Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6101 - 6150 OF 15613 RESULTS

January 1, 2015

Randomized study of danoprevir/ritonavir-based therapy for HCV genotype 1 patients with prior partial or null responses to peginterferon/ribavirin

Journal of Hepatology, ISSN: 16000641 01688278

Jordan J. Feld; Ira M. Jacobson; Donald Jensen; Graham R. Foster; Stanislas Pol; Edward Tam; Maciej Jablkowski; Hanna Berak; John M. Vierling; Eric Yoshida; Héctor R. Perez-Gomez; Astrid Scalori; Gregory J. Hooper; Jorge A. Tavel; Mercidita T. Navarro; Saba Shahdad; Rohit Kulkarni; Sophie Le Pogam; Nájera; Simon Eng; Chin Yin Lim; Nancy Shulman; Ellen S. Yetzer

January 1, 2015

Tocilizumab in rheumatoid arthritis: A case study of safety evaluations of a large postmarketing data set from multiple data sources

Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172

Jeffrey R. Curtis; Susana Perez-Gutthann; Samy Suissa; Pavel Napalkov; Natasha Singh; Liz Thompson; Benjamin Porter-Brown

January 1, 2015

Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinoma

Genes and Cancer, ISSN: 19476027 19476019

Chen; James Lee; Noelyn Kljavin; Benjamin Haley; Anneleen Daemen; Leisa Johnson; Yuxin Liang

January 1, 2015

The VEGF receptor family

Receptor Tyrosine Kinases: Family and Subfamilies,

Guanglei Zhuang; Napoleone Ferrara

January 1, 2015

Caspase-3 deficiency results in disrupted synaptic homeostasis and impaired attention control

Journal of Neuroscience, ISSN: 15292401 02706474

Shih-Ching Lo; Yuanyuan Wang; Martin Weber; Jessica L. Larson; Kimberly Scearce-Levie; Morgan Sheng

January 1, 2015

Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis

Thorax, ISSN: 14683296 00406376

Daryle J. DePianto; Sanjay Chandriani; Abbas Alexander; Guiquan Jia; Elsa N. N'Diaye; Patrick Caplazi; Steven E. Kauder; Sabyasachi Biswas; Satyajit K. Karnik; Connie Ha; Zora Modrusan; Michael A. Matthay; Kukreja; Harold R. Collard; Jackson G. Egen; Paul J. Wolters; Joseph R. Arron

January 1, 2015

Neoadjuvant breast cancer treatment as a sensitive setting for trastuzumab biosimilar development and extrapolation

Future Oncology, ISSN: 17448301 14796694

Christian Jackisch; Frank A. Scappaticci; Dominik Heinzmann; Fabio Bisordi; Thomas Schreitmüller; Gunter Von Minckwitz; Javier Cortés

January 1, 2015

Orchestrating high-throughput genomic analysis with Bioconductor

Nature Methods, ISSN: 15487105 15487091

Wolfgang Huber; Vincent J. Carey; Robert Gentleman; Simon Anders; Marc Carlson; Benilton S. Carvalho; Hector Corrada Bravo; Sean Davis; Laurent Gatto; Thomas Girke; Raphael Gottardo; Florian Hahne; Kasper D. Hansen; Rafael A. Irizarry; Michael Lawrence; Michael I. Love; James MacDonald; Valerie Obenchain; Andrzej K. Oles̈; Hervé Pagès; Alejandro Reyes; Paul Shannon; Gordon K. Smyth; Dan Tenenbaum; Levi Waldron; Martin Morgan

January 1, 2015

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation

Immunity, ISSN: 10974180 10747613

Natalia B. Pikor; Jillian L. Astarita; Leslie Summers-Deluca; Georgina Galicia; Joy Qu; Lesley A. Ward; Susan Armstrong; Claudia X. Dominguez; Deepali Malhotra; Brendan Heiden; Robert Kay; Valera Castanov; Hanane Touil; Louis Boon; Paul O'Connor; Amit Bar-Or; Alexandre Prat; Valeria Ramaglia; Samuel Ludwin; Shannon J. Turley; Jennifer L. Gommerman

January 1, 2015

Expanded change protocols: Benefits, cost considerations, and regulatory views

BioProcess International, ISSN: 15426319

Nadine Ritter; Julia Edwards; Stefanie Pluschkell; Suzanne Stella; Rebekah Logan; Chana Fuchs; Wassim Nashabeh; Rohin Mahtre

January 1, 2015

United States comparative costs and absenteeism of diabetic ophthalmic conditions

Postgraduate Medicine, ISSN: 19419260 00325481

Richard A. Brook; Nathan L. Kleinman; Sunil Patel; Jim E. Smeeding; Ian A. Beren; Adam Turpcu

