Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5801 - 5850 OF 15613 RESULTS

July 1, 2015

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer

Pharmacology and Therapeutics, ISSN: 1879016X 01637258

Deepak Sampath; Tanja S. Zabka; Misner; Thomas O'Brien; Peter Dragovich

July 1, 2015

Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice

Diabetologia, ISSN: 14320428 0012186X

Samantha L. Hocking; Rebecca L. Stewart; Amanda E. Brandon; Eurwin Suryana; Ella Stuart; Emily M. Baldwin; Ganesh Kolumam; Zora Modrusan; Jagath R. Junutula; Jenny E. Gunton; Michael Medynskyj; Sinead P. Blaber; Elisabeth Karsten; Benjamin R. Herbert; David E. James; Gregory J. Cooney; Michael M. Swarbrick

July 1, 2015

The Cost-Effectiveness of Ranibizumab for the Treatment of Diabetic Macular Edema

Ophthalmology, ISSN: 15494713 01616420

Gary C. Brown; Melissa M. Brown; Adam Turpcu; Yamina Rajput

July 1, 2015

Risk of corticosteroid-related adverse events in asthma patients with high oral corticosteroid use

Allergy and Asthma Proceedings, ISSN: 15396304 10885412

James L. Zazzali; Michael S. Broder; Theodore A. Omachi; Eunice Chang; Gordon H. Sun; Karina Raimundo

July 1, 2015

Response-adapted therapy for aggressive non-Hodgkin's lymphomas based on early [18F] FDG-PET scanning: ECOG-ACRIN Cancer Research Group study (E3404)

British Journal of Haematology, ISSN: 13652141 00071048

Lode J. Swinnen; Hailun Li; Andrew Quon; Randy D. Gascoyne; Fangxin Hong; Erik A. Ranheim; Thomas M. Habermann; Brad Kahl; Sandra J. Horning; Ranjana H. Advani

July 1, 2015

A phase II, multicenter, open-label, 3-cohort trial evaluating the efficacy and safety of vismodegib in operable basal cell carcinoma

Journal of the American Academy of Dermatology, ISSN: 10976787 01909622

Howard Sofen; Kenneth G. Gross; Leonard Goldberg; Harry Sharata; Tiffani K. Hamilton; Barbara Egbert; Benjamin Lyons; Jeannie Hou; Ivor Caro

July 1, 2015

Changes in asthma control, work productivity, and impairment with omalizumab: 5-year EXCELS study results

Allergy and Asthma Proceedings, ISSN: 15396304 10885412

James L. Zazzali; Karina Raimundo; Benjamin L. Trzaskoma; Karin Rosén; Michael Schatz

July 1, 2015

Disease characteristics, treatment patterns, prognosis, outcomes and lymphoma-related mortality in elderly follicular lymphoma in the United States

British Journal of Haematology, ISSN: 13652141 00071048

Chadi Nabhan; Michelle Byrtek; Ashish Rai; Keith Dawson; Zhou; Brian K. Link; Jonathan W. Friedberg; Zelenetz; Matthew J. Maurer; James R. Cerhan; Christopher R. Flowers

July 1, 2015

Hydrophobic interaction chromatography for antibody drug conjugate drug distribution analysis

American Pharmaceutical Review, ISSN: 10998012

Tao Chen; Kelly Zhang; Jason Gruenhagen; Colin D. Medley

July 1, 2015

Effectiveness of rituximab for the treatment of rheumatoid arthritis in patients with prior exposure to anti-TNF: Results from the CORRONA registry

Journal of Rheumatology, ISSN: 14992752 0315162X

Leslie R. Harrold; Reed; Ashwini Shewade; Robert Magner; Katherine C. Saunders; Ani John; Joel M. Kremer; Jeffrey D. Greenberg

July 1, 2015

Notch receptor-ligand engagement maintains hematopoietic stem cell quiescence and niche retention

Stem Cells, ISSN: 15494918 10665099

Weihuan Wang; Shuiliang Yu; Grant Zimmerman; Yiwei Wang; Jay Myers; Vionnie W. C. Yu; Dan Huang; Xiaoran Huang; Jeongsup Shim; Yuanshuai Huang; William Xin; Peter Qiao; Minhong Yan; Wei Xin; David T. Scadden; Pamela Stanley; John Lowe; Alex Y. Huang; Christian W. Siebel; Lan Zhou

July 1, 2015

Projected clinical, resource use, and fiscal impacts of implementing low-dose computed tomography lung cancer screening in Medicare

Journal of Oncology Practice, ISSN: 1935469X 15547477

Joshua A. Roth; Sean D. Sullivan; Bernardo H. L. Goulart; Arliene Ravelo; Joanna C. Sanderson; Scott D. Ramsey

