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DISPLAYING 5251 - 5300 OF 15613 RESULTS

Visual and Anatomic Outcomes in Patients with Diabetic Macular Edema with Limited Initial Anatomic Response to Ranibizumab in RIDE and RISE Presented in part at: American Academy of Ophthalmology Annual Meeting, October 2014, Chicago, Illinois; And 38th Macula Society Annual Meeting, February 2015, Scottsdale, Arizona.
Ophthalmology, ISSN: 15494713 01616420
Dante Joseph Pieramici; Pin-Wen Wang; Beiying Ding; Shamika Gune
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Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Gerd R. Burmester; William F. Rigby; Ronald Van Vollenhoven; Jonathan Kay; Rubbert-Roth; Ariella Kelman; Sophie Dimonaco; Nina Mitchell
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Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Sebastian Unizony; Villarreal; Miloslavsky; Na Lu; Merkel; Spiera; Seo; Langford; Hoffman; Kallenberg; E. William St. Clair; Iklé; Tchao; Linna Ding; Paul Brunetta; Hyon Choi; Paul A. Monach; Fervenza; John H. Stone; Specks
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Assessment of disease-related therapeutic protein drug-drug interaction for etrolizumab in patients with moderately to severely active ulcerative colitis
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Xiaohui Wei; Jane R. Kenny; Leslie Dickmann; Romeo MacIuca; Looney; Meina Tao Tang
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Cost-Effectiveness Model for Chemoimmunotherapy Options in Patients with Previously Untreated Chronic Lymphocytic Leukemia Unsuitable for Full-Dose Fludarabine-Based Therapy
Value in Health, ISSN: 15244733 10983015
Ursula Becker; Andrew Briggs; Santiago G. Moreno; Joshua A. Ray; Phuong Ngo; Kunal Samanta
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Cycling in the nucleus: Regulation of RNA 3' processing and nuclear organization of replication-dependent histone genes
Current Opinion in Cell Biology, ISSN: 18790410 09550674
Valentina Romeo; Daniel Schümperli
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Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Ernst Ahlberg; Alexander Amberg; Lisa Beilke; Dave Bower; Kevin P. Cross; Laura Custer; Kevin A. Ford; Jacky Van Gompel; James Harvey; Masamitsu Honma; Robert A. Jolly; Elisabeth Joossens; Raymond Kemper; Michelle Kenyon; Naomi Kruhlak; Lara Kuhnke; Penny Leavitt; Russell Naven; Claire Neilan; Donald P. Quigley; Dana Shuey; Hans-Peter Spirkl; Lidiya Stavitskaya; Andrew Teasdale; Angela White; Joerg Wichard; Craig Zwickl; Glenn J. Myatt
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Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Alexander Amberg; Lisa Beilke; Joel P. Bercu; Dave Bower; Alessandro Brigo; Kevin P. Cross; Laura Custer; Krista Dobo; Eric Dowdy; Kevin A. Ford; Susanne Glowienke; Jacky Van Gompel; James Harvey; Catrin Hasselgren; Masamitsu Honma; Robert A. Jolly; Raymond Kemper; Michelle Kenyon; Naomi Kruhlak; Penny Leavitt; Scott Miller; Wolfgang Muster; John Nicolette; Andreja Plaper; Mark Powley; Donald P. Quigley; M. Vijayaraj Reddy; Hans-Peter Spirkl; Lidiya Stavitskaya; Andrew Teasdale; Sandy Weiner; Dennie S. Welch; Angela White; Joerg Wichard; Glenn J. Myatt
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NLRP3 recruitment by NLRC4 during Salmonella infection
Journal of Experimental Medicine, ISSN: 15409538 00221007
Yan Qu; Shahram Misaghi; Kim Newton; Maltzman; Anita Izrael-Tomasevic; David Arnott; Vishva M. Dixit
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Depletion of major pathogenic cells in asthma by targeting CRTh2
JCI insight, ISSN: 23793708
Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif
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Depletion of major pathogenic cells in asthma by targeting CRTh2
JCI insight, ISSN: 23793708
Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Jo-Anne Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif
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Depletion of major pathogenic cells in asthma by targeting CRTh2
JCI insight,
Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Jo-Anne Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif
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An enzymatic deconjugation method for the analysis of small molecule active drugs on antibody-drug conjugates
mAbs, ISSN: 19420870 19420862
Yi Li; Christine Gu; Jason Gruenhagen; Peter M. Yehl; Nik P. Chetwyn; Colin D. Medley
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Reproducible pharmacogenomic profiling of cancer cell line panels
Nature, ISSN: 14764687 00280836
Matthias Peter; Eva Lin; Jenille Tan; Yihong Yu; Billy Lam; Steve Lianoglou; Richard M. Neve; Scott E. Martin; Jeffrey Settleman; Robert Yauch; Richard Bourgon
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Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)
ACS Medicinal Chemistry Letters, ISSN: 19485875
Alexander M. Taylor; Alexandre Côté; Michael C. Hewitt; Richard Pastor; Yves Leblanc; Christopher G. Nasveschuk; F. Anthony Romero; Terry Crawford; Nico Cantone; Hariharan Jayaram; Jeremy Setser; Jeremy Murray; Beresini; Gladys De Leon Boenig; Zhongguo Chen; Andrew R. Conery; Richard T Cummings; Leslie A. Dakin; E. Megan Flynn; Oscar W Huang; Susan Kaufman; Patricia J. Keller; James R. Kiefer; Tommy Lai; Yingjie Li; Jiangpeng Liao; Wenfeng Liu; Henry Lu; Eneida Pardo; Vickie Tsui; Jian Wang; Yongyun Wang; Zhaowu Xu; Fen Yan; Dong Yu; Laura E. Zawadzke; Xiaoqin Zhu; Xiaoyu Zhu; Robert J. Sims; Andrea G Cochran; Steve Bellon; James E. Audia; Steven Magnuson; Brian K Albrecht
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Mechanistic Insights into Radical-Mediated Oxidation of Tryptophan from ab Initio Quantum Chemistry Calculations and QM/MM Molecular Dynamics Simulations
Journal of Physical Chemistry A, ISSN: 15205215 10895639
Geoffrey P. F. Wood; Alavattam Sreedhara; Jamie M. R. Moore; John Wang; Bernhardt L. Trout
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Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin-2 Inducible T-Cell Kinase (ITK) Inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Alexander Heifetz; Giancarlo Trani; Matteo Aldeghi; Colin H. Mackinnon; Paul A. McEwan; Frederick A. Brookfield; Ewa I. Chudyk; Mike Bodkin; Zhonghua Pei; Jason D. Burch; Daniel F. Ortwine
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Randomized open-label phase II trial of apitolisib (GDC-0980), a novel inhibitor of the PI3K/mammalian target of rapamycin pathway, versus everolimus in patients with metastatic renal cell carcinoma
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Thomas Powles; Lackner; Stephane Oudard; Bernard Escudier; Christy Ralph; Janet E. Brown; Robert E. Hawkins; Daniel Castellano; Brian I. Rini; Michael D. Staehler; Alain Ravaud; Wei Lin; Bridget O'Keeffe; Wang; Shan Lu; Jill M. Spoerke; Huw; Michelle Byrtek; Rui Zhu; Joseph A. Ware; Robert J. Motzer
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Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms
Cell Reports, ISSN: 22111247
Karen Yap; Yixin Xiao; Brad A. Friedman; H. Shawn Je; Eugene V. Makeyev
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Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial
The Lancet, ISSN: 1474547X 01406736
Jonathan E. Rosenberg; Jean Hoffman-Censits; Thomas Powles; Michiel S Van Der Heijden; Arjun V. Balar; Andrea Necchi; Nancy Dawson; Peter H O'Donnell; Ani Balmanoukian; Yohann Loriot; Sandy Srinivas; Margitta M. Retz; Petros Grivas; Richard W. Joseph; Matthew D. Galsky; Mark T. Fleming; Petrylak; Jose Luis Perez-Gracia; Howard A. Burris; Daniel Castellano; Christina Canil; Joaquim Bellmunt; Dean Bajorin; Dorothee Nickles; Richard Bourgon; Garrett M Frampton; Na Cui; Sanjeev Mariathasan; Oyewale Abidoye; Gregg D. Fine; Robert Dreicer
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EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells
Nature, ISSN: 14764687 00280836
Jianhua Li; Erick Lu; Tangsheng Yi; Jason G. Cyster
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The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation
Nature Communications, ISSN: 20411723
Nadia Martinez-Martin; Sree R. Ramani; Jason A. Hackney; Irene Tom; Bernd Wranik; Michelle Chan; Johnny Wu; Maciej Paluch; Kentaro Takeda; Hass; Hilary F. Clark; Lino C. Gonzalez Jr.
