Genentech: Publications

January 1, 2014

Pharmacokinetics and pharmacodynamics of CD4-anchoring Bi-functional fusion inhibitor in monkeys

Pharmaceutical Research, ISSN: 1573904X 07248741

Xingrong Liu; Ying C. Ou; Jun Zhang; Ago Ahene; Douglas Clark; Su-Chun Hsieh; Matthew Cooper; Changhua Ji

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January 1, 2014

A tiered approach to address regulatory drug metabolite-related issues in drug development

Bioanalysis, ISSN: 17576199 17576180

Shuguang Ma; Swapan K. Chowdhury

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January 1, 2014

Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases

Current Topics in Medicinal Chemistry, ISSN: 18734294 15680266

Flygare; Michelle R. Arkin

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January 1, 2014

Implementing high-temperature short-time media treatment in commercial-scale cell culture manufacturing processes

Applied Microbiology and Biotechnology, ISSN: 14320614 01757598

Michael Pohlscheidt; Salim Charaniya; Fikret Kulenovic; Mahalia Corrales; Masaru Shiratori; Justin Bourret; Steven Meier; Eric Fallon; Robert Kiss

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January 1, 2014

Combination of PIM and JAK2 inhibitors synergistically suppresses MPN cell proliferation and overcomes drug resistance

Oncotarget, ISSN: 19492553

Shih-Min A. Huang; Anlai Wang; Rita Greco; Zhifang Li; Claude Barberis; Michel Tabart; Vinod Patel; Laurent Schio; Raelene Hurley; Hong Cheng; Christoph Lengauer; Jack Pollard; James Watters; Carlos Garcia-Echeverria; Dmitri Wiederschain; Francisco Adrian; JingXin Zhang

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January 1, 2014

Genomic landscape of metastatic colorectal cancer

Nature Communications, ISSN: 20411723

Josien C. Haan; Mariette Labots; Christian Rausch; Miriam Koopman; Jolien Tol; Leonie J. M. Mekenkamp; Mark A. Van De Wiel; Danielle Israeli; Hendrik F. Van Essen; Nicole C. T. Van Grieken; Quirinus J. M. Voorham; Linda J. W. Bosch; Xueping Qu; Omar Kabbarah; Henk M. W. Verheul; Iris D. Nagtegaal; Cornelis J. A. Punt; Bauke Ylstra; Gerrit A. Meijer

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January 1, 2014

Phase I dose-escalation study of onartuzumab as a single agent and in combination with bevacizumab in patients with advanced solid malignancies

Clinical Cancer Research, ISSN: 15573265 10780432

Ravi Salgia; Premal Patel; John Bothos; Wei Yu; Stephen M. Eppler; Priti Hegde; Shuang Bai; Surinder Kaur; Ihsan Nijem; Daniel V.T. Catenacci; Amy Peterson; Ratain; Blase Polite; Janice M. Mehnert; Rebecca A. Moss

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January 1, 2014

Use of anti-malarial drugs and the risk of developing eye disorders

Travel Medicine and Infectious Disease, ISSN: 14778939 18730442

Cornelia Schneider; Miriam Adamcova; Susan S. Jick; Patricia Schlagenhauf; Mary K. Miller; Hans-Georg Rhein; Christoph R. Meier

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January 1, 2014

A Homozygous PDE6D Mutation in Joubert Syndrome Impairs Targeting of Farnesylated INPP5E Protein to the Primary Cilium

Human Mutation, ISSN: 10597794 10981004

Sophie Thomas; Kevin J. Wright; Stéphanie Le Corre; Alessia Micalizzi; Marta Romani; Avinash Abhyankar; Julien Saada; Isabelle Perrault; Jeanne Amiel; Julie Litzler; Emilie Filhol; Nadia Elkhartoufi; Mandy Kwong; Jean-Laurent Casanova; Nathalie Boddaert; Wolfgang Baehr; Stanislas Lyonnet; Arnold Munnich; Lydie Burglen; Nicolas Chassaing; Ferechté Encha-Ravazi; Michel Vekemans; Joseph G. Gleeson; Enza Maria Valente; Peter K Jackson; Iain A. Drummond; Sophie Saunier; Tania Attié-Bitach

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January 1, 2014

The effect of rifampicin, a prototypical CYP3A4 inducer, on erlotinib pharmacokinetics in healthy subjects

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Marta Hamilton; Julie Wolf; Drolet; Scott Fettner; Ashok Rakhit; Karsten Witt; Bert L. Lum

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January 1, 2014

Effect of meal and antisecretory agents on the pharmacokinetics of danoprevir/ritonavir in healthy volunteers

