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DISPLAYING 4401 - 4450 OF 15603 RESULTS

Primary PFS and safety analyses of a randomized phase III study of carboplatin + paclitaxel +/− bevacizumab, with or without atezolizumab in 1L non-squamous metastatic nsclc (IMPOWER150)
Annals of Oncology, ISSN: 15698041 09237534
Martin Reck; Mark A. Socinski; Federico Cappuzzo; Orlandi; Stroyakovskii; Nogami; Rodriguez-Abreu; Moro-Sibilot; Thomas; Fabrice Barlesi; Finley; Kelsch; Lee; Coleman; Shen; Marcin Kowanetz; Ariel Lopez-Chavez; Alan Sandler; Jotte
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TGF-β signalling attenuates tumour response to PD-L1 checkpoint blockade by contributing to retention of T cells in the peritumoural stroma
Annals of Oncology, ISSN: 15698041 09237534
Sanjeev Mariathasan; Shannon J. Turley; Dorothee Nickles; Alessandra Castiglioni; Yuen; Wang; Edward E; Koeppen; Jillian L. Astarita; Rafael Cubas; Suchit Jhunjhunwala; Yang; Yasin Senbabaoglu; Michiel S Van Der Heijden; Yohann Loriot; Ira Mellman; Daniel S. Chen; Priti Hegde; Richard Bourgon; Thomas Powles
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Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model
npj Systems Biology and Applications, ISSN: 20567189
Kirouac; Gabriele Schaefer; Jocelyn Chan; Mark Merchant; Christine Orr; Shih-Min A. Huang; John Moffat; Lichuan Liu; Kapil Gadkar; Ramanujan
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Erratum to: Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model (npj Systems Biology and Applications, (2017), 3, 1, (14), 10.1038/s41540-017-0016-1)
npj Systems Biology and Applications, ISSN: 20567189
Kirouac; Gabriele Schaefer; Jocelyn Chan; Mark Merchant; Christine Orr; Shih-Min A. Huang; John Moffat; Lichuan Liu; Kapil Gadkar; Ramanujan
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Statistical characterization of therapeutic protein modifications
Scientific Reports, ISSN: 20452322
Tsung-Heng Tsai; Zhiqi Hao; Qiuting Hong; Benjamin Moore; Cinzia Stella; Jeffrey H. Zhang; Yan Chen; Michael Kim; Theo Koulis; Gregory Ryslik; Erik Verschueren; Fred Jacobson; William E. Haskins; Olga Vitek
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Atezolizumab in platinum-treated locally advanced or metastatic urothelial carcinoma: Post-progression outcomes from the phase II IMvigor210 study
Annals of Oncology, ISSN: 15698041 09237534
Andrea Necchi; Richard W. Joseph; Yohann Loriot; Jean Hoffman-Censits; Jose Luis Perez-Gracia; Petrylak; Christina L. Derleth; Darren Tayama; Qian Zhu; Beiying Ding; Constanze Kaiser; Jonathan E. Rosenberg
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Reversed-phase chromatography with large pore superficially porous particles for high throughput immunoglobulin G2 disulfide isoform separation
Journal of Chromatography A, ISSN: 18733778 00219673
Bingchuan Wei; Bing Zhang; Barry E. Boyes; Taylor Zhang
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2017 White Paper on recent issues in bioanalysis: A global perspective on immunogenicity guidelines & biomarker assay performance (Part 3-LBA: Immunogenicity, biomarkers and PK assays)
Bioanalysis, ISSN: 17576199 17576180
Shalini Gupta; Richards; Lakshmi Amaravadi; Steven Piccoli; Binodh DeSilva; Renuka Pillutla; Lauren Stevenson; Devangi Mehta; Montserrat Carrasco-Triguero; Robert J. Neely; Michael A. Partridge; Roland F Staack; Xuemei Zhao; Boris Gorovits; Gerry Kolaitis; Giane Sumner; Kay Stubenrauch; Zou; Shashi Amur; Chris Beaver; Isabella Berger; Flora Berisha; Herbert Birnboeck; Joe Bower; Seongeun Julia Cho; Isabelle Cludts; Cocea; Lorella Di Donato; Saloumeh Kadkhodayan Fischer; Stephanie Fraser; Fabio Garofolo; Sam Haidar; Jonathan Haulenbeek; Charles Hottenstein; Jenny Hu; Akiko Ishii-Watabe; Rafiqul Islam; Darshana Jani; John Kadavil; John Kamerud; Daniel Kramer; Pekka Kurki; Stephen MacMannis; Jim McNally; Ashley Mullan; Apollon Papadimitriou; Joao Pedras-Vasconcelos; Soma Ray; Afshin Safavi; Yoshiro Saito; Natasha Savoie; Marianne Scheel Fjording; Kara Scheibner; John Smeraglia; An Song; Bruce C. Stouffer; Nilufer Tampal; Barry Van Der Strate; Thorsten Verch; Jan Welink; Yuanxin Xu; Tong-Yuan Yang; Lilian Yengi; Jianing Zeng; Yan Zhang; Yanhua Zhang; Stephen Zoog
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A phase i dose-escalation study of the safety and pharmacokinetics of pictilisib in combination with erlotinib in patients with advanced solid tumors
