Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6451 - 6500 OF 15613 RESULTS

April 15, 2014

A phase 2 trial of dacomitinib (PF-00299804), an oral, irreversible pan-HER (human epidermal growth factor receptor) inhibitor, in patients with advanced non-small cell lung cancer after failure of prior chemotherapy and erlotinib

Cancer, ISSN: 10970142 0008543X

Karen L. Reckamp; Giuseppe Giaccone; D. Ross Camidge; Shirish M. Gadgeel; Fadlo R. Khuri; Jeff A. Engelman; Marianna Koczywas; Arun Rajan; Alicyn K. Campbell; Diana Gernhardt; Ana Ruiz-Garcia; Stephen Letrent; Jane Liang; Ian Taylor; Joseph P. O'Connell; Pasi A. Jänne

April 10, 2014

Molecular Basis for Specific Recognition of Bacterial Ligands by NAIP/NLRC4 Inflammasomes

Molecular Cell, ISSN: 10974164 10972765

Jeannette L. Tenthorey; Eric M. Kofoed; Matthew D. Daugherty; HarmitS. Malik; Russell E. Vance

April 10, 2014

Reactions of benzene and 3-methylpyrrole with the •oH and •oOH radicals: An assessment of contemporary density functional theory methods

Journal of Physical Chemistry A, ISSN: 15205215 10895639

Geoffrey P. F. Wood; Alavattam Sreedhara; Jamie M. R. Moore; Bernhardt L. Trout

April 7, 2014

Specific catalysis of asparaginyl deamidation by carboxylic acids: Kinetic, thermodynamic, and quantitative structure-property relationship analyses

Molecular Pharmaceutics, ISSN: 15438392 15438384

Brian D. Connolly; Benjamin Tran; Jamie M. R. Moore; Vikas Sharma; Andrew Kosky

April 7, 2014

Screening methods to identify indole derivatives that protect against reactive oxygen species induced tryptophan oxidation in proteins

Molecular Pharmaceutics, ISSN: 15438392 15438384

Parbir Grewal; Mary Mallaney; Kimberly Lau; Alavattam Sreedhara

April 7, 2014

Selective inhibition of mutant ras protein through covalent binding

Angewandte Chemie - International Edition, ISSN: 15213773 14337851

Joachim Rudolph; David Stokoe

April 1, 2014

Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth

Journal of Immunology, ISSN: 15506606 00221767

John H. Kehrl; Lalage M. Wakefield; Anita B. Roberts; Sonia Jakowlew; Melchor Alvarez-Mon; Rik Derynck; Michael B. Sporn; Anthony S. Fauci

April 1, 2014

Measuring health in pulmonary hypertension: Emphasising the right end-point?

European Respiratory Journal, ISSN: 13993003 09031936

Mardi Gomberg-Maitland; Hubert Chen

April 1, 2014

Limiting degradation of reactive antibody drug conjugate intermediates in HPLC method development

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085 1873264X

Yi Li; Colin D. Medley; Kelly Zhang; Larry Wigman; Nik P. Chetwyn

April 1, 2014

Inflammasome-dependent and -independent IL-18 production mediates immunity to the ISCOMATRIX adjuvant

Journal of Immunology, ISSN: 15506606 00221767

Nicholas S. Wilson; Peter Duewell; Becky Yang; Yun Li; Scot A. Marsters; Sandra Koernig; Eicke Latz; Eugene Maraskovsky; Adriana Baz Morelli; Max Schnurr; Avi Ashkenazi

April 1, 2014

The role of periostin in tissue remodeling across health and disease

Cellular and Molecular Life Sciences, ISSN: 14209071 1420682X

Simon J. Conway; Kenji Izuhara; Yasusei Kudo; Judith Litvin; Roger Markwald; Gaoliang Ouyang; Joseph R. Arron; Cecile Holweg; Akira Kudo

March 27, 2014

In search of magic bullets: The golden age of immunotherapeutics

Cell, ISSN: 10974172 00928674

John J. O'Shea; Yuka Kanno; Andrew A. Chan

March 26, 2014

Lymph node-independent liver metastasis in a model of metastatic colorectal cancer

Nature Communications, ISSN: 20411723

Ida Enquist; Zinaida Good; Adrian M. Jubb; Fuh; Xi Wang; Melissa Junttila; Erica L. Jackson; Kevin G. Leong

March 26, 2014

Method for cellular imaging of palmitoylated proteins with clickable probes and proximity ligation applied to hedgehog, tubulin, and ras

Journal of the American Chemical Society, ISSN: 15205126 00027863

Xinxin Gao; Rami N. Hannoush

March 21, 2014

Next generation MUT-MAP, a high-sensitivity high-throughput microfluidics chip-based mutation analysis panel

PLoS ONE, ISSN: 19326203

Erica Schleifman; Rachel Tam; Rajesh Patel; Alison Tsan; Teiko Sumiyoshi; Ling Fu; Rupal Desai; Nancy Schoenbrunner; Thomas W. Myers; Keith Bauer; Edward Smith; Rajiv Raja

March 19, 2014

Bayesian D-optimal designs for poisson regression models

Communications in Statistics - Theory and Methods, ISSN: 03610926 1532415X

Ying Zhang; Keying Ye

March 18, 2014

Dipole-dipole interaction in antibody solutions: Correlation with viscosity behavior at high concentration

Pharmaceutical Research, ISSN: 1573904X 07248741

Shubhadra N. Singh; Sandeep Yadav; Steven J. Shire; Devendra S. Kalonia

March 18, 2014

High-Resolution 3D Imaging of Intact Transparent Organs by 3DISCO

Fluorescence Microscopy: Super-Resolution and other Novel Techniques,

Ali Ertürk

March 18, 2014

Epidemiology and natural history of central venous access device use and infusion pump function in the NO16966 trial

British Journal of Cancer, ISSN: 15321827 00070920

Chu; Daniel Haller; Cartwright; Chris Twelves; Cassidy; Sun; Muhammad Saif; Edward McKenna; Lee; Hans-Joachim Schmoll

March 11, 2014

Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

John R. Teijaro; Kevin B. Walsh; Stephanie Rice; Hugh Rosen; Michael B.A. Oldstone

March 7, 2014

A turn-key approach for large-scale identification of complex posttranslational modifications

Journal of Proteome Research, ISSN: 15353893 15353907

Jian Wang; Veronica G. Anania; Jeff Knott; John Rush; Jennie R. Lill; Philip E. Bourne; Nuno Bandeira

March 5, 2014

Is SIRT2 required for necroptosis?

Nature, ISSN: 00280836 14764687

Kim Newton; Joanne M. Hildebrand; Zhirong Shen; Diego Rodriguez; Silvia Alvarez-Diaz; Sean Petersen; Saumil Shah; Dugger; Chunzi Huang; Johan Auwerx; Vandenabeele; Douglas R. Green; Avi Ashkenazi; Vishva M. Dixit; William J. Kaiser; Andreas Strasser; Alexei Degterev; John Silke

March 3, 2014

Assessment of the hepatic CYP reductase null mouse model and its potential application in drug discovery

Molecular Pharmaceutics, ISSN: 15438384 15438392

Jason Boggs; Cornelis E. Hop; Erin McNamara; Yuzhong Deng; Kirsten Messick; Kristina West; Edna F. Choo

March 1, 2014

Patient-reported outcomes from EMILIA, a randomized phase 3 study of trastuzumab emtansine (T-DM1) versus capecitabine and lapatinib in human epidermal growth factor receptor 2-positive locally advanced or metastatic breast cancer

Cancer, ISSN: 0008543X 10970142

Manfred Welslau; Diéras; Joo-Hyuk Sohn; Sara A. Hurvitz; Deepa Lalla; Liang Fang; Betsy Althaus; Ellie Guardino; David W. Miles

March 1, 2014

The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections

Infection and Immunity, ISSN: 00199567 10985522

Shrinivas Bishu; Nydiaris Herna´ndez-Santos; Michelle R. Simpson-Abelson; Anna R. Huppler; Heather R. Conti; Nico Ghilardi; Anna J. Mamo; Sarah L. Gaffen

March 1, 2014

Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: Immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy

Virology, ISSN: 00426822 10960341

John R. Teijaro; Kevin B. Walsh; James P. Long; Kevin P. Tordoff; Gregory V. Stark; Amie J. Eisfeld; Yoshihiro Kawaoka; Hugh Rosen; Michael B.A. Oldstone

March 1, 2014

A Brief Overview of the 32nd Annual STP Symposium on the Toxicologic Pathology of the Digestive Tract and Pancreas

Veterinary Pathology, ISSN: 03009858 15442217

Dimitry Danilenko; Prashant R. Nambiar; Mark F. Cesta

March 1, 2014

Analysis of safety data in clinical trials using a recurrent event approach

Pharmaceutical Statistics, ISSN: 15391604 15391612

Qi Gong; Barbara Tong; Alexander Strasak; Liang Fang

March 1, 2014

Interactions between MUC1 and p120 catenin regulate dynamic features of cell adhesion, motility, and metastasis

Cancer Research, ISSN: 15387445 00085472

Xiang Liu; Chunhui Yi; Yunfei Wen; Prakash Radhakrishnan; Jarrod Tremayne; Thongtan Dao; Keith R. Johnson; Michael A. Hollingsworth

March 1, 2014

Metastatic basal cell carcinoma: Prognosis dependent on anatomic site and spread of disease

European Journal of Cancer, ISSN: 09598049 18790852

Margaret McCusker; Nicole Basset-Seguin; Reinhard Dummer; Karl Lewis; Dirk Schadendorf; Aleksandar Sekulic; Jeannie Hou; Lisa I. Wang; Huibin Yue; Axel Hauschild

March 1, 2014

Solvent-based formulations for intravenous mouse pharmacokinetic studies: Tolerability and recommended solvent dose limits

Xenobiotica, ISSN: 00498254 13665928

Evan A Thackaberry; Xiaojing Wang; Michelle G. Schweiger; Kirsten Messick; Nicole R. Valle; Brian J. Dean; Amy Sambrone; Terri Bowman; Minli Xie

March 1, 2014

The role of body mass index in survival outcome for lymphoma patients: US intergroup experience

Annals of Oncology, ISSN: 09237534 15698041

Fangxin Hong; Thomas M. Habermann; Leo I. Gordon; Hochster; Randy D. Gascoyne; Morrison; Richard I. Fisher; Nancy L. Bartlett; Patrick J. Stiff; Bruce D. Cheson; Michael Crump; Sandra J. Horning; Brad Kahl

March 1, 2014

Sequential C3 and C5 direct C-H arylation of imidazo[1,2-a]pyrazines with (Hetero)aryl bromides

European Journal of Organic Chemistry, ISSN: 1434193X 10990690

Brett M. Johnson; Malcolm P. Huestis

March 1, 2014

Psoriasis-like skin lesions are dependent on IL-23 but develop in the absence of IL-22 in a model mouse

Journal of Dermatological Science, ISSN: 09231811 1873569X

Mikiro Takaishi; Kimiko Nakajima; Wenjun Ouyang; Shigetoshi Sano

March 1, 2014

Investigations into the mechanisms of pyridine ring cleavage in vismodegibs

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

S. Cyrus Khojasteh; Qin Yue; Shuguang Ma; Georgette M. Castanedo; Jacob Z. Chen; Joseph P. Lyssikatos; Teresa Mulder; Ryan Takahashi; Justin Ly; Kirsten Messick; Wei Jia; Lichuan Liu; Cornelis E. Hop; Harvey Wong

March 1, 2014

DropArray™, a wall-less 96-well plate for uptake and immunofluorescence microscopy, confirms CD22 recycles

Traffic, ISSN: 13989219 16000854

Gladys S. Ingle; Suzie J. Scales

March 1, 2014

Discriminative motif analysis of high-throughput dataset

Bioinformatics, ISSN: 13674803 14602059

Zizhen Yao; Kyle L. Macquarrie; Abraham P. Fong; Stephen J. Tapscott; Walter L. Ruzzo; Robert Gentleman

March 1, 2014

The role of body mass index in survival outcome for lymphoma patients: US intergroup experience

Annals of Oncology, ISSN: 09237534 15698041

Fangxin Hong; Thomas M. Habermann; Leo I. Gordon; Hochster; Randy D. Gascoyne; Morrison; Richard I. Fisher; Nancy L. Bartlett; Patrick J. Stiff; Bruce D. Cheson; Michael Crump; Sandra J. Horning; Wojciech Jurczak

February 25, 2014

Clinical validation of a PCR assay for the detection of EGFR mutations in non-small-cell lung cancer: Retrospective testing of specimens from the EURTAC trial

PLoS ONE, ISSN: 19326203

Susana Benlloch; Maria F. Botero; Jordi Beltran-Alamillo; Clara Mayo; Ana Gimenez-Capitán; Itziar De Aguirre; Cristina Queralt; Jose Luis Ramirez; Santiago Ramón Y Cajal; Barbara Klughammer; Mariette Schlegel; Walter Bordogna; David Chen; Guili Zhang; Barbara Kovach; Felice Shieh; John F. Palma; Lin Wu; H. Jeffrey Lawrence; Miquel Taron

February 21, 2014

A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3

Nature, ISSN: 00280836 14764687

Aditya Murthy; Yun Li; Ivan Peng; Mike Reichelt; Anand K. Katakam; Rajkumar Noubade; Merone Roose-Girma; Jason Devoss; Laurie Diehl; Robert R. Graham; Menno Van Lookeren Campagne

February 20, 2014

Tuning of Antigen Sensitivity by T Cell Receptor-Dependent Negative Feedback Controls T Cell Effector Function in Inflamed Tissues

Immunity, ISSN: 10747613 10974180

Tetsuya Honda; Jackson G. Egen; Tim Lämmermann; Wolfgang Kastenmüller; Parizad Torabi-Parizi; Ronald N. Germain

February 20, 2014

The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria

Immunity, ISSN: 10747613 10974180

Judith Behnsen; Stefan Jellbauer; Christina P. Wong; Robert A. Edwards; Michael D. George; Wenjun Ouyang; Manuela Raffatellu

February 19, 2014

The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth

Nature Communications, ISSN: 20411723

Hyunjoo Kim; Ho-June Lee; Yumin Oh; Seon-Guk Choi; Se-Hoon Hong; Hyo-Jin Kim; Song-Yi Lee; Ji-Woo Choi; Deog Su Hwang; Key-Sun Kim; Hyo-Joon Kim; Jianke Zhang; Hyun-Jo Youn; Dong-Young Noh; Yong-Keun Jung

February 19, 2014

Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer

New England Journal of Medicine, ISSN: 15334406 00284793

Sandra M. Swain; Baselga; Sung-Bae Kim; Jungsil Ro; Vladimir Semiglazov; Mario Campone; Eva Ciruelos; Jean-Marc Ferrero; Andreas Schneeweiss; Sarah Heeson; Emma Clark; Graham Ross; Benyunes; Javier Cortés

February 18, 2014

Further insights into the effects of pre-organizing the BimBH3 Helix

ACS Chemical Biology, ISSN: 15548937 15548929

Toru Okamoto; David Segal; Zobel; Anna V. Fedorova; Hong Yang; Wayne J. Fairbrother; David C.S. Huang; Brian J. Smith; Deshayes; Czabotar

February 18, 2014

A chemoselective Reformatsky-Negishi approach to α-haloaryl esters

Tetrahedron, ISSN: 00404020 14645416

Brian Wong; Xin Linghu; James J. Crawford; Joy Drobnick; Wendy Lee; Haiming Zhang

February 18, 2014

IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Monica Gostissa; Bjoern Schwer; Amelia Chang; Junchao Dong; Robin M. Meyers; Gregory T. Marecki; Vivian W. Choi; Roberto Chiarle; Ali A. Zarrin; Frederick W. Alt

February 15, 2014

Pathogen-related differences in the abundance of presented antigen are reflected in CD4+ T cell dynamic behavior and effector function in the lung

Journal of Immunology, ISSN: 00221767 15506606

Parizad Torabi-Parizi; Nienke Vrisekoop; Wolfgang Kastenmüller; Michael Y. Gerner; Jackson G. Egen; Ronald N. Germain

February 13, 2014

Fragment-based identification of amides derived from trans-2-(pyridin-3-yl) cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Anthony M. Giannetti; Xiaozhang Zheng; Nicholas J. Skelton; Weiru Wang; Brandon Bravo; Kenneth W. Bair; Timm Baumeister; Eric Cheng; Lisa Crocker; Yezhen Feng; Janet Gunzner; Yen-Ching Ho; Rongbao Hua; Bianca M. Liederer; Yongbo Liu; Xiaolei Ma; Thomas O'Brien; Jason Oeh; Deepak Sampath; Youming Shen; Chengcheng Wang; Leslie Wang; Hongxing Wu; Yang Xiao; Po-Wai Yuen; Mark Zak; Guiling Zhao; Qiang Zhao; Peter Dragovich

February 13, 2014

Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type i 1/2 kinase inhibitors

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Steven T. Staben; Jianwen A. Feng; Karen Lyle; Marcia Belvin; Jason Boggs; Jason D. Burch; Ching-Ching Chua; Haifeng Cui; Antonio G. DiPasquale; Lori S. Friedman; Christopher E. Heise; Koeppen; Adrian Kotey; Robert Mintzer; Angela Oh; David Allen Roberts; Lionel Rouge; Joachim Rudolph; Christine Tam; Weiru Wang; Yisong Xiao; Amy Young; Yamin Zhang; Klaus P. Hoeflich

Join Our Team

The little things we do every day add up to big breakthroughs. Making a difference in the lives of millions starts when you make a change in yours.

Two Scientists Walk Into a Bar

Two Scientists Walk Into a Bar

Listen to our podcast, where researchers talk about their work answering the toughest questions in human biology.