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Publications

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DISPLAYING 5601 - 5650 OF 15613 RESULTS

Stratified medicine in inflammatory disorders: From theory to practice
Clinical Immunology, ISSN: 15217035 15216616
Joseph R. Arron; Michael J. Townsend; Mary E. Keir; Brian L. Yaspan; Andrew A. Chan
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Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates
Pharmaceutical Research, ISSN: 1573904X 07248741
Amrita Kamath; Suhasini Iyer
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Semi-mechanism-based population pharmacokinetic modeling of the hedgehog pathway inhibitor vismodegib
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Lu; Wang; Gao; Mark J. Dresser; Richard A. Graham; Jin Y. Jin
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Clinical pharmacology, creating current and future success in drug development
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Mark Rogge; Mark J. Dresser; Michael J. Fossler; Donald Heald; S. Aubrey Stoch; Konstantina M. Vanevski; Akintunde Bello
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Population pharmacokinetics of oseltamivir in non-pregnant and pregnant women
British Journal of Clinical Pharmacology, ISSN: 13652125 03065251
Venkateswaran C. Pillai; Kelong Han; Richard H. Beigi; Gary D. Hankins; Shannon Clark; Mary F. Hebert; Thomas R. Easterling; Anne Zajicek; Zhaoxia Ren; Steve N. Caritis; Raman Venkataramanan
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Baseline predictors of 12-month treatment response to ranibizumab in patients with wet age-related macular degeneration
American Journal of Ophthalmology, ISSN: 18791891 00029394
Carl D. Regillo; Brandon G. Busbee; Allen C. Ho; Beiying Ding; Zdenka Haskova
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Outcome-driven cluster analysis with application to microarray data
PLoS ONE, ISSN: 19326203
Jessie Hsu; Dianne M. Finkelstein; David Schoenfeld
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Population pharmacokinetics and dosing implications for cobimetinib in patients with solid tumors
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Kelong Han; Jin Y. Jin; Mathilde Marchand; Stephen M. Eppler; Nicholas Choong; Stephen P. Hack; Nalin Tikoo; Rene Bruno; Mark J. Dresser; Luna Musib; Nageshwar Budha
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Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Burdick; Shumei Wang; Christopher E. Heise; Borlan Pan; Jake Drummond; Jianping Yin; Lauren Goeser; Steven Magnuson; Jeff Blaney; John Moffat; Weiru Wang; Huifen Chen
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Design of clinical trials with failure-time endpoints and interim analyses: An update after fifteen years
Contemporary Clinical Trials, ISSN: 15592030 15517144
Pei He; Tze Leung Lai; Zheng Su
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TRAF2 is a biologically important necroptosis suppressor
Cell Death and Differentiation, ISSN: 14765403 13509047
Sean Petersen; Tom T. Chen; David Lawrence; Scot A. Marsters; François Gonzalvez; Avi Ashkenazi
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Host cell proteins in biotechnology-derived products: A risk assessment framework
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Christina de Zafra; Quarmby; Kathleen Francissen; Vanderlaan; Judith Zhu-Shimoni
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Fully-automated, high-throughput micro-computed tomography analysis of body composition enables therapeutic efficacy monitoring in preclinical models
International Journal of Obesity, ISSN: 14765497 03070565
Shelby K. Wyatt; Kai H. Barck; Lance Kates; Jose Zavala-Solorio; Ross; Ganesh Kolumam; Junichiro Sonoda; Richard A. D. Carano
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Disease characteristics, treatment patterns, and outcomes of follicular lymphoma in patients 40 years of age and younger: An analysis from the National Lymphocare Study
Annals of Oncology, ISSN: 15698041 09237534
Carla Casulo; Bann-Mo Day; Keith Dawson; Zhou; Christopher R. Flowers; Charles M. Farber; John Hainsworth; James R. Cerhan; Brian K. Link; Zelenetz; Jonathan W. Friedberg
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Evaluation of the International Prognostic Score (IPS-7) and a Simpler Prognostic Score (IPS-3) for advanced Hodgkin lymphoma in the modern era
British Journal of Haematology, ISSN: 13652141 00071048
