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DISPLAYING 4751 - 4800 OF 16569 RESULTS

Transcriptomic analysis of hepatocellular carcinoma reveals molecular features of disease progression and tumor immune biology
npj Precision Oncology, ISSN: 2397768X
Kwame Okrah; Somayeh S. Tarighat; Bonnie Liu; Koeppen; Marie-Claire Wagle; Cheng; Sun; Anwesha Dey; Chang; Sumiyoshi; Zineb Mounir; Cummings; Garret M. Hampton; Lukas Amler; Jane Fridlyand; Priti Hegde; Shannon J. Turley; Lackner; Shih-Min A. Huang
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Transcriptomic analysis of hepatocellular carcinoma reveals molecular features of disease progression and tumor immune biology
npj Precision Oncology, ISSN: 2397768X
Kwame Okrah; Somayeh S. Tarighat; Bonnie Liu; Koeppen; Marie-Claire Wagle; Cheng; Sun; Anwesha Dey; Matthew T. Chang; Teiko Sumiyoshi; Zineb Mounir; Cummings; Garret M. Hampton; Lukas Amler; Jane Fridlyand; Priti Hegde; Shannon J. Turley; Lackner; Shih-Min A. Huang
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A Tet-Off gene expression system for validation of antifungal drug targets in a murine invasive pulmonary aspergillosis model
Scientific Reports, ISSN: 20452322
Yutian Peng; Hua Zhang; Min Xu; Man-Wah Tan
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ASC- A nd caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages
Scientific Reports, ISSN: 20452322
Bettina L. Lee; Kathleen M. Mirrashidi; Irma B. Stowe; Sarah K. Kummerfeld; Colin K. Watanabe; Benjamin Haley; Trinna L. Cuellar; Mike Reichelt; Nobuhiko Kayagaki
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Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes
Nature Communications, ISSN: 20411723
David S. Hewings; Johanna Heideker; Taylur P. Ma; Andrew P. AhYoung; Farid El Oualid; Alessia Amore; Gregory T. Costakes; Daniel Kirchhofer; Bradley Brasher; Thomas H. Pillow; Nataliya Popovych; Till Maurer; Carsten Schwerdtfeger; William F. Forrest; Kebing Yu; Flygare; Matthew Bogyo; Ingrid E. Wertz
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Antibody-mediated stabilization of NRG1 induces behavioral and electrophysiological alterations in adult mice
Scientific Reports, ISSN: 20452322
Sara L. Dominguez; Ganapati V. Hegde; Jesse E. Hanson; Hong Xiang; Danielle Mandikian; C. Andrew Boswell; Cecilia Chiu; Yan Wu; Siao Ping Tsai; Daniel Fleck; Martin Weber; Hai Ngu; Kimberly Scearce-Levie; Erica L. Jackson
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A targeted boost-and-sort immunization strategy using Escherichia coli BamA identifies rare growth inhibitory antibodies
Scientific Reports, ISSN: 20452322
Rajesh Vij; Zhonghua Lin; Nancy Y. Chiang; Jean-Michel Vernes; Kelly M. Storek; Summer Park; Joyce Chan; Y. Gloria Meng; Laetitia Comps-Agrar; Patricia Luhn; Sophia Lee; Kellen Schneider; Jack Bevers; Inna Zilberleyb; Christine Tam; Christopher M. Koth; Min Xu; Avinash Gill; Marcy Auerbach; Peter A. Smith; Steven T. Rutherford; Nakamura; Dhaya Seshasayee; Jian Payandeh; James T. Koerber
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Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy
Scientific Reports, ISSN: 20452322
Kenneth J. Katschke Jr.; Hongkang Xi; Christian Cox; Tom Truong; Yann Malato; Wyne P. Lee; Brent Mckenzie; Rommel Arceo; Jianhua Tao; Linda Rangell; Mike Reichelt; Laurie Diehl; Justin Elstrott; Robby M. Weimer; Menno Van Lookeren Campagne
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Testosterone is an endogenous regulator of BAFF and splenic B cell number
Nature Communications, ISSN: 20411723