January 1, 2015

Enhancing efficiency of trace metals analysis using a validated generic ICP-OES method

American Pharmaceutical Review, ISSN: 10998012

Ila Patel; Venkatramani; Colin D. Medley; Kavita Mistry; Larry Wigman; Nik P. Chetwyn

January 1, 2015

Creating a specialist protein resource network: A meeting report for the protein bioinformatics and community resources retreat

Database, ISSN: 17580463

Patricia C. Babbitt; Pantelis G. Bagos; Amos Bairoch; Alex Bateman; Arnaud Chatonnet; Mark J. Chen; David J. Craik; Robert D. Finn; David Gloriam; Daniel H. Haft; Bernard Henrissat; Gemma L. Holliday; Vignir Isberg; Quentin Kaas; David Landsman; Nicolas Lenfant; Gerard Manning; Nozomi Nagano; Narayanaswamy Srinivasan; Claire O'Donovan; Kim D. Pruitt; Ramanathan Sowdhamini; Neil D. Rawlings; Milton H. Saier Jr.; Joanna L. Sharman; Michael Spedding; Konstantinos D. Tsirigos; Ake Vastermark; Gerrit Vriend

January 1, 2015

The authors explore and define common industry approaches and practices when applying GMPs in early development

Pharmaceutical Technology, ISSN: 21507376 15432521

Q. Chan Li; Jackson D. Pellett; Michael Szulc; Mark D. Trone; Kirby Wong-Moon

January 1, 2015

A biopharmaceutical industry perspective on single-use sensors for biological process applications

BioPharm International, ISSN: 19391862 1542166X

Bradley H. Diehl; Mark A. Lapack; Tony Y. Wang; Robert E. Kottmeier; Stacey M. Kaneshiro; Michael C. Brandenstein; Yongchun Zhang; Yuk Chun Chiu; Seongkyu Yoon; Victor Saucedo

January 1, 2015

Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: Addressing methodologic issues of plasma membrane isolation and expression-activity relationship

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Vineet Kumar; Bhagwat Prasad; Gabriela Patilea; Anshul Gupta; Laurent Salphati; Raymond Evers; Cornelis E. Hop; Jashvant D. Unadkat

January 1, 2015

Development and implementation of a double-blind corticosteroid-tapering regimen for a clinical trial

International Journal of Rheumatology, ISSN: 16879279 16879260

Neil Collinson; Katie Tuckwell; Frank Habeck; Monique Chapman; Micki Klearman; John H. Stone

January 1, 2015

First million-dollar syringe could be a sight for sore eyes

Managed Care, ISSN: 10623388

Thomas Morrow

January 1, 2015

Predictors of early discontinuation of pegylated interferon for reasons other than lack of efficacy in United States veterans with chronic hepatitis c

Gastroenterology Nursing, ISSN: 15389766 1042895X

Joanne Lafleur; Hoop; Korner; Scott L. Duvall; Timothy Morgan; Prashant K. Pandya; Jian Han; Kristin Knippenberg; Richard E. Nelson

January 1, 2015

Evaluation of detection sensitivity in comprehensive two-dimensional liquid chromatography separations of an active pharmaceutical ingredient and its degradants

Analytical and Bioanalytical Chemistry, ISSN: 16182650 16182642

Dwight R. Stoll; Eric S. Talus; David C. Harmes; Kelly Zhang

January 1, 2015

Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells

Oncotarget, ISSN: 19492553

Nitu Bansal; Prasun J. Mishra; Mark Stein; Robert S. DiPaola; Joseph R. Bertino

January 1, 2015

Anemia Predicts Sustained Virological Response in Cirrhotic and Noncirrhotic Patients with Chronic Hepatitis C Treated with Peginterferon Alfa-2a and Ribavirin

Current Hepatitis Reports, ISSN: 15410706 15403416

Reau; Korner; Jian Han; Donald Jensen

January 1, 2015

Safety, virology and pharmacokinetics of oseltamivir in infants with laboratory-confirmed influenza: A Phase I/II, prospective, open-label, multicentre clinical trial

Antiviral Therapy, ISSN: 20402058 13596535

Barbara A. Rath; Jerzy Brzostek; Sara Guillén; Vis Niranjan; Colombe Chappey; Craig R. Rayner; Barry Clinch

January 1, 2015

Validation of a method for the determination of thiocyanate in human plasma by UV/VIS spectrophotometry and application to a Phase I clinical trial of GDC-0425

Translational and Clinical Pharmacology, ISSN: 22890882

Young G. Shin; Henri Meijering; Fred H. van Heuveln; Jaap Wieling; Jason S Halladay; Srikumar Sahasranaman; Cornelis E. Hop