Catherine S. Diefenbach; Hailun Li; Fangxin Hong; Leo I. Gordon; Richard I. Fisher; Nancy L. Bartlett; Michael Crump; Randy D. Gascoyne; Henry Wagner; Patrick J. Stiff; Bruce D. Cheson; Douglas A. Stewart; Brad Kahl; Jonathan W. Friedberg; Kristie A Blum; Thomas M. Habermann; Joseph M. Tuscano; Richard T. Hoppe; Sandra J. Horning; Ranjana H. Advani
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Evaluation of the International Prognostic Score (IPS-7) and a Simpler Prognostic Score (IPS-3) for advanced Hodgkin lymphoma in the modern era
British Journal of Haematology, ISSN: 13652141 00071048
Catherine S. Diefenbach; Hailun Li; Fangxin Hong; Leo I. Gordon; Richard I. Fisher; Nancy L. Bartlett; Michael Crump; Randy D. Gascoyne; Henry Wagner; Patrick J. Stiff; Bruce D. Cheson; Douglas A. Stewart; Wojciech Jurczak; Jonathan W. Friedberg; Kristie A Blum; Thomas M. Habermann; Joseph M. Tuscano; Richard T. Hoppe; Sandra J. Horning; Ranjana H. Advani
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Considerations for Requiring Subjects to Provide a Response to Electronic Patient-Reported Outcome Instruments
Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790
Paul O’Donohoe; J. Jason Lundy; Ari Gnanasakthy; Alison Greene
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Non-clinical disposition and metabolism of DM1, a component of trastuzumab emtansine (T-DM1), in sprague dawley rats
Drug Metabolism Letters, ISSN: 18723128
Shen; Daniela Bumbaca; Qin Yue; Ola M. Saad; Jay Tibbitts; S. Cyrus Khojasteh; Sandhya Girish
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Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
European Respiratory Journal, ISSN: 13993003 09031936
Dominick E. Shaw; Ana R. Sousa; Stephen J. Fowler; Louise J. Fleming; Graham Roberts; Julie Corfield; Ioannis Pandis; Aruna T. Bansal; Elisabeth H. Bel; Charles Auffray; Chris H. Compton; Hans Bisgaard; Enrica Bucchioni; Massimo Caruso; Chanez; Barbro Dahlén; Sven-Erik Dahlen; Kerry Dyson; Urs Frey; Thomas Geiser; Maria Gerhardsson De Verdier; David Gibeon; Yi-Ke Guo; Simone Hashimoto; Gunilla Hedlin; Elizabeth Jeyasingham; Pieter-Paul W. Hekking; Tim Higenbottam; Ildikó Horváth; Alan J. Knox; Norbert Krug; Veit J. Erpenbeck; Lars X. Larsson; Nikos Lazarinis; Matthews; Roelinde Middelveld; Paolo Montuschi; Jacek Musial; David Myles; Laurie Pahus; Thomas Sandström; Wolfgang Seibold; Florian Singer; Karin Strandberg; Jorgen Vestbo; Nadja Vissing; Christophe Von Garnier; Ian Adcock; Scott Wagers; Anthony Rowe; Peter Howarth; Ariane H. Wagener; Ratko Djukanovic; Peter J. Sterk; Kian Fan Chung
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Randomized trial of efficacy and safety of dornase alfa delivered by eRapid nebulizer in cystic fibrosis patients
Journal of Cystic Fibrosis, ISSN: 18735010 15691993
Gregory S. Sawicki; Will Chou; Karina Raimundo; Benjamin L. Trzaskoma; Michael W. Konstan
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Immunological hallmarks of stromal cells in the tumour microenvironment
Nature Reviews Immunology, ISSN: 14741741 14741733
Shannon J. Turley; Viviana Cremasco; Jillian L. Astarita
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Efficient conditional knockout targeting vector construction using co-selection BAC recombineering (CoSBR)
Nucleic Acids Research, ISSN: 13624962 03051048
Robert J. Newman; Merone Roose-Girma; Søren Warming
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Blinding properties of methods for supplying drug kits to investigational sites
Contemporary Clinical Trials Communications, ISSN: 24518654
Ron Yu; Daniel A. Coleman
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A novel design for randomized immuno-oncology clinical trials with potentially delayed treatment effects
Contemporary Clinical Trials Communications, ISSN: 24518654
Pei He; Zheng Su
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nature, ISSN: 14764687 00280836
Nobuhiko Kayagaki; Irma B. Stowe; Bettina L. Lee; Karen M. O'Rourke; Keith R. Anderson; Søren Warming; Trinna L. Cuellar; Benjamin Haley; Merone Roose-Girma; Qui Phung; Peter S. Liu; Jennie R. Lill; Hong Li; Jiansheng Wu; Sarah K. Kummerfeld; Juan Zhang; Wyne P. Lee; Scott J. Snipas; Guy S. Salvesen; Lucy X. Morris; Linda Fitzgerald; Yafei Zhang; Edward M. Bertram; Christopher C. Goodnow; Vishva M. Dixit
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Survival and Racial Differences of Non-Small Cell Lung Cancer in the United States Military
Journal of General Internal Medicine, ISSN: 15251497 08848734
