Genentech: Publications

January 1, 2014

Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X

Journal of Experimental Medicine, ISSN: 15409538 00221007

Naik; Webster; Jason Devoss; Jinfeng Liu; Rowena Suriben; Vishva M. Dixit

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January 1, 2014

Peptide level immunoaffinity enrichment enhances ubiquitination site identification on individual proteins

Molecular and Cellular Proteomics, ISSN: 15359476 15359484

Veronica G. Anania; Victoria Pham; Xiaodong Huang; Alexandre Masselot; Jennie R. Lill; Donald S. Kirkpatrick

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January 1, 2014

Toward understanding ubiquitin-modifying enzymes: From pharmacological targeting to proteomics

Trends in Pharmacological Sciences, ISSN: 18733735 01656147

Jennie R. Lill; Ingrid E. Wertz

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January 1, 2014

B-cell function modulation in multiple sclerosis: A new therapeutic paradigm

Future Neurology, ISSN: 14796708 17486971

Andrew A. Chan; Albert Jan Schutte

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January 1, 2014

Quality by design approach for viral clearance by protein a chromatography

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Min Zhang; George R. Miesegaes; M. Violet Lee; Daniel A. Coleman; Bin Yang; Melody Trexler-Schmidt; Lenore A Norling; Philip M. Lester; Kurt Brorson; Qi Chen

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January 1, 2014

Resin-Assisted enrichment of thiols as a general strategy for proteomic profiling of cysteine-based reversible modifications

Nature Protocols, ISSN: 17542189 17502799

Jia Guo; Matthew J. Gaffrey; Dian Su; Tao Liu; David G. Camp; Richard D. Smith; Wei-Jun Qian

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January 1, 2014

A practical discussion of risk management for manufacturing of pharmaceutical products

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

A. Hamid Mollah; Harold S. Baseman; Mike Long; Anurag S. Rathore

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January 1, 2014

Evaluation of 2-[18F]fluoroacetate kinetics in rodent models of cerebral hypoxia-ischemia

Journal of Cerebral Blood Flow and Metabolism, ISSN: 15597016 0271678X

Yu Ouyang; Jeff N. Tinianow; Simon R. Cherry; Jan Marik

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January 1, 2014

Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Xiaozhang Zheng; Timm Baumeister; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Jian Lin; Dominic J. Reynolds; Geeta Sharma; Chase C. Smith; Zhongguo Wang; Peter Dragovich; Angela Oh; Weiru Wang; Mark Zak; Yunli Wang; Po-Wai Yuen; Kenneth W. Bair

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January 1, 2014

Survival and lifetime costs associated with first-line bevacizumab use in older patients with metastatic colorectal cancer

Oncologist, ISSN: 1549490X 10837159

Veena Shankaran; David Mummy; Lisel Koepl; Aasthaa Bansal; Dana K. Mirick; Elaine B. Yu; Rob Morlock; Sarika Ogale; Scott D. Ramsey

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January 1, 2014

Safety and effectiveness of bevacizumab-containing treatment for non-small-cell lung cancer: Final results of the ARIES observational cohort study

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Thomas J. Lynch; David Spigel; Julie Brahmer; Neal Fischbach; Jennifer Garst; Mohammad Jahanzeb; Priya Kumar; Regina M. Vidaver; Antoinette J. Wozniak; Susan Fish; E. Dawn Flick; Larry Leon; Sebastien J. Hazard; Michael Kosty

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January 1, 2014

Long-term fracture rates seen with continued ibandronate treatment: Pooled analysis of DIVA and MOBILE long-term extension studies

Osteoporosis International, ISSN: 0937941X 14332965

Miller; Recker; Harris; Silverman; Felsenberg; Reginster; Bann-Mo Day; Charles E. Barr; Masanauskaite

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January 1, 2014

Selection and screening using antibody phage display libraries

Methods in Molecular Biology, ISSN: 10643745

Patrick Koenig; Fuh

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January 1, 2014

A supported liquid extraction-LC-MS/MS method for determination of GDC-0980 (Apitolisib), a dual small-molecule inhibitor of class 1A phosphoinositide 3-kinase and mammalian target of rapamycin, in human plasma

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Xiao Ding; Li; McKnight; Schmidt; Strooisma; Shimizu; Faber; Joseph A. Ware; Brian J. Dean

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January 1, 2014

Rheological characterization and injection forces of concentrated protein formulations: An alternative predictive model for non-Newtonian solutions

European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411

Andrea Allmendinger; Stefan Fischer; Joerg Huwyler; Hanns-Christian Mahler; Edward Schwarb; Isidro E. Zarraga; Robert Mueller