Oncologist, ISSN: 1549490X 10837159
Stephen Leong; Rebecca A. Moss; Daniel W. Bowles; Joseph A. Ware; Jing Zhou; Jill M. Spoerke; Lackner; Geetha Shankar; Jennifer L. Schutzman; Ruud van der Noll; Emile E. Voest; Jan H. M. Schellens
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Found in translation: How preclinical research is guiding the clinical development of the BCL2-selective inhibitor venetoclax
Cancer Discovery, ISSN: 21598290 21598274
Joel D. Leverson; Deepak Sampath; Andrew J. Souers; Saul H. Rosenberg; Wayne J. Fairbrother; Amiot; Marina Konopleva; Anthony Letai
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Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity
Scientific Reports, ISSN: 20452322
Simon Hansen; Jakob C. Stüber; Patrick Ernst; Alexander Koch; Daniel Bojar; Alexander Batyuk; Pluckthun
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Tissue Localization of Glycosphingolipid Accumulation in a Gaucher Disease Mouse Brain by LC-ESI-MS/MS and High-Resolution MALDI Imaging Mass Spectrometry
SALAS Discovery, ISSN: 24725560 24725552
E. Ellen Jones; Wujuan Zhang; Xueheng Zhao; Cristine Quiason; Stephanie Dale; Sheerin Shahidi-Latham; Gregory A. Grabowski; Kenneth D.R. Setchell; Richard R. Drake; Ying Sun
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Identification of Small-Molecule Noncovalent Binders Utilizing SAMDI Technology
SALAS Discovery, ISSN: 24725560 24725552
Erica Vanderporten; Michael D. Scholle; John Sherrill; John C. Tran; Yichin Liu
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Design, synthesis, and biological evaluation of pyrrolobenzodiazepine-containing hypoxia-activated prodrugs
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Peter Dragovich; Broccatelli; Jinhua Chen; Peter W. Fan; Hoa Le; Mao; Thomas H. Pillow; Andrew G. Polson; John Wai; Zijin Xu; Hui Yao; Donglu Zhang
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Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Li Di; Christopher Breen; Rob Chambers; Sean T. Eckley; Robert Fricke; Avijit Ghosh; Paul Harradine; Kalvass; Stacy Ho; Caroline A. Lee; Punit H. Marathe; Everett J. Perkins; Mark Qian; Susanna Tse; Zhengyin Yan; Zamek-Gliszczynski
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Baseline asthma burden, comorbidities, and biomarkers in omalizumab-treated patients in PROSPERO
Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206
Bradley E. Chipps; Robert S. Zeiger; Allan T. Luskin; William W. Busse; Benjamin L. Trzaskoma; Evgeniya Antonova; Hooman Pazwash; Susan L. Limb; Paul G. Solari; Noelle M. Griffin; Thomas B. Casale
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Population pharmacokinetics of trastuzumab emtansine in previously treated patients with HER2-positive advanced gastric cancer (AGC)
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Shang-Chiung Chen; Kagedal; Yuying Gao; Wang; Marie-Laurence Harle-Yge; Sandhya Girish; Jin Y. Jin; Chunze Li
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Exposure–response analyses of trastuzumab emtansine in patients with HER2-positive advanced breast cancer previously treated with trastuzumab and a taxane
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Chunze Li; Wang; Shang-Chiung Chen; Russell D. Wada; Dan Lu; Xin Wang; Daniel Polhamus; Jonathan French; Shweta Vadhavkar; Alexander Strasak; Melanie Smitt; Amita Joshi; Meghna Samant; Angelica Quartino; Jin Y. Jin; Sandhya Girish
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Non-canonical reader modules of BAZ1A promote recovery from DNA damage
Nature Communications, ISSN: 20411723
Mariano Oppikofer; Meredith Sagolla; Benjamin Haley; Hui-Min Zhang; Sarah K. Kummerfeld; Jawahar Sudhamsu; E. Megan Flynn; Tianyi Bai; Jennifer Zhang; Claudio Ciferri; Andrea G Cochran
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Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP)
Scientific Reports, ISSN: 20452322
Travis W. Bainbridge; Diana Ronai Dunshee; Noelyn Kljavin; Nicholas J. Skelton; Junichiro Sonoda; James A. Ernst
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Serum periostin, IgE, and SE-IgE can be used as biomarkers to identify moderate to severe chronic rhinosinusitis with nasal polyps
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Karin Jonstam; Marit Westman; Gabriële Holtappels; Cécile T.J. Holweg; Claus Bachert
