Genentech: Publications

August 1, 2015

Determination of GDC-0980 (apitolisib), a small molecule dual phosphatidylinositide 3-kinase/mammalian target of rapamycin inhibitor in dog plasma by LC-MS/MS to support a GLP toxicology study

Biomedical chromatography : BMC, ISSN: 10990801 02693879

Xiao Ding; Laurent Salphati; Amy H. Kim; Eric Morinello; Lisa Wong; Jodie Pang; Percey; Meng; Reuschel; Brian J. Dean

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August 1, 2015

Lebrikizumab in moderate-to-severe asthma: Pooled data from two randomised placebo-controlled studies

Thorax, ISSN: 14683296 00406376

Nicola A. Hanania; Michael Noonan; Jonathan Corren; Phillip Korenblat; Zheng; Saloumeh Kadkhodayan Fischer; Melissa Cheu; Wendy Putnam; Elaine R. Murray; Heleen Scheerens; Cécile T.J. Holweg; Romeo MacIuca; Sarah Gray; Ramona Doyle; Mcclintock; Julie Olsson; Matthews; Karl Yen

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August 1, 2015

Phase 1 randomized, double-blind, placebo-controlled study of RG7667, an anticytomegalovirus combination monoclonal antibody therapy, in healthy adults

Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804

Julie H. Ishida; Tracy Burgess; Michael A. Derby; Pearline A. Brown; Mauricio Maia; Rong Deng; Brinda Emu; Becket Feierbach; Ashley Fouts; X. Charlene Liao; Jorge A. Tavel

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August 1, 2015

Influence of Glycosylated Hemoglobin on the Efficacy of Ranibizumab for Diabetic Macular Edema A Post Hoc Analysis of the RIDE/RISE Trials

Ophthalmology, ISSN: 15494713 01616420

Alok S. Bansal; Rahul N. Khurana; Mark R. Wieland; Pin-Wen Wang; Sherri A. Van Everen; Lisa Tuomi

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August 1, 2015

Metabolism and disposition of cabozantinib in healthy male volunteers and pharmacologic characterization of its major metabolites

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Steven Lacy; Bih Hsu; Dale Miles; Dana Aftab; Ronghua Wang; Linh Nguyen

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August 1, 2015

Insights on the immunogenicity of antibody-drug conjugates

Bioanalysis, ISSN: 17576199 17576180

Montserrat Carrasco-Triguero

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August 1, 2015

Bioanalytical approaches for characterizing catabolism of antibody-drug conjugates

Bioanalysis, ISSN: 17576199 17576180

Ola M. Saad; Shen; Keyang Xu; S. Cyrus Khojasteh; Sandhya Girish; Surinder Kaur

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August 1, 2015

Small molecule kinase inhibitors in veterinary oncology

Veterinary Journal, ISSN: 15322971 10900233

Webster

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August 1, 2015

Deciphering the crosstalk among IL-1 and IL-10 family cytokines in intestinal immunity

Trends in Immunology, ISSN: 14714981 14714906

Paolo Manzanillo; Celine Eidenschenk; Wenjun Ouyang

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August 1, 2015

Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer's Disease Neuroimaging Initiative (ADNI) CSF

Proteomics - Clinical Applications, ISSN: 18628354 18628346

Spellman; Kristin R. Wildsmith; Lee Honigberg; Marianne Tuefferd; David Baker; Nandini Raghavan; Angus C. Nairn; Pascal Croteau; Michael Schirm; René Allard; Julie Lamontagne; Daniel Chelsky; Steven Hoffmann; William Z. Potter

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August 1, 2015

Strategies to compare clinical antitherapeutic antibody data when changing assay platforms: A case study

Bioanalysis, ISSN: 17576199 17576180

Zhihua Julia Qiu; Yong Ying; Sock-Cheng Lewin-Koh; Daniel A. Coleman; Suzanne Brignoli; Robert Hendricks; Patricia Siguenza; Quarmby; Saloumeh Kadkhodayan Fischer; An Song

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July 31, 2015

A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components

Journal of Controlled Release, ISSN: 18734995 01683659

Hanne M. Kinnunen; Vikas Sharma; Luis Rodrigo Contreras-Rojas; Yafei Yu; Chlöe Alleman; Alavattam Sreedhara; Stefan Fischer; Leslie A. Khawli; Stefan T. Yohe; Daniela Bumbaca; Thomas W. Patapoff; Daugherty; Mrsny

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July 31, 2015

STatistically Assigned Response Criteria in Solid Tumors (STARCIST)

Cancer Imaging, ISSN: 14707330

Thomas Bengtsson; Sandra M. Sanabria-Bohorquez; Timothy J. McCarthy; David S. Binns; Rodney Hicks; De Crespigny

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July 30, 2015

Targeting the effect of VEGF in diabetic macular edema (2)

New England Journal of Medicine, ISSN: 15334406 00284793

Anthony P. Adamis; Jason S. Ehrlich; Anne E. Fung

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July 27, 2015

HER2 screening data from ToGA: targeting HER2 in gastric and gastroesophageal junction cancer

Gastric Cancer, ISSN: 14363305 14363291

Eric Van Cutsem; Bang; Feng Feng-yi; Jian M. Xu; Keun-Wook Lee; Shun-Chang Jiao; Jorge León Chong; Roberto I. López-Sanchez; Timothy Price; Oleg Gladkov; Oliver Stoss; Julie Hill; Vivian W. Ng; Michaela Lehle; Marlene Thomas; Astrid Kiermaier; Josef Rüschoff

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July 25, 2015

Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease

Mucosal Immunology, ISSN: 19353456 19330219

Nalle; Turner

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July 24, 2015

Synthesis of 1-substituted 3-amino-1H-1,2,4-triazoles from ethyl N-(5-phenyl-1,2,4-oxadiazol-3-yl)formimidate

Tetrahedron, ISSN: 14645416 00404020

Jeff Shen; Haiming Zhang

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July 24, 2015

Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9

AAPS Journal, ISSN: 15507416

Nageshwar Budha; Maya Leabman; Jin Y. Jin; D. Russell Wada; Amos Baruch; Kun Peng; Whittemore G. Tingley; John Davis

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July 24, 2015

Advancing Product Quality: a Summary of the Inaugural FDA/PQRI Conference

AAPS Journal, ISSN: 15507416

Lawrence X. Yu; Jeffrey Baker; Susan C. Berlam; Ashley Boam; Brandreth; Lucinda Buhse; Thomas Cosgrove; David Doleski; Lynne Ensor; Joseph Famulare; Mohan Ganapathy; Gustavo Grampp; David Hussong; Robert Iser; Gordon Johnston; Filippos Kesisoglou; Mansoor Khan; Steven Kozlowski; Emanuela Lacana; Sau L. Lee; Stephen Miller; Sarah Pope Miksinski; Christine M. V. Moore; Theresa Mullin; Raju; Andre Raw; Susan Rosencrance; Mark Rosolowsky; Paul Stinavage; Hayden Thomas; Russell Wesdyk; Joerg Windisch; Sivakumar Vaithiyalingam

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July 24, 2015

Mitigation of opioid off-target effects and identification of structural drivers of opioid receptor engagement for BACE-1 small molecule inhibitors

Toxicology Mechanisms and Methods, ISSN: 15376524 15376516

Dolores Diaz; Donna M. Dambach; Michael Siu; Kevin W. Hunt; Allen A. Thomas; Joseph P. Lyssikatos; Xingrong Liu; Sock-Cheng Lewin-Koh; Bobbi McCray; Kevin A. Ford

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July 24, 2015

Workshop Report: AAPS Workshop on Method Development, Validation, and Troubleshooting of Ligand-Binding Assays in the Regulated Environment

AAPS Journal, ISSN: 15507416

Marian Kelley; Lauren Stevenson; Michaela Golob; Viswanath Devanarayan; Joao Pedras-Vasconcelos; Roland F Staack; Rand Jenkins; Brian Booth; Eric Wakshull; Ronald Bowsher; Marie Rock; Sherri Dudal; Binodh DeSilva

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July 21, 2015

Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass

Cell Reports, ISSN: 22111247

Mark J. Solloway; Azadeh Madjidi; Chunyan Gu; Jeffrey Eastham-Anderson; Holly J. Clarke; Noelyn Kljavin; Jose Zavala-Solorio; Lance Kates; Brad A. Friedman; Matthew J. Brauer; Jianyong Wang; Oliver Fiehn; Ganesh Kolumam; Howard M. Stern; John Lowe; Andrew S. Peterson; Bernard B. Allan

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July 18, 2015

Big data analysis of treatment patterns and outcomes among elderly acute myeloid leukemia patients in the United States

Annals of Hematology, ISSN: 14320584 09395555

Bruno C. Medeiros; Sacha Satram-Hoang; Deborah Hurst; Khang Q. Hoang; Faiyaz Momin; Carolina Reyes

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July 17, 2015

Single-Step Synthesis of 5,6,7,8-Tetrahydroindolizines via Annulation of 2-Formylpiperidine and 1,3-Dicarbonyl Compounds

Organic Letters, ISSN: 15237052 15237060

Simona S. Capomolla; Ngiap-Kie Lim; Haiming Zhang

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July 15, 2015

Detection and dynamic changes of EGFR mutations from circulating tumor DNA as a predictor of survival outcomes in NSCLC Patients treated with first-line intercalated erlotinib and chemotherapy

Clinical Cancer Research, ISSN: 15573265 10780432

Tony Mok; Yi-Long Wu; Jin Soo Lee; Chong-Jen Yu; Virote Sriuranpong; Jennifer Sandoval-Tan; Guia Ladrera; Sumitra Thongprasert; Vichien Srimuninnimit; Meilin Liao; Yunzhong Zhu; Caicun Zhou; Fatima Fuerte; Benjamin Margono; Wei Wen; Julie Tsai; Matt Truman; Barbara Klughammer; David S. Shames; Lin Wu

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July 15, 2015

A novel anti-CD22 anthracycline-based antibody-drug conjugate (ADC) that overcomes resistance to auristatin-based ADCs

Clinical Cancer Research, ISSN: 15573265 10780432

Shang-Fan Yu; Bing Zheng; MaryAnn Go; Jeffrey Lau; Spencer; Helga Raab; Robert Soriano; Suchit Jhunjhunwala; Robert Cohen; Michele Caruso; Paul G. Polakis; Flygare; Andrew G. Polson

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July 15, 2015

An antibody-drug conjugate directed against lymphocyte antigen 6 complex, locus E (LY6E) provides robust tumor killing in a wide range of solid tumor malignancies

Clinical Cancer Research, ISSN: 15573265 10780432

Jyoti Asundi; Lisa Crocker; Jarrod Tremayne; Peter Chang; Sakanaka; Josh Tanguay; Spencer; Sreedevi Chalasani; Luis; Karen Gascoigne; Rupal Desai; Rajiv Raja; Brad A. Friedman; Matthias Peter; Paul G. Polakis; Ron Firestein

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July 14, 2015

Design of a selective substrate and activity based probe for human neutrophil serine protease 4

PLoS ONE, ISSN: 19326203

Paulina Kasperkiewicz; Marcin Poreba; Scott J. Snipas; S. Jack Lin; Daniel Kirchhofer; Guy S. Salvesen; Marcin Drag

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July 13, 2015

Anti-CD22 and anti-CD79B antibody drug conjugates are active in different molecular diffuse large B-cell lymphoma subtypes

Leukemia, ISSN: 14765551 08876924

Pfeifer; Bing Zheng; Erdmann; Koeppen; Mccord; Grau; Staiger; Akiko Chai; Thomas Sandmann; Madle; Dörken; Yu-Waye Chu; Chen; Lebovic; Gilles Salles; Myron S. Czuczman; Palanca-Wessels; Oliver W. Press; Ranjana H. Advani; Morschhauser; Bruce D. Cheson; Lenz; Ott; Andrew G. Polson; Kirsten E. Mundt; Lenz

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July 11, 2015

Comparative healthcare costs in patients with metastatic melanoma in the USA

Melanoma Research, ISSN: 14735636 09608931

Chun-Lan Chang; Vernon F. Schabert; Julie Munakata; Prina Donga; Sarang Abhyankar; Carolina Reyes; Yeun Mi Yim

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July 10, 2015

Using whole genome analysis to examine recombination across diverse sequence types of Staphylococcus aureus

PLoS ONE, ISSN: 19326203

Elizabeth M. Driebe; Jason W. Sahl; Chandler Roe; Jolene R. Bowers; James M. Schupp; John D. Gillece; Erin Kelley; Lance B. Price; Talima R. Pearson; Crystal M. Hepp; Pius M. Brzoska; Craig A. Cummings; Manohar Furtado; Paal S. Andersen; Marc Stegger; David M. Engelthaler; Paul S. Keim

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July 9, 2015

Discovery of 1-{4-[3-Fluoro-4-((3 S,6 R)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORγ) Inverse Agonist

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Benjamin P. Fauber; Olivier René; Yuzhong Deng; Jason Devoss; Celine Eidenschenk; Christine Everett; Arunima Ganguli; Alberto Gobbi; Julie Hawkins; Adam R. Johnson; Hank La; Justin Lesch; Peter Lockey; Maxine Norman; Wenjun Ouyang; Susan Summerhill; Harvey Wong

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July 9, 2015

Key challenges in the treatment of rare pediatric skeletal genetic disorders: from bench to bedside

Drug Discovery Today, ISSN: 18785832 13596446

Florence Lorget; Laurence Legeai-Mallet

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July 7, 2015

BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase

Nature Communications, ISSN: 20411723

Asad M. Taherbhoy; Oscar W Huang; Andrea G Cochran

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July 6, 2015

Solid-State Characterization of Novel Propylene Glycol Ester Solvates Isolated from Lipid Formulations

Molecular Pharmaceutics, ISSN: 15438392 15438384

Paroma Chakravarty; Sanjeev Kothari; Alan Deese; Joseph W. Lubach

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July 6, 2015

Oral immunotherapy and anti-IgE antibody treatment for food allergy

World Allergy Organization Journal, ISSN: 19394551

Dale T. Umetsu; Rima Rachid; Lynda C. Schneider

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July 3, 2015

Computational predictions of the site of metabolism of cytochrome P450 2D6 substrates: Comparative analysis, molecular docking, bioactivation and toxicological implications

Drug Metabolism Reviews, ISSN: 10979883 03602532

Kevin A. Ford; Gregory Ryslik; Jasleen K. Sodhi; Jason S Halladay; Dolores Diaz; Donna M. Dambach; Melisa Masuda

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July 3, 2015

Understanding and Addressing the Unbounded “Likelihood” Problem

American Statistician, ISSN: 15372731 00031305

Shiyao Liu; Huaiqing Wu; William Q. Meeker

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July 2, 2015

Direct and indirect targeting of MYC to treat acute myeloid leukemia

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Sam Brondfield; Sushma Umesh; Alexandra Corella; Johannes Zuber; Amy R. Rappaport; Coline Gaillard; Scott W. Lowe; Andrei Goga; Scott Kogan

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July 2, 2015

Direct and indirect targeting of MYC to treat acute myeloid leukemia

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Sam Brondfield; Sushma Umesh; Alexandra Corella; Johannes Zuber; Amy R. Rappaport; Coline Gaillard; Scott W. Lowe; Andrei Goga; Scott C. Kogan