January 1, 2015

The BioMart community portal: An innovative alternative to large, centralized data repositories

Nucleic Acids Research, ISSN: 13624962 03051048

Damian Smedley; Syed Haider; Durinck; Luca Pandini; Paolo Provero; James Allen; Olivier Arnaiz; Mohammad H.amza Awedh; Richard Baldock; Giulia Barbiera; Philippe Bardou; Tim Beck; Andrew Blake; Merideth Bonierbale; Anthony J. Brookes; Gabriele Bucci; Iwan Buetti; Sarah Burge; Cédric Cabau; Joseph W. Carlson; Claude Chelala; Charalambos Chrysostomou; Davide Cittaro; Olivier Collin; Raul Cordova; Rosalind J. Cutts; Erik Dassi; Alex Di Genova; Anis Djari; Anthony Esposito; Heather Estrella; Eduardo Eyras; Julio Fernandez-Banet; Simon Forbes; Robert C. Free; Takatomo Fujisawa; Emanuela Gadaleta; Jose M. Garcia-Manteiga; David Goodstein; Kristian Gray; José Afonso Guerra-Assunção; Bernard Haggarty; Dong-Jin Han; Byung Woo Han; Todd Harris; Jayson Harshbarger; Robert K. Hastings; Richard D. Hayes; Claire Hoede; Shen Hu; Zhi-Liang Hu; Lucie Hutchins; Zhengyan Kan; Hideya Kawaji; Aminah Keliet; Arnaud Kerhornou; Sunghoon Kim; Rhoda Kinsella; Christophe Klopp; Lei Kong; Daniel Lawson; Dejan Lazarevic; Ji-Hyun Lee; Thomas Letellier; Chuan-Yun Li; Pietro Lio; Chu-Jun Liu; Jie Luo; Alejandro Maass; Jerome Mariette; Thomas Maurel; Stefania Merella; Azza Mostafa Mohamed; Francois Moreews; Ibounyamine Nabihoudine; Nelson Ndegwa; Céline Noirot; Cristian Perez-Llamas; Michael Primig; Alessandro Quattrone; Hadi Quesneville; Davide Rambaldi; James Reecy; Michela Riba; Steven Rosanoff; Amna Ali Saddiq; Elisa Salas; Olivier Sallou; Rebecca Shepherd; Reinhard Simon; Linda Sperling; William Spooner; Daniel M. Staines; Delphine Steinbach; Kevin Stone; Elia Stupka; Jon W. Teague; Abu Z. Dayem Ullah; Jun Wang; Doreen Ware; Marie Wong-Erasmus; Ken Youens-Clark; Amonida Zadissa; Shi-Jian Zhang; Arek Kasprzyk

January 1, 2015

Challenges and considerations for development of therapeutic proteins in pediatric patients

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Yi Zhang; Xiaohui Wei; Gaurav Bajaj; Jeffrey S. Barrett; Bernd Meibohm; Amita Joshi; Manish Gupta

January 1, 2015

Oxidative degradation of polysorbate surfactants studied by liquid chromatography-mass spectrometry

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Oleg V. Borisov; Junyan A. Ji; Y. John Wang

January 1, 2015

Sensitive and direct determination of lithium by mixed-mode chromatography and charged aerosol detection

Journal of Chromatography A, ISSN: 18733778 00219673

Lulu Dai; Larry Wigman; Kelly Zhang

January 1, 2015

Effect of individual fc methionine oxidation on FcRn binding: Met252 oxidation impairs fcrn binding more profoundly than Met428 oxidation

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Xuan Gao; Junyan A. Ji; Karthik Veeravalli; Y. John Wang; Taylor Zhang; William Mcgreevy; Kai Zheng; Robert F. Kelley; Mike Laird; Jun Liu; Cromwell

January 1, 2015

Molecular assessment of monoclonal antibody-based therapeutics enabling lead selection for clinical development

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Vikas Sharma; Robert F. Kelley

January 1, 2015

Pharmacokinetics/pharmacodynamics and disposition of antibody-drug conjugates

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Siddharth Sukumaran; Kedan Lin

January 1, 2015

Application of QbD principles to late-stage formulation development for biological liquid products

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Alavattam Sreedhara; Wong; Yvonne Lentz; Karin Schoenhammer; Christoph Stark

January 1, 2015

Application of quality by design principles to the drug product technology transfer process

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Fred Lim; Jagannathan Sundaram; Alavattam Sreedhara

January 1, 2015

Drug substance frozen storage and thawing

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Philippe Lam; Fred Lim; Samir Sane

