Cravillion; Chong Han; Haiming Zhang; Francis Gosselin
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OTULIN limits cell death and inflammation by deubiquitinating LUBAC
Nature, ISSN: 14764687 00280836
Klaus D. Heger; Katherine E. Wickliffe; Ada Ndoja; Juan Zhang; Aditya Murthy; Dugger; Maltzman; Felipe de Sousa e Melo; Jeffrey Hung; Yi Zeng; Erik Verschueren; Donald S. Kirkpatrick; Domagoj Vucic; Wyne P. Lee; Merone Roose-Girma; Robert J. Newman; Søren Warming; Yi-Chun Hsiao; László Kömüves; Webster; Kim Newton; Vishva M. Dixit
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Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche
Nature, ISSN: 14764687 00280836
Ysbrand M. Nusse; Adam K. Savage; Pauline Marangoni; Axel K. M. Rosendahl-Huber; Tyler A. Landman; Frederic J. De Sauvage; Richard M. Locksley; Ophir D. Klein
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Interplay of DDP4 and IP-10 as a potential mechanism for cell recruitment to tuberculosis lesions
Frontiers in Microbiology, ISSN: 1664302X
Thomas Blauenfeldt; Linda Petrone; Franca del Nonno; Andrea Baiocchini; Laura Falasca; Teresa Chiacchio; Vincent Bondet; Valentina Vanini; Fabrizio Palmieri; Gianni Galluccio; Armanda Casrouge; Jesper Eugen-Olsen; Matthew L. Albert; Delia Goletti; Darragh Duffy; Morten Ruhwald
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