July 1, 2015

Kinetic Modeling of Methionine Oxidation in Monoclonal Antibodies from Hydrogen Peroxide Spiking Studies

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Ada Hui; Lam; Christopher Kuehl; Ulla Grauschopf; Y. John Wang

July 1, 2015

Response-adapted therapy for aggressive non-Hodgkin's lymphomas based on early [18F] FDG-PET scanning: ECOG-ACRIN Cancer Research Group study (E3404)

British Journal of Haematology, ISSN: 13652141 00071048

Lode J. Swinnen; Hailun Li; Andrew Quon; Randy D. Gascoyne; Fangxin Hong; Erik A. Ranheim; Thomas M. Habermann; Wojciech Jurczak; Sandra J. Horning; Ranjana H. Advani

June 30, 2015

Responses to discussants of 'Joint modeling of survival and longitudinal non-survival data: Current methods and issues. report of the DIA Bayesian joint modeling working group'

Statistics in Medicine, ISSN: 10970258 02776715

A. Lawrence Gould; Mark Ernest Boye; Michael J. Crowther; Joseph G. Ibrahim; George Quartey; Sandrine Micallef; Frederic Y. Bois

June 30, 2015

Joint modeling of survival and longitudinal non-survival data: Current methods and issues. Report of the DIA Bayesian joint modeling working group

Statistics in Medicine, ISSN: 10970258 02776715

A. Lawrence Gould; Mark Ernest Boye; Michael J. Crowther; Joseph G. Ibrahim; George Quartey; Sandrine Micallef; Frederic Y. Bois

June 30, 2015

The evolutionary divergence of TRPA1 channel: heat-sensitive, cold-sensitive and temperature-insensitive

Temperature, ISSN: 23328959 23328940

Jun Chen

June 29, 2015

Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling

Journal of Experimental Medicine, ISSN: 15409538 00221007

Derek A. Holmes; Eric Suto; Wyne P. Lee; Qinglin Ou; Qian Gong; Hamish R.C. Smith; Patrick Caplazi; Andrew A. Chan

June 26, 2015

Final report on exposure during pregnancy from a pregnancy registry for quadrivalent human papillomavirus vaccine

Vaccine, ISSN: 18732518 0264410X

Mary Ann Goss; Fabio Lievano; Karyn M. Buchanan; Margaret M. Seminack; Michael L. Cunningham; Adrian Dana

June 26, 2015

The role of FcεRI expressed in dendritic cells and monocytes

Cellular and Molecular Life Sciences, ISSN: 14209071 1420682X

Jeoung-Sook Shin; Alexandra M. Greer

June 25, 2015

Structure-Guided Design of Group i Selective p21-Activated Kinase Inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

James J. Crawford; Wendy Lee; Ignacio Aliagas; Simon Mathieu; Klaus P. Hoeflich; Wei Zhou; Weiru Wang; Lionel Rouge; Lesley J. Murray; Hank La; Ning Liu; Peter W. Fan; Jonathan Cheong; Christopher E. Heise; Sreemathy Ramaswamy; Robert Mintzer; Yanzhou Liu; Qi Chao; Joachim Rudolph

June 25, 2015

Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Lewis Gazzard; Karen Williams; Huifen Chen; Lorraine Axford; Elizabeth M. Blackwood; Brenda Burton; Kerry Chapman; Peter H. Crackett; Joy Drobnick; Charles Ellwood; Jennifer A. Epler; Michael Flagella; Emanuela Gancia; Matthew Gill; Simon Goodacre; Jason S Halladay; Joanne F. M. Hewitt; Hazel Hunt; Samuel Kintz; Joseph P. Lyssikatos; Calum Macleod; Sarah Major; Guillaume Médard; Raman Narukulla; Judi Ramiscal; Stephen Schmidt; Eileen Seward; Wiesmann; Ping Wu; Sharon Fong Yee; Ivana Yen; Shiva Malek

June 25, 2015

Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination

Cell Death and Disease, ISSN: 20414889

Maria Cristina De Almagro; Tatiana Goncharov; Kim Newton; Domagoj Vucic

June 23, 2015

Phosphoregulatory protein 14-3-3 facilitates SAC1 transport from the endoplasmic reticulum

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Kanika Bajaj Pahuja; Jinzhi Wang; Anastasia Blagoveshchenskaya; Lillian Lim; Madhusudhan; Peter Mayinger; Randy Schekman

June 19, 2015

Development of an Expedient Process for the Multi-Kilogram Synthesis of Chk1 Inhibitor GDC-0425

Organic Process Research and Development, ISSN: 1520586X 10836160

Andreas Stumpf; Zhigang Cheng; Brian Wong; Mark E. Reynolds; Remy Angelaud; James Girotti; Alan Deese; Christine Gu; Lewis Gazzard

