Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5951 - 6000 OF 15613 RESULTS

April 1, 2015

Functional analysis of protective IL1RL1 variants associated with asthma risk: To the editor

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Vladimir Ramirez-Carrozzi; Amy Dressen; Patrick J. Lupardus; Brian L. Yaspan; Rajita Pappu

April 1, 2015

Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse

Molecular Biology of the Cell, ISSN: 19394586 10591524

Anne Reversat; Maria-Isabel Yuseff; Danielle Lankar; Odile Malbec; Dorian Obino; Mathieu Maurin; Naga Venkata Gayathri Penmatcha; Alejandro Amoroso; Lucie Sengmanivong; Gregg G. Gundersen; Ira Mellman; François Darchen; Claire Desnos; Paolo Pierobon; Ana-Maria Lennon-Duménil

March 27, 2015

Precise and efficient antibody epitope determination through library design, yeast display and next-generation sequencing

Journal of Molecular Biology, ISSN: 10898638 00222836

Thomas Van Blarcom; Andrea Rossi; Davide Foletti; Purnima Sundar; Steven Pitts; Christine Bee; Jody Melton Witt; Zea Melton; Adela Hasa-Moreno; Lee Shaughnessy; Dilduz Telman; Lora Zhao; Wai Ling Cheung; Jan Berka; Wenwu Zhai; Pavel Strop; Javier Chaparro-Riggers; David L. Shelton; Jaume Pons; Arvind Rajpal

March 26, 2015

MAP4K4 regulates integrin-FERM binding to control endothelial cell motility

Nature, ISSN: 14764687 00280836

Philip Vitorino; Stacey Yeung; Ailey Crow; Jesse Bakke; Tanya Smyczek; Kristina West; Erin McNamara; Jeffrey Eastham-Anderson; Stephen Gould; Seth F. Harris; Chudi O. Ndubaku; Weilan Ye

March 25, 2015

Atom-Atom-Path similarity and Sphere Exclusion clustering: Tools for prioritizing fragment hits

Journal of Cheminformatics, ISSN: 17582946

Alberto Gobbi; Anthony M. Giannetti; Huifen Chen; Man-Ling Lee

March 25, 2015

Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues

PLoS ONE, ISSN: 19326203

Scott D. Patterson; John M. Rossi; Katherine L. Paweletz; Dan Fitzpatrick; C. Glenn Begley; Leigh Busse; Steve Elliott; Ian McCaffery

March 20, 2015

A novel Respiratory Syncytial Virus (RSV) F subunit vaccine adjuvanted with GLA-SE elicits robust protective TH1-type humoral and cellular immunity in rodent models

PLoS ONE, ISSN: 19326203

Stacie L. Lambert; Shahin Aslam; Elizabeth Stillman; Mia MacPhail; Christine Nelson; Bodrey Ro; Rosemary Sweetwood; Yuk Man Lei; Jennifer C. Woo; Roderick S. Tang

March 19, 2015

An industry statistician's perspective on personalized health care drug development

Design and Analysis of Clinical Trials for Predictive Medicine,

Jane Fridlyand; Ru-Fang Yeh; Howard M. Mackey; Thomas Bengtsson; Paul Delmar; Spaniolo; Lieberman

March 18, 2015

GPU-accelerated compartmental modeling analysis of DCE-MRI data from glioblastoma patients treated with bevacizumab

PLoS ONE, ISSN: 19326203

Yu-Han H. Hsu; Ziyin Huang; Gregory Z. Ferl; Chee Ng

March 18, 2015

Regulation of the oncoprotein Smoothened by small molecules

Nature Chemical Biology, ISSN: 15524469 15524450

Hayley J. Sharpe; Weiru Wang; Rami N. Hannoush; Frederic J. De Sauvage

March 18, 2015

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

Science Translational Medicine, ISSN: 19466242 19466234

Joel D. Leverson; Darren C. Phillips; Michael J. Mitten; Erwin R. Boghaert; Dolores Diaz; Stephen K. Tahir; Lisa D. Belmont; Paul M. Nimmer; Yu Xiao; Xiaoju Max Ma; Kym N Lowes; Peter J. Kovar; Jun Chen; Sha Jin; Morey L. Smith; John Xue; Haichao Zhang; Anatol Oleksijew; Terrance J. Magoc; Kedar S. Vaidya; Daniel H. Albert; Jacqueline M. Tarrant; Nghi La; Le Wang; Zhi-Fu Tao; Michael D. Wendt; Deepak Sampath; Saul H. Rosenberg; Chris Tse; David C.S. Huang; Wayne J. Fairbrother; Steven W. Elmore; Andrew J. Souers