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The impact of persistence with therapy on inpatient admissions and emergency room visits in the US among patients with multiple sclerosis
Journal of Medical Economics, ISSN: 1941837X 13696998
Nina Parikh Thomas; Suellen Curkendall; Amanda M. Farr; Elaine B. Yu; Hurley
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Mismatch repair deficiency testing in clinical practice
Expert Review of Molecular Diagnostics, ISSN: 17448352 14737159
Natalia Buza; James Ziai; Pei Hui
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NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22
Journal of Clinical Investigation, ISSN: 15588238 00219738
Marianne R. Spalinger; Stephanie Kasper; Claudia Gottier; Silvia Lang; Kirstin Atrott; Stephan R. Vavricka; Sylvie Scharl; Petrus M. Gutte; Markus G. Grütter; Hans-Dietmar Beer; Emmanuel Contassot; Andrew A. Chan; Xuezhi Dai; David J. Rawlings; Florian Mair; Burkhard Becher; Werner Falk; Fried; Gerhard Rogler; Michael Scharl
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Roles of periostin in respiratory disorders
American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X
Kenji Izuhara; Simon J. Conway; Bethany B. Moore; Hisako Matsumoto; Cécile T.J. Holweg; Matthews; Joseph R. Arron
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Clearance of extractables and leachables from single-use technologies via ultrafiltration/diafiltration operations
Biotechnology Progress, ISSN: 15206033
Nicholas Magarian; Kate Lee; Kunal Nagpal; Ken Skidmore; Ekta Mahajan
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Exploring concordance of Patient-Reported information on patientsLikeMe and medical claims data at the patient level
Journal of Medical Internet Research, ISSN: 14388871
Gabriel S. Eichler; Elisenda Cochin; Jian Han; Hu; Timothy E. Vaughan; Paul Wicks; Charles E. Barr; Jenny Devenport
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Expression profile of BCL-2, BCL-XL, and MCL-1 predicts pharmacological response to the BCL-2 selective antagonist venetoclax in multiple myeloma models
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Elizabeth A. Punnoose; Joel D. Leverson; Franklin V. Peale Jr.; Erwin R. Boghaert; Lisa D. Belmont; Nguyen Tan; Amy Young; Michael J. Mitten; Ellen Ingalla; Darbonne; Anatol Oleksijew; Paul Tapang; Peng Yue; Jason Oeh; Leslie Lee; Maïga; Wayne J. Fairbrother; Amiot; Andrew J. Souers; Deepak Sampath
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Prediction and quantification of splice events from RNA-seq data
PLoS ONE, ISSN: 19326203
Leonard D. Goldstein; Yi Cao; Gregoire Pau; Michael Lawrence; Thomas D Wu; Somasekar Seshagiri; Robert Gentleman
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Perspective on a Modified Developmental and Reproductive Toxicity Testing Strategy for Cancer Immunotherapy
International Journal of Toxicology, ISSN: 1092874X 10915818
Prell; Wendy Halpern; Gautham K. Rao
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Targeting Cell Death Pathways for Therapeutic Intervention in Kidney Diseases
Seminars in Nephrology, ISSN: 15584488 02709295
Garg; Domagoj Vucic
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Patterns of early and delayed visual response to ranibizumab treatment for neovascular age-related macular degeneration
JAMA Ophthalmology, ISSN: 21686165