January 1, 2015

Solid state considerations for early development

American Pharmaceutical Review, ISSN: 10998012

Jeffrey Stults

January 1, 2015

Analytical technologies for genotoxic impurities in pharmaceutical compounds

LCGC North America, ISSN: 15275949

Archana Kumar; Kelly Zhang; Larry Wigman

January 1, 2015

Separation science in drug development, part I: High-throughput purification

LCGC North America, ISSN: 15275949

Joseph H. Pease; Brent Murphy; Mengling Wong; Michael W. Dong

January 1, 2015

Separation science in drug development, part II: High-throughput characterization

LCGC North America, ISSN: 15275949

Baiwei Lin; Joseph H. Pease; Michael W. Dong

January 1, 2015

Iridium(III)-catalyzed benzylic amine directed C-H sulfonamidation of arenes with sulfonyl azides

ChemCatChem, ISSN: 18673899 18673880

Heng Chen; Malcolm P. Huestis

January 1, 2015

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

Nature Genetics, ISSN: 15461718 10614036

Durinck; Eric Stawiski; Andrea Pavía-Jiménez; Zora Modrusan; Payal Kapur; Bijay S. Jaiswal; Na Zhang; Vanina Toffessi-Tcheuyap; Thong T Nguyen; Kanika Bajaj Pahuja; Ying-Jiun J. Chen; Sadia Saleem; Subhra Chaudhuri; Sherry Heldens; Marlena Jackson; Samuel Peña-Llopis; Joseph Guillory; Toy; Connie Ha; Corissa J. Harris; Eboni Holloman; Haley M Hill; Stinson; Rivers; Vasantharajan Janakiraman; Weiru Wang; Lisa N. Kinch; Nick V Grishin; Matthias Peter; Bernard Chow; Julian S. Gehring; Jens Reeder; Gregoire Pau; Thomas D Wu; Vitaly Margulis; Yair Lotan; Arthur Sagalowsky; Ivan Pedrosa; Frederic J. De Sauvage; James Brugarolas; Somasekar Seshagiri

January 1, 2015

Manufacturing of High-Concentration Monoclonal Antibody Formulations via Spray Drying-the Road to Manufacturing Scale

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Benson Gikanga; Robert Turok; Ada Hui; Mayumi Bowen; Oliver B. Stauch; Maa

January 1, 2015

Cognitive deficits, changes in synaptic function, and brain pathology in a mouse model of normal aging

eNeuro, ISSN: 23732822

Martin Weber; Tiffany Wu; Jesse E. Hanson; Nazia M. Alam; Hilda Solanoy; Hai Ngu; Benjamin E. Lauffer; Han H. Lin; Sara L. Dominguez; Jens Reeder; Jennifer A. Tom; Pascal Steiner; Oded Foreman; Glen T. Prusky; Kimberly Scearce-Levie

January 1, 2015

Comparison of Healthcare Costs Between Rheumatoid Arthritis Patients Treated with Infused Biologics After Switching from Another Biologic

Drugs - Real World Outcomes, ISSN: 21989788 21991154

Stephen S. Johnston; Donna McMorrow; Amanda M. Farr; Paul Juneau; Sarika Ogale

January 1, 2015

Exploring protein-protein interactions using peptide libraries displayed on phage

Phage Display in Biotechnology and Drug Discovery, Second Edition,

Deshayes; Jacob E. Corn

January 1, 2015

Antibody humanization and affinity maturation using phage display

Phage Display in Biotechnology and Drug Discovery, Second Edition,

Jonathan S. Marvin; Henry B. Lowman

January 1, 2015

Viral clearance of traditional unit operations: virus-retentive filtration

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Qi Chen; Dayue Chen

January 1, 2015

Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI?

Scientific World Journal, ISSN: 1537744X 23566140

Savita V. Dandapani; Ying Zhang; Richard Jennelle; Yvonne G. Lin

January 1, 2015

Female bias in systemic lupus erythematosus is associated with the differential expression of X-linked toll-like receptor 8

Frontiers in Immunology, ISSN: 16643224

Gabrielle McDonald; Nicholas Cabal; Augustin Vannier; Benjamin Umiker; Raymund H. Yin; Arturo V. Orjalo; Hans E. Johansson; Jin-Hwan Han; Thereza Imanishi-Kari

January 1, 2015

Toward an era of utilizing methionine overproducing hosts for recombinant protein production in Escherichia coli

Bioengineered, ISSN: 21655987 21655979

Karthik Veeravalli; Mike Laird

January 1, 2015

Separation science in drug development, part 1: High-throughput purification

LC-GC Europe, ISSN: 14716577

Mengling Wong; Brent Murphy; Joseph H. Pease; Michael W. Dong

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