Journal of Pharmacy and Pharmacology, ISSN: 00223573 20427158

Peter N. Morcos; Sebastian A. Moreira; Mercidita T. Navarro; Núria Bech; Amanda Quatkemeyer; Patrick F. Smith; Barbara J. Brennan

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January 1, 2014

Risk of hospitalized bacterial infections associated with biologic treatment among US veterans with rheumatoid arthritis

Arthritis Care and Research, ISSN: 21514658 2151464X

Jeffrey R. Curtis; Yang; Patkar; Chen; Jasvinder A. Singh; Cannon; Ted R. Mikuls; Delzell; Saag; Safford; Scott L. Duvall; Kimberly Alexander; Pavel Napalkov; Kevin L. Winthrop; Burton; Kamauu; Baddley

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January 1, 2014

Budesonide nebulization added to systemic prednisolone in the treatment of acute asthma in children: A double-blind, randomized, controlled trial

Chest, ISSN: 19313543 00123692

Abdullah A. Alangari; Nidal Malhis; Mohamed Mubasher; Najwa Al-Ghamedi; Mohamad Al-Tannir; Muhammad Riaz; Dale T. Umetsu; Saleh Al-Tamimi

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January 1, 2014

Changes in PIK3CA mutation status are not associated with recurrence, metastatic disease or progression in endocrine-treated breast cancer

Breast Cancer Research and Treatment, ISSN: 15737217 01676806

Arthur; Turnbull; Renshaw; Keys; Thomas; Wilson; Lackner; Sims; Dixon

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January 1, 2014

Whole-Slide Imaging and Automated Image Analysis: Considerations and Opportunities in the Practice of Pathology

Veterinary Pathology, ISSN: 03009858 15442217

Webster; Dunstan

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January 1, 2014

Emerging technologies in extracellular vesicle-based molecular diagnostics

Expert Review of Molecular Diagnostics, ISSN: 17448352 14737159

Shidong Jia; Davide Zocco; Michael L. Samuels; Michael F. Chou; Roger Chammas; Johan Skog; Natasa Zarovni; Fatemeh Momen-Heravi; Winston Patrick Kuo

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January 1, 2014

Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: Reciprocal suppression with VEGF

Journal of Cellular Physiology, ISSN: 10974652 00219541

Jikui Shen; David F. Choy; Tsunehiko Yoshida; Takeshi Iwase; Gulnar Hafiz; Bing Xie; Sean F. Hackett; Joseph R. Arron; Peter A. Campochiaro

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January 1, 2014

Progression-free survival as a surrogate endpoint for overall survival in glioblastoma: A literature-based meta-analysis from 91 trials

Neuro-Oncology, ISSN: 15235866 15228517

Kelong Han; Melanie Ren; Wick; Lauren E. Abrey; Asha Das; Jin Y. Jin; David A. Reardon

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January 1, 2014

The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling

Molecular and Cellular Biology, ISSN: 10985549 02707306

Bo Cen; Ying Xiong; Jin H. Song; Sandeep Mahajan; Rachel DuPont; Kristen McEachern; Daniel J. DeAngelo; Jorge E. Cortes; Mark D. Minden; Allen Ebens; Alice Mims; Amanda LaRue; Andrew S. Kraft

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January 1, 2014

Using RNAi screening technologies to interrogate the extrinsic apoptosis pathway

Methods in Enzymology, ISSN: 15577988 00766879

Jean-Philippe Stephan

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January 1, 2014

New challenges and opportunities in nonclinical safety testing of biologics

Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300

Andreas Baumann; Kelly Flagella; Roy Forster; Lolke de Haan; Sven Kronenberg; Mathias Locher; Wolfgang F. Richter; Frank-Peter Theil; Marque Todd

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January 1, 2014

Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine

Nature Chemical Biology, ISSN: 15524469 15524450

Xinxin Gao; Rami N. Hannoush

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January 1, 2014

Pathology in drug discovery and development

Journal of Pathology, ISSN: 00223417 10969896

Adrian M. Jubb; Koeppen; Jorge S. Reis-Filho

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January 1, 2014

Population pharmacokinetics and exposure-response analyses of trastuzumab in patients with advanced gastric or gastroesophageal junction cancer

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Valérie F. Cosson; Vivian W. Ng; Michaela Lehle; Bert L. Lum

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January 1, 2014

Effect of adjuvant capecitabine or fluorouracil, with or without oxaliplatin, on survival outcomes in stage III colon cancer and the effect of oxaliplatin on post-relapse survival: A pooled analysis of individual patient data from four randomised controlled trials

The Lancet Oncology, ISSN: 14745488 14702045

Hans-Joachim Schmoll; Chris Twelves; Sun; Michael J O'Connell; Cartwright; Edward McKenna; Muhammad Saif; Lee; Greg Yothers; Daniel Haller