Anna S. Wilhelmson; Marta Lantero Rodriguez; Alexandra Stubelius; Per Fogelstrand; Inger Johansson; Matthew B. Buechler; Steve Lianoglou; Varun N. Kapoor; Maria E. Johansson; Johan B. Fagman; Amanda Duhlin; Prabhanshu Tripathi; Alessandro Camponeschi; Bo T. Porse; Antonius G. Rolink; Hans Nissbrandt; Shannon J. Turley; Hans Carlsten; Inga-Lill Mårtensson; Mikael C. I. Karlsson; Åsa Tivesten
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Comprehensive analysis of single molecule sequencing-derived complete genome and whole transcriptome of Hyposidra talaca nuclear polyhedrosis virus
Scientific Reports, ISSN: 20452322
Thong T Nguyen; Kushal Suryamohan; Boney Kuriakose; Vasantharajan Janakiraman; Mike Reichelt; Subhra Chaudhuri; Joseph Guillory; Neethu Divakaran; Rabins; Ridhi Goel; Bhabesh Deka; Suman Sarkar; Preety Ekka; Yu-Chih Tsai; Derek Vargas; Sam Santhosh; Sangeetha Mohan; Chen-Shan Chin; Jonas Korlach; George Thomas; Azariah Babu; Somasekar Seshagiri
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No difference in cardiovascular risk of tocilizumab versus abatacept for rheumatoid arthritis: A multi-database cohort study
Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172
Seoyoung C. Kim; Daniel H. Solomon; James R. Rogers; Sara Gale; Micki Klearman; Khaled Sarsour; Sebastian Schneeweiss
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Next generation sequencing identifies novel diseaseassociated BEST1 mutations in Bestrophinopathy patients
Scientific Reports, ISSN: 20452322
Thong T Nguyen; Poornachandra; Anshuman Verma; Ruchir A. Mehta; Sameer Phalke; Rajani Battu; Vedam Laxmi Ramprasad; Andrew S. Peterson; Arkasubhra Ghosh; Somasekar Seshagiri
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Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells
Nature Communications, ISSN: 20411723
Erika López-Arribillaga; Verónica Rodilla; Carlota Colomer; Anna Vert; Amy Shelton; Jason H. Cheng; Bing Yan; Abel Gonzalez-Perez; Melissa Junttila; Mar Iglesias; Ferran Torres; Joan Albanell; Alberto Villanueva; Anna Bigas; Christian W. Siebel; Lluis Espinosa
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Erratum to: Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy (Scientific Reports, (2018), 8, 1, (7348), 10.1038/s41598-018-25557-8)
Scientific Reports, ISSN: 20452322
Kenneth J. Katschke Jr.; Hongkang Xi; Christian Cox; Tom Truong; Yann Malato; Wyne P. Lee; Brent Mckenzie; Rommel Arceo; Jianhua Tao; Linda Rangell; Mike Reichelt; Laurie Diehl; Justin Elstrott; Robby M. Weimer; Menno Van Lookeren Campagne
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Erratum to: Comprehensive analysis of single molecule sequencing-derived complete genome and whole transcriptome of Hyposidra talaca nuclear polyhedrosis virus (Scientific Reports, (2018), 8, 1, (8924), 10.1038/s41598-018-27084-y)
Scientific Reports, ISSN: 20452322
Thong T Nguyen; Kushal Suryamohan; Boney Kuriakose; Vasantharajan Janakiraman; Mike Reichelt; Subhra Chaudhuri; Joseph Guillory; Neethu Divakaran; Rabins; Ridhi Goel; Bhabesh Deka; Suman Sarkar; Preety Ekka; Yu-Chih Tsai; Derek Vargas; Sam Santhosh; Sangeetha Mohan; Chen-Shan Chin; Jonas Korlach; George Thomas; Azariah Babu; Somasekar Seshagiri
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First inter-laboratory study of a Supercritical Fluid Chromatography method for the determination of pharmaceutical impurities