Glenn Stoller; Gregg T. Kokame; Richard F. Dreyer; Howard Shapiro; Lisa Tuomi
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Delay in initiation of adjuvant trastuzumab therapy leads to decreased overall survival and relapse-free survival in patients with HER2-positive non-metastatic breast cancer
Breast Cancer Research and Treatment, ISSN: 15737217 01676806
Christopher Gallagher; Kenneth More; Tripthi V. Kamath; Anthony Masaquel; Annie Guérin; Raluca Ionescu-Ittu; Marjolaine Gauthier-Loiselle; Roy Nitulescu; Nicholas Sicignano; Elizabeth Butts; Eric Q. Wu; Brian Barnett
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Prospective design of anti-transferrin receptor bispecific antibodies for optimal delivery into the human brain
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Jitendra Kanodia; Kapil Gadkar; Daniela Bumbaca; Yin Zhang; Raymond K. Tong; Wilman Luk; Kwame Hoyte; Yanmei Lu; Kristin R. Wildsmith; Jessica A. Couch; Ryan J. Watts; Dennis; James A. Ernst; Kimberly Scearce-Levie; Jasvinder K. Atwal; Ramanujan; Sean B. Joseph
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Serum periostin in obstructive airways Disease
European Respiratory Journal, ISSN: 13993003 09031936
James Fingleton; Irene Braithwaite; Justin Travers; Darren Bowles; Rianne Strik; Rob Siebers; Cécile T.J. Holweg; Matthews; Mark Weatherall; Beasley
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Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha-Positive, PIK3CA-Mutant Breast Cancer
Clinical Cancer Research, ISSN: 15573265 10780432
Wei Yang; Sarah R. Hosford; Lloye M. Dillon; Kevin Shee; Stephanie C. Liu; Jennifer R. Bean; Laurent Salphati; Jodie Pang; Xiaolin Zhang; Michelle Nannini; Eugene Demidenko; Darcy Bates; Lionel D. Lewis; Jonathan D. Marotti; Alan R. Eastman; Todd W. Miller
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Characterization of a sensitive mouse Aβ40 PD biomarker assay for Alzheimer's disease drug development in wild-type mice
Bioanalysis, ISSN: 17576199 17576180
Yanmei Lu; Kwame Hoyte; William H. Montgomery; Wilman Luk; Dongping He; William J. Meilandt; Y. Joy Yu Zuchero; Jasvinder K. Atwal; Kimberly Scearce-Levie; Ryan J. Watts; Laura DeForge
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A six-stage workflow for robust application of systems pharmacology
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Kapil Gadkar; Kirouac; Donald E. Mager; Van Der Graaf; Ramanujan
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Generation and characterization of a Breast cancer resistance protein humanized mouse model s
Molecular Pharmacology, ISSN: 15210111 0026895X
Shannon Dallas; Laurent Salphati; David Gomez-Zepeda; Thomas Wanek; Liangfu Chen; Xiaoyan Chu; Jeevan Kunta; Mario Mezler; Marie-Claude Menet; Stephanie Chasseigneaux; Xavier Declèves; Oliver Langer; Esaie Pierre; Karen Diloreto; Carolin Hoft; Loic Laplanche; Jodie Pang; Tony Pereira; Clara Andonian; Damir Simic; Anja Rode; Jocelyn Yabut; Xiaolin Zhang; Nico Scheer
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ImmunoPET helps predicting the efficacy of antibody-drug conjugates targeting TENB2 and STEAP1
Oncotarget, ISSN: 19492553
Simon P. Williams; Annie Ogasawara; Jeff N. Tinianow; Judith E. Flores; David Kan; Jeffrey Lau; MaryAnn Go; Alexander N. Vanderbilt; Herman S. Gill; Li Miao; Joshua Goldsmith; Bonnee Rubinfeld; Mao; Ron Firestein; Shang-Fan Yu; Jan Marik; Anton G.T. Terwisscha van Scheltinga
