Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4801 - 4850 OF 16569 RESULTS

Resolution of unexpected pregnancy-related findings in a rat embryofetal development and toxicokinetic study of monoclonal antibodies specific for hCMV
Birth Defects Research, ISSN: 24721727
Paula Katavolos; Prell; Doris Zane; Rong Deng; Wendy Halpern
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Draft genome sequence of an erwinia tracheiphila isolate from an infected muskmelon (Cucumis melo)
Microbiology Resource Announcements, ISSN: 2576098X
Lori R. Shapiro; Andres Andrade; Erin D. Scully; Jorge Rocha; Joseph N. Paulson; Roberto Kolter
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A20-binding inhibitor of NF-κB (ABIN) 2 negatively regulates allergic airway inflammation
Journal of Experimental Medicine, ISSN: 15409538 00221007
Sonia Ventura; Florencia Cano; Yashaswini Kannan; Felix Breyer; Michael J. Pattison; Mark S. Wilson; Steven C. Ley
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Targeting the MAPK Pathway in RAS Mutant Cancers
Cold Spring Harbor Perspectives in Medicine, ISSN: 21571422
Sarah G. Hymowitz; Shiva Malek
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Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease
PLoS Genetics, ISSN: 15537404 15537390
Nisha Rathore; Sree R. Ramani; Homer Pantua; Jian Payandeh; Tushar Bhangale; Arthur Wuster; Manav Kapoor; Yonglian Sun; Sharookh B. Kapadia; Lino C. Gonzalez Jr.; Ali A. Zarrin; Alison M. Goate; David V. Hansen; Timothy W. Behrens; Robert R. Graham
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Assessment of OATP transporter-mediated drug–drug interaction using physiologically-based pharmacokinetic (PBPK) modeling – a case example
Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782
Yuan Chen; Rui Zhu; Fang Ma; Jialin Mao; Eugene C. Chen; Edna F. Choo; Srikumar Sahasranaman; Lichuan Liu
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A method for manual and automated multiplex RNAscope in situ hybridization and immunocytochemistry on cytospin samples
PLoS ONE, ISSN: 19326203
Sara Chan; Audrey Filézac de L’Etang; Linda Rangell; Patrick Caplazi; John Lowe; Valentina Romeo
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Multiproduct resin reuse for clinical and commercial manufacturing - Methodology and acceptance criteria
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Rizwan Sharnez; Steve Doares; Shane Manning; Krunal Mehta; Ekta Mahajan; Angela To; William Daniels; Judy Glynn; Sagar Dhamane; Xiaona Wen; Yunjuan Wang; Pankaj Gour; Constanze Guenther; Derek Foley; Ronan Hayes; Adam Mott; Sunil Prabhu; Dawn Tavalsky; Michael Hendershot; David Haas; Ashley Hesslein; Norbert Schuelke; Hendri Tjandra
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Safety and clinical activity of atezolizumab in head and neck cancer: Results from a phase I trial
Annals of Oncology, ISSN: 15698041 09237534
A. Dimitrios Colevas; Rastilav Bahleda; Fadi S. Braiteh; Ani Balmanoukian; Brana; Chau; Indrani Sarkar; Luciana L. Molinero; William Grossman; Fairooz F. Kabbinavar; Marcella Fassò; Carol O’Hear; John D. Powderly
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Systemic Safety in Ranibizumab-Treated Patients with Neovascular Age-Related Macular Degeneration: A Patient-Level Pooled Analysis
Kidney International Reports, ISSN: 24686530
Marco A. Zarbin; Steve Francom; Susanna M. Grzeschik; Lisa Tuomi; Zdenka Haskova; Wayne Macfadden; Philippe Margaron; Howard Snow; Alan Cruess; Giovanni Staurenghi; Cornelia Dunger-Baldauf
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IMpower133: Primary efficacy and safety + CNS-related adverse events in a phase I/III study of first-line (1L) atezolizumab + carboplatin + etoposide in extensive-stage SCLC (ES-SCLC)
Annals of Oncology, ISSN: 15698041
Tony SK Mok; Martin Reck; Leora Horn; Lam; David S. Shames; Liu; Fairooz F. Kabbinavar; Lin; Alan Sandler; Stephen V. Liu
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CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts
Alzheimer's and Dementia, ISSN: 15525279 15525260
Oskar Hansson; John P. Seibyl; Erik Stomrud; Henrik Zetterberg; John Q. Trojanowski; Tobias Bittner; Valeria Lifke; Veronika Corradini; Udo Eichenlaub; Richard Batrla; Katharina Buck; Katharina Zink; Christina Rabe; Kaj Blennow; Leslie Shaw
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A method for manual and automated multiplex RNAscope in situ hybridization and immunocytochemistry on cytospin samples
PLoS ONE, ISSN: 19326203
Sara M. Chan; Audrey Filézac de L’Etang; Linda Rangell; Patrick Caplazi; John Lowe; Valentina Romeo
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Lymphocytes are a major source of circulating soluble dipeptidyl peptidase 4
Clinical and Experimental Immunology, ISSN: 13652249 00099104
Armanda Casrouge; Sauer; Rosa Barreira da Silva; Tejera-Alhambra; Sánchez-Ramón; Cancrini; Molly A. Ingersoll; Aiuti; Matthew L. Albert
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Mitigation of Oxidation in Therapeutic Antibody Formulations: a Biochemical Efficacy and Safety Evaluation of N-Acetyl-Tryptophan and L-Methionine
Pharmaceutical Research, ISSN: 1573904X 07248741
Michelle Z. Dion; Danielle L. Leiske; Vikas Sharma; Christina L. Zuch de Zafra; Cleo M. Salisbury
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MOdified NARanjo Causality Scale for ICSRs (MONARCSi): A Decision Support Tool for Safety Scientists
Drug Safety, ISSN: 11791942 01145916
Shaun M. Comfort; Darren Dorrell; Shawman Meireis; Jennifer Fine
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Observational Study Design in Veterinary Pathology, Part 2: Methodology
Veterinary Pathology, ISSN: 15442217 03009858
Jeff L. Caswell; Laura L. Bassel; Jamie L. Rothenburger; Andrea Gröne; Jan Merrill Sargeant; Amanda P. Beck; Stina Ekman; Katherine Nicole Gibson-Corley; Thijs Kuiken; Elise E.B. LaDouceur; David K. Meyerholz; Francesco Carlo Origgi; Horst Posthaus; Simon Lawrence Priestnall; Lorenzo Ressel; Leslie C. Sharkey; Leandro B.C. Teixeira; Kazuyuki Uchida; Jerrold Michael Ward; Joshua D. Webster; Jyoji Yamate
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Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Kim Newton; Dugger; Arundhati Sengupta Ghosh; Ron Ferrando; Felix Chu; Janet Tao; Wendy Lam; Susan Haller; Sara M. Chan; Susan Sa; Debra Dunlap; Jeffrey Eastham-Anderson; Hai Ngu; Jeffrey Hung; French; Webster; Brad Bolon; Jinfeng Liu; Rohit Reja; Sarah K. Kummerfeld; Ying-Jiun Chen; Zora Modrusan; Joe Lewcock; Vishva M. Dixit
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GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Shumei Wang; Vickie Tsui; Terry Crawford; James E. Audia; Burdick; Beresini; Alexandre Côté; Richard T Cummings; Martin Duplessis; E. Megan Flynn; Michael C. Hewitt; Hon-Ren Huang; Hariharan Jayaram; Ying Jiang; Shivangi Joshi; Jeremy Murray; Christopher G. Nasveschuk; Eneida Pardo; Florence Poy; F. Anthony Romero; Yong Tang; Alexander M. Taylor; Jian Wang; Zhaowu Xu; Laura E. Zawadzke; Xiaoyu Zhu; Brian K Albrecht; Steven Magnuson; Steve Bellon; Andrea G Cochran
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Kinase Inhibitors for the Treatment of Immunological Disorders: Recent Advances
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Marian C. Bryan; Naomi S. Rajapaksa
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Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1)