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Amandine Dispas; Roland Marini; Vincent Desfontaine; Jean-Luc Veuthey; Dorina Kotoni; Luca Gioacchino Losacco; Adrian Clarke; Charlene Muscat Galea; Debby Mangelings; Brandon M. Jocher; Erik L. Regalado; Katerina Plachká; Lucie Nováková; Benjamin Wuyts; Isabelle François; Michael Gray; Andrew J. Aubin; Abhijit Tarafder; Maxime Cazes; Christophe Desvignes; Loic Villemet; Morgan Sarrut; Adrien Raimbault; Elise Lemasson; Eric Lesellier; Caroline West; Tomas Leek; Mengling Wong; Lulu Dai; Kelly Zhang; Alexandre Grand-Guillaume Perrenoud; Claudio Brunelli; Philippe Hennig; Sophie Bertin; Fabien Mauge; Nathalie Da Costa; William P. Farrell; Madeleine Hill; Niranjan Desphande; Manish Grangrade; Santosh Sadaphule; Ravi Yadav; Sandesh Rane; Shankar Shringare; Marion Iguiniz; Sabine Heinisch; Julien Lefevre; Estelle Corbel; Nicolas Roques; Yvan Vander Heyden; Davy Guillarme; Philippe Hubert
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Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
Science, ISSN: 10959203 00368075
Pontus Orning; Dan Weng; Kristian Starheim; Dmitry Ratner; Zachary Best; Bettina L. Lee; Alexandria Brooks; Shiyu Xia; Hao Wu; Michelle A. Kelliher; Scott B. Berger; Peter J. Gough; John Bertin; Megan K. Proulx; Jon D. Goguen; Nobuhiko Kayagaki; Katherine A. Fitzgerald; Egil Lien
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Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer
New England Journal of Medicine, ISSN: 15334406 00284793
Schmid; Sylvia Adams; Hope S. Rugo; Andreas Schneeweiss; Carlos H. Barrios; Iwata; Diéras; Roberto Hegg; Seock-Ah Im; Shaw Wright; Henschel; Luciana L. Molinero; Chui; Roel Funke; Amreen Husain; Eric P. Winer; Sherene Loi; Leisha A. Emens
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Preanalytical approaches to improve recovery of amyloid-β peptides from CSF as measured by immunological or mass spectrometry-based assays
Alzheimer's Research and Therapy, ISSN: 17589193
Stephen P. Schauer; William R. Mylott; Moucun Yuan; Rand Jenkins; William Mathews; Lee Honigberg; Kristin R. Wildsmith
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Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma
Science Translational Medicine, ISSN: 19466242 19466234
Hart S. Dengler; Xiumin Wu; Ivan Peng; Rinderknecht; Youngsu Kwon; Eric Suto; Pawan Bir Kohli; Marya Liimatta; Kathy Barrett; Julia Lloyd; Cain; Mike Briggs; Stephanie Addo; Gary Salmon; Savita Ubhayakar; Gauri Deshmukh; Sheerin Shahidi-Latham; Cristine M. Quiason-Huynh; Janet Jackman; John Liu; Nicholas C. Ray; Simon Goodacre; Adam R. Johnson; Brent Mckenzie; Wyne P. Lee; Mark Zak; Jane R. Kenny; Nico Ghilardi
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Insensitivity to pain upon adult-onset deletion of nav1.7 or its blockade with selective inhibitors
Journal of Neuroscience, ISSN: 15292401 02706474
Shannon D. Shields; Lunbin Deng; Rebecca M. Reese; Michelle Dourado; Janet Tao; Oded Foreman; Jae H. Chang; David Hackos
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A 2D LC-MS/MS Strategy for Reliable Detection of 10-ppm Level Residual Host Cell Proteins in Therapeutic Antibodies
Analytical Chemistry, ISSN: 15206882 00032700
Feng Yang; Donald Walker; Jeannine Schoenfelder; Joe Carver; Alice Zhang; Delia Li; Reed J. Harris; Stults; X. Christopher Yu; David A. Michels
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Trophic factors in inflammation and regeneration: The role of ManF and CDNF
Frontiers in Physiology, ISSN: 1664042X
Pedro Sousa-Victor; Heinrich Jasper; Joana Neves
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Prediction of methionine oxidation risk in monoclonal antibodies using a machine learning method
mAbs, ISSN: 19420870 19420862
Kannan Sankar; Kam Hon Hoi; Yizhou Yin; Prasanna Ramachandran; Nisana Andersen; Amy Hilderbrand; Paul McDonald; Christoph Spiess; Qing Zhang
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Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia
mAbs, ISSN: 19420870 19420862
Douglas Leipold; Isabel Figueroa; Shabkhaiz Masih; Brandon Latifi; Victor Yip; Shen; Randall Dere; Montserrat Carrasco-Triguero; M. Violet Lee; Ola M. Saad; Luna Liu; Jintang He; Dian Su; Keyang Xu; Brian R. Vuillemenot; Steven T. Laing; Melissa Schutten; Katherine R. Kozak; Bing Zheng; Andrew G. Polson; Amrita Kamath
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Site-specific conjugation allows modulation of click reaction stoichiometry for pretargeted SPECT imaging
mAbs, ISSN: 19420870 19420862
Danielle Mandikian; Hanine Rafidi; Pragya Adhikari; Priya Venkatraman; Lidia Nazarova; Gabriel Fung; Isabel Figueroa; Gregory Z. Ferl; Sheila Ulufatu; Jason Ho; Cynthia McCaughey; Jeffrey Lau; Shang-Fan Yu; Saileta Prabhu; Jack D. Sadowsky; C. Andrew Boswell
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Charge variant native mass spectrometry benefits mass precision and dynamic range of monoclonal antibody intact mass analysis
mAbs, ISSN: 19420870 19420862
Aaron O. Bailey; Guanghui Han; Wilson Phung; Paul Gazis; Jennifer Sutton; Jonathan L. Josephs; Wendy N. Sandoval
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Notch signaling mediated by delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice
Blood, ISSN: 15280020 00064971
Vedran Radojcic; Katelyn Paz; Jooho Chung; Jing Du; Eric Perkey; Ryan Flynn; Sanja Ivcevic; Michael Zaiken; Ann Friedman; Minhong Yan; Maria A. Pletneva; Stefanie Sarantopoulos; Christian W. Siebel; Bruce R. Blazar; Ivan Maillard
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Clinical activity and safety of atezolizumab in patients with recurrent glioblastoma
Journal of Neuro-Oncology, ISSN: 15737373 0167594X
Rimas V. Lukas; Jordi Rodon; Kevin Becker; Eric T. Wong; Kent Shih; Mehdi Touat; Marcella Fassò; Osborne; Luciana L. Molinero; Carol O’Hear; William Grossman; Joachim Baehring
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Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations
Cancer Cell, ISSN: 18783686 15356108
Kanika Bajaj Pahuja; Thong T Nguyen; Bijay S. Jaiswal; Kumar Prabhash; Tarjani M. Thaker; Kate Senger; Subhra Chaudhuri; Noelyn Kljavin; Aju Antony; Sameer Phalke; Prasanna Kumar; Marco Mravic; Eric Stawiski; Derek Vargas; Durinck; Ravi Gupta; Arati Khanna-Gupta; Sally E. Trabucco; Ethan S. Sokol; Ryan J. Hartmaier; Ashish Singh; Anuradha Chougule; Vaishakhi Trivedi; Amit Dutt; Vijay Patil; Amit Joshi; Vanita Noronha; James Ziai; Sripad D. Banavali; Vedam Laxmi Ramprasad; William F. DeGrado; Raphael Bueno; Natalia Jura; Somasekar Seshagiri
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AlphaE Integrin Expression Is Increased in the Ileum Relative to the Colon and Unaffected by Inflammation
Journal of Crohn's and Colitis, ISSN: 18764479
Ryan Ichikawa; Christopher A. Lamb; Jeffrey Eastham-Anderson; Alexis Scherl; Laura Raffals; William A. Faubion Jr.; Miriam R. Bennett; Anna K. Long; John C. Mansfield; John A. Kirby; Mary E. Keir
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Understanding Phase Behavior of Nearly Energetically Equivalent Polymorphs to Achieve Controlled Crystallization for a Nav1.7 Pain Inhibitor Compound
Molecular Pharmaceutics, ISSN: 15438392 15438384
Paroma Chakravarty; Antonio G. DiPasquale; Andreas Stumpf; Joseph W. Lubach; Karthik Nagapudi
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Evaluating the Utility of Canine Mdr1 Knockout Madin-Darby Canine Kidney i Cells in Permeability Screening and Efflux Substrate Determination
Molecular Pharmaceutics, ISSN: 15438392 15438384
Eugene C. Chen; Broccatelli; Emile G. Plise; Buyun Chen; Liling Liu; Jonathan Cheong; Shu Zhang; Jamie Jorski; Katherine Gaffney; Kayla K. Umemoto; Laurent Salphati
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Self-reported healthcare utilization by adults with diabetic retinopathy in the United States
Ophthalmic Epidemiology, ISSN: 17445086 09286586
Jeffrey R. Willis; Quan V. Doan; Michelle Gleeson; Zdenka Haskova; Pradeep Ramulu; Lawrence S. Morse; Ronald A. Cantrell
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Airway pathological heterogeneity in asthma: Visualization of disease microclusters using topological data analysis
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Salman Siddiqui; Aarti Shikotra; Matthew Richardson; Emma Doran; David F. Choy; Alex Bell; Cary D. Austin; Jeffrey Eastham-Anderson; Beverley Hargadon; Joseph R. Arron; Andrew J. Wardlaw; Chris E. Brightling; Liam G. Heaney; Peter Bradding
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A pharmacology guided approach for setting limits on product-related impurities for bispecific antibody manufacturing
Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X 10568719
Sharmila Rajan; Junichiro Sonoda; Timothy Tully; Ambrose Jon Williams; Feng Yang; Frank D. Macchi; Terry Hudson; Mark Chen; Shannon Liu; Nicole R. Valle; Kyra J. Cowan; Thomas R. Gelzleichter
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Type 2 Biomarkers and Prediction of Future Exacerbations and Lung Function Decline in Adult Asthma
Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198
Ruth Semprini; Mathew Williams; Alex Semprini; Alice McDouall; James Fingleton; Cécile T.J. Holweg; Mark Weatherall; Beasley; Irene Braithwaite
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Effect of OATP1B1/1B3 Inhibitor GDC-0810 on the Pharmacokinetics of Pravastatin and Coproporphyrin I/III in Healthy Female Subjects
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Lichuan Liu; Sravanthi Cheeti; Yoshida; Edna F. Choo; Eugene C. Chen; Buyun Chen; Mary Gates; Stina M. Singel; Roland Morley; Joseph A. Ware; Srikumar Sahasranaman
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Development of a label-free FcRn-mediated transcytosis assay for in vitro characterization of FcRn interactions with therapeutic antibodies and Fc-fusion proteins
Journal of Immunological Methods, ISSN: 18727905 00221759
Shan Chung; Yuwen L. Lin; Van Nguyen; Lynn Kamen; Kai Zheng; Bianca Vora; An Song
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Tutorial on Monoclonal Antibody Pharmacokinetics and Its Considerations in Early Development
Clinical and Translational Science, ISSN: 17528062 17528054
Meric A. Ovacik; Kedan Lin
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Crystal anisotropy explains structure-mechanics impact on tableting performance of flufenamic acid polymorphs
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Abhay Jain; Harsh S. Shah; Paul R. Johnson; Ajit S. Narang; Ken R. Morris; Rahul V. Haware
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NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis
Nature Immunology, ISSN: 15292916 15292908
Zuliang Jie; Jin-Young Yang; Meidi Gu; Hui Wang; Xiaoping Xie; Yanchuan Li; Ting Liu; Lele Zhu; Jianhong Shi; Lingyun Zhang; Xiaofei Zhou; Donghyun Joo; Hans D. Brightbill; Yingzi Cong; Daniel Lin; Xuhong Cheng; Shao-Cong Sun
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Lymphocytes are a major source of circulating soluble dipeptidyl peptidase 4
Clinical and Experimental Immunology, ISSN: 13652249 00099104
Armanda Casrouge; Sauer; Barreira da Silva; Tejera-Alhambra; Sánchez-Ramón; Cancrini; Molly A. Ingersoll; Aiuti; Matthew L. Albert
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Mitigation of Oxidation in Therapeutic Antibody Formulations: a Biochemical Efficacy and Safety Evaluation of N-Acetyl-Tryptophan and L-Methionine
Pharmaceutical Research, ISSN: 1573904X 07248741
Michelle Z. Dion; Danielle L. Leiske; Vikas K. Sharma; Christina L. Zuch de Zafra; Cleo M. Salisbury
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Achieving greater efficiency and higher confidence in single-cell cloning by combining cell printing and plate imaging technologies
Biotechnology Progress, ISSN: 15206033 87567938
Mandy Yim; David Shaw
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Development and clinical validation of the Genedrive point-of-care test for qualitative detection of hepatitis C virus
Gut, ISSN: 14683288 00175749
Alba Llibre; Yusuke Shimakawa; Estelle Mottez; Shaun Ainsworth; Tan-Phuc Buivan; Rick Firth; Elliott Harrison; Arielle R Rosenberg; Jean-François Meritet; Arnaud Fontanet; Pablo Castan; Antonio Madejón; Mark Laverick; Allison Glass; Raquel Viana; Stanislas Pol; C Patrick McClure; William Lucien Irving; Gino Miele; Matthew L. Albert; Darragh Duffy
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Tissue Physiology of Cynomolgus Monkeys: Cross-Species Comparison and Implications for Translational Pharmacology
AAPS Journal, ISSN: 15507416
Danielle Mandikian; Isabel Figueroa; Amy Oldendorp; Hanine Rafidi; Sheila Ulufatu; Michelle G. Schweiger; Jessica A. Couch; Noel Dybdal; Sean B. Joseph; Saileta Prabhu; Gregory Z. Ferl; C. Andrew Boswell
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Bleeding events and safety outcomes in persons with haemophilia A with inhibitors: A prospective, multi-centre, non-interventional study
Haemophilia, ISSN: 13652516 13518216
Johnny N. Mahlangu; Johannes Oldenburg; Michael U. Callaghan; Midori Shima; Elena Santagostino; Maggie Moore; Michael Recht; Claudia Garcia; Renchi Yang; Michaela Lehle; Harrison Macharia; Elina Asikanius; Gallia Levy; Kruse-Jarres
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FIR: Efficacy, Safety, and Biomarker Analysis of a Phase II Open-Label Study of Atezolizumab in PD-L1–Selected Patients With NSCLC
Journal of Thoracic Oncology, ISSN: 15561380 15560864
David Spigel; Jamie E. Chaft; Scott Gettinger; Bo H. Chao; Luc Dirix; Schmid; Laura Q.M. Chow; Rodney Hicks; Larry Leon; Jill Fredrickson; Marcin Kowanetz; Alan Sandler; Roel Funke; Naiyer A. Rizvi
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Disrupting Gram-negative bacterial outer membrane biosynthesis through inhibition of the lipopolysaccharide transporter MsbA
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Mary Kate Alexander; Anh Miu; Angela Oh; Mike Reichelt; Hoangdung Ho; Cecile Chalouni; Sharada Labadie; Lan Wang; Jun Liang; Nicholas N. Nickerson; Huiyong Hu; Lan Yu; Miaofen Du; Donghong Yan; Summer Park; Janice Kim; Min Xu; Benjamin D. Sellers; Hans E. Purkey; Nicholas J. Skelton; Michael F. T. Koehler; Jian Payandeh; Vishal A. Verma; Yiming Xu; Christopher M. Koth; Mireille Nishiyama
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