March 15, 2015

A probabilistic method to report predictions from a human liver microsomes stability QSAR model: A practical tool for drug discovery

Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X

Ignacio Aliagas; Alberto Gobbi; Timothy P. Heffron; Man-Ling Lee; Daniel F. Ortwine; Mark Zak; S. Cyrus Khojasteh

March 15, 2015

Potent and selective Bruton's tyrosine kinase inhibitors: Discovery of GDC-0834

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Wendy B. Young; Jim Barbosa; Peter Blomgren; Meire C. Bremer; James J. Crawford; Donna M. Dambach; Steven L. Gallion; Sarah G. Hymowitz; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joseph W. Lubach; Jen MacAluso; Patricia M. MacIejewski; Brigitte Maurer; Scott A. Mitchell; Daniel F. Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; C. Gregory Sowell; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Kevin S. Currie

March 15, 2015

TRAF4-SMURF2-mediated DAZAP2 degradation is critical for IL-25 signaling and allergic airway inflammation

Journal of Immunology, ISSN: 15506606 00221767

Jarod A. Zepp; Ling Wu; Wen Qian; Wenjun Ouyang; Mark Aronica; Serpil Erzurum; Xiaoxia Li

March 15, 2015

Transient blockade of delta-like notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation

Journal of Immunology, ISSN: 15506606 00221767

Sherri Wood; Jiane Feng; Jooho Chung; Vedran Radojcic; Ashley R. Sandy-Sloat; Ann Friedman; Amy Shelton; Minhong Yan; Christian W. Siebel; D. Keith Bishop; Ivan Maillard

March 14, 2015

Effect of a Modified Saquinavir/Ritonavir Dosing Regimen with Lower Dose Lead-In Phase on QTc Interval, Pharmacokinetics, Antiviral Activity and Safety in Treatment-Naïve HIV-1-Infected Patients

Drugs in R and D, ISSN: 11796901 11745886

Marta Boffito; Akil Jackson; Anton Pozniak; Mylene Giraudon; Rohit Kulkarni; Maria Connie Abelardo; Indravadan H. Patel; Peter N. Morcos

March 14, 2015

Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis

Mucosal Immunology, ISSN: 19353456 19330219

Jennifer Bates; Ken Flanagan; Lian Mo; Naruhisa Ota; Jiabing Ding; Ho; Liu; Merone Roose-Girma; Søren Warming; Laurie Diehl

March 14, 2015

Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis

Mucosal Immunology, ISSN: 19353456 19330219

Jennifer Bates; Ken Flanagan; Lian Mo; Naruhisa Ota; Jiabing Ding; Ho; Scot D. Liu; Merone Roose-Girma; Søren Warming; Laurie Diehl

March 14, 2015

Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis

Mucosal Immunology, ISSN: 19353456 19330219

Jennifer Bates; Ken Flanagan; Lian Mo; Naruhisa Ota; Ding; Ho; Liu; Merone Roose-Girma; Søren Warming; Laurie Diehl

March 13, 2015

Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Jacomijn P. Dijksterhuis; Bolormaa Baljinnyam; Karen Stanger; Hakki O. Sercan; Yun Ji; Osler Andres; Jeffrey S. Rubin; Rami N. Hannoush; Gunnar Schulte

March 12, 2015

Considerations on Immunogenicity

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,

Thomas R. Gelzleichter; Eric Wakshull

March 12, 2015

Minor structural change to tertiary sulfonamide RORC ligands led to opposite mechanisms of action

ACS Medicinal Chemistry Letters, ISSN: 19485875

Olivier René; Benjamin P. Fauber; Gladys De Leon Boenig; Brenda Burton; Celine Eidenschenk; Christine Everett; Alberto Gobbi; Sarah G. Hymowitz; Adam R. Johnson; James R. Kiefer; Marya Liimatta; Peter Lockey; Maxine Norman; Wenjun Ouyang; Heidi J. A. Wallweber; Harvey Wong

March 12, 2015

Gaps and Future Challenges

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,

Joerg Bluemel; Sven Korte; Emanuel Schenck; Gerhard F. Weinbauer

March 12, 2015

Opportunities for Implementing the 3 Rs in Drug Development and Safety Assessment Studies Using Nonhuman Primates

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,

Kathryn Chapman; Kathryn Bayne; Jessica A. Couch; Thierry Decelle; John Finch; Lolke de Haan; Tina Koban; Lars Fris Mikkelsen; Wolfgang Müller; Helen Palmer; Mark Prescott

March 12, 2015

Developmental and Reproductive Toxicity Testing

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment,

Gerhard F. Weinbauer; Christopher J. Bowman; Wendy Halpern; Gary Chellman

March 12, 2015

Rapid antidepressants stimulate the decoupling of GABA B receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η

