Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8601 - 8650 OF 16688 RESULTS

Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity
mAbs, ISSN: 19420870 19420862
Whitney Shatz; Shan Chung; Bing Li; Brett Marshall; Max L. Tejada; Wilson Phung; Wendy N. Sandoval; Robert F. Kelley; Justin M. Scheer
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High eosinophil count: A potential biomarker for assessing successful omalizumab treatment effects
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
William W. Busse; Sheldon Spector; Karin Rosén; Yan Wang; Oral Alpan
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Comparison of in vitro-in vivo extrapolation of biliary clearance using an empirical scaling factor versus transport-based scaling factors in sandwich-cultured rat hepatocytes
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Peng Zou; Xingrong Liu; Susan C. Wong; Meihua Rose Feng; Bianca M. Liederer
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Molecular Heterogeneity, Biomarker Discovery, and Targeted Therapy in Asthma
Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care,
Joseph R. Arron; Harris
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Effect of ionic strength and pH on the physical and chemical stability of a monoclonal antibody antigen-binding fragment
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Tingting Wang; Ozan S. Kumru; Li Yi; Y. John Wang; Jennifer Zhang; Jae Hyun Kim; Sangeeta B. Joshi; C. Russell Middaugh; David B. Volkin
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Antibody therapeutics in cancer
Science, ISSN: 10959203 00368075
Mark X. Sliwkowski; Ira Mellman
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Large-scale integrative network-based analysis identifies common pathways disrupted by copy number alterations across cancers
BMC Genomics, ISSN: 14712164
Tae Hyun Hwang; Gowtham Atluri; Rui Kuang; Vipin Kumar; Timothy Starr; Kevin A.T. Silverstein; Matthias Peter; Zemin Zhang; Jinfeng Liu
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Early Characterization of Biosimilar Therapeutics
Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics,
Thomas R. Gelzleichter
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Omalizumab in patients with symptomatic chronic idiopathic/spontaneous urticaria despite standard combination therapy
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Allen P. Kaplan; Dennis Ledford; Ashby; Janice Canvin; James L. Zazzali; Edward Conner; Joachim Veith; Nikhil Kamath; Petra Staubach; Thilo Jakob; Robert G. Stirling; Piotr Kuna; William Berger; Marcus Maurer; Karin Rosén
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The authors reply
New England Journal of Medicine, ISSN: 15334406 00284793
Marcus Maurer; Karin Rosén; Hsin-Ju Hsieh
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On the accuracy of a one-compartment approach for determination of drug terminal half-life
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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Multimodal microvascular imaging reveals that selective inhibition of class I PI3K is sufficient to induce an antivascular response
Neoplasia (United States), ISSN: 14765586 15228002
Deepak Sampath; Jason Oeh; Shelby K. Wyatt; Tim C. Cao; Koeppen; Jeffrey Eastham-Anderson; Liliane Robillard; Calvin Ho; Ross; Guanglei Zhuang; Hani Bou-Reslan; Philip Vitorino; Kai H. Barck; Sharon E. Ungersma; Jean-Michel Vernes; Maresa Caunt; Nicholas Van Bruggen; Weilan Ye; Ulka Vijapurkar; Yu-Ju Gloria Meng; Napoleone Ferrara; Lori S. Friedman; Richard A. D. Carano
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Analysis of cognitive, functional, health service use, and cost trajectories prior to and following memory loss
Journals of Gerontology - Series B Psychological Sciences and Social Sciences, ISSN: 10795014
Joseph E. Gaugler; Martha Hovater; David L. Roth; Joseph A. Johnston; Robert L. Kane; Khaled Sarsour
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Overview of Biopharmaceuticals and Comparison with Small-molecule Drug Development
Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics,
Theresa Reynolds; Christina de Zafra; Amy H. Kim; Thomas R. Gelzleichter
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Nonclinical Development of Multi-targeting Biopharmaceuticals
Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics,
Prell; Donna W. Lee; Wendy Halpern; Anu V. Connor
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Degradation of a pharmaceutical in HPLC grade methanol containing trace level formaldehyde
Pharmaceutical Development and Technology, ISSN: 10979867 10837450
Qiqing Zhong; Sarah Stowers; Nathaniel Segraves; Kenley K. Ngim; Kelly Zhang; Tracy Bostick; Alan Deese; Nik P. Chetwyn
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Asparagine deamidation dependence on buffer type, pH, and temperature
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Amanda L. Pace; Wong; Taylor Zhang; Kao; Y. John Wang
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NMDA receptor subunit diversity: Impact on receptor properties, synaptic plasticity and disease
Nature Reviews Neuroscience, ISSN: 14710048 1471003X
Pierre Paoletti; Camilla Bellone; Qiang Zhou
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Label-free high-throughput assays to screen and characterize novel lactate dehydrogenase inhibitors
Analytical Biochemistry, ISSN: 10960309 00032697
Erica Vanderporten; Lauren Frick; Rebecca Turincio; Peter Thana; William LaMarr; Yichin Liu
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Sensitivity and specificity of diagnostic accuracy in alzheimer's disease: A synthesis of existing evidence
American Journal of Alzheimer's Disease and other Dementias, ISSN: 19382731 15333175
Joseph E. Gaugler; Robert L. Kane; Joseph A. Johnston; Khaled Sarsour
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Biopharmaceuticals
Haschek and Rousseaux's Handbook of Toxicologic Pathology, Third Edition: Volume 1-3,
Wendy Halpern; David Hutto
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Treatment patterns and clinical outcomes in patients with metastatic colorectal cancer initially treated with FOLFOX-Bevacizumab or FOLFIRI-bevacizumab: Results from ARIES, a bevacizumab observational cohort study
Oncologist, ISSN: 10837159 1549490X
Bendell; Bekaii-Saab; Cohn; Herbert Hurwitz; Kozloff; Haluk Tezcan; Roach; Yong Mun; Susan Fish; E. Dawn Flick; Darshan Dalal; Grothey
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Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator
Journal of Biotechnology, ISSN: 18734863 01681656
Huong Le; Santosh Kabbur; Luciano Pollastrini; Ziran Sun; Mills; Kevin Johnson; George Karypis; Hu
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MTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations
Cancer Letters, ISSN: 03043835 18727980
Ulka Vijapurkar; Liliane Robillard; Siqun Zhou; Michael Degtyarev; Kui Lin; Tom Truong; Jarrod Tremayne; Berry; Zhonghua Pei; Lori S. Friedman; Elizabeth M. Blackwood; Marcia Belvin
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TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer
Molecular Cell, ISSN: 10972765 10974164
François Gonzalvez; David Lawrence; Becky Yang; Sharon Fong Yee; Pitti; Scot A. Marsters; Victoria Pham; Jean-Philippe Stephan; Jennie R. Lill; Avi Ashkenazi
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Development of capillary size exclusion chromatography for the analysis of monoclonal antibody fragments extracted from human vitreous humor
Journal of Chromatography A, ISSN: 00219673 18733778
Jennifer C. Rea; Yun Lou; Joel Cuzzi; Yuhua Hu; Isabella de Jong; Yajun Jennifer Wang; Dell Farnan
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Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Michael F. T. Koehler; Philippe Bergeron; Elizabeth M. Blackwood; Krista K. Bowman; Yunghsiang Chen; Gauri Deshmukh; Xiao Ding; Jennifer A. Epler; Kevin Lau; Leslie Lee; Lichuan Liu; Cuong Q. Ly; Shiva Malek; Jim Nonomiya; Jason Oeh; Daniel F. Ortwine; Deepak Sampath; Steve Sideris; Lan Trinh; Tom Truong; Jiansheng Wu; Zhonghua Pei; Joseph P. Lyssikatos
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Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Michael T. Lipari; Wei Li; Paul Moran; Monica Kong-Beltran; Tao Sai; Joyce Lai; S. Jack Lin; Ganesh Kolumam; Jose Zavala-Solorio; Anita Izrael-Tomasevic; David Arnott; Jianyong Wang; Andrew S. Peterson; Daniel Kirchhofer
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The structure of human DNase I bound to magnesium and phosphate ions points to a catalytic mechanism common to members of the DNase I-like superfamily
Biochemistry, ISSN: 15204995 00062960
Goetz Parsiegla; Christophe Noguere; Santell; Lazarus; Yves Bourne
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LUZ-Y, a novel platform for the mammalian cell production of full-length IgG-bispecific antibodies
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Bernd Wranik; Erin Christensen; Gabriele Schaefer; Janet Jackman; Andrew C. Vendel; Dan L. Eaton
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Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators
PLoS ONE, ISSN: 19326203
Justin M. Scheer; Wendy N. Sandoval; J. Michael Elliott; Lily Shao; Luis; Sock-Cheng Lewin-Koh; Gabriele Schaefer; Richard L. Vandlen
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Dynamic randomization and a randomization model for clinical trials data
Statistics in Medicine, ISSN: 02776715 10970258
Lee D. Kaiser
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A comparison of least squares and conditional maximum likelihood estimators under volume endpoint censoring in tumor growth experiments
Statistics in Medicine, ISSN: 02776715 10970258
Kingshuk Roy Choudhury; Finbarr O'Sullivan; Ian Kasman; Greg D. Plowman
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Multiple secretoglobin 1A1 genes are differentially expressed in horses
BMC Genomics, ISSN: 14712164
Olivier Côté; Brandon N. Lillie; Michael Anthony Hayes; Mary Ellen Clark; Laura van den Bosch; Paula Katavolos; Laurent Viel; Dorothee Bienzle
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Studying dissolution with a model integrating solid-liquid interface kinetics and diffusion kinetics