Christina Brzezniak; Sacha Satram-Hoang; Hans-Peter Goertz; Carolina Reyes; Ashok Gunuganti; Christopher Gallagher; Corey A. Carter
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Inhibition of DYRK1A and GSK3B induces human β-cell proliferation
Nature Communications, ISSN: 20411723
Weijun Shen; Brandon Taylor; Qihui Jin; Van Nguyen-Tran; Shelly Meeusen; You-Qing Zhang; Anwesh Kamireddy; Austin Swafford; Andrew F. Powers; John Walker; John Lamb; Badry Bursalaya; Michael Didonato; George Harb; Minhua Qiu; Christophe Filippi; Lisa Deaton; Carolina N. Turk; Wilma L. Suarez-Pinzon; Yahu Liu; Xueshi Hao; Tingting Mo; Shanshan Yan; Jing Li; Ann E. Herman; Bernhard J. Hering; Tom Wu; Martin Seidel; Peter McNamara; Richard Glynne; Bryan A. Laffitte
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Interactions between Peptide and Preservatives: Effects on Peptide Self-Interactions and Antimicrobial Efficiency in Aqueous Multi-Dose Formulations
Pharmaceutical Research, ISSN: 1573904X 07248741
Heljo; Ross; Isidro E. Zarraga; Pappenberger; Hanns-Christian Mahler
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Prepregnancy Risk Factors for Preterm Birth and the Role of Maternal Nativity in a Low-Income, Hispanic Population
Maternal and Child Health Journal, ISSN: 15736628 10927875
Stephanie A. Leonard; Catherine M. Crespi; Denise Gee; Yuda Zhu; Shannon E. Whaley
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The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression
Science, ISSN: 10959203 00368075
Hung; Pratt; Sundararaman; Towsend; Christina Chaivorapol; Tushar Bhangale; Robert R. Graham; Ward Ortmann; Criswell; Yeo; Timothy W. Behrens
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Kinome screen identifies PFKFB3 and glucose metabolism as important regulators of the insulin/insulin-like growth factor (IGF)-1 signaling pathway
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Sophie Trefely; Poh-Sim Khoo; James R. Krycer; Rima Chaudhuri; Daniel J. Fazakerley; Benjamin L. Parker; Ghazal Sultani; James Lee; Jean-Philippe Stephan; Eric Torres; Kenneth Jung; Coenraad Kuijl; David E. James; Jagath R. Junutula; Jacqueline Stöckli
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Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies
Neuron, ISSN: 10974199 08966273
Nga Bien-Ly; C. Andrew Boswell; Surinc Er Jeet; Thomas G. Beach; Kwame Hoyte; Wilman Luk; Vera Shihadeh; Sheila Ulufatu; Oded Foreman; Yanmei Lu; Jason Devoss; Marcel P Van Der Brug; Ryan J. Watts
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Absolute Quantitation of Intact Recombinant Antibody Product Variants Using Mass Spectrometry
Analytical Chemistry, ISSN: 15206882 00032700
Frank D. Macchi; Feng Yang; Charlene Li; Chenchen Wang; Anh Nguyen Dang; Joseph C. Marhoul; Hui-Min Zhang; Timothy Tully; Hongbin Liu; X. Christopher Yu; David A. Michels
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Randomized phase II trial comparing obinutuzumab (GA101) with rituximab in patients with relapsed CD20+ indolent B-Cell non-hodgkin lymphoma: Final analysis of the GAUSS study
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Laurie H. Sehn; Andre Goy; Fritz C. Offner; Giovanni Martinelli; Dolores Caballero; Ole Gadeberg; Tara Baetz; Zelenetz; Gianluca Gaidano; Luis E. Fayad; Rena Buckstein; Jonathan W. Friedberg; Michael Crump; Branimir Jaksic; Pier Luigi Zinzani; Swaminathan Padmanabhan Iyer; Deniz Sahin; Akiko Chai; Guenter Fingerle-Rowson; Oliver W. Press
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PTEN loss in circulating tumour cells correlates with PTEN loss in fresh tumour tissue from castration-resistant prostate cancer patients
British Journal of Cancer, ISSN: 15321827 00070920
Elizabeth A. Punnoose; Roberta Ferraldeschi; Edith Szafer-Glusman; Eric K Tucker; Sankar Mohan; Penelope Flohr; Ruth Riisnaes; Susana Miranda; Ines Figueiredo; Daniel Nava Rodrigues; Aurelius Omlin; Carmel Pezaro; Jin Zhu; Lukas Amler; Premal Patel; Yibing Yan; Natalee Bales; Shannon L. Werner; Jessica Louw; Ajay Pandita; Dena Marrinucci; Gerhardt Attard; De Bono
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Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses
Immunity, ISSN: 10974180 10747613
Tangsheng Yi; Jianhua Li; Hsin Chen; Jiaxi Wu; Jinping An; Ying Xu; Yongmei Hu; Clifford Lowell; Jason G. Cyster
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Palladium-Catalyzed Ring Expansion of Spirocyclopropanes to Form Caprolactams and Azepanes
Journal of Organic Chemistry, ISSN: 15206904 00223263