Molecular Psychiatry, ISSN: 14765578 13594184

Workman; Patrick C. G. Haddick; Bush; Dilly; Niere; Zemelman; Raab-Graham

March 10, 2015

IgE/FcεRI-mediated antigen cross-presentation by dendritic cells enhances anti-tumor immune responses

Cell Reports, ISSN: 22111247

Barbara Platzer; KutluG. Elpek; Viviana Cremasco; Kristi Baker; MadeleineM. Stout; Cornelia Schultz; Eleonora Dehlink; Kai-TingC. Shade; RobertM. Anthony; Blumberg; Shannon J. Turley; Edda Fiebiger

March 9, 2015

Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma

Cancer Cell, ISSN: 18783686 15356108

Hayley J. Sharpe; Gregoire Pau; Gerrit J. P. Dijkgraaf; Nicole Basset-Seguin; Zora Modrusan; Thomas Januario; Vickie Tsui; Alison B. Durham; Andrzej A. Dlugosz; Matthias Peter; Richard Bourgon; Jean Y. Tang; Kavita Y. Sarin; Luc Dirix; David C. Fisher; Charles M. Rudin; Howard Sofen; Michael R. Migden; Robert Yauch; Frederic J. De Sauvage

March 3, 2015

β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Chunmei Fu; Xinjun Liang; Weiguo Cui; Julia L. Ober-Blöbaum; Joseph Vazzana; Protul A. Shrikant; Kelvin P. Lee; Björn E. Clausen; Ira Mellman; Aimin Jiang

March 2, 2015

Investigation of Drug-Excipient Interactions in Lapatinib Amorphous Solid Dispersions Using Solid-State NMR Spectroscopy

Molecular Pharmaceutics, ISSN: 15438392 15438384

Yang Song; Xinghao Yang; Xin Chen; Haichen Nie; Stephen Byrn; Joseph W. Lubach

March 2, 2015

Distinct organization and regulation of the outer kinetochore KMN network downstream of CENP-C and CENP-T

Current Biology, ISSN: 18790445 09609822

Florencia Rago; Karen Gascoigne; Iain M. Cheeseman

March 1, 2015

Incidence of giant cell arteritis and characteristics of patients: Data-driven analysis of comorbidities

Arthritis Care and Research, ISSN: 21514658 2151464X

Hans Petri; Alan Nevitt; Khaled Sarsour; Pavel Napalkov; Neil Collinson

March 1, 2015

Economic evaluation of tocilizumab monotherapy compared to adalimumab monotherapy in the treatment of severe active rheumatoid arthritis

Value in Health, ISSN: 15244733 10983015

Josh J. Carlson; Sarika Ogale; Fred Dejonckheere; Sean D. Sullivan

March 1, 2015

The Consequences of Diminishing Industry Support on the Independent Education Landscape: An Evidence-Based Analysis of the Perceived and Realistic Impact on Professional Development and Patient Care Among Oncologists

Journal of Cancer Education, ISSN: 15430154 08858195

Caroline Robinson; John Ruggiero; Mazi Abdolrasulnia; B. Stephen Burton

March 1, 2015

Occupational exposures are associated with worse morbidity in patients with chronic obstructive pulmonary disease

American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X

Laura M. Paulin; Gregory B. Diette; Paul D. Blanc; Nirupama Putcha; Mark D. Eisner; Richard E. Kanner; Andrew J. Belli; Stephanie Christenson; Donald P. Tashkin; MeiLan Han; Graham Barr; Nadia N. Hansel

March 1, 2015

Necroptosis: Pathway diversity and characteristics

Seminars in Cell and Developmental Biology, ISSN: 10963634 10849521

Maria Cristina De Almagro; Domagoj Vucic

March 1, 2015

Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase

Toxicological Sciences, ISSN: 10960929 10966080

Tanja S. Zabka; Jatinder Singh; Preeti Dhawan; Bianca M. Liederer; Jason Oeh; Ariel Kauss; Yang Xiao; Mark Zak; Tori Lin; Bobbi McCray; Nghi La; Trung Nguyen; Joseph Beyer; Cindy A. Farman; Hirdesh Uppal; Peter Dragovich; Thomas O'Brien; Deepak Sampath; Misner

March 1, 2015

Relationship between serum low-density lipoprotein cholesterol and in-hospital mortality following acute myocardial infarction (the lipid paradox)

American Journal of Cardiology, ISSN: 18791913 00029149

Vanessa S. Reddy; Quang T. Bui; Joan R. Jacobs; Susan M. Begelman; Dave P. Miller; William J. French

March 1, 2015

Differential effects of targeting Notch receptors in a mouse model of liver cancer

