Genentech: Publications

August 1, 2016

Medicare Expenditures of Individuals with Alzheimer's Disease and Related Dementias or Mild Cognitive Impairment Before and After Diagnosis

Journal of the American Geriatrics Society, ISSN: 15325415 00028614

Pei-Jung Lin; Yue Zhong; Howard Fillit; Er Chen; Peter J. Neumann

View on Scopus

August 1, 2016

Predicting vision gains with anti-VEGF therapy in neovascular age-related macular degeneration patients by using low-luminance vision

British Journal of Ophthalmology, ISSN: 00071161

Ronald E.P. Frenkel; Howard Shapiro; Ivaylo Stoilov

View on Scopus

August 1, 2016

Validation of a biotherapeutic immunoaffinity-LC-MS/MS assay in monkey serum: 'plug-And-play' across seven molecules

Bioanalysis, ISSN: 17576199 17576180

Surinder Kaur; Luna Liu; Diego F. Cortes; Junlong Shao; Rand Jenkins; William R. Mylott; Keyang Xu

View on Scopus

August 1, 2016

Scientific and Regulatory Policy Committee Points to Consider Review: Inclusion of Reproductive and Pathology End Points for Assessment of Reproductive and Developmental Toxicity in Pharmaceutical Drug Development

Toxicologic Pathology, ISSN: 15331601 01926233

Wendy Halpern; Mehrdad Ameri; Christopher J. Bowman; Michael R. Elwell; Michael L. Mirsky; Julian Oliver; Karen S. Regan; Amera K. Remick; Vicki L. Sutherland; Kary E. Thompson; Claudine Tremblay; Midori Yoshida; Lindsay Tomlinson

View on Scopus

August 1, 2016

Interpolymer Complexation Between Polyox and Carbopol, and Its Effect on Drug Release From Matrix Tablets

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Feng Zhang; Joseph W. Lubach; Watson Na; Samad Momin

View on Scopus

August 1, 2016

Disease, treatment, and outcome differences between men and women with follicular lymphoma in the United States

American Journal of Hematology, ISSN: 10968652 03618609

Chadi Nabhan; Zhou; Bann-Mo Day; Keith Dawson; Zelenetz; Jonathan W. Friedberg; James R. Cerhan; Brian K. Link; Christopher R. Flowers

View on Scopus

August 1, 2016

Going beyond common drug metabolizing enzymes: Case studies of biotransformation involving aldehyde oxidase, γ-glutamyl transpeptidase, cathepsin B, flavin-containing monooxygenase, and ADP-ribosyltransferase

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Peter W. Fan; Donglu Zhang; Jason S Halladay; James Driscoll; S. Cyrus Khojasteh

View on Scopus

August 1, 2016

Population pharmacokinetics of bevacizumab in cancer patients with external validation

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Kelong Han; Thomas Peyret; Mathilde Marchand; Angelica Quartino; Nathalie H. Gosselin; Sandhya Girish; David E. Allison; Jin Y. Jin

View on Scopus

August 1, 2016

Properties and mechanisms of drug release from matrix tablets containing poly(ethylene oxide) and poly(acrylic acid) as release retardants

European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411

Feng Zhang; Fan Meng; Joseph W. Lubach; Joseph Koleng; Watson

View on Scopus

August 1, 2016

Predictors of Diabetic Macular Edema Treatment Frequency with Ranibizumab During the Open-Label Extension of the RIDE and RISE Trials

Ophthalmology, ISSN: 15494713 01616420

Charles C. Wykoff; Michael J. Elman; Carl D. Regillo; Beiying Ding; Na Lu; Ivaylo Stoilov

View on Scopus

August 1, 2016

Expression, purification, and characterization of recombinant human and murine milk fat globule-epidermal growth factor-factor 8

Protein Expression and Purification, ISSN: 10465928

Erick R. Castellanos; Claudio Ciferri; Wilson Phung; Wendy N. Sandoval; Marissa L. Matsumoto

View on Scopus

August 1, 2016

Comparison of BALB/c and B6-albino mouse strain blastocysts as hosts for the injection of C57BL6/N-derived C2 embryonic stem cells