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January 1, 2014

Protein crystallization image classification with elastic net

Progress in Biomedical Optics and Imaging - Proceedings of SPIE, ISSN: 16057422

Jeffrey Hung; John Collins; Mehari Weldetsion; Oliver Newland; Eric Chiang; Steve Guerrero; Kazunori Okada

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January 1, 2014

Profiling cancer genemutations in clinical formalin-fixed, paraffin-embedded colorectal tumor specimens using targeted next-generation sequencing

Oncologist, ISSN: 1549490X 10837159

Liangxuan Zhang; Liangjing Chen; Sachin Sah; Gary J. Latham; Rajesh Patel; Qinghua Song; Koeppen; Rachel Tam; Erica Schleifman; Haider Mashhedi; Sreedevi Chalasani; Ling Fu; Teiko Sumiyoshi; Rajiv Raja; William F. Forrest; Garret M. Hampton; Lackner; Priti Hegde; Shidong Jia

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January 1, 2014

Efficacy and safety of an anti-IL-13 mAb in patients with severe asthma: A randomized trial

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Erika H. De Boever; Claire Ashman; Anthony P. Cahn; Nicholas W. Locantore; Phil Overend; Isabelle J. Pouliquen; Adrian P. Serone; Tracey J. Wright; Mair M. Jenkins; Inderpal S. Panesar; Sivayogan S. Thiagarajah; Sally E. Wenzel

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January 1, 2014

Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake

Science China Life Sciences, ISSN: 16747305

LiLi Qian; ChangZu Cai; PengFei Yuan; Sun-Young Jeong; XiaoZhou Yang; Venita I. DeAlmeida; James A. Ernst; Michael Costa; Stanley N. Cohen; WenSheng Wei

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January 1, 2014

A new player on the psoriasis block: IL-17A- and IL-22-producing innate lymphoid cells

Journal of Investigative Dermatology, ISSN: 15231747 0022202X

Nicole L. Ward; Dale T. Umetsu

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January 1, 2014

AKT-induced tamoxifen resistance is overturned by RRM2 inhibition

Molecular Cancer Research, ISSN: 15573125 15417786

Khyati N. Shah; Kshama R. Mehta; David Peterson; Marie Evangelista; John C. Livesey; Jesika S. Faridi

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January 1, 2014

Phase 1b study of safety, tolerability and efficacy of R1507, a monoclonal antibody to IGF-1R in combination with multiple standard oncology regimens in patients with advanced solid malignancies

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Daruka Mahadevan; Gregory Ryan Sutton; Rafael Arteta-Bulos; Chris J. Bowden; Paul J. E. Miller; Rachel Elizabeth Swart; Mark S. Walker; Paul Haluska; Pamela N. Münster; John Marshall; Omid Hamid; Razelle Kurzrock

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January 1, 2014

Interrogation of in vivo protein-protein interactions using transgenic mouse models and stable isotope labeling

Methods in Molecular Biology, ISSN: 10643745

Anwesha Dey; Jiansheng Wu; Donald S. Kirkpatrick

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January 1, 2014

IAP family of cell death and signaling regulators

Methods in Enzymology, ISSN: 15577988 00766879

John Silke; Domagoj Vucic

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January 1, 2014

Comparison of treatment patterns and economic outcomes in metastatic breast cancer patients initiated on trastuzumab versus lapatinib: A retrospective analysis

SpringerPlus, ISSN: 21931801

Annie Guérin; Deepa Lalla; Geneviève Gauthier; Amy Styles; Eric Q. Wu; Anthony Masaquel; Melissa Brammer

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January 1, 2014

Investigation of adverse-event-related costs for patients with metastatic breast cancer in a real-world setting

Oncologist, ISSN: 1549490X 10837159

Sara A. Hurvitz; Annie Guérin; Melissa Brammer; Ellie Guardino; Zheng-Yi Zhou; Dominick Latremouille Viau; Eric Q. Wu; Deepa Lalla

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January 1, 2014

Tailoring small molecules for an allosteric site on procaspase-6

ChemMedChem, ISSN: 18607179 18607187

Jeremy Murray; Anthony M. Giannetti; Micah Steffek; Paul Gibbons; Brian R. Hearn; Frederick Cohen; Christine Tam; Christine D. Pozniak; Brandon Bravo; Joe Lewcock; Priyadarshini Jaishankar; Cuong Q. Ly; Xianrui Zhao; Yinyan Tang; Preeti Chugha; Michelle R. Arkin; Flygare; Adam R. Renslo

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January 1, 2014

Immunomodulation and lymphoma in humans

Journal of Immunotoxicology, ISSN: 1547691X

Rafael Ponce; Thomas R. Gelzleichter; Helen G. Haggerty; Shawn Heidel; Matthew S. Holdren; Herve Lebrec; R. Daniel Mellon; Marc Pallardy