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A biologist's field guide to multiplexed quantitative proteomics
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Corey Bakalarski; Donald S. Kirkpatrick
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Current approaches for absorption, distribution, metabolism, and excretion characterization of antibody-drug conjugates: An industry white paper
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Eugenia Kraynov; Amrita Kamath; Markus Walles; Edit Tarcsa; Antoine Deslandes; Ramaswamy A. Iyer; Amita Datta-Mannan; Priya Sriraman; Michaela Bairlein; Johnny J. Yang; Matthew Barfield; Guangqing Xiao; Escandon; Weirong Wang; Dan A. Rock; Nagendra V. Chemuturi; David J. Moore
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Fc-galactosylation modulates antibody-dependent cellular cytotoxicity of therapeutic antibodies
Molecular Immunology, ISSN: 18729142 01615890
Marco Thomann; Katharina Reckermann; Dietmar Reusch; Jessica Prasser; Max L. Tejada
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Simultaneous determination of itraconazole, hydroxy itraconazole, keto itraconazole and N-desalkyl itraconazole concentration in human plasma using liquid chromatography with tandem mass spectrometry
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Xiaorong Liang; Michael Van Parys; Xiao Ding; Ning Zeng; Luke Bi; Drew Dorshort; McKnight; Dennis Milanowski; Jialin Mao; Yuan Chen; Joseph A. Ware; Brian J. Dean; Cornelis E. Hop; Yuzhong Deng
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Understanding the impact of second-hand smoke exposure on clinical outcomes in participants with COPD in the SPIROMICS cohort
Thorax, ISSN: 14683296 00406376
Nirupama Putcha; R Graham Barr; MeiLan Han; Prescott G. Woodruff; Eugene R. Bleecker; Richard E. Kanner; Fernando J. Martinez; Benjamin M. Smith; Donald P. Tashkin; Russell P. Bowler; Mark D. Eisner; Stephen I. Rennard; Robert A. Wise; Nadia N. Hansel
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Effectiveness of bevacizumab exposure beyond disease progression in patients with non-small-cell lung cancer: Analyses of the ARIES observational cohort study
Pharmacoepidemiology and Drug Safety, ISSN: 10991557 10538569
Larry Leon; Michael Kosty; Mohammad Jahanzeb; David Spigel; Antoinette J. Wozniak; Julie Brahmer; Susan Fish; E. Dawn Flick; Sebastien J. Hazard; Thomas J. Lynch
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Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma
Pharmaceutical Research, ISSN: 1573904X 07248741
Jialin Mao; Suzanne Tay; S. Cyrus Khojasteh; Yuan Chen; Cornelis E. Hop; Jane R. Kenny
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Ritonavir-boosted danoprevir-based regimens in treatment-naive and prior null responders with HCV genotype 1 or 4 and compensated cirrhosis
Hepatology International, ISSN: 19360541 19360533
Edward J. Gane; Régine Rouzier; Tarek Hassanein; Catherine Stedman; Wlodzimierz Mazur; Viera Kupcova; Sophie Le Pogam; Simon Eng; Athina Voulgari; Peter N. Morcos; Barbara J. Brennan; Astrid Scalori; James A. Thommes
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CD133 does not enrich for the stem cell activity in vivo in adult mouse prostates
Stem Cell Research, ISSN: 18767753 18735061
Xing Wei; Arturo V. Orjalo; Li Xin
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