Transgenic Research, ISSN: 15739368 09628819

Tuija M. Alcantar; Rhonda Wiler; Xin Y. Rairdan

View on Scopus

July 29, 2016

Reducing the risk of failure: Biomarker-guided trial design

Nature Reviews Drug Discovery, ISSN: 14741784 14741776

Michael J. Townsend; Joseph R. Arron

View on Scopus

July 29, 2016

A high-throughput hydrophilic interaction liquid chromatography coupled with a charged aerosol detector method to assess trisulfides in IgG1 monoclonal antibodies using tris(2-carboxyethyl)phosphine reaction products: Tris(2-carboxyethyl)phosphine-oxide and tris(2-carboxyethyl)phosphine-sulfide

Journal of Chromatography A, ISSN: 18733778 00219673

Christopher Cornell; Amish Karanjit; Yan Chen; Fred Jacobson

View on Scopus

July 29, 2016

Crystal structures of the human doublecortin C- and N-terminal domains in complex with specific antibodies

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Dominique Burger; Martine Stihle; Ashwani Sharma; Paola Di Lello; Jörg Benz; Brigitte D'Arcy; Maja Debulpaep; David Fry; Walter Huber; Thomas Kremer; Toon Laeremans; Hugues Matile; Ross; Arne C. Rufer; Guillaume Schoch; Michel O. Steinmetz; Jan Steyaert; Markus G. Rudolph; Ralf Thoma; Armin Ruf

View on Scopus

July 27, 2016

Comment on "nRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis"

Science Translational Medicine, ISSN: 19466242 19466234

Jérémie Decalf; Rosa Barreira da Silva; Scott Werneke; Matthew L. Albert

View on Scopus

July 20, 2016

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

Neuron, ISSN: 10974199 08966273

Felix L. Yeh; Yuanyuan Wang; Irene Tom; Lino C. Gonzalez Jr.; Morgan Sheng

View on Scopus

July 20, 2016

Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates

Bioconjugate Chemistry, ISSN: 15204812 10431802

Jose Ponte; Xiuxia Sun; Nicholas C. Yoder; Nathan Fishkin; Rassol Laleau; Jennifer A. Coccia; Leanne Lanieri; Megan Bogalhas; Lintao Wang; Sharon Wilhelm; Wayne C. Widdison; Jan Pinkas; Thomas A. Keating; Ravi Chari; Hans Erickson; John M. Lambert

View on Scopus

July 19, 2016

The Itch to degrade ROR-γt

Nature Immunology, ISSN: 15292916 15292908

Sascha Rutz; Wenjun Ouyang

View on Scopus

July 15, 2016

Green Chemistry Articles of Interest to the Pharmaceutical Industry

Organic Process Research and Development, ISSN: 1520586X 10836160

Rakeshwar Bandichhor; Apurba Bhattacharya; Marian C. Bryan; Andrew Cosbie; Alba Díaz-Rodríguez; Louis Diorazio; Zhongbo Fei; Kenneth Fraunhoffer; John Hayler; Matthew Hickey; Luke Humphreys; Paul Richardson; Scott Roberts; Timothy White; Stijn Wuyts; Jingjun Yin

View on Scopus

July 15, 2016

A sensitive mutation screening method supporting cell line development for biotherapeutics

Analytical Biochemistry, ISSN: 10960309 00032697

Ildana Valisheva; Reed J. Harris; Judith Zhu-Shimoni

View on Scopus

July 15, 2016

Validation and determination of taselisib, a β-sparing phosphoinositide 3-kinase (PI3K) inhibitor, in human plasma by LC-MS/MS

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Xiao Ding; Faber; Shi; McKnight; Dorshorst; Joseph A. Ware; Brian J. Dean

View on Scopus

July 15, 2016

A simple and sensitive method to analyze genotoxic impurity hydrazine in pharmaceutical materials

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Jennifer Wang; Samuel H. Yang; Kelly Zhang

View on Scopus

July 15, 2016

Treatment with a human recombinant monoclonal IgG antibody against oxidized LDL in atherosclerosis-prone pigs reduces cathepsin S in coronary lesions

International Journal of Cardiology, ISSN: 18741754 01675273

Christian Bo Poulsen; Ahmed Ludvigsen Al-Mashhadi; Karin von Wachenfeldt; Jacob Fog Bentzon; Lars Bo Nielsen; Rozh H. Al-Mashhadi; Jesper Thygesen; Lars Tolbod; Jens Rolighed Larsen; Jørgen Frøkiær; Ahmed Tawakol; Esad Vucic; Jill Fredrickson; Amos Baruch; Björn Frendéus; Anna-Karin Robertson; Søren Kragh Moestrup; Ludovic Drouet; Erling Falk