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January 1, 2014

In vivo antigen-driven plasmablast enrichment in combination with antigen-specific cell sorting to facilitate the isolation of rare monoclonal antibodies from human B cells

Nature Protocols, ISSN: 17502799 17542189

Zhonghua Lin; Nancy Y. Chiang; Ning Chai; Dhaya Seshasayee; Wyne P. Lee; Mercedesz Balazs; Nakamura; Lee R. Swem

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January 1, 2014

Amphiregulin and pten evoke a multimodal mechanism of acquired resistance to PI3k inhibition

Genes and Cancer, ISSN: 19476027 19476019

Kyle A. Edgar; Lisa Crocker; Eric Cheng; Marie-Claire Wagle; Matthew Wongchenko; Yibing Yan; Wilson; Nicholas A. Dompe; Richard M. Neve; Marcia Belvin; Deepak Sampath; Lori S. Friedman; Jeffery J. Wallin

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January 1, 2014

Genetic markers of bevacizumab-induced hypertension

Angiogenesis, ISSN: 15737209 09696970

Diether Lambrechts; Matthieu Moisse; Paul Delmar; David W. Miles; Natasha Leighl; Bernard Escudier; Eric Van Cutsem; Aruna T. Bansal; Peter Carmeliet; Stefan J. Scherer; Sanne De Haas; Celine Pallaud

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January 1, 2014

Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized fab-antigen complexes

mAbs, ISSN: 19420870 19420862

Sherry L. La Porte; Eigenbrot; Ultsch; Ho; Davide Foletti; Alison Forgie; Kevin C. Lindquist; David L. Shelton; Jaume Pons

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January 1, 2014

Complete knockout of the lactate dehydrogenase A gene is lethal in pyruvate dehydrogenase kinase 1, 2, 3 down-regulated CHO cells

Molecular Biotechnology, ISSN: 15590305 10736085

Shirley S. M. Yip; Meixia Zhou; John C. Joly; Snedecor; Amy Shen; Yongping Crawford

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January 1, 2014

Population pharmacokinetic and covariate analysis of pertuzumab, a HER2-targeted monoclonal antibody, and evaluation of a fixed, non-weight-based dose in patients with a variety of solid tumors

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Amit Garg; Angelica Quartino; Jing Li; Jin Y. Jin; D. Russell Wada; Hanbin Li; Javier Cortés; Virginia McNally; Graham Ross; Jennifer Visich; Bert L. Lum

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January 1, 2014

Geographic atrophy: Clinical features and potential therapeutic approaches

Ophthalmology, ISSN: 15494713 01616420

Frank G. Holz; Erich C. Strauss; Steffen Schmitz-Valckenberg; Menno Van Lookeren Campagne

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January 1, 2014

Bispecific therapeutics for ophthalmic indications: Target selection and the optimal molecular format

Expert Review of Ophthalmology, ISSN: 17469902 17469899

Jennifer Le Couter; Justin M. Scheer

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January 1, 2014

Intraocular pressure in eyes receiving monthly ranibizumab in 2 pivotal age-related macular degeneration clinical trials

Ophthalmology, ISSN: 15494713 01616420

Sophie J. Bakri; Darius M. Moshfeghi; Steve Francom; Amy Chen Rundle; Daniel S. Reshef; Paul P. Lee; Carol Schaeffer; Roman G. Rubio; Phillip Lai

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January 1, 2014

The effect of mild to moderate renal impairment on the pharmacokinetics of the nucleoside analog hepatitis C virus polymerase inhibitor mericitabine

Drug Development Research, ISSN: 10982299 02724391

Joshua Haznedar; Sebastian A. Moreira; Thomas Marbury; Richard Robson; William Smith; Rohit Kulkarni; Marie L. Munson; James A. Thommes; Annabelle Lemenuel-Diot; Carla Washington; Patrick F. Smith; Ya-Chi Chen

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January 1, 2014

Treatment patterns and clinical outcomes for patients with de novo versus recurrent HER2-positive metastatic breast cancer

Breast Cancer Research and Treatment, ISSN: 15737217 01676806

Denise A. Yardley; Peter A. Kaufman; Adam Brufsky; Marianne Ulcickas Yood; Hope S. Rugo; Musa Mayer; Quah; Bongin Yoo; Debasish Tripathy

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January 1, 2014

Internal virus polarization model for virus retention by the Ultipor® VF Grade DV20 membrane

Biotechnology Progress, ISSN: 15206033 87567938

Nigel B. Jackson; Meisam Bakhshayeshi; Andrew Zydney; Amit Mehta; Robert Van Reis; Ralf Kuriyel

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