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July 1, 2015

Vented Spikes Improve Delivery from Intravenous Bags with No Air Headspace

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

William J. Galush; Travis A. Horst

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July 1, 2015

Predictors of Functional and Anatomic Outcomes in Patients with Diabetic Macular Edema Treated with Ranibizumab

Ophthalmology, ISSN: 15494713 01616420

Raafay Sophie; Na Lu; Peter A. Campochiaro

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July 1, 2015

Health-related quality of life in a randomized phase III study of bevacizumab, temozolomide, and radiotherapy in newly diagnosed glioblastoma

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Martin J. B. Taphoorn; Roger Henriksson; Andrew Bottomley; Timothy Cloughesy; Wick; Warren Mason; Frank Saran; Ryo Nishikawa; Magalie Hilton; Christina Theodore-Oklota; Arliene Ravelo; Olivier L. Chinot

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July 1, 2015

Comparative Study of Analytical Techniques for Determining Protein Charge

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Dana I. Filoti; Steven J. Shire; Sandeep Yadav; Thomas M. Laue

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July 1, 2015

Use of cassette dosing to enhance the throughput of rat brain microdialysis studies

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Gauri Deshmukh; Kefeng Sun; Bianca M. Liederer; Xiao Ding; Xingrong Liu

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July 1, 2015

Conformational Isomerism in Solid State of AMG 853 - Structure Studies Using Solid-State Nuclear Magnetic Resonance and X-ray Diffraction

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Kiang; Karthik Nagapudi; Tian Wu; Matthew L. Peterson; Janan Jona; Richard J. Staples; Peter W. Stephens

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July 1, 2015

Intratumoral heterogeneity: From diversity comes resistance

Clinical Cancer Research, ISSN: 15573265 10780432

Ariel Pribluda; Cecile C. de la Cruz; Erica L. Jackson

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July 1, 2015

Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex

EBioMedicine, ISSN: 23523964

Ganesh Kolumam; Mark Chen; Raymond K. Tong; Jose Zavala-Solorio; Lance Kates; Nicholas Van Bruggen; Ross; Shelby K. Wyatt; Vineela D. Gandham; Richard A. D. Carano; Diana Ronai Dunshee; Ai-Luen Wu; Benjamin Haley; Keith R. Anderson; Søren Warming; Xin Y. Rairdan; Nicholas Lewin-Koh; Yingnan Zhang; Johnny Gutierrez; Amos Baruch; Thomas R. Gelzleichter; Dale Stevens; Sharmila Rajan; Travis W. Bainbridge; Jean-Michel Vernes; Meng; James Ziai; Robert Soriano; Matthew J. Brauer; Yongmei Chen; Scott Stawicki; Hok Seon Kim; Laetitia Comps-Agrar; Luis; Christoph Spiess; Yan Wu; James A. Ernst; Owen P. McGuinness; Andrew S. Peterson; Junichiro Sonoda

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July 1, 2015

Upregulation of periostin and reactive stroma is associated with primary chemoresistance and predicts clinical outcomes in epithelial ovarian cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Lisa Ryner; Yinghui Guan; Ron Firestein; Yuanyuan Xiao; Younjeong Choi; Christina Rabe; Shan Lu; Eloisa Fuentes; Huw; Lackner; Ling Fu; Lukas Amler; Carlos Bais; Wang

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July 1, 2015

Sulfonic Acid Salts of Donepezil and Stabilization of Amorphous Donepezil via Formation of Amorphous Salts

Crystal Growth and Design, ISSN: 15287505 15287483

Sun Hye Lee; Jae Ho Bae; Yeojin Park; Bishal Raj Adhikari; Chen Mao; Daeyoung Kim; Kyung Im Kim; Sung Kwon Kang; Eun Hee Lee

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