View on Scopus

July 14, 2016

Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality

PLoS Biology, ISSN: 15457885 15449173

Mario Novkovic; Lucas Onder; Jovana Cupovic; Jun Abe; David Bomze; Viviana Cremasco; Elke Scandella; Jens V. Stein; Gennady Bocharov; Shannon J. Turley; Burkhard Ludewig

View on Scopus

July 14, 2016

Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality

PLoS Biology, ISSN: 15449173

Mario Novkovic; Lucas Onder; Jovana Cupovic; Jun Abe; David Bomze; Viviana Cremasco; Elke Scandella; Jens V. Stein; Gennady Bocharov; ShannonJ. Turley; Burkhard Ludewig

View on Scopus

July 13, 2016

The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer

eLife, ISSN: 2050084X

James D. Joseph; Beatrice Darimont; Wei Zhou; Alfonso Arrazate; Amy Young; Ellen Ingalla; Kimberly Walter; Robert A. Blake; Jim Nonomiya; Zhengyu Guan; Kategaya; Steven P. Govek; Andiliy G. Lai; Mehmet Kahraman; Dan Brigham; John Sensintaffar; Nhin Lu; Gang Shao; Jing Qian; Kate Grillot; Michael Moon; Rene Prudente; Eric Bischoff; Kyoung-Jin Lee; Celine Bonnefous; Karensa L. Douglas; Jackaline D. Julien; Johnny Y. Nagasawa; Anna Aparicio; Josh Kaufman; Benjamin Haley; Jennifer M. Giltnane; Ingrid E. Wertz; Lackner; Michelle Nannini; Deepak Sampath; Luis J. Schwarz; H. Charles Manning; Mohammed Noor Tantawy; Carlos L. Arteaga; Richard A. Heyman; Peter J. Rix; Lori S. Friedman; Nicholas D. Smith; Ciara Metcalfe; Jeffrey H. Hager

View on Scopus

July 13, 2016

Modeling and simulation of maintenance treatment in first-line non-small cell lung cancer with external validation

BMC Cancer, ISSN: 14712407

Kelong Han; Laurent Claret; Alan Sandler; Asha Das; Jin Y. Jin; Rene Bruno

View on Scopus

July 12, 2016

NeuCode Proteomics Reveals Bap1 Regulation of Metabolism

Cell Reports, ISSN: 22111247

Joshua M. Baughman; Christopher M. Rose; Ganesh Kolumam; Webster; Emily M. Wilkerson; Anna E Merrill; Timothy W. Rhoads; Rajkumar Noubade; Paula Katavolos; Justin Lesch; Donald S. Stapleton; Mary E. Rabaglia; Kathy L. Schueler; Raymond Asuncion; Melanie Domeyer; Jose Zavala-Solorio; Michael Reich; Jason Devoss; Mark P. Keller; Alan D. Attie; Alexander S. Hebert; Michael S. Westphall; Joshua J Coon; Donald S. Kirkpatrick; Anwesha Dey

View on Scopus

July 12, 2016

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Robin A. Aglietti; Alberto Estevez; Aaron Gupta; Monica Gonzalez Ramirez; Peter S. Liu; Nobuhiko Kayagaki; Claudio Ciferri; Vishva M. Dixit; Erin C. Dueber

View on Scopus

July 7, 2016

Length Matters: MINDY Is a New Deubiquitinase Family that Preferentially Cleaves Long Polyubiquitin Chains

Molecular Cell, ISSN: 10974164 10972765

Till Maurer; Ingrid E. Wertz

View on Scopus

July 3, 2016

Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A

mAbs, ISSN: 19420870 19420862

Priyanka Gupta; Amrita Kamath; Summer Park; Chiu; Jeff Lutman; Mauricio Maia; Man-Wah Tan; Min Xu; Lee R. Swem; Rong Deng

View on Scopus

July 2, 2016

Immunomodulatory antibodies for the treatment of lymphoma: Report on the CALYM Workshop

OncoImmunology, ISSN: 2162402X 21624011

Roch Houot; Philippe Gaulard; Schreiber; Ira Mellman; Olivier Lambotte; Pierre G. Coulie; Thierry Fest; Alan Korman; Ronald Levy; Margaret A. Shipp; Karin Tarte; Holbrook E. K. Kohrt; Aurélien Marabelle; Stephen Ansell; Hervé Watier; Andrea van Elsas; Arun Balakumaran; Frederick Arce Vargas; Sergio A. Quezada; Gilles Salles; Daniel Olive