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January 1, 2014

Safety and effectiveness of bevacizumab treatment for metastatic colorectal cancer: Final results from the Avastin® Registry - Investigation of Effectiveness and Safety (ARIES) observational cohort study

Clinical Oncology, ISSN: 14332981 09366555

Herbert Hurwitz; Bekaii-Saab; Bendell; Cohn; Kozloff; Roach; Yong Mun; Susan Fish; E. Dawn Flick; Grothey

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January 1, 2014

Modeling approach to investigate the effect of neonatal Fc receptor binding affinity and anti-therapeutic antibody on the pharmacokinetic of humanized monoclonal anti-tumor necrosis factor-α IgG antibody in cynomolgus monkey

European Journal of Pharmaceutical Sciences, ISSN: 09280987 18790720

Chee Ng; Kelly M. Loyet; Suhasini Iyer; Fielder; Rong Deng

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January 1, 2014

Nanosuspension delivery of paclitaxel to xenograft mice can alter drug disposition and anti-tumor activity

Nanoscale Research Letters, ISSN: 1556276X 19317573

Po-Chang Chiang; Stephen Gould; Michelle Nannini; Ann R. Qin; Yuzhong Deng; Alfonso Arrazate; Kimberly R. Kam; Yingqing Ran; Harvey Wong

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January 1, 2014

Inverse regression for longitudinal data

Annals of Statistics, ISSN: 00905364

Ci-Ren Jiang; Wei Yu; Jane-Ling Wang

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January 1, 2014

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

Nature, ISSN: 14764687 00280836

Etienne Meunier; Mathias S. Dick; Roland F. Dreier; Nura Schürmann; Daniela Kenzelmann Broz; Søren Warming; Merone Roose-Girma; Dirk Bumann; Nobuhiko Kayagaki; Kiyoshi Takeda; Masahiro Yamamoto; Petr Broz

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January 1, 2014

Meeting report: 2013 PDA Virus & TSE Safety Forum

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Hannelore Willkommen; Johannes Blümel; Kurt Brorson; Dayue Chen; Qi Chen; Albrecht Gröner; Brian R. Hubbard; Thomas R. Kreil; Michel Ruffing; Sol Ruiz; Dorothy Scott; Glenda Silvester

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January 1, 2014

Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma

International Journal of Cancer, ISSN: 00207136 10970215

Dusten Unruh; Kevin Turner; Ramprasad Srinivasan; Begüm Kocatürk; Xiaoyang Qi; Zhengtao Chu; Bruce J. Aronow; David R. Plas; Catherine A. Gallo; Holger Kalthoff; Daniel Kirchhofer; Wolfram Ruf; Syed A. Ahmad; Fred V. Lucas; Henri H. Versteeg; Vladimir Y. Bogdanov

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January 1, 2014

Using gene expression to improve the power of genome-wide association analysis

Human Heredity, ISSN: 14230062 00015652

Yen-Yi Ho; Emily C. Baechler; Ward Ortmann; Timothy W. Behrens; Robert R. Graham; Tushar Bhangale; Wei Pan

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January 1, 2014

Filling of high-concentration monoclonal antibody formulations into pre-filled syringes: Filling parameter investigation and optimization

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Wendy Shieu; Sarah A. Torhan; Edwin K. Chan; Aaron Hubbard; Benson Gikanga; Oliver B. Stauch; Maa

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January 1, 2014

Regulated cell death: signaling and mechanisms

Annual review of cell and developmental biology, ISSN: 15308995

Avi Ashkenazi; Guy S. Salvesen

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January 1, 2014

Independent radiologic review: Bevacizumab in combination with gemcitabine and carboplatin in recurrent ovarian cancer

Gynecologic Oncology, ISSN: 10956859 00908258

Carol Aghajanian; Barbara Goff; Lawrence R. Nycum; Yan Wang; Amreen Husain; Stephanie V. Blank

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January 1, 2014

Meeting report - Workshop on spike characterizations and virus removal by filtration: Trends and new developments

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Hannelore Willkommen; Johannes Blümel; Kurt Brorson; Dayue Chen; Chen; Albrecht Gröner; Brian R. Hubbard; Thomas R. Kreil; Michel Ruffing; Sol Ruiz; Dorothy Scott; Glenda Silvester

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January 1, 2014

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging

Nature, ISSN: 14764687 00280836

Laila Ritsma; Saskia I.J. Ellenbroek; Anoek Zomer; Hugo J. Snippert; Frederic J. De Sauvage; Benjamin D. Simons; Hans Clevers; Jacco Van Rheenen

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January 1, 2014

Early treatment discontinuation and switching in first-line metastatic breast cancer: The role of patient-reported symptom burden