Olivier René; Iain A. Stepek; Alberto Gobbi; Benjamin P. Fauber; Simon Gaines
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Role of Cosolute-Protein Interactions in the Dissociation of Monoclonal Antibody Clusters
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Thomas M. Scherer
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Lipids assist the membrane insertion of a BAM-independent outer membrane protein
Scientific Reports, ISSN: 20452322
Gerard H. M. Huysmans; Ingrid Guilvout; Mohamed Chami; Nicholas N. Nickerson; Anthony P. Pugsley
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Notch signal strength controls cell fate in the haemogenic endothelium
Nature Communications, ISSN: 20411723
Leonor Gama-Norton; Eva Ferrando; Cristina Ruiz-Herguido; Zenhy Liu; Jordi Guiu; Abul B.M.M.K. Islam; Sung-Uk Lee; Minhong Yan; Cynthia J. Guidos; Nuria López-Bigas; Takahiro Maeda; Lluis Espinosa; Raphael Kopan; Anna Bigas
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Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe
Cell Reports, ISSN: 22111247
Jaakko Mattila; Essi Havula; Erja Suominen; Mari Teesalu; Ida Surakka; Riikka Hynynen; Helena Kilpinen; Juho Väänänen; Iiris Hovatta; Reijo Käkelä; Samuli Ripatti; Thomas Sandmann; Ville Hietakangas
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Safety of onartuzumab in patients with solid tumors: Experience to date from the onartuzumab clinical trial program
PLoS ONE, ISSN: 19326203
Roland Morley; Alison Cardenas; Peter Hawkins; Yasuyo Suzuki; Virginia Paton; See Phan; Mark Merchant; Jessie Hsu; Wei Yu; Qi Xia; Daniel Koralek; Patricia Luhn; Wassim Aldairy
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A subset of human bromodomains recognizes butyryllysine and crotonyllysine histone peptide modifications
Structure, ISSN: 18784186 09692126
E. Megan Flynn; Oscar W Huang; Florence Poy; Mariano Oppikofer; Steve Bellon; Yong Tang; Andrea G Cochran
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A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia
Leukemia and Lymphoma, ISSN: 10292403 10428194
Thomas J. Kipps; Herbert Eradat; Sebastian Grosicki; John Catalano; Walter Cosolo; Iryna S. Dyagil; Sreeni Yalamanchili; Akiko Chai; Srikumar Sahasranaman; Elizabeth A. Punnoose; Deborah Hurst; Halyna Pylypenko
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Intravitreal administration of known phototoxicants in the rabbit fails to produce phototoxicity: Implications for phototoxicity testing of intravitreally administered small molecule therapeutics
Cutaneous and Ocular Toxicology, ISSN: 15569535 15569527
Evan A Thackaberry; Cindy A. Farman; Vlad Bantseev; Chris Schuetz; Julia F. Baker; Michael H. Brown; Douglas B. Learn
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Negishi Approach to 1,5-Disubstituted 3-Amino-1H-1,2,4-triazoles
Organic Letters, ISSN: 15237052 15237060
Jeff Shen; Brian Wong; Christine Gu; Haiming Zhang
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Gene expression of INPP5F as an independent prognostic marker in fludarabine-based therapy of chronic lymphocytic leukemia
Blood Cancer Journal, ISSN: 20445385
Palermo; Maisel; Martin Barrett; Helen Smith; Guillemette Duchateau-Nguyen; Tri Quang Nguyen; Ru-Fang Yeh; Annika Dufour; Tadeusz Robak; David Dornan; Martin Weisser
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Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Snahel Patel; Seth F. Harris; Paul Gibbons; Gauri Deshmukh; Amy Gustafson; Terry Kellar; Han Lin; Xingrong Liu; Yanzhou Liu; Yichin Liu; Changyou Ma; Kimberly Scearce-Levie; Arundhati Sengupta Ghosh; Young G. Shin; Hilda Solanoy; Jian Wang; Bei Wang; Jianping Yin; Michael Siu; Joe Lewcock
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Unliganded fibroblast growth factor receptor 1 forms density-independent dimers
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Laetitia Comps-Agrar; Diana Ronai Dunshee; Dan L. Eaton; Junichiro Sonoda
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Scientific and Regulatory Policy Committee Points-to-consider Paper∗: Drug-induced Vascular Injury Associated with Nonsmall Molecule Therapeutics in Preclinical Development: Part I. Biotherapeutics
Toxicologic Pathology, ISSN: 15331601 01926233
Kendall S. Frazier; Jeffery A. Engelhardt; Pierluigi Fant; Silvia Guionaud; Scott P. Henry; Michael W. Leach; Calvert Louden; Marshall S. Scicchitano; James L. Weaver; Tanja S. Zabka
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