View on Scopus

July 1, 2016

Protective and detrimental effects of neuroectodermal cell–derived tissue factor in mouse models of stroke

JCI insight,

Shaobin Wang; Brandi Reeves; Erica Sparkenbaugh; Janice Russell; Zbigniew Soltys; Hua Zhang; James E. Faber; Nigel S. Key; Daniel Kirchhofer; D. Neil Granger; Nigel Mackman; Rafal Pawlinski

View on Scopus

July 1, 2016

Validation of a spectral method for quantitative measurement of color in protein drug solutions

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Jian Yin; Trevor E. Swartz; Jian Zhang; Thomas W. Patapoff; Bartolo Chen; Joseph C. Marhoul; Norman Shih; Bruce Kabakoff; Kimia Rahimi

View on Scopus

July 1, 2016

Hydrolysis of polysorbate 20 and 80 by a range of carboxylester hydrolases

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Andrew C. McShan; Pervina Kei; Junyan A. Ji; Daniel C. Kim; Y. John Wang

View on Scopus

July 1, 2016

A spectral method for color quantitation of a protein drug solution

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Trevor E. Swartz; Jian Yin; Thomas W. Patapoff; Travis A. Horst; Susan M. Skieresz; Gordon Leggett; Charles Morgan; Kimia Rahimi; Joseph C. Marhoul; Bruce Kabakoff

View on Scopus

July 1, 2016

Preclinical safety profile of a depleting antibody against CRTh2 for asthma: Well tolerated despite unexpected CRTh2 expression on vascular pericytes in the central nervous system and gastric mucosa

Toxicological Sciences, ISSN: 10960929 10966080

Kathila S. Rajapaksa; Tao Huang; Neeraj Sharma; Shannon Liu; Margaret Solon; Arthur Reyes; Sarah Paul; Angie Yee; Janet Tao; Sreedevi Chalasani; Nga Bien-Ly; Kai H. Barck; Richard A. D. Carano; Jianyong Wang; Linda Rangell; Meire C. Bremer; Dimitry Danilenko; Paula Katavolos; Isidro Hötzel; Karin Reif; Cary D. Austin

View on Scopus

July 1, 2016

Reply

Gastroenterology, ISSN: 15280012 00165085

Mary E. Keir; Tew; Jason A. Hackney

View on Scopus

July 1, 2016

Cellular Interrogation: Exploiting Cell-to-Cell Variability to Discriminate Regulatory Mechanisms in Oscillatory Signalling

PLoS Computational Biology, ISSN: 15537358 1553734X

Javier Estrada; Natalie Andrew; Daniel Gibson; Frederick Chang; Florian Gnad; Jeremy Gunawardena

View on Scopus

July 1, 2016

Phosphoproteome analysis of the MAPK pathway reveals previously undetected feedback mechanisms

Proteomics, ISSN: 16159861 16159853

Florian Gnad; Sophia Doll; Kyung Song; Matthew P. Stokes; John Moffat; Bonnie Liu; David Arnott; Jeffery J. Wallin; Lori S. Friedman; Georgia Hatzivassiliou; Marcia Belvin

View on Scopus

July 1, 2016

Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network

Proteomics, ISSN: 16159861 16159853

Florian Gnad; Jeffery J. Wallin; Kyle A. Edgar; Sophia Doll; David Arnott; Liliane Robillard; Donald S. Kirkpatrick; Matthew P. Stokes; Ulka Vijapurkar; Georgia Hatzivassiliou; Lori S. Friedman; Marcia Belvin

View on Scopus

July 1, 2016

Simulations to Predict Clinical Trial Outcome of Bevacizumab Plus Chemotherapy vs. Chemotherapy Alone in Patients With First-Line Gastric Cancer and Elevated Plasma VEGF-A

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Kelong Han; Laurent Claret; Piao; Priti Hegde; Amita Joshi; Powell; Jin Y. Jin; Rene Bruno

View on Scopus

July 1, 2016

Quantitative comparison of DNA methylation assays for biomarker development and clinical applications

