Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6251 - 6300 OF 15613 RESULTS

November 28, 2014

Backbone cyclization of a recombinant cystine-knot peptide by engineered Sortase A

FEBS Letters, ISSN: 18733468 00145793

Karen Stanger; Till Maurer; Harini Kaluarachchi; Mary Coons; Yvonne Franke; Rami N. Hannoush

November 27, 2014

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

Nature, ISSN: 14764687 00280836

Roy S. Herbst; Jean-Charles Soria; Marcin Kowanetz; Gregg D. Fine; Omid Hamid; Michael S. Gordon; Jeffrey A. Sosman; David McDermott; John D. Powderly; Scott Gettinger; Holbrook E. K. Kohrt; Leora Horn; Donald Lawrence; Sandra Rost; Maya Leabman; Yuanyuan Xiao; Ahmad Mokatrin; Koeppen; Priti Hegde; Ira Mellman; Daniel S. Chen; F. Stephen Hodi

November 27, 2014

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

Nature, ISSN: 14764687 00280836

Thomas Powles; Joseph Paul Eder; Gregg D. Fine; Fadi S. Braiteh; Yohann Loriot; Cristina Cruz; Joaquim Bellmunt; Howard A. Burris; Petrylak; Siew-Leng Teng; Xiaodong Shen; Zachary Boyd; Priti Hegde; Daniel S. Chen; Nicholas J. Vogelzang

November 27, 2014

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

Nature, ISSN: 14764687 00280836

Mahesh Yadav; Suchit Jhunjhunwala; Qui Phung; Patrick J. Lupardus; Josh Tanguay; Stephanie M. Bumbaca; Christian Franci; Tommy K. Cheung; Jens Fritsche; Toni Weinschenk; Zora Modrusan; Ira Mellman; Jennie R. Lill; Lélia Delamarre

November 27, 2014

Single-cell in situ imaging of palmitoylation in fatty-acylated proteins

Nature Protocols, ISSN: 17502799 17542189

Xinxin Gao; Rami N. Hannoush

November 20, 2014

Molecular simulations of the pairwise interaction of monoclonal antibodies

Journal of Physical Chemistry B, ISSN: 15205207 15206106

Mauro Lapelosa; Thomas W. Patapoff; Isidro E. Zarraga

November 19, 2014

Quantification of residual solvents in antibody drug conjugates using gas chromatography

Analytica Chimica Acta, ISSN: 18734324 00032670

Colin D. Medley; Jacob Kay; Yi Li; Jason Gruenhagen; Peter M. Yehl; Nik P. Chetwyn

November 19, 2014

Drugs for macular degeneration

JAMA - Journal of the American Medical Association, ISSN: 15383598 00987484

Ivaylo Stoilov; Anne E. Fung; Roman G. Rubio

November 19, 2014

Evaluating Source Data Verification as a Quality Control Measure in Clinical Trials

Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790

Nicole Sheetz; Brett Wilson; Joanne Benedict; Esther Huffman; Andy Lawton; Mark Travers; Patrick Nadolny; Stephen Young; Kyle Given; Lawrence Florin

November 19, 2014

The blood-brain barrier's gut check

Science Translational Medicine, ISSN: 19466242 19466234

Nga Bien-Ly; Ryan J. Watts

November 18, 2014

Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Shan-Shan Wang; Yi-Feng Gu; Nicholas Wolff; Karoliina Stefanius; Alana Christie; Anwesha Dey; Robert E. Hammer; Xian-Jin Xie; Dinesh Rakheja; Ivan Pedrosa; Thomas Carroll; Renée M. McKay; Payal Kapur; James Brugarolas

November 18, 2014

A microRNA upregulated in asthma airway T cells promotes T H 2 cytokine production

Nature Immunology, ISSN: 15292916 15292908

Laura J. Simpson; Sana Patel; Nirav R. Bhakta; David F. Choy; Hans D. Brightbill; Xin Ren; Yanli Wang; Heather H. Pua; Dirk Baumjohann; Misty M. Montoya; Marisella Panduro; Kelly A. Remedios; Xiaozhu Huang; John V. Fahy; Joseph R. Arron; Prescott G. Woodruff; K. Mark Ansel

November 13, 2014

Combined vemurafenib and cobimetinib in BRAF-mutated melanoma

New England Journal of Medicine, ISSN: 15334406 00284793

James Larkin; Paolo A. Ascierto; Brigitte Dréno; Victoria Atkinson; Gabriella Liszkay; Michele Maio; Mario Mandala; Lev Demidov; Daniil Stroyakovskiy; Luc Thomas; Luis De La Cruz-Merino; Caroline Dutriaux; Claus Garbe; Mika A. Sovak; Ilsung Chang; Nicholas Choong; Stephen P. Hack; McArthur; Antoni Ribas

November 12, 2014

Collateral vessel presence in branch and central retinal vein occlusions and their impact on visual acuity and anatomical gains: A retrospective analysis

Retina, ISSN: 15392864 0275004X

Rishi Singh; Tamara Lee; Linda Yau; Roman G. Rubio

November 12, 2014

Direct medical costs and resource use for treating central and branch retinal vein occlusion in commercially insured working-age and medicare populations

Retina, ISSN: 15392864 0275004X

Ivan J. Suñer; Jay Margolis; Kimberly Ruiz; Irwin Tran; Paul P. Lee

November 12, 2014

Regulation of neuronal gene expression and survival by basal NMDA receptor activity: A role for histone deacetylase 4

Journal of Neuroscience, ISSN: 15292401 02706474

Yelin Chen; Yuanyuan Wang; Zora Modrusan; Morgan Sheng; Joshua S. Kaminker

November 10, 2014

HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme

Developmental Cell, ISSN: 18781551 15345807

Marco Osterwalder; Dario Speziale; Malak Shoukry; Rajiv Mohan; Robert Ivanek; Manuel Kohler; Christian Beisel; Xiaohui Wen; Suzie J. Scales; Vincent M. Christoffels; Axel Visel; Javier Lopez-Rios; Rolf Zeller

November 7, 2014

Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Janice Maloney; Travis W. Bainbridge; Amy Gustafson; Shuo Zhang; Roxanne Kyauk; Pascal Steiner; Marcel P Van Der Brug; Yichin Liu; James A. Ernst; Ryan J. Watts; Jasvinder K. Atwal

November 7, 2014

Development of a robust RNA-based classifier to accurately determine ER, PR, and HER2 status in breast cancer clinical samples

Breast Cancer Research and Treatment, ISSN: 15737217 01676806

Wilson; Yuanyuan Xiao; Jill M. Spoerke; Jane Fridlyand; Koeppen; Eloisa Fuentes; Huw; Ilma Abbas; Arjan Gower; Erica Schleifman; Rupal Desai; Ling Fu; Teiko Sumiyoshi; Joyce A. O’Shaughnessy; Garret M. Hampton; Lackner

November 5, 2014

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

Science Translational Medicine, ISSN: 19466242 19466234

Y. Joy Yu; Jasvinder K. Atwal; Yin Zhang; Raymond K. Tong; Kristin R. Wildsmith; Christine Tan; Nga Bien-Ly; Maria Hersom; Janice Maloney; William J. Meilandt; Daniela Bumbaca; Kapil Gadkar; Kwame Hoyte; Wilman Luk; Yanmei Lu; James A. Ernst; Kimberly Scearce-Levie; Jessica A. Couch; Dennis; Ryan J. Watts

November 3, 2014

Role of P-glycoprotein on the brain penetration and brain pharmacodynamic activity of the MEK inhibitor cobimetinib

Molecular Pharmaceutics, ISSN: 15438392 15438384

Edna F. Choo; Justin Ly; Jocelyn Chan; Sheerin Shahidi-Latham; Kirsten Messick; Emile G. Plise; Cristine Quiason; Lulu Yang

November 1, 2014

Associations Between Preterm Birth, Low Birth Weight, andPostpartum Health in a Predominantly Hispanic WICPopulation

Journal of Nutrition Education and Behavior, ISSN: 14994046

Stephanie A. Leonard; Denise Gee; Yuda Zhu; Catherine M. Crespi; Shannon E. Whaley

November 1, 2014

Subcutaneous Tocilizumab Versus Placebo in Combination With Disease-Modifying Antirheumatic Drugs in Patients With Rheumatoid Arthritis

Arthritis Care and Research, ISSN: 21514658 2151464X

Alan Kivitz; Ewa Olech; Michael Borofsky; Beatriz M. Zazueta; Federico Navarro-Sarabia; Sebastião C. Radominski; Merrill; Lucy Rowell; Clare Nasmyth-Miller; Bao; Stephen Wright; Janet E. Pope

November 1, 2014

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

mAbs, ISSN: 19420870 19420862

Amrita Kamath; Victor Yip; Priyanka Gupta; C. Andrew Boswell; Daniela Bumbaca; Peter Haughney; Joni Castro; Siao Ping Tsai; Glenn Pacheco; Ross; Minhong Yan; Lisa A. Damico; Leslie A. Khawli; Shen

November 1, 2014

The proteome and phosphoproteome of Neurospora crassa in response to cellulose, sucrose and carbon starvation

Fungal Genetics and Biology, ISSN: 10960937 10871845

Yi Xiong; Samuel T. Coradetti; Xin Li; Marina A. Gritsenko; Therese Clauss; Vlad Petyuk; David G. Camp; Richard D. Smith; Jamie H.D. Cate; Feng Yang; N. Louise Glass

November 1, 2014

HAM-5 Functions As a MAP Kinase Scaffold during Cell Fusion in Neurospora crassa

PLoS Genetics, ISSN: 15537404 15537390

Wilfried Jonkers; Abigail C. Leeder; Charles Ansong; Yuexi Wang; Feng Yang; Trevor L. Starr; David G. Camp; Richard D. Smith; N. Louise Glass

November 1, 2014

Critical role of bioanalytical strategies in investigation of clinical PK observations, a phase I case study

mAbs, ISSN: 19420870 19420862

Kun Peng; Keyang Xu; Luna Liu; Robert Hendricks; Reginald Delarosa; Erickson; Nageshwar Budha; Maya Leabman; An Song; Surinder Kaur; Saloumeh Kadkhodayan Fischer

November 1, 2014

Ubiquitination in disease pathogenesis and treatment

Nature Medicine, ISSN: 1546170X 10788956

Doris Popovic; Domagoj Vucic; Ivan Dikic

November 1, 2014

IAP proteins and their therapeutic potential

Cell Death: Mechanism and Disease,

Domagoj Vucic

November 1, 2014

Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3

Cell Death and Differentiation, ISSN: 14765403 13509047

Koenig; Naik; Rohrbeck; Herold; Trounson; Bouillet; Thomas; Voss; Andreas Strasser; Coultas

November 1, 2014

Characterizing monoclonal antibody structure by carbodiimide/GEE footprinting

mAbs, ISSN: 19420870 19420862

Parminder Kaur; Sara Tomechko; Janna Kiselar; Wuxian Shi; Galahad Deperalta; Aaron T. Wecksler; Giridharan Gokulrangan; Victor Ling; Mark R. Chance

November 1, 2014

Pharmacokinetics of ranibizumab after intravitreal administration in patients with retinal vein occlusion or diabetic macular edema

Ophthalmology, ISSN: 15494713 01616420

Yi Zhang; Zhenling Yao; Nitin Kaila; Peter Kuebler; Jennifer Visich; Mauricio Maia; Lisa Tuomi; Jason S. Ehrlich; Roman G. Rubio; Peter A. Campochiaro

November 1, 2014

Twenty-four-month efficacy and safety of 0.5 mg or 2.0 mg ranibizumab in patients with subfoveal neovascular age-related macular degeneration

Ophthalmology, ISSN: 15494713 01616420

Allen C. Ho; Brandon G. Busbee; Carl D. Regillo; Mark R. Wieland; Sherri A. Van Everen; Zhengrong Li; Roman G. Rubio; Phillip Lai

November 1, 2014

Prevalence of and risk factors for diabetic macular edema in the United States

JAMA Ophthalmology, ISSN: 21686165

Rohit Varma; Neil M. Bressler; Quan V. Doan; Michelle Gleeson; Mark Danese; Julie K. Bower; Elizabeth Selvin; Chantal M. Dolan; Jennifer T. Fine; Shoshana Colman; Adam Turpcu

November 1, 2014

Treatment patterns and outcomes among patients with metastatic melanoma treated in community practice

International Journal of Dermatology, ISSN: 13654632 00119059

Mark S. Walker; Carolina Reyes; Jiandong Kerr; Sacha Satram-Hoang; Edward J. Stepanski

November 1, 2014

Assessing stability-indicating methods for coelution by two-dimensional liquid chromatography with mass spectrometric detection

Journal of Separation Science, ISSN: 16159314 16159306

Venkatramani; James Girotti; Larry Wigman; Nicholas Chetwyn

November 1, 2014

Rituximab for the treatment of relapses in antineutrophil cytoplasmic antibody-associated vasculitis

Arthritis and Rheumatology, ISSN: 23265205 23265191

Miloslavsky; Specks; Merkel; Seo; Spiera; Langford; Hoffman; Cees Kallenberg; St.clair; Tchao; Viviano; Linna Ding; Iklé; Villarreal; Brett Jepson; Paul Brunetta; Allen; Fervenza; Duvuru Geetha; Keogh; Kissin; Monach; Peikert; Stegeman; Steven R. Ytterberg; John H. Stone

November 1, 2014

VEGF modulates synaptic activity in the developing spinal cord

Developmental Neurobiology, ISSN: 1932846X 19328451

Sylvaine Guérit; Anne-Emilie Allain; Céline Léon; William Cazenave; Napoleone Ferrara; Pascal Branchereau; Andréas Bikfalvi

November 1, 2014

Standardized extractables testing protocol for single-use systems in biomanufacturing

Pharmaceutical Engineering, ISSN: 02738139

Weibing Ding; Gary Madsen; Ekta Mahajan; Seamus O'Connor; Ken Wong

November 1, 2014

It's time to regulate: Coping with product-induced nongenetic clonal instability in CHO cell lines via regulated protein expression

Biotechnology Progress, ISSN: 15206033 87567938

Shahram Misaghi; Chang; Snedecor

November 1, 2014

A generic UHPLC-UV-MS method for cleaning verification of highly potent drugs

American Pharmaceutical Review, ISSN: 10998012

Syed Salman Lateef; Vinayak Ak; Michael W. Dong; Christine Gu

November 1, 2014

An antimesothelin-monomethyl auristatin E conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Suzie J. Scales; Nidhi Gupta; Glenn Pacheco; Ron Firestein; French; Koeppen; Linda Rangell; Vivian Barry-Hamilton; Luis; Josefa Chuh; Yin Zhang; Gladys S. Ingle; Aimee Fourie-O'Donohue; Katherine R. Kozak; Ross; Dennis; Spencer

October 30, 2014

Efficacy and safety of pateclizumab (anti-lymphotoxin-α) compared to adalimumab in rheumatoid arthritis: A head-to-head phase 2 randomized controlled study (The ALTARA Study)

Arthritis Research and Therapy, ISSN: 14786362 14786354

William P. Kennedy; J. Abraham Simon; Carolyn Offutt; Priscilla Horn; Ann E. Herman; Michael J. Townsend; Meina Tao Tang; Jane L. Grogan; Frank Hsieh; John C. Davis

October 29, 2014

Assessment of HER 2 testing patterns, HER 2+ disease, and the utilization of HER 2-directed therapy in early breast cancer

Breast Cancer: Targets and Therapy, ISSN: 11791314

David D. Stenehjem; Minkyoung Yoo; Sudhir K. Unni; Mukul Singhal; Hillevi Bauer; Kim Saverno; Quah; Anthony Masaquel; Diana I. Brixner

October 23, 2014

Rational use of plasma protein and tissue binding data in drug design

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Xingrong Liu; Matthew Wright; Cornelis E. Hop

October 23, 2014

Dendritic cells control fibroblastic reticular network tension and lymph node expansion

Nature, ISSN: 14764687 00280836

Sophie E. Acton; Aaron J. Farrugia; Jillian L. Astarita; Diego Mourão-Sá; Robert P. Jenkins; Emma Nye; Steven Hooper; Janneke Van Blijswijk; Neil C. Rogers; Kathryn J. Snelgrove; Ian Rosewell; Luis F. Moita; Gordon Stamp; Shannon J. Turley; Erik Sahai; Caetano Reise Sousa

October 23, 2014

A structural portrait of the PDZ domain family

Journal of Molecular Biology, ISSN: 10898638 00222836

Andreas Ernst; Brent A. Appleton; Ylva Ivarsson; Yingnan Zhang; David Gfeller; Wiesmann; Sachdev S. Sidhu

October 19, 2014

Composite end points to assess delay of disability progression by MS treatments

Multiple Sclerosis Journal, ISSN: 14770970 13524585

Jiameng Zhang; Waubant; Cutter; Wolinsky; Leppert

October 17, 2014

HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span

Science, ISSN: 10959203 00368075

Nathan A. Baird; Peter M. Douglas; Milos S. Simic; Ana P. C. Rodrigues; James J. Moresco; Suzanne C. Wolff; John R. Yates; Gerard Manning; Andrew Dillin

October 15, 2014

Synthesis of (+)-crocacin D and simplified bioactive analogues

Bioorganic and Medicinal Chemistry, ISSN: 14643391

Adele E. Pasqua; Frank D. Ferrari; James J. Crawford; William G. Whittingham; Rodolfo Marquez

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