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Marcin Kowanetz; Wei Zou; Scott Gettinger; Koeppen; Mark Kockx; Schmid; Edward E. Kadel III; Ignacio I. Wistuba; Jamie E. Chaft; Naiyer A. Rizvi; David Spigel; Alexander Spira; Fred R. Hirsch; Victor Cohen; Dustin Smith; Zachary Boyd; Natasha Miley; Susan Flynn; Vincent Leveque; David S. Shames; Ballinger; Mocci; Geetha Shankar; Roel Funke; Garret M. Hampton; Alan Sandler; Lukas Amler; Ira Mellman; Daniel S. Chen; Priti Hegde
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Evaluating the Impact of a Decade of Funding from the Green Chemistry Institute Pharmaceutical Roundtable
Organic Process Research and Development, ISSN: 1520586X 10836160
Stefan G. Koenig; David Leahy; Andrew S. Wells
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A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition
Nature, ISSN: 14764687 00280836
Brian Biehs; Gerrit J. P. Dijkgraaf; Robert Piskol; Bruno Alicke; Soufiane Boumahdi; Franklin V. Peale Jr.; Stephen Gould; Frederic J. De Sauvage
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Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3
Science Translational Medicine, ISSN: 19466242 19466234
Dionysos S. Slaga; Diego Ellerman; T. Noelle Lombana; Rajesh Vij; Ji Li; Maria Hristopoulos; Robyn Clark; Jennifer A. Johnston; Amy Shelton; Elaine Mai; Kapil Gadkar; Amy Lo; James T. Koerber; Klara Totpal; Prell; Genee Y. Lee; Christoph Spiess; Teemu T. Junttila
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Targeted LC-MS/MS Proteomics-Based Strategy to Characterize in Vitro Models Used in Drug Metabolism and Transport Studies
Analytical Chemistry, ISSN: 15206882 00032700
Meijuan Juang Xu; Neha Saxena; Marc Vrana; Haeyoung Zhang; Vineet Kumar; Sarah Faye Billington; Cyrus Khojasteh; Scott A. Heyward; Jashvant D. Unadkat; Bhagwat Prasad
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Conventional wastewater treatment and reuse site practices modify bacterial community structure but do not eliminate some opportunistic pathogens in reclaimed water
Science of the Total Environment, ISSN: 18791026 00489697
Prachi Kulkarni; Nathan D. Olson; Joseph N. Paulson; Mihai Pop; Cynthia Maddox; Emma Claye; Rachel E. Rosenberg Goldstein; Manan Sharma; Shawn G. Gibbs; Emmanuel F. Mongodin; Amy R. Sapkota
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Chemotherapy combines effectively with Anti-PD-L1 treatment and can augment antitumor responses
Journal of Immunology, ISSN: 15506606 00221767
Rafael Cubas; Marina Moskalenko; Jeanne Cheung; Michelle Yang; Erin McNamara; Huizhong Xiong; Sabine Hoves; Carola H. Ries; Kim; Stephen Gould
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Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors
Cancer Cell, ISSN: 18783686 15356108
Ivana Yen; Frances Shanahan; Mark Merchant; Christine Orr; Thomas Hunsaker; Matthew Durk; Hank La; Xiaolin Zhang; Scott E. Martin; Eva Lin; John Chan; Yihong Yu; Dhara Amin; Richard M. Neve; Amy Gustafson; Avinashnarayan Venkatanarayan; Scott A. Foster; Joachim Rudolph; Christiaan N. Klijn; Shiva Malek
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Quality assessment and interference detection in targeted mass spectrometry data using machine learning 03 Chemical Sciences 0301 Analytical Chemistry
Clinical Proteomics, ISSN: 15590275 15426416
Shadi Toghi Eshghi; Paul Auger; W Rodney Mathews
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Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin
Journal of Organic Chemistry, ISSN: 15206904 00223263
Scott Savage; Andrew McClory; Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Colin Masui; Sarah J. Robinson; Chong Han; Christoph Ochs; Pankaj D. Rege; Francis Gosselin
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High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants
mAbs, ISSN: 19420870 19420862
Danielle DiCara; Nisana Andersen; Ruby Chan; James A. Ernst; Gai Ayalon; Greg A. Lazar; Nick Agard; Amy Hilderbrand; Isidro Hötzel
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Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole
Xenobiotica, ISSN: 13665928 00498254
Molly Lin; Justin Ly; Ryan Takahashi; John Chen; Alan Deese; Sarah J. Robinson; Aleksandr Kolesnikov; Susan C. Wong; Xiaojing Wang; Jae H. Chang
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Cost-effectiveness of obinutuzumab plus bendamustine followed by obinutuzumab monotherapy for the treatment of follicular lymphoma patients who relapse after or are refractory to a rituximab-containing regimen in the US
Journal of Medical Economics, ISSN: 1941837X 13696998
Gregory F. Guzauskas; Anthony Masaquel; Carolina Reyes; Coen A. Bernaards; Tania Krivasi; David L. Veenstra
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Characterization of in vivo biotransformations for trastuzumab emtansine by high-resolution accurate-mass mass spectrometry
mAbs, ISSN: 19420870 19420862
Jintang He; Shang-Fan Yu; Sharon Fong Yee; Surinder Kaur; Keyang Xu
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Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model
mAbs, ISSN: 19420870 19420862
Shun xin Wang-Lin; Chenguang Zhou; Amrita Kamath; Kyu Hong; Neelima Koppada; Ola M. Saad; Montserrat Carrasco-Triguero; S. Cyrus Khojasteh; Rong Deng
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Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid
mAbs, ISSN: 19420870 19420862
Rina Fong; Kimberly K. Kajihara; Matthew Chen; Isidro Hötzel; Sanjeev Mariathasan; Wouter L. W. Hazenbos; Patrick J. Lupardus
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The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function
Cell Reports, ISSN: 22111247
Sairy Hernandez; Jing Qing; Rebecca Hong Thibodeau; Xiangnan Du; Summer Park; Hyang-Mi Lee; Min Xu; Soyoung Oh; Armando Navarro; Merone Roose-Girma; Robert J. Newman; Søren Warming; Michelle Nannini; Deepak Sampath; Kim; Jane L. Grogan; Ira Mellman
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Susceptibility of Antibody CDR Residues to Chemical Modifications Can Be Revealed Prior to Antibody Humanization and Aid in the Lead Selection Process
Molecular Pharmaceutics, ISSN: 15438392 15438384
Ankai Xu; Hok Seon Kim; Samarkand Estee; Sharon Viajar; William J. Galush; Avinash Gill; Isidro Hötzel; Greg A. Lazar; Paul McDonald; Nisana Andersen; Christoph Spiess
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Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer
Nature Cell Biology, ISSN: 14764679 14657392
Kristiaan J. Lenos; Daniël M. Miedema; Sophie C. Lodestijn; Lisanne E. Nijman; Tom van den Bosch; Xavier Romero Ros; Filipe C. Lourenço; Maria C. Lecca; Maartje van der Heijden; Sanne M. van Neerven; Anita van Oort; Nicolas Leveille; Ronja S. Adam; Felipe de Sousa e Melo; Joy Otten; Patrick Veerman; Guillaume Hypolite; Lianne Koens; Scott K. Lyons; Stassi; Douglas J. Winton; Jan Paul Medema; Edward Morrissey; Maarten F. Bijlsma; Louis Vermeulen
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Using pH Gradient Dissolution with In-Situ Flux Measurement to Evaluate Bioavailability and DDI for Formulated Poorly Soluble Drug Products
AAPS PharmSciTech, ISSN: 15309932
Jane Li; Konstantin Tsinman; Oksana Tsinman; Larry Wigman
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Humoral immunity goes hormonal: Studies of mice demonstrate a link between the female hormone estrogen and protection against bacteremia and sepsis through the induction of natural antibodies to eshcerichia coli
Nature Immunology, ISSN: 15292916 15292908
Joseph Chavarria-Smith; Wouter L. W. Hazenbos; Menno van Lookeren Campagne
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Anatomy and physiology of the digestive tract of drosophila melanogaster
Genetics, ISSN: 19432631 00166731
Irene Miguel-Aliaga; Heinrich Jasper; Bruno Lemaitre
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Serum periostin as a biomarker in eosinophilic granulomatosis with polyangiitis
PLoS ONE, ISSN: 19326203
Rennie L. Rhee; Cecile Holweg; Kit Wong; David Cuthbertson; Simon Carette; Nader A. Khalidi; Curry L. Koening; Langford; Carol A. McAlear; Paul A. Monach; Larry W. Moreland; Christian Pagnoux; Seo; Specks; Antoine G. Sreih; Steven R. Ytterberg; Peter A. Merkel
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Pertuzumab plus trastuzumab and chemotherapy for HER2-positive metastatic gastric or gastro-oesophageal junction cancer (JACOB): final analysis of a double-blind, randomised, placebo-controlled phase 3 study
The Lancet Oncology, ISSN: 14745488 14702045
Tabernero; Paulo M. Hoff; Lin Shen; Atsushi Ohtsu; Manish A. Shah; Karen Cheng; Chunyan Song; Haiyan Wu; Jennifer Eng-Wong; Katherine Kim; Yoon-Koo Kang
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Evaluation of no evidence of progression or active disease (NEPAD) in patients with primary progressive multiple sclerosis in the ORATORIO trial
Annals of Neurology, ISSN: 15318249 03645134
Wolinsky; Montalban; Stephen L. Hauser; Giovannoni; Patrick Vermersch; Corrado Bernasconi; Gurpreet Deol-Bhullar; Hideki Garren; Peter Chin; Belachew; Ludwig Kappos
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Humoral immunity goes hormonal: Studies of mice demonstrate a link between the female hormone estrogen and protection against bacteremia and sepsis through the induction of natural antibodies to eshcerichia coli
Nature Immunology, ISSN: 15292916 15292908
Joseph Chavarria-Smith; Wouter L. W. Hazenbos; Menno van Lookeren Campagne
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Ranibizumab Induces Regression of Diabetic Retinopathy in Most Patients at High Risk of Progression to Proliferative Diabetic Retinopathy
Kidney International Reports, ISSN: 24686530
Charles C. Wykoff; David Eichenbaum; Daniel B. Roth; Lauren Hill; Anne E. Fung; Zdenka Haskova
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Identification of biological axes associated with stage II/III CRC recurrence risk and outcome after adjuvant therapy revealed a T-effector-independent prognostic role for granzyme B
Annals of Oncology, ISSN: 15698041
Meghna Das Thakur; Akshata R. Udyavar; Thomas Sandmann; Li; Bosch; William E. O'Gorman; Li; Amelia Au-Yeung; Chikara Takahashi; Richard Bourgon; Daemen; Priti Hegde; Carlos Bais
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Molecular correlates differentiate response to atezolizumab (atezo) + bevacizumab (bev) vs sunitinib (sun): Results from a phase III study (IMmotion151) in untreated metastatic renal cell carcinoma (mRCC)
Annals of Oncology, ISSN: 15698041
Brian I Rini; Mahrukh Huseni; Michael B. Atkins; David McDermott; Thomas Powles; Bernard Escudier; Romain Banchereau; L-F Liu; Ning Leng; Fan; Doss; Sam C. Nalle; Carroll; Li; Christina Schiff; Marjorie Green; Robert J. Motzer
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Clinical and analytical validation of an FDA approved comprehensive genomic profiling (CGP) assay incorporating multiple companion diagnostics for targeted and immunotherapies
Annals of Oncology, ISSN: 15698041
Li; James X. Sun; Skoletsky; Milbury; Burns; W-K Yip; Dewal; He; Tuesdell; Peters; Erica Schleifman; Johannes Noé; Jenkins; Elvin; Geoff A. Otto; Doron Lipson; Jeffrey S. Ross; Vincent A. Miller; Doherty; Vietz
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