Breast Cancer Research and Treatment, ISSN: 15737217 01676806

Mark S. Walker; Anthony Masaquel; Jiandong Kerr; Deepa Lalla; Oyewale Abidoye; Arthur C. Houts; Lee S. Schwartzberg

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January 1, 2014

Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling

Cancer Cell, ISSN: 18783686 15356108

Jacob R. Haling; Jawahar Sudhamsu; Ivana Yen; Steve Sideris; Wendy N. Sandoval; Wilson Phung; Brandon Bravo; Anthony M. Giannetti; Ariana Peck; Alexandre Masselot; Tony Morales; Darin Smith; Barbara J. Brandhuber; Sarah G. Hymowitz; Shiva Malek

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January 1, 2014

Use of cassette dosing approach to examine the effects of P-glycoprotein on the brain and cerebrospinal fluid concentrations in wild-type and P-glycoprotein knockout rats

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Xingrong Liu; Jonathan Cheong; Xiao Ding; Gauri Deshmukh

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January 1, 2014

The effects of a high-fat meal on single-dose vemurafenib pharmacokinetics

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Antoni Ribas; Weijiang Zhang; Ilsung Chang; Keisuke Shirai; Marc S. Ernstoff; Adil Daud; C. Lance Cowey; Gregory Daniels; Elizabeth Seja; Elizabeth O'Laco; John A. Glaspy; Bartosz Chmielowski; Todd Hill; Andrew K. Joe; Joseph F. Grippo

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January 1, 2014

Navigating the regulatory CMC landscape in China

Pharmaceutical Engineering, ISSN: 02738139

Xiling Song; Min Gui; Maurice Parlane

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January 1, 2014

Syntheses of [3H2]T0901317 and a labeled structural isomer, and characterization of the dispersed labeled compounds via 19F NMR

Journal of Labelled Compounds and Radiopharmaceuticals, ISSN: 03624803 10991344

Benjamin P. Fauber; Adam R. Johnson; Stephen Bowerman; Brenda Burton; Adam Colebrook; Annerley Flynn; Gareth Harrold; Steve Huhn; Gary Jones; Peter Lockey; Maxine Norman; Olivier René; Harvey Wong

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January 1, 2014

Quantitative cumulative biodistribution of antibodies in mice: Effect of modulating binding affinity to the neonatal Fc receptor

mAbs, ISSN: 19420870 19420862

Victor Yip; Enzo Palma; Devin B. Tesar; Eduardo E. Mundo; Daniela Bumbaca; Elizabeth K. Torres; Noe A. Reyes; Shen; Fielder; Saileta Prabhu; Leslie A. Khawli; C. Andrew Boswell

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January 1, 2014

Murine models of inflammatory bowel disease (IBD): Challenges of modeling human disease

Toxicologic Pathology, ISSN: 01926233 15331601

Jason Devoss; Laurie Diehl

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January 1, 2014

Interleukin-22: A bridge between epithelial innate host defense and immune cells

Cytokine Frontiers: Regulation of Immune Responses in Health and Disease,

Xiaoting Wang; Wenjun Ouyang

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January 1, 2014

The First Myriapod Genome Sequence Reveals Conservative Arthropod Gene Content and Genome Organisation in the Centipede Strigamia maritima

PLoS Biology, ISSN: 15457885 15449173

Ariel D. Chipman; David E. K. Ferrier; Carlo Brena; Jiaxin Qu; Daniel S. T. Hughes; Reinhard Schröder; Montserrat Torres-Oliva; Nadia Znassi; Huaiyang Jiang; Francisca C. Almeida; Claudio R. Alonso; Zivkos Apostolou; Peshtewani Aqrawi; Wallace Arthur; Jennifer C. J. Barna; Kerstin P. Blankenburg; Daniela Brites; Salvador Capella-Gutiérrez; Marcus Coyle; Peter K. Dearden; Louis Du Pasquier; Elizabeth J. Duncan; Dieter Ebert; Cornelius Eibner; Galina Erikson; Peter D. Evans; Cassandra G. Extavour; Liezl Francisco; Toni Gabaldón; William Q. Gillis; Elizabeth A. Goodwin-Horn; Jack E. Green; Sam Griffiths-Jones; Cornelis J. P. Grimmelikhuijzen; Sai Gubbala; Roderic Guigó; Yi Han; Frank Hauser; Paul Havlak; Luke Hayden; Sophie Helbing; Michael Holder; Jerome H. L. Hui; Julia P. Hunn; Vera S. Hunnekuhl; LaRonda Jackson; Mehwish Javaid; Shalini N. Jhangiani; Francis M. Jiggins; Tamsin E. Jones; Tobias S. Kaiser; Divya Kalra; Nathan J. Kenny; Viktoriya Korchina; Christie L. Kovar; F. Bernhard Kraus; François Lapraz; Sandra L. