Genentech: Publications

January 1, 2014

Antibody-drug conjugates: An emerging modality for the treatment of cancer

Annals of the New York Academy of Sciences, ISSN: 17496632 00778923

Mauricio Leal; Puja Sapra; Sara A. Hurvitz; Peter Senter; Alan Wahl; Melissa Schutten; Dhaval K. Shah; Nahor Haddish-Berhane; Omar Kabbarah

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January 1, 2014

Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections

Journal of Experimental Medicine, ISSN: 15409538 00221007

Heather R. Conti; Alanna C. Peterson; Lucas Brane; Anna R. Huppler; Nydiaris Herna´ndez-Santos; Natasha Whibley; Abhishek V. Garg; Michelle R. Simpson-Abelson; Gregory A. Gibson; Anna J. Mamo; Lisa C. Osborne; Shrinivas Bishu; Nico Ghilardi; Ulrich Siebenlist; Simon C. Watkins; David Artis; Mandy J. McGeachy; Sarah L. Gaffen

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January 1, 2014

Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in patients with severe asthma

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Lorcan P. McGarvey; Claire A. Butler; Susan Stokesberry; Liam Polley; Stephen McQuaid; Hani'Ah Abdullah; Sadaf Ashraf; Mary K. McGahon; Tim M. Curtis; Joseph R. Arron; David F. Choy; Timothy J. Warke; Peter Bradding; Madeleine Ennis; Alexander Zholos; Richard W. Costello; Liam G. Heaney

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January 1, 2014

Safety and efficacy of vemurafenib in BRAFV600E and BRAFV600K mutation-positive melanoma (BRIM-3): Extended follow-up of a phase 3, randomised, open-label study

The Lancet Oncology, ISSN: 14745488 14702045

McArthur; Paul B. Chapman; Caroline Robert; James Larkin; John B. Haanen; Reinhard Dummer; Antoni Ribas; Hogg; Omid Hamid; Paolo A. Ascierto; Claus Garbe; Alessandro Testori; Michele Maio; Paul Lorigan; Celeste Lebbe; Thomas Jouary; Dirk Schadendorf; Steven J. O'Day; John M. Kirkwood; Alexander M. M. Eggermont; Brigitte Dréno; Jeffrey A. Sosman; Keith Flaherty; Ming Yin; Ivor Caro; Suzanne Cheng; Kerstin Trunzer; Axel Hauschild

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January 1, 2014

Combination of vemurafenib and cobimetinib in patients with advanced BRAFV600-mutated melanoma: A phase 1b study

The Lancet Oncology, ISSN: 14745488 14702045

Antoni Ribas; Rene Gonzalez; Anna Pavlick; Omid Hamid; Thomas F Gajewski; Adil Daud; Lawrence Flaherty; Theodore Logan; Bartosz Chmielowski; Karl Lewis; Damien Kee; Peter Boasberg; Ming Yin; Iris Chan; Luna Musib; Nicholas Choong; Igor Puzanov; McArthur

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January 1, 2014

Discovery of highly potent, selective, and brain-penetrant aminopyrazole Leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Anthony A. Estrada; Bryan K. Chan; Charles Baker-Glenn; Alan Beresford; Burdick; Mark Chambers; Huifen Chen; Sara L. Dominguez; Jennafer Dotson; Jason H. Drummond; Michael Flagella; Reina N. Fuji; Andrew Gill; Jason S Halladay; Seth F. Harris; Timothy P. Heffron; Tracy L. Kleinheinz; Donna W. Lee; Claire E. Le Pichon; Xingrong Liu; Joseph P. Lyssikatos; Andrew D. Medhurst; John Moffat; Kevin Nash; Kimberly Scearce-Levie; Zejuan Sheng; Daniel G. Shore; Susan C. Wong; Shuo Zhang; Xiaolin Zhang; Haitao Zhu; Zachary K. Sweeney

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January 1, 2014

Epiregulin gene expression as a biomarker of benefit from cetuximab in the treatment of advanced colorectal cancer

British Journal of Cancer, ISSN: 15321827 00070920

Jonker; Karapetis; Harbison; O'Callaghan; Tu; Simes; Malone; Christiane Langer; Niall C. Tebbutt; Timothy Price; Shapiro; Siu; Wong; Bjarnason; Moore; John Zalcberg; Khambata-Ford

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January 1, 2014

Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma

Eye, ISSN: 14765454 0950222X

Jae H. Kang; Stephanie J. Loomis; Brian L. Yaspan; Jessica Cooke Bailey; Robert N. Weinreb; Richard K. Lee; Paul R. Lichter; Donald L. Budenz; Yutao Liu; Tony Realini; Douglas Gaasterland; Terry Gaasterland; Friedman; Catherine A. McCarty; Sayoko E. Moroi; Olson; Schuman; Kuldev Singh; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; Murray Brilliant; Arthur J. Sit; Christen; John Fingert; Forman; Buys; Peter Kraft; Kang Zhang; R. Rand Allingham; Brian W. Kunkle; Julia E. Richards; Michael A. Hauser; Jonathan L. Haines; Janey L. Wiggs; Louis R. Pasquale

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January 1, 2014

Manifestations of cardiac disease in carotid duplex ultrasound examination

JACC: Cardiovascular Imaging, ISSN: 18767591 1936878X

Surabhi Madhwal; Sandra Yesenko; Esther Soo Hyun Kim; Margaret Park; Susan M. Begelman; Heather L. Gornik

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January 1, 2014

Evaluation of time-dependent CYP3A4 inhibition using human hepatocytes

Methods in Pharmacology and Toxicology, ISSN: 19406053 15572153

Yuan Chen; Adrian J. Fretland

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January 1, 2014

Assessment and reporting of the clinical immunogenicity of therapeutic proteins and peptides - Harmonized terminology and tactical recommendations

AAPS Journal, ISSN: 15507416

Gopi Shankar; Arkin; Cocea; Viswanath Devanarayan; Susan Kirshner; Kromminga; Quarmby; Richards; Schneider; Subramanyam; Steven J. Swanson; Verthelyi; Yim

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January 1, 2014

Response to: 'Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria: A critical appraisal'

British Journal of Dermatology, ISSN: 13652133 00070963

Karin Rosén; Marcus Maurer; Hsin-Ju Hsieh; Sarbjit S. Saini; Clive E. Grattan; Ana Gimenéz-Arnau; Sunil Agarwal; Ramona Doyle; Janice Canvin; Allen P. Kaplan; Thomas B. Casale

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January 1, 2014

Pathway connectivity and signaling coordination in the yeast stress-activated signaling network

Molecular Systems Biology, ISSN: 17444292

Deborah Chasman; Yi-Hsuan Ho; David B Berry; Corey M Nemec; Matthew E Macgilvray; James Hose; Anna E Merrill; M Violet Lee; Jessica L Will; Joshua J Coon; Aseem Z Ansari; Mark Craven; Audrey P Gasch

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January 1, 2014

A mechanistic pharmacokinetic model elucidating the disposition of trastuzumab emtansine (T-DM1), an Antibody-Drug Conjugate (ADC) for treatment of metastatic breast cancer

AAPS Journal, ISSN: 15507416

Brendan C. Bender; Douglas Leipold; Keyang Xu; Shen; Jay Tibbitts; Lena E. Friberg

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January 1, 2014

Innate immunity in the lung regulates the development of asthma

Immunological Reviews, ISSN: 1600065X 01052896

Rosemarie H. Dekruyff; Sanhong Yu; Hye Young Kim; Dale T. Umetsu

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January 1, 2014

Influence of glycosylation pattern on the molecular properties of monoclonal antibodies

mAbs, ISSN: 19420870 19420862

Kai Zheng; Mark Yarmarkovich; Christopher Bantog; Robert Bayer; Thomas W. Patapoff

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January 1, 2014

Site-specific antibody drug conjugates for cancer therapy

mAbs, ISSN: 19420862 19420870

Siler Panowski; Sunil Bhakta; Helga Raab; Paul G. Polakis; Jagath R. Junutula

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January 1, 2014

Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo

Developmental Dynamics, ISSN: 10970177 10588388

Lisa M. Galli; Roeben N. Munji; Susan C. Chapman; Ann Easton; Lydia Li; Ouma Onguka; Joseph S. Ramahi; Rowena Suriben; Linda A. Szabo; Camilla Teng; Baouyen Tran; Rami N. Hannoush; Laura W. Burrus

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January 1, 2014

Genetic analysis reveals that Amyloid Precursor Protein and Death Receptor 6 function in the same pathway to control axonal pruning independent of β-secretase

Journal of Neuroscience, ISSN: 15292401 02706474

Olav Olsen; Dara Y. Kallop; Todd McLaughlin; Sarah Huntwork-Rodriguez; Zhuhao Wu; Cynthia D. Duggan; David J. Simon; Yanmei Lu; Courtney Easley-Neal; Kentaro Takeda; Hass; Alexander Jaworski; Dennis D.M. O'Leary; Robby M. Weimer; Marc Tessier-Lavigne

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January 1, 2014

A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models

Journal of Neuroscience, ISSN: 15292401 02706474

Dara Y. Kallop; William J. Meilandt; Alvin Gogineni; Courtney Easley-Neal; Tiffany Wu; Adrian M. Jubb; Murat Yaylaoglu; Mehrdad Shamloo; Marc Tessier-Lavigne; Kimberly Scearce-Levie; Robby M. Weimer

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January 1, 2014

Measuring NAD+ levels in mouse blood and tissue samples via a surrogate matrix approach using LC-MS/MS

Bioanalysis, ISSN: 17576199 17576180

Xiaorong Liang; Lulu Yang; Ann R. Qin; Justin Ly; Bianca M. Liederer; Kirsten Messick; Shuguang Ma; Mark Zak; Peter Dragovich; Brian J. Dean; Cornelis E. Hop; Yuzhong Deng

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January 1, 2014

Subcutaneous pharmacokinetics of the cardiac hormone vessel dilator

Clinical and Experimental Pharmacology and Physiology, ISSN: 14401681 03051870

Qingyu Zhou; Glenn Whelan; Shu-Feng Zhou; Meghan L. Lane; David L. Vesely

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January 1, 2014

NRROS negatively regulates reactive oxygen species during host defence and autoimmunity

Nature, ISSN: 14764687 00280836

Rajkumar Noubade; Kit Wong; Naruhisa Ota; Sascha Rutz; Celine Eidenschenk; Patricia A. Valdez; Jiabing Ding; Ivan Peng; Andrew Sebrell; Patrick Caplazi; Jason Devoss; Robert Soriano; Tao Sai; Rongze Lu; Zora Modrusan; Jason A. Hackney; Wenjun Ouyang

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January 1, 2014

Targeting protein-protein interaction by small molecules

Annual Review of Pharmacology and Toxicology, ISSN: 15454304 03621642

Lingyan Jin; Weiru Wang; Guowei Fang

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January 1, 2014

Qualification and application of a liquid chromatography-tandem mass spectrometric method for the determination of human Aβ1-40 and Aβ1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction

Archives of Pharmacal Research, ISSN: 19763786 02536269

Young G. Shin; Lee Hamm; Stanley Murakami; Kenji Buirst; Michael H. Buonarati; April Cox; Kelly Regal; Kevin W. Hunt; Kimberly Scearce-Levie; Ryan J. Watts; Xingrong Liu

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January 1, 2014

Macular epiretinal brachytherapy in treated age-related macular degeneration (meritage): Month 24 safety and efficacy results

Retina, ISSN: 15392864 0275004X

Robert Petrarca; Pravin U. Dugel; Michael Bennett; Adiel Barak; Dov Weinberger; Jeffrey Nau; Timothy L. Jackson

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January 1, 2014

Role of IL-22 in microbial host defense

Current Topics in Microbiology and Immunology, ISSN: 21969965 0070217X

Celine Eidenschenk; Sascha Rutz; Oliver Liesenfeld; Wenjun Ouyang

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January 1, 2014

Rational selection of alternative, environmentally compatible surfactants for biotechnological production of pharmaceuticals-A step toward green biotechnology

Environmental Toxicology and Chemistry, ISSN: 15528618 07307268

Jürg Oliver Straub; Russel Shearer; Martin Studer

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January 1, 2014

Safety and tolerability of double-dose and duration oseltamivir regimens in patients with H1N1pdm09

Infectious Diseases in Clinical Practice, ISSN: 15369943 10569103

Lisa Cupelli; Mohammed Bailony; Tracy Burgess; Regina Dutkowski

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January 1, 2014

Intracellular effects of the hepatitis c virus nucleoside polymerase inhibitor ro5855 (mericitabine parent) and ribavirin in combination

Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804

Ma; Sophie Le Pogam; Fletcher; Hinojosa-Kirschenbaum; Javanbakht; Yan; Jiang; Inocencio; Klumpp; Nájera

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January 1, 2014

Molecular and cellular heterogeneity in the Rheumatoid Arthritis synovium: Clinical correlates of synovitis

Best Practice and Research: Clinical Rheumatology, ISSN: 15321770 15216942

Michael J. Townsend

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January 1, 2014

Ocular toxicity in BRAF mutant cutaneous melanoma patients treated with vemurafenib

American Journal of Ophthalmology, ISSN: 18791891 00029394

Christina H. Choe; McArthur; Ivor Caro; John H. Kempen; Ravi K. Amaravadi

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January 1, 2014

Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions

New England Journal of Medicine, ISSN: 15334406 00284793

Valentin Goede; Kirsten Fischer; Raymonde Busch; Anja Engelke; Barbara Eichhorst; Clemens M. Wendtner; Tatiana Chagorova; Javier De La Serna; Marie-Sarah Dilhuydy; Thomas Illmer; Stephen Opat; Carolyn J. Owen; Olga Samoylova; Karl-Anton Kreuzer; Stephan Stilgenbauer; Hartmut Doḧner; Anton W. Langerak; Matthias Ritgen; Kneba; Elina Asikanius; Kathryn Humphrey; Michael Wenger; Michael Hallek

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January 1, 2014

Treatment practice in the elderly patient with chronic lymphocytic leukemia - Analysis of the combined SEER and Medicare database

Annals of Hematology, ISSN: 14320584 09395555

Sacha Satram-Hoang; Carolina Reyes; Khang Q. Hoang; Faiyaz Momin; Sandra Skettino

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January 1, 2014

A phase I study of PRO131921, a novel anti-CD20 monoclonal antibody in patients with relapsed/refractory CD20+ indolent NHL: Correlation between clinical responses and AUC pharmacokinetics

Clinical Immunology, ISSN: 15217035 15216616

Carla Casulo; Julie Vose; William Y. Ho; Brad Kahl; Mark Brunvand; Andre Goy; Yvette Kasamon; Bruce D. Cheson; Jonathan W. Friedberg

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January 1, 2014

Apoptosis initiation through the cell-extrinsic pathway

Methods in Enzymology, ISSN: 15577988 00766879

Pradeep Nair; Min Lu; Sean Petersen; Avi Ashkenazi

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January 1, 2014

Identification and cost of adverse events in metastatic breast cancer in taxane and capecitabine based regimens

SpringerPlus, ISSN: 21931801

Ryan N. Hansen; Scott D. Ramsey; Deepa Lalla; Anthony Masaquel; Tripthi V. Kamath; Melissa Brammer; Sara A. Hurvitz; Sean D. Sullivan

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January 1, 2014

A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with moderate to severe rheumatoid arthritis (SUMMACTA study)

Annals of the Rheumatic Diseases, ISSN: 00034967 14682060

Gerd R. Burmester; Rubbert-Roth; Alain Cantagrel; Stephen Hall; Piotr Leszczynski; Daniel Feldman; Madura J. Rangaraj; Georgia Roane; Charles Ludivico; Peng Lu; Lucy Rowell; Bao; Eduardo F. Mysler

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January 1, 2014

Platelet-derived growth factor C promotes revascularization in ischemic limbs of diabetic mice

Journal of Vascular Surgery, ISSN: 10976809 07415214

Junji Moriya; Xiumin Wu; Jose Zavala-Solorio; Ross; Xiao Huan Liang; Napoleone Ferrara

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January 1, 2014

Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: Quo vadis?

Drug Discovery Today, ISSN: 18785832 13596446

Andreas Baumann; Dietrich Tuerck; Saileta Prabhu; Leslie Dickmann; Jennifer Sims

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January 1, 2014

STAT3 activation in tumor cell-free lymph nodes predicts a poor prognosis for gastric cancer

International Journal of Clinical and Experimental Pathology, ISSN: 19362625

Li-Jun Wu; Hai-Xia Li; Xiao-Ting Luo; Rongze Lu; Yun-Fang Ma; Rui Wang; Jun Zhang; Dong-Qin Yang; Hua Yu; Jie Liu

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January 1, 2014

A multicenter, randomized, double-blinded, placebo-controlled phase III study of Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR III)

International Journal of Stroke, ISSN: 17474949 17474930

Wendy C. Ziai; Stanley Tuhrim; Karen Lane; Nichol Mcbee; Kennedy Lees; Jesse Dawson; Kenneth Butcher; Paul Vespa; David W. Wright; Penelope M. Keyl; A. David Mendelow; Carlos Kase; Christine Wijman; Marc Lapointe; Sayona John; Richard Thompson; Carol Thompson; Steven Mayo; Pat Reilly; Scott Janis; Issam Awad; Daniel F. Hanley

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January 1, 2014

T-bet regulates immunity to Francisella tularensis live vaccine strain infection, particularly in lungs

Infection and Immunity, ISSN: 10985522 00199567

Amanda A. Melillo; Oded Foreman; Catharine M. Bosio; Karen L. Elkins

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January 1, 2014

Erratum to "Doubling down on the PI3K-AKTmTOR pathway enhances the antitumor efficacy of parp inhibitor in triple negative breast cancer model beyond BRCA-ness" [Neoplasia 16 (2014) 43-72]

Neoplasia (United States), ISSN: 14765586 15228002

Pradip De; Yuling Sun; Jennifer H. Carlson; Lori S. Friedman; Brian R. Leyland-Jones; Nandini Dey

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January 1, 2014

Investigators' Experience With Expedited Safety Reports Prior to the FDA's Final IND Safety Reporting Rule

Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790

Judith M. Kramer; David Vock; Howard E. Greenberg; Cheri Janning; Lynda Szczech; Miklos Salgo; Suzanne Gagnon; Susan Ellenberg

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January 1, 2014

An improved and robust DNA immunization method to develop antibodies against extracellular loops of multi-transmembrane proteins

mAbs, ISSN: 19420862 19420870

Meredith Hazen; Sunil Bhakta; Rajesh Vij; Steven Randle; Dara Y. Kallop; Vicki Chiang; Isidro Htzel; Bijay S. Jaiswal; Karen E. Ervin; Bing Li; Robby M. Weimer; Paul G. Polakis; Richard H. Scheller; Jagath R. Junutula; Hongo

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January 1, 2014

Special Focus on Investigative Techniques

Veterinary Pathology, ISSN: 03009858 15442217

Ramos-Vara; Webster

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January 1, 2014

Targeting IgE to facilitate oral immunotherapy for food allergy: A potential new role for anti-IgE therapy?

Expert Review of Clinical Immunology, ISSN: 17448409 1744666X

Dale T. Umetsu

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January 1, 2014

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling

Nature, ISSN: 14764687 00280836

Norihiro Nakamura; Jennie R. Lill; Qui Phung; Zhaoshi Jiang; Corey Bakalarski; Ann De Mazière; Judith Klumperman; Megan Schlatter; Lélia Delamarre; Ira Mellman

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January 1, 2014

Antiviral treatment of influenza in children: A retrospective cohort study

Advances in Therapy, ISSN: 18658652 0741238X

Lizheng Shi; Mark Loveless; Philip Spagnuolo; Mengxi Zhang; Shuqian Liu; Jinan Liu; Yaping Xu; Er Chen; Jian Han

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