June 18, 2015

Transcription factor ATF4 induces NLRP1 inflammasome expression during endoplasmic reticulum stress

PLoS ONE, ISSN: 19326203

Andrea D'Osualdo; Veronica G. Anania; Kebing Yu; Jennie R. Lill; Randal J. Kaufman; Shu-Ichi Matsuzawa; John C. Reed

June 18, 2015

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Nature Chemical Biology, ISSN: 15524469 15524450

Elayne Chan-Penebre; Kristy G. Kuplast; Christina R. Majer; P Ann Boriack-Sjodin; Tim J. Wigle; L Danielle Johnston; Nathalie Rioux; Michael J. Munchhof; Lei Jin; Suzanne L. Jacques; Kip A. West; Trupti Lingaraj; Kimberly Stickland; Scott A. Ribich; Alejandra Raimondi; Margaret Porter Scott; Nigel J. Waters; Roy M. Pollock; Jesse J. Smith; Olena Barbash; Melissa Pappalardi; Thau F. Ho; Kelvin Nurse; Khyati P. Oza; Kathleen T. Gallagher; Ryan Kruger; Mikel P. Moyer; Robert A. Copeland; Richard Chesworth; Kenneth W. Duncan

June 18, 2015

Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer

BMC Genomics, ISSN: 14712164

Florian Gnad; Sophia Doll; Gerard Manning; David Arnott; Zemin Zhang

June 18, 2015

Drugs versus placebo for dysthymia

Cochrane database of systematic reviews (Online : Update Software), ISSN: 1469493X

Mauricio Silva de Lima; Joanna Moncrieff; Bernardo G. O Soares

June 15, 2015

Histopathology in mouse models of rheumatoid arthritis

Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development,

Patrick Caplazi; Laurie Diehl

June 15, 2015

Application of cultured human mast cells (CHMC) for the design and structure-activity relationship of IgE-mediated mast cell activation inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Ankush Argade; Somasekhar Bhamidipati; Hui Li; David Carroll; Jeffrey Clough; Holger Keim; Catherine Sylvain; Alexander B. Rossi; Christina Coquilla; Sarkiz D. Issakani; Esteban S. Masuda; Donald G. Payan; Rajinder Singh

June 15, 2015

Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Ankush Argade; Somasekhar Bhamidipati; Hui Li; Catherine Sylvain; Jeffrey Clough; David Carroll; Holger Keim; Sylvia Braselmann; Vanessa Taylor; Haoran Zhao; Ellen Herlaar; Sarkiz D. Issakani; Brian R. Wong; Esteban S. Masuda; Donald G. Payan; Rajinder Singh

June 15, 2015

Ig Repertoire Constructor: A novel algorithm for antibody repertoire construction and immunoproteogenomics analysis

Bioinformatics, ISSN: 14602059 13674803

Yana Safonova; Stefano Bonissone; Eugene Kurpilyansky; Ekaterina Starostina; Alla Lapidus; Stinson; Laura DePalatis; Wendy N. Sandoval; Jennie R. Lill; Pavel A. Pevzner

June 15, 2015

Baculovirus display for discovery of low-affinity extracellular receptor-ligand interactions using protein microarrays

Analytical Biochemistry, ISSN: 10960309 00032697

Irene Tom; Alberto Estevez; Krista K. Bowman; Lino C. Gonzalez Jr.

June 13, 2015

An integrated suite of modeling tools that empower scientists in structure- and property-based drug design

Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X

Jianwen A. Feng; Ignacio Aliagas; Philippe Bergeron; Jeff Blaney; Erin K. Bradley; Michael F. T. Koehler; Man-Ling Lee; Daniel F. Ortwine; Vickie Tsui; Johnny Wu; Alberto Gobbi

June 11, 2015

Leveraging the Pre-DFG Residue Thr-406 to Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series

ACS Medicinal Chemistry Letters, ISSN: 19485875

Joachim Rudolph; Ignacio Aliagas; James J. Crawford; Simon Mathieu; Wendy Lee; Qi Chao; Ping Dong; Lionel Rouge; Weiru Wang; Christopher E. Heise; Lesley J. Murray; Hank La; Yanzhou Liu; Gerard Manning; François Diederich; Klaus P. Hoeflich

June 11, 2015

Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Benjamin P. Fauber; Alberto Gobbi; Kirk D. Robarge; Aihe Zhou; Adrian Barnard; Jianhua Cao; Yuzhong Deng; Celine Eidenschenk; Christine Everett; Arunima Ganguli; Julie Hawkins; Adam R. Johnson; Hank La; Maxine Norman; Gary Salmon; Susan Summerhill; Wenjun Ouyang; Wei Tang; Harvey Wong

