Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6351 - 6400 OF 15613 RESULTS

September 1, 2014

Genetically engineered knock-in and conditional knock-in mouse models of cancer

Cold Spring Harbor Protocols, ISSN: 15596095 19403402

Amy Rappaport; Leisa Johnson

September 1, 2014

Biomarker analyses from a placebo-controlled phase II study evaluating erlotinib±onartuzumab in advanced non-small cell lung cancer: MET expression levels are predictive of patient benefit

Clinical Cancer Research, ISSN: 10780432

Koeppen; Wei Yu; Jiping Zha; Ajay Pandita; Elicia M. Penuel; Linda Rangell; Rajiv Raja; Sankar Mohan; Rajesh Patel; Rupal Desai; Ling Fu; An Do; Vaishali Parab; Xiaoling Xia; Thomas Januario; Sharianne G. Louie; Ellen H. Filvaroff; David S. Shames; Ignacio I. Wistuba; Marina Lipkind; Jenny Huang; Mirella Lazarov; Vanitha Ramakrishnan; Lukas Amler; See Phan; Premal Patel; Amy Peterson; Robert Yauch

September 1, 2014

Challenges with overall survival as an endpoint for efficacy assessment in first line metastatic breast cancer randomized controlled clinical trials and the investigation of truncated overall survival as an alternative endpoint

Memo - Magazine of European Medical Oncology, ISSN: 18655076 18655041

Neate; Alexander Strasak; Hans Ulrich Burger; Barbara Tong; Lee D. Kaiser

August 27, 2014

Accurate analysis of boronic pinacol esters using low residual silanol silica based reversed phase HPLC

Journal of Liquid Chromatography and Related Technologies, ISSN: 1520572X 10826076

Archana Kumar; Tania Ng; Sushant Malhotra; Jason Gruenhagen; Larry Wigman

August 27, 2014

Whole genome sequencing and analysis of plant growth promoting bacteria isolated from the rhizosphere of plantation crops coconut, cocoa and arecanut

PLoS ONE, ISSN: 19326203

Alka Gupta; Murali Gopal; George Thomas; Vinu Manikandan; John Gajewski; George Thomas; Somasekar Seshagiri; Stephan C. Schuster; Preeti Rajesh; Ravi Gupta

August 23, 2014

Relationships between computer-extracted mammographic texture pattern features and BRCA1/2 mutation status: A cross-sectional study

Breast Cancer Research, ISSN: 1465542X 14655411

Gretchen L. Gierach; Hui Li; Jennifer T. Loud; Mark H. Greene; Catherine K. Chow; Li Lan; Sheila A. Prindiville; Jennifer Eng-Wong; Peter W. Soballe; Claudia Giambartolomei; Phuong L. Mai; Claudia E. Galbo; Kathryn Nichols; Kathleen A. Calzone; Olufunmilayo I. Olopade; Mitchell H. Gail; Maryellen L. Giger

August 20, 2014

Similar prevalence of low-abundance drug-resistant variants in treatment-naive patients with genotype 1a and 1b hepatitis C virus infections as determined by ultradeep pyrosequencing

PLoS ONE, ISSN: 19326203

Severine Margeridon-Thermet; Sophie Le Pogam; Lewyn Li; Tommy F. Liu; Nancy Shulman; Robert W. Shafer; Nájera

August 15, 2014

Randomized phase Ib/II trial of rilotumumab or ganitumab with panitumumab versus panitumumab alone in patients with wild-type KRAS metastatic colorectal cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Eric Van Cutsem; Cathy Eng; Elzbieta Nowara; Anna Swieboda-Sadlej; Niall C. Tebbutt; Edith Mitchell; Irina Davidenko; Joe Stephenson; Elena Elez; Hans Prenen; Hongjie Deng; Rui Tang; Ian McCaffery; Kelly S. Oliner; Lisa Chen; Jennifer Gansert; Elwyn Loh; Dominic Smethurst; Tabernero

August 15, 2014

Characterization of asparagine 330 deamidation in an Fc-fragment of IgG1 using cation exchange chromatography and peptide mapping

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232

Taylor Zhang; Jennifer Hu; Amanda L. Pace; Wong; Y. John Wang; Kao

August 15, 2014

Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Benjamin P. Fauber; Olivier René; Gladys De Leon Boenig; Brenda Burton; Yuzhong Deng; Celine Eidenschenk; Christine Everett; Alberto Gobbi; Sarah G. Hymowitz; Adam R. Johnson; Hank La; Marya Liimatta; Peter Lockey; Maxine Norman; Wenjun Ouyang; Weiru Wang; Harvey Wong

August 15, 2014

Cutting edge: RIPK1 kinase inactive mice are viable and protected from TNF-Induced necroptosis in vivo

Journal of Immunology, ISSN: 15506606 00221767

Apostolos Polykratis; Nicole Hermance; Matija Zelic; Justine Roderick; Chun Kim; Trieu-My Van; Thomas H. Lee; Francis K.M. Chan; Manolis Pasparakis; Michelle A. Kelliher

August 15, 2014

Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Peter Dragovich; Benjamin P. Fauber; Jason Boggs; Jinhua Chen; Laura B. Corson; Charles Z. Ding; Eigenbrot; Hongxiu Ge; Anthony M. Giannetti; Thomas Hunsaker; Sharada Labadie; Chiho Li; Yichin Liu; Yingchun Liu; Shuguang Ma; Shiva Malek; David Peterson; Keith Pitts; Hans E. Purkey; Kirk D. Robarge; Laurent Salphati; Steve Sideris; Ultsch; Erica Vanderporten; Jing Wang; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang; Aihe Zhou

August 15, 2014

Gtpbp2 is required for BMP signaling and mesoderm patterning in Xenopus embryos

Developmental Biology, ISSN: 1095564X 00121606

Arif Kirmizitas; William Q. Gillis; Haitao Zhu; Gerald H. Thomsen

August 13, 2014

Temperature dependence of the complexation mechanism of celecoxib and hydroxyl-β-cyclodextrin in aqueous solution

Pharmaceutics, ISSN: 19994923

Po-Chang Chiang; Yue Shi; Yong Cui

August 13, 2014

Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis

Science Translational Medicine, ISSN: 19466242 19466234

Anne L. Fletcher; Jessica S. Elman; Jillian L. Astarita; Ryan Murray; Nima Saeidi; Joshua D'Rozario; Konstantin Knoblich; Flavian D. Brown; Frank A Schildberg; Janice M. Nieves; Tracy S. P. Heng; Richard L. Boyd; Shannon J. Turley; Biju Parekkadan

August 12, 2014

A phase IIa dose-finding and safety study of first-line pertuzumab in combination with trastuzumab, capecitabine and cisplatin in patients with HER2-positive advanced gastric cancer

British Journal of Cancer, ISSN: 15321827 00070920

Yoon-Koo Kang; Rha; Tassone; Barriuso; Ron Yu; Szado; Amit Garg; Bang

August 12, 2014

Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma

British Journal of Cancer, ISSN: 15321827 00070920

Lindi Chen; Zhao; Halliday; Berry; Raphaël F. Rousseau; Steven A. Middleton; Gwen L. Nichols; Del Bello; Piergentili; David R. Newell; John Lunec; Deborah A. Tweddle

August 11, 2014

Drug resistance via feedback activation of stat3 in oncogene-addicted cancer cells

Cancer Cell, ISSN: 18783686 15356108

Ho-June Lee; Guanglei Zhuang; Yi Cao; Pan Du; Hyo-Jin Kim; Jeffrey Settleman

August 7, 2014

MBASED: Allele-specific expression detection in cancer tissues and cell lines

Genome Biology, ISSN: 1474760X 14747596

Oleg Mayba; Houston N. Gilbert; Jinfeng Liu; Matthias Peter; Suchit Jhunjhunwala; Zhaoshi Jiang; Colin K. Watanabe; Zemin Zhang

August 5, 2014

Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration

Science Signaling, ISSN: 19379145 19450877

Juliane Mooz; Tripat Kaur Oberoi-Khanuja; Gregory S. Harms; Weiru Wang; Bijay S. Jaiswal; Somasekar Seshagiri; Ritva Tikkanen; Krishnaraj Rajalingam

August 1, 2014

Combined administration of RG7652, a recombinant human monoclonal antibody against PCSK9, and atorvastatin does not result in reduction of immune function

Toxicological Sciences, ISSN: 10960929

Thomas R. Gelzleichter; Wendy Halpern; Roy Erwin; Amos Baruch; Maya Leabman; Abigail S. Forrest; Christina Satterwhite; Kun Peng; Jennifer Chilton; Dale Stevens

August 1, 2014

Investigation of excipient compatibility and associated degradations for the formulation development of a small molecule pharmaceutical compound

American Pharmaceutical Review, ISSN: 10998012

Jane Li; Hong Lin; Christine Gu; Priscilla Mantik; Stefanie Gee; Peter M. Yehl

August 1, 2014

Analytical strategies for genotoxic impurities in the pharmaceutical industry

American Pharmaceutical Review, ISSN: 10998012

Venkatramani; Mohammad Al-Sayah

July 17, 2014

PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia

Blood, ISSN: 15280020 00064971

Martin Weisser; Ru-Fang Yeh; Guillemette Duchateau-Nguyen; Palermo; Tri Quang Nguyen; Xiaoyan Shi; Susanna Y. Stinson; Nancy Yu; Annika Dufour; Tadeusz Robak; Galina Salogub; Anna Dmoszynska; Philippe Solal-Celigny; Krzysztof Warzocha; Javier Loscertales; John Catalano; Loree Larratt; Viktor A. Rossiev; Isabelle Bence-Bruckler; Christian H. Geisler; Marco Montillo; Kirsten Fischer; Anna-Maria Fink; Michael Hallek; Johannes Bloehdorn; Raymonde Busch; Axel Benner; Hartmut Doḧner; Nancy Valente; Michael Wenger; Stephan Stilgenbauer; David Dornan

July 16, 2014

Statistical modeling of the drug load distribution on trastuzumab emtansine (Kadcyla), a lysine-linked antibody drug conjugate

Bioconjugate Chemistry, ISSN: 15204812 10431802

Michael Kim; Yan Chen; Joseph C. Marhoul; Fred Jacobson

July 16, 2014

Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains

PLoS ONE, ISSN: 19326203

Travis W. Bainbridge; Venita I. DeAlmeida; Anita Izrael-Tomasevic; Cecile Chalouni; Borlan Pan; Joshua Goldsmith; Alia P. Schoen; Gabriel Quinones; Ryan Kelly; Jennie R. Lill; Wendy N. Sandoval; Michael Costa; Paul G. Polakis; David Arnott; Bonnee Rubinfeld; James A. Ernst

July 16, 2014

Activity-induced Nr4a1 regulates spine density and distribution pattern of excitatory synapses in pyramidal neurons

Neuron, ISSN: 10974199 08966273

Yelin Chen; Yuanyuan Wang; Ali Ertürk; Dara Y. Kallop; Zhiyu Jiang; Robby M. Weimer; Joshua S. Kaminker; Morgan Sheng

July 15, 2014

Cellular mechanisms for response heterogeneity among L2/3 pyramidal cells in whisker somatosensory cortex

Journal of Neurophysiology, ISSN: 15221598 00223077

Justin Elstrott; Kelly B. Clancy; Haani Jafri; Igor Akimenko; Daniel E. Feldman

July 15, 2014

MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein

Genes and Development, ISSN: 15495477 08909369

Monica S. Guo; Taylor B. Updegrove; Emily Gogol; Svetlana A. Shabalina; Carol A. Gross; Gisela Storz

July 15, 2014

VariantAnnotation: A Bioconductor package for exploration and annotation of genetic variants

Bioinformatics, ISSN: 14602059 13674803

Valerie Obenchain; Michael Lawrence; Vincent J. Carey; Stephanie M. Gogarten; Paul Shannon; Martin Morgan

July 15, 2014

PILRα negatively regulates mouse inflammatory arthritis

Journal of Immunology, ISSN: 15506606 00221767

Yonglian Sun; Patrick Caplazi; Juan Zhang; Anita Mazloom; Sarah K. Kummerfeld; Gabriel Quinones; Kate Senger; Justin Lesch; Ivan Peng; Andrew Sebrell; Wilman Luk; Yanmei Lu; Zhonghua Lin; Kai H. Barck; Judy Young; Mariela Del Rio; Sophie M. Lehar; Vida Asghari; Wei Yu Lin; Sanjeev Mariathasan; Jason Devoss; Shahram Misaghi; Mercedesz Balazs; Tao Sai; Benjamin Haley; Hass; Min Xu; Wenjun Ouyang; Flavius Martin; Wyne P. Lee; Ali A. Zarrin

July 10, 2014

Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible t-cell kinase inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Jason D. Burch; Kevin Lau; John J. Barker; Frederick A. Brookfield; Yong Chen; Yuan Chen; Eigenbrot; Claire Ellebrandt; Moulay Hicham Alaoui Ismaili; Adam R. Johnson; Daniel Kordt; Colin H. Mackinnon; Paul A. McEwan; Daniel F. Ortwine; Daniel B. Stein; Xiaolu Wang; Dirk Winkler; Po-Wai Yuen; Yamin Zhang; Ali A. Zarrin; Zhonghua Pei

July 7, 2014

Imaging cleared intact biological systems at a cellular level by 3DISCO

Journal of Visualized Experiments, ISSN: 1940087X

Ali Ertürk; Daniel Lafkas; Cecile Chalouni

July 3, 2014

Comparative efficacy of biologics as monotherapy and in combination with methotrexate on patient reported outcomes (PROs) in rheumatoid arthritis patients with an inadequate response to conventional DMARDs - a systematic review and network meta-analysis

Health and Quality of Life Outcomes, ISSN: 14777525

Jeroen P. Jansen; Felicity Buckley; Fred Dejonckheere; Sarika Ogale

July 3, 2014

Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides

Organic Letters, ISSN: 15237052 15237060

Olivier René; Benjamin P. Fauber; Sushant Malhotra; Herbert M. Yajima

July 2, 2014

Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production

Science Translational Medicine, ISSN: 19466242 19466234

Gauvreau; Harris; Boulet; Heleen Scheerens; Fitzgerald; Wendy Putnam; Cockcroft; Davis; Richard Leigh; Zheng; Barbro Dahlén; Yehong Wang; Romeo MacIuca; Mayers; X. Charlene Liao; Lawren C. Wu; Matthews; O'Byrne

July 1, 2014

The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation

Cancer Research, ISSN: 15387445 00085472

Debasish Raha; Wilson; Jing Peng; David Peterson; Peng Yue; Marie Evangelista; Catherine Wilson; Mark Merchant; Jeffrey Settleman

July 1, 2014

Rituximab and three dexamethasone cycles provide responses similar to splenectomy in women and those with immune thrombocytopenia of less than two years duration

Haematologica, ISSN: 15928721 03906078

James B. Bussel; Christina S. Lee; Caroline Seery; Allison A. Imahiyerobo; Michaela V. Thompson; Diane Catellier; Ithamar G. Turenne; Vivek L. Patel; Paul A. Basciano; Rebecca Elstrom; Waleed Ghanima

July 1, 2014

Treatment emergent suicidal ideation and behavior

Suicide: Phenomenology and Neurobiology,

Sian Ratcliffe; Phillip B. Chappell; Janel Boyce-Rustay; Svetlana Gloukhova; Denise M. Oleske

July 1, 2014

Endogenously expressed IL-13Rα2 attenuates IL-13- mediated responses but does not activate signaling in human lung fibroblasts

Journal of Immunology, ISSN: 15506606 00221767

Sanjay Chandriani; Daryle J. DePianto; Elsa N. N'Diaye; Abbas Alexander; Janet Jackman; Jack Bevers; Vladimir Ramirez-Carrozzi; Rajita Pappu; Steven E. Kauder; Toy; Connie Ha; Zora Modrusan; Lawren C. Wu; Harold R. Collard; Paul J. Wolters; Jackson G. Egen; Joseph R. Arron

July 1, 2014

Predicting Discontinuation of Pegylated Interferon as a Result of Lack of Efficacy in United States Veterans With Chronic Hepatitis C on Dual Therapy

Annals of Pharmacotherapy, ISSN: 15426270 10600280

Richard E. Nelson; Hoop; Korner; Scott L. Duvall; Candace Hayden; Kristin Knippenberg; Timothy Morgan; Prashant K. Pandya; Jian Han; Joanne Lafleur

July 1, 2014

Balancing benefit and risk of medicines: A systematic review and classification of available methodologies

Pharmacoepidemiology and Drug Safety, ISSN: 10991557 10538569

Shahrul Mt-Isa; Christine Hallgreen; Nan Wang; Georgy Genov; Ian Hirsch; Davide Luciani; Lawrence D. Phillips; George Quartey; Sinan B. Sarac; Isabelle Stoeckert; Ioanna Tzoulaki; Alain Micaleff; Deborah Ashby; Billy Amzal; Simon Ashworth; Alex Asiimwe; Johan Bring; Torbjorn Callreus; Edmond Kakit Chan; Christoph Dierig; Gerald Downey; David Gelb; Alesia Goginsky; Richard Hermann; Steve Hobbiger; Kimberley S. Hockley; Diana Hughes; Juhaeri Juhaeri; Silvia Kuhls; Alfons Lieftucht; Marilyn Metcalf; Jeremiah Mwangi; Richard Nixon; Rebecca Noel; John Pears; Ruth Peters; Lawrence Phillips; Susan Shepherd; Elizabeth Swain J.; Andrew Thomson; Laurence Titeux; Rianne van den Ham; Tjeerd van Staa; Edward Waddingham; Lesley Wise

July 1, 2014

Asymmetric stereodivergent strategy towards aminocyclitols

Chemistry - A European Journal, ISSN: 15213765 09476539

Barry M. Trost; Sushant Malhotra

July 1, 2014

Development of a comprehensive near infrared spectroscopy calibration model for rapid measurements of moisture content in multiple pharmaceutical products

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085 1873264X

Dipak Mainali; Jane Li; Peter M. Yehl; Nicholas Chetwyn

July 1, 2014

The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation

Cancer Research, ISSN: 15387445 00085472

Debasish Raha; Wilson; Jing Peng; David Peterson; Peng Yue; Marie Evangelista; Catherine Wilson; Mark Merchant; Jeffrey Settleman

June 30, 2014

Estimated cases of blindness and visual impairment from neovascular age-related macular degeneration avoided in Australia by ranibizumab treatment

PLoS ONE, ISSN: 19326203

Paul Mitchell; Neil M. Bressler; Quan V. Doan; Chantal M. Dolan; Alberto Ferreira; Aaron Osborne; Elena Rochtchina; Mark Danese; Shoshana Colman; Andrew K. Wong

June 25, 2014

Direct reprogramming of human fibroblasts to hepatocyte-like cells by synthetic modified mRNAs

PLoS ONE, ISSN: 19326203

Kamen P. Simeonov; Hirdesh Uppal

June 20, 2014

Development of a semi-automated high throughput transient transfection system

Journal of Biotechnology, ISSN: 18734863 01681656

Aaron B. Bos; Joseph N. Duque; Sunil Bhakta; Farzam Farahi; Lindsay A. Chirdon; Jagath R. Junutula; Peter D. Harms; Athena W. Wong

June 19, 2014

From cancer genomics to precision oncology - Tissue's still an issue

Cell, ISSN: 10974172 00928674

Robert L. Cohen; Jeffrey Settleman

June 19, 2014

E-Cadherin Couples Death Receptors to the Cytoskeleton to Regulate Apoptosis

Molecular Cell, ISSN: 10974164 10972765

Min Lu; Scot A. Marsters; Ye; Luis; Lino C. Gonzalez Jr.; Avi Ashkenazi

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