Hepatology, ISSN: 15273350 02709139

Erik G. Huntzicker; Kathy Hötzel; Lisa Choy; Li Che; Ross; Gregoire Pau; Neeraj Sharma; Christian W. Siebel; Xin Chen; French

March 1, 2015

Mixing monoclonal antibody formulations using bottom-mounted mixers: impact of mechanism and design on drug product quality

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Benson Gikanga; Yufei Chen; Oliver B. Stauch; Maa

March 1, 2015

Anxiety and health-related quality of life among patients with low-tumor burden non-Hodgkin lymphoma randomly assigned to two different rituximab dosing regimens: Results from ECOG Trial E4402 (RESORT)

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Lynne I. Wagner; Fengmin Zhao; Fangxin Hong; Marna Williams; Randy D. Gascoyne; John C. Krauss; Ranjana H. Advani; Ronald S. Go; Thomas M. Habermann; Joseph W. Leach; Brian O'Connor; Stephen J. Schuster; Cella; Sandra J. Horning; Wojciech Jurczak

March 1, 2015

A novel therapeutic strategy to rescue the immune effector function of proteolytically inactivated cancer therapeutic antibodies

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Xuejun Fan; Randall J. Brezski; Hui Deng; Pooja M. Dhupkar; Yun Shi; Anneliese Gonzalez; Songlin Zhang; Michael Rycyzyn; William R. Strohl; Robert E. Jordan; Ningyan Zhang; Zhiqiang An

March 1, 2015

Comparison of statistical and operational properties of subject randomization procedures for large multicenter clinical trial treating medical emergencies

Contemporary Clinical Trials, ISSN: 15592030 15517144

Wenle Zhao; Yunming Mu; Darren Tayama; Sharon D. Yeatts

March 1, 2015

A prospective observational study of oseltamivir safety and tolerability in infants and young children ≤24 months

Pharmacoepidemiology and Drug Safety, ISSN: 10991557 10538569

Barbara A. Rath; William A. Blumentals; Mary K. Miller; Kathryn Starzyk; Boguslaw Tetiurka; Martina Wollenhaupt

March 1, 2015

Preclinical Pharmacokinetic/Pharmacodynamic Modeling and Simulation in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape

AAPS Journal, ISSN: 15507416

Edgar Schuck; Tonika Bohnert; Arijit Chakravarty; Valeriu Damian-Iordache; Christopher Gibson; Cheng-Pang Hsu; Tycho Heimbach; Anu Shilpa Krishnatry; Bianca M. Liederer; Jing Lin; Tristan Maurer; Jerome T Mettetal; Daniel R Mudra; Marjoleen JMA Nijsen; Joseph Raybon; Patricia Schroeder; Virna Schuck; Satyendra Suryawanshi; Yaming Su; Patrick Trapa; Alice Tsai; Majid Vakilynejad; Shining Wang; Harvey Wong

March 1, 2015

Anxiety and health-related quality of life among patients with low-tumor burden non-Hodgkin lymphoma randomly assigned to two different rituximab dosing regimens: Results from ECOG Trial E4402 (RESORT)

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Lynne I. Wagner; Fengmin Zhao; Fangxin Hong; Marna Williams; Randy D. Gascoyne; John C. Krauss; Ranjana H. Advani; Ronald S. Go; Thomas M. Habermann; Joseph W. Leach; Brian O'Connor; Stephen J. Schuster; Cella; Sandra J. Horning; Brad Kahl

March 1, 2015

Efficacy of Hedgehog pathway inhibitors in basal cell carcinoma

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Nicole Basset-Seguin; Hayley J. Sharpe; Frederic J. De Sauvage

March 1, 2015

Symptom burden and quality of life among women with HER2+ metastatic breast cancer

Breast Journal, ISSN: 15244741 1075122X

Musa Mayer; Kathleen Lang; Sara A. Hurvitz; Deepa Lalla; Victoria Federico; Melissa Brammer; Joseph Menzin; Debasish Tripathy

March 1, 2015

Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayerss

Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565

Tianxiang Han; William R. Proctor; Chester L. Costales; Hao Cai; Ruth S. Everett; Dhiren R. Thakker

March 1, 2015

Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid

Toxicology Mechanisms and Methods, ISSN: 15376524 15376516

Jacqueline M. Tarrant; Preeti Dhawan; Jatinder Singh; Tanja S. Zabka; Emer Clarke; Garry Dossantos; Peter Dragovich; Deepak Sampath; Tori Lin; Bobbi McCray; Nghi La; Trung Nguyen; Ariel Kauss; Donna M. Dambach; Misner; Dolores Diaz; Hirdesh Uppal

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