June 10, 2015

Human DNA helicase B interacts with the replication initiation protein Cdc45 and facilitates Cdc45 binding onto chromatin

Experimental Cell Research, ISSN: 10902422 00144827

Jeannine Gerhardt; Gulfem D. Guler; Ellen Fanning

June 9, 2015

SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML

Science Signaling, ISSN: 19379145 19450877

Domenico Fasci; Veronica G. Anania; Jennie R. Lill; Guy S. Salvesen

June 9, 2015

L-type amino-acid transporter 1 (LAT1): A therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia

Leukemia, ISSN: 14765551 08876924

Célia Rosilio; Marielle Nebout; Véronique Imbert; Emmanuel Griessinger; Zouhour Neffati; Benadiba; Thijs Hagenbeek; Hergen Spits; Julie Reverso; Ambrosetti; Jean-François Michiels; Bailly-Maitre; Endou; Wempe; Jean-François Peyron

June 5, 2015

Immunoaffinity enrichment coupled to quantitative mass spectrometry reveals ubiquitin-mediated signaling events

Journal of Molecular Biology, ISSN: 10898638 00222836

Kebing Yu; Lilian Phu; Eugene Varfolomeev; Daisy J. Bustos; Domagoj Vucic; Donald S. Kirkpatrick

June 2, 2015

A phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE)

Annals of the Rheumatic Diseases, ISSN: 14682060 00034967

Kenneth C. Kalunian; Merrill; Romeo MacIuca; Jacqueline McBride; Michael J. Townsend; Xiaohui Wei; John C. Davis; William P. Kennedy

June 2, 2015

On the analytical superiority of 1D NMR for fingerprinting the higher order structure of protein therapeutics compared to multidimensional NMR methods

Analytical Chemistry, ISSN: 15206882 00032700

Leszek Poppe; John B. Jordan; Gary Rogers; Paul D. Schnier

June 1, 2015

Association of the interferon signature metric with serological disease manifestations but not global activity scores in multiple cohorts of patients with SLE

Lupus Science and Medicine, ISSN: 20538790

William P. Kennedy; Romeo MacIuca; Kristen Wolslegel; Tew; Abbas Alexander; Christina Chaivorapol; Alyssa M. Morimoto; Jacqueline McBride; Paul Brunetta; Bruce C. Richardson; John C. Davis; Timothy W. Behrens; Michael J. Townsend

June 1, 2015

A novel reaction mediated by human aldehyde oxidase: Amide hydrolysis of GDC-0834

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Jasleen K. Sodhi; Susan C. Wong; Donald S. Kirkpatrick; Lichuan Liu; S. Cyrus Khojasteh; Cornelis E. Hop; John T. Barr; Jeffrey P. Jones; Jason S Halladay

June 1, 2015

Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Edna F. Choo; Sarah Woolsey; Kevin Dement; Justin Ly; Kirsten Messick; Ann R. Qin; Ryan Takahashi

June 1, 2015

Imaging MALDI MS of dosed brain tissues utilizing an alternative analyte pre-extraction approach

Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305

Cristine Quiason; Sheerin Shahidi-Latham

June 1, 2015

Design of coltuximab ravtansine, a CD19-targeting antibody-drug conjugate (ADC) for the treatment of B-cell malignancies: Structure-activity relationships and preclinical evaluation

Molecular Pharmaceutics, ISSN: 15438392 15438384

E. Erica Hong; Hans Erickson; Robert J. Lutz; Kathleen R. Whiteman; Gregory Jones; Yelena Kovtun; Veronique Blanc; John M. Lambert

June 1, 2015

Semi-mechanistic multiple-analyte pharmacokinetic model for an antibody-drug-conjugate in cynomolgus monkeys

Pharmaceutical Research, ISSN: 1573904X 07248741

Dan Lu; Jin Y. Jin; Sandhya Girish; Priya Agarwal; Dongwei Li; Saileta Prabhu; Randall Dere; Ola M. Saad; Denise Nazzal; Neelima Koppada; Ramanujan; Chee Ng

June 1, 2015

Safety and Pharmacokinetics/Pharmacodynamics of the First-in-Class Dual Action HER3/EGFR Antibody MEHD7945A in locally advanced or metastatic epithelial tumors

Clinical Cancer Research, ISSN: 15573265 10780432

Dejan Juric; Rodrigo Dienstmann; Andrés Cervantes; Manuel Hidalgo; Wells A. Messersmith; George R. Blumenschein; Tabernero; Desamparados Roda; Antonio Calles; Antonio Jimeno; Xiaodong Wang; Sandra M. Sanabria-Bohorquez; Cecilia Leddy; Catherine Littman; Amy V. Kapp; David S. Shames; Elicia M. Penuel; Lukas Amler; Andrea Pirzkall; Baselga

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