Analytical Chemistry, ISSN: 00032700 15206882
Jeff Y. Gao
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Mutation Scanning Using MUT-MAP, a High-Throughput, Microfluidic Chip-Based, Multi-Analyte Panel
PLoS ONE, ISSN: 19326203
Rajesh Patel; Alison Tsan; Rachel Tam; Rupal Desai; Nancy Schoenbrunner; Thomas W. Myers; Keith Bauer; Edward Smith; Rajiv Raja
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Molecular pathways: Next-generation immunotherapy-inhibiting programmed death-ligand 1 and programmed death-1
Clinical Cancer Research, ISSN: 10780432 15573265
Daniel S. Chen; Bryan Irving; F. Stephen Hodi
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The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma
International Journal of Cancer, ISSN: 00207136 10970215
Momen Elshazley; Sato; Tetsunari Hase; Ryo Yamashita; Kenya Yoshida; Shinya Toyokuni; Futoshi Ishiguro; Hirotaka Osada; Yoshitaka Sekido; Kohei Yokoi; Noriyasu Usami; David S. Shames; Masashi Kondo; Adi Gazdar; Minna; Yoshinori Hasegawa
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Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models
Clinical Cancer Research, ISSN: 10780432 15573265
Jill M. Spoerke; Carol O'Brien; Huw; Koeppen; Jane Fridlyand; Rainer Brachmann; Matthias Peter; Ajay Pandita; Sankar Mohan; Deepak Sampath; Lori S. Friedman; Berry; Garret M. Hampton; Lukas Amler; David S. Shames; Lackner
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Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Sharada Labadie; Peter Dragovich; Kathy Barrett; Wade S. Blair; Philippe Bergeron; Christine Chang; Gauri Deshmukh; Eigenbrot; Nico Ghilardi; Paul Gibbons; Christopher A. Hurley; Adam R. Johnson; Jane R. Kenny; Pawan Bir Kohli; Janusz J. Kulagowski; Marya Liimatta; Patrick J. Lupardus; Rohan Mendonca; Jeremy Murray; Rebecca Pulk; Steven Shia; Micah Steffek; Savita Ubhayakar; Ultsch; Anne Van Abbema; Stuart I. Ward; Mark Zak
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miR-451 regulates dendritic cell cytokine responses to influenza infection
Journal of Immunology, ISSN: 00221767 15506606
Carrie M. Rosenberger; Rebecca L. Podyminogin; Garnet Navarro; Guo-Wei Zhao; Peter S. Askovich; Mitchell J. Weiss; Alan Aderem
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Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria
Immunity, ISSN: 10747613 10974180
Rajatava Basu; Darrell B. O'Quinn; Daniel J. Silberger; Trenton R. Schoeb; Lynette Fouser; Wenjun Ouyang; Robin D. Hatton; Casey T. Weaver
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A caspase cascade regulating developmental axon degeneration
Journal of Neuroscience, ISSN: 02706474 15292401
David J. Simon; Robby M. Weimer; Todd McLaughlin; Dara Y. Kallop; Karen Stanger; Jing Yang; Dennis D.M. O'Leary; Rami N. Hannoush; Marc Tessier-Lavigne
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Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6
PLoS ONE, ISSN: 19326203
Christopher E. Heise; Jeremy Murray; Katherine E. Augustyn; Brandon Bravo; Preeti Chugha; Frederick Cohen; Anthony M. Giannetti; Paul Gibbons; Rami N. Hannoush; Brian R. Hearn; Priyadarshini Jaishankar; Cuong Q. Ly; Kinjalkumar Shah; Karen Stanger; Micah Steffek; Yinyan Tang; Xianrui Zhao; Joe Lewcock; Adam R. Renslo; Flygare; Michelle R. Arkin
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Author response: Validation of the national eye institute visual function questionnaire-25 (NEIVFQ-25) in age-related macular degeneration
Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783
Peggy Orr; Anne M. Rentz; Mary Kay Margolis; Dennis A. Revicki; Chantal M. Dolan; Shoshana Colman; Jennifer T. Fine; Neil M. Bressler
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Characterizing ubiquitination sites by peptide-based immunoaffinity enrichment
Molecular and Cellular Proteomics, ISSN: 15359476 15359484
Daisy J. Bustos; Corey Bakalarski; Yanling Yang; Junmin Peng; Donald S. Kirkpatrick
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Microwave-assisted protein staining, destaining, and in-gel/in-solution digestion of proteins
Methods in Molecular Biology, ISSN: 10643745
Jennie R. Lill; Victor J. Nesatyy
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Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways
Journal of Cell Biology, ISSN: 00219525 15408140
Bryan Lo; Geraldine Strasser; Meredith Sagolla; Cary D. Austin; Melissa Junttila; Ira Mellman
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Phosphoproteome of Pristionchus pacificus provides insights into architecture of signaling networks in nematode models
Molecular and Cellular Proteomics, ISSN: 15359476 15359484
Nadine Borchert; Karsten Krug; Florian Gnad; Amit Sinha; Ralf J. Sommer; Boris Macek
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A phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission
Clinical Cancer Research, ISSN: 10780432 15573265
Stanley B. Kaye; Louis Fehrenbacher; Robert Holloway; Amnon Amit; Beth Karlan; Brian Slomovitz; Paul Sabbatini; Ling Fu; Robert Yauch; Ilsung Chang; Josina C. Reddy
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