Nature Biotechnology, ISSN: 15461696 10870156

Christoph Bock; Florian Halbritter; Francisco J. Carmona; Sascha Tierling; Paul Datlinger; Yassen Assenov; María Berdasco; Anke K. Bergmann; Keith Booher; Florence Busato; Mihaela Campan; Christina Dahl; Christina M. Dahmcke; Dinh Diep; Agustín F. Fernández; Clarissa Gerhauser; Andrea Haake; Katharina Heilmann; Thomas Holcomb; Dianna Hussmann; Mitsuteru Ito; Ruth Kläver; Martin Kreutz; Marta Kulis; Virginia Lopez; Shalima S. Nair; Dirk S. Paul; Nongluk Plongthongkum; Wenjia Qu; Ana C. Queirós; Frank Reinicke; Guido Sauter; Thorsten Schlomm; Aaron Statham; Clare Stirzaker; Ruslan Strogantsev; Rocío G. Urdinguio; Kimberly Walter; Dieter Weichenhan; Daniel J. Weisenberger; Beck; Susan J. Clark; Manel Esteller; Anne C. Ferguson-Smith; Mario F. Fraga; Per Guldberg; Lise Lotte Hansen; Peter W. Laird; José I. Martín-Subero; Anders O. H. Nygren; Ralf Peist; Christoph Plass; David S. Shames; Reiner Siebert; Xueguang Sun; Jörg Tost; Jörn Walter; Kun Zhang

View on Scopus

July 1, 2016

Uncovering a dual regulatory role for caspases during endoplasmic reticulum stress-induced cell death

Molecular and Cellular Proteomics, ISSN: 15359484 15359476

Veronica G. Anania; Kebing Yu; Florian Gnad; Rebecca R. Pferdehirt; Han Li; Taylur P. Ma; Diana Jeon; Nikolaus Fortelny; William F. Forrest; Avi Ashkenazi; Christopher Overall; Jennie R. Lill

View on Scopus

July 1, 2016

Engineering highly potent and selective microproteins against Nav1.7 sodium channel for treatment of pain

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Anatoly Shcherbatko; Andrea Rossi; Davide Foletti; Guoyun Zhu; Oren Bogin; Meritxell Galindo Casas; Mathias Rickert; Adela Hasa-Moreno; Victor Bartsevich; Andreas Crameri; Alexander R. Steiner; Robert A. Henningsen; Avinash Gill; Jaume Pons; David L. Shelton; Arvind Rajpal; Pavel Strop

View on Scopus

July 1, 2016

Evaluation of Heavy-Chain C-Terminal Deletion on Product Quality and Pharmacokinetics of Monoclonal Antibodies

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Guoying Jiang; X. Christopher Yu; Daniela Bumbaca; Zhilan Hu; Annamarie Amurao; Duenas; Marc Wong; Iverson; Kai Zheng; Lam; Jia Chen; Roxanne Vega; Sheila Ulufatu; Cecilia Leddy; Helen Davis; Amy Shen; Wong; Reed J. Harris; Y. John Wang; Dongwei Li

View on Scopus

July 1, 2016

Native MS and ECD Characterization of a Fab–Antigen Complex May Facilitate Crystallization for X-ray Diffraction

Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305

Ying Zhang; Weidong Cui; Aaron T. Wecksler; Hao Zhang; Patricia Molina; Galahad Deperalta; Michael L. Gross

View on Scopus

July 1, 2016

The Impact of Systemic Factors on Clinical Response to Ranibizumab for Diabetic Macular Edema Presented in part at: 38th Macula Society Annual Meeting, February 2015, Scottsdale, Arizona.

Ophthalmology, ISSN: 15494713 01616420

Rishi Singh; Karishma Habbu; Justis P. Ehlers; M. Cecilia Lansang; Lauren Hill; Ivaylo Stoilov

View on Scopus

July 1, 2016

Implementation of mechanism of action biology-driven early drug development for children with cancer

European Journal of Cancer, ISSN: 18790852 09598049

Andy Pearson; Ralf Herold; Raphaël F. Rousseau; Chris Copland; Brigid Bradley-Garelik; Debbie Binner; Renaud Capdeville; Hubert Caron; Jacqueline Carleer; Louis Chesler; Birgit Geoerger; Pamela Kearns; Lynley V. Marshall; Stefan M. Pfister; Gudrun Schleiermacher; Jeffrey Skolnik; Cesare Spadoni; Jaroslav Sterba; Hendrick Van Den Berg; Martina Uttenreuther-Fischer; Olaf Witt; Koen Norga; Gilles Vassal; Georger; Iannone; Jakacki; Russo

View on Scopus

Attention: This page may not render properly. The browser you are using, Internet Explorer 10, is no longer supported.

Publications

Join Our Team

Two Scientists Walk Into a Bar