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Platform model describing pharmacokinetic properties of vc-MMAE antibody–drug conjugates
Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 15738744 1567567X
Kagedal; Leonid Gibiansky; Jian Xu; Xin Wang; Divya Samineni; Shang-Chiung Chen; Dan Lu; Priya Agarwal; Wang; Ola M. Saad; Neelima Koppada; Bernard M. Fine; Jin Y. Jin; Sandhya Girish; Chunze Li
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Photodegradation Pathways of Protein Disulfides: Human Growth Hormone
Pharmaceutical Research, ISSN: 1573904X 07248741
Daniel Steinmann; Olivier Mozziconacci; Rupesh Bommana; John F. Stobaugh; Y. John Wang; Christian Schöneich
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Anaphylaxis associated with omalizumab administration: Risk factors and patient characteristics
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Phillip Lieberman; Ilisten Jones; Richa Rajwanshi; Karin Rosén; Dale T. Umetsu
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Population pharmacokinetics and exposure–response of trastuzumab emtansine in advanced breast cancer previously treated with ≥2 HER2-targeted regimens
British Journal of Clinical Pharmacology, ISSN: 13652125 03065251
Shang-Chiung Chen; Angelica Quartino; Daniel Polhamus; Matthew Riggs; Jonathan French; Xin Wang; Shweta Vadhavkar; Melanie Smitt; Silke Hoersch; Alexander Strasak; Jin Y. Jin; Sandhya Girish; Chunze Li
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Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes
Nature Communications, ISSN: 20411723
Vagheesh M. Narasimhan; Raheleh Rahbari; Aylwyn Scally; Arthur Wuster; Dan Mason; Yali Xue; John Wright; Richard C. Trembath; Eamonn R Maher; David A. van Heel; Adam Auton; Matthew E. Hurles; Chris Tyler-Smith; Richard Durbin
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Real-world Direct Health Care Costs for Metastatic Colorectal Cancer Patients Treated With Cetuximab or Bevacizumab-containing Regimens in First-line or First-line Through Second-line Therapy
Clinical Colorectal Cancer, ISSN: 19380674 15330028
Stephen S. Johnston; Kathleen Wilson; Helen Varker; Elisabetta Malangone-Monaco; Paul Juneau; Ellen Riehle; Sacha Satram-Hoang; Nicolas Sommer; Sarika Ogale
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Discrepancies between patient-reported outcomes, and endoscopic and histological appearance in UC
Gut, ISSN: 14683288 00175749
Jean-Frédéric Colombel; Mary E. Keir; Alexis Scherl; Rui Zhao; Gert De Hertogh; William A. Faubion Jr.; Timothy T. Lu
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A Diagnostic Approach for Rodent Progressive Cardiomyopathy and Like Lesions in Toxicology Studies up to 28 Days in the Sprague Dawley Rat (Part 2 of 2)
Toxicologic Pathology, ISSN: 15331601 01926233
James R. Hailey; Beverly E. Maleeff; Heath C. Thomas; Gail Pearse; Jan C. Klapwijk; Patrizia G. Cristofori; Brian R. Berridge; Carie L. Kimbrough; George A. Parker; Daniel Morton; Susan A. Elmore; Jerry F. Hardisty; Noel Dybdal; David A. Rehagen; James D. Fikes; Martin Lamb; Kathleen Biddle; Bernard S. Buetow; Vinicius Carreira; Abraham Nyska; Niraj K. Tripathi; Heather C. Workman; Jean-Guy Bienvenu; Ingrid Brees; James R. Turk; Rick R. Adler
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A Diagnostic Approach for Rodent Progressive Cardiomyopathy and Like Lesions in Toxicology Studies up to 28 Days in the Sprague Dawley Rat (Part 1 of 2)
Toxicologic Pathology, ISSN: 15331601 01926233
James R. Hailey; Beverly E. Maleeff; Heath C. Thomas; Gail Pearse; Jan C. Klapwijk; Patrizia G. Cristofori; Brian R. Berridge; Carie L. Kimbrough; George A. Parker; Daniel Morton; Susan A. Elmore; Jerry F. Hardisty; Noel Dybdal; David A. Rehagen; James D. Fikes; Martin Lamb; Kathleen Biddle; Bernard S. Buetow; Vinicius Carreira; Abraham Nyska; Niraj K. Tripathi; Heather C. Workman; Jean-Guy Bienvenu; Ingrid Brees; James R. Turk; Rick R. Adler
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Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis: Experience from 92 Sites in an Open-Label US Expanded Access Program
Pulmonary Therapy, ISSN: 23641746 23641754
Lisa H Lancaster; Lake Morrison; Alexander Auais; Beiying Ding; Ahmar Iqbal; Boris Polman; Kevin R. Flaherty
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What evidence do we need for biomarker qualification?
Science Translational Medicine, ISSN: 19466242 19466234
Chris Leptak; Joseph P. Menetski; John A. Wagner; Jiri Aubrecht; Linda Brady; Martha Brumfield; William W. Chin; Steven Hoffmann; Gary J. Kelloff; Gabriela Lavezzari; Rajesh Ranganathan; John-Michael Sauer; Frank D. Sistare; Tanja S. Zabka; David Wholley
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GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
F. Anthony Romero; Jeremy Murray; Kwong Wah Lai; Vickie Tsui; Brian K Albrecht; Le An; Beresini; Gladys De Leon Boenig; Sarah M. Bronner; Emily Chan; Kevin Chen; Zhongguo Chen; Edna F. Choo; Kyle Clagg; Clark; Terry Crawford; Patrick Cyr; Denise De Almeida Nagata; Karen Gascoigne; Jane L. Grogan; Georgia Hatzivassiliou; Wei Huang; Thomas Hunsaker; Susan Kaufman; Stefan G. Koenig; Ruina Li; Yingjie Li; Xiaorong Liang; Jiangpeng Liao; Wenfeng Liu; Justin Ly; Jonathan M. Maher; Colin Masui; Mark Merchant; Yingqing Ran; Alexander M. Taylor; John Wai; Fei Wang; Xiaocang Wei; Dong Yu; Bing-Yan Zhu; Xiaoyu Zhu; Steven Magnuson
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Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins via a Syn-Elimination Approach
Organic Letters, ISSN: 15237052 15237060
Ngiap-Kie Lim; Patrick Weiss; Beryl X. Li; Christina H. McCulley; Stephanie R. Hare; Bronwyn L. Bensema; Teresa A. Palazzo; Dean J. Tantillo; Haiming Zhang; Francis Gosselin
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Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye
mAbs, ISSN: 19420870 19420862
Devin B. Tesar; Jacob Luoma; Emily A. Wyatt; Catherine Shi; Whitney Shatz; Hass; Mary Mathieu; Li Yi; Jacob E. Corn; Katie F. Maass; Kathryn Wang; Michelle Z. Dion; Nisana Andersen; Kelly M. Loyet; Menno Van Lookeren Campagne; Karthikan Rajagopal; Leslie Dickmann; Justin M. Scheer; Robert F. Kelley
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Preclinical pharmacokinetic characterization of an adipose tissue-targeting monoclonal antibody in obese and non-obese animals
mAbs, ISSN: 19420870 19420862
Sharmila Rajan; Danielle Mandikian; Amos Baruch; Thomas R. Gelzleichter; Dale Stevens; Junichiro Sonoda; Kyra J. Cowan; C. Andrew Boswell; Stefanich
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Patients' priorities in selecting chronic lymphocytic leukemia treatments
Blood advances, ISSN: 24739537 24739529
Carol Mansfield; Anthony Masaquel; Jessie Sutphin; Elisa Weiss; Meghan Gutierrez; Jennifer Wilson; Marco Boeri; Jia Li; Carolina Reyes
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PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Thomas Januario; Ye; Russell Bainer; Bruno Alicke; Tunde Smith; Benjamin Haley; Zora Modrusan; Stephen Gould; Robert Yauch
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An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD
Blood, ISSN: 15280020 00064971
Jonathan C. Poe; Wei Jia; Hsuan Su; Sarah Anand; Jeremy J. Rose; Prasanthi V. Tata; Amy N. Suthers; Corbin D. Jones; Pei Fen Kuan; Benjamin G. Vincent; Jonathan S. Serody; Mitchell E. Horwitz; Vincent T. Ho; Steve Pavletic; Fran Hakim; Kouros Owzar; Dadong Zhang; Bruce R. Blazar; Christian W. Siebel; Nelson J. Chao; Ivan Maillard; Stefanie Sarantopoulos
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Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Yong Ma; Yue Fu; S. Cyrus Khojasteh; Deepak Dalvie; Donglu Zhang
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FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia
Cell Metabolism, ISSN: 19327420 15504131
Tian Lan; Donald A. Morgan; Kamal Rahmouni; Junichiro Sonoda; Xiaorong Fu; Shawn C. Burgess; William L. Holland; Steven A. Kliewer; David J. Mangelsdorf
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B cell-derived IL-4 acts on podocytes to induce proteinuria and foot process effacement
JCI insight, ISSN: 23793708
Alfred H.J. Kim; Jun-Jae Chung; Shreeram Akilesh; Ania Koziell; Sanjay Jain; Jeffrey B. Hodgin; Mark J. Miller; Thaddeus S. Stappenbeck; Jeffrey H. Miner; Andrey S. Shaw
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Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control
Cell, ISSN: 10974172 00928674
Richard G. Yau; Kerstin Doerner; Erick R. Castellanos; Diane L. Haakonsen; Achim Werner; Nan Wang; X. William Yang; Nadia Martinez-Martin; Marissa L. Matsumoto; Vishva M. Dixit; Michael Rape
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Concordance between plasma-based and tissue-based next-generation sequencing in LOTUS
The Lancet Oncology, ISSN: 14745488 14702045
Sung-Bae Kim; Rebecca Dent; Matthew Wongchenko; Stina M. Singel; Baselga
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Monitoring and Targeting Anti-VEGF Induced Hypoxia within the Viable Tumor by 19F–MRI and Multispectral Analysis
Neoplasia (United States), ISSN: 14765586 15228002
Yunzhou Shi; Jason Oeh; Anna Hitz; Maj Hedehus; Jeffrey Eastham-Anderson; Franklin V. Peale Jr.; Patricia Hamilton; Thomas O'Brien; Deepak Sampath; Richard A. D. Carano
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An exploratory, open-label, randomized, multicenter study to investigate the pharmacodynamics of a glycoengineered antibody (imgatuzumab) and cetuximab in patients with operable head and neck squamous cell carcinoma
Annals of Oncology, ISSN: 15698041 09237534
Stéphane Temam; Spicer; Farzaneh; Jean-Charles Soria; Oppenheim; McGurk; Antoine Hollebecque; Sarini; Hussain; Soehrman Brossard; Manenti; Stefan Evers; Paul Delmar; Di Scala; Christoph Mancao; Feuerhake; Luc Andries; Ott; Passioukov; Delord
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Effect of docetaxel duration on clinical outcomes: Exploratory analysis of CLEOPATRA, a phase III randomized controlled trial
Annals of Oncology, ISSN: 15698041 09237534
David W. Miles; Im; Fung; Bongin Yoo; Adam Knott; Sarah Heeson; Beattie; Sandra M. Swain
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Combining "bottom-up" and "top-down" approaches to assess the impact of food and gastric pH on pictilisib (GDC-0941) pharmacokinetics
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Tong Lu; Grazyna Fraczkiewicz; Laurent Salphati; Nageshwar Budha; Gena Dalziel; Gillian S. Smelick; Kari M. Morrissey; John Davis; Jin Y. Jin; Joseph A. Ware
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A new lead to NLRP3 inhibition
Journal of Experimental Medicine, ISSN: 15409538 00221007
Lamkanfi; Vishva M. Dixit
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Higher order structure of proteins in biopharmaceutical development
Pharmacopeial Forum, ISSN: 15421945 03634655
Yves Aubin; Michael D. Brenowitz; Edward Chess; Thomas M. Laue; Jasper C. Lin; Donald MacLean; John P. Marino; Linda O. Narhi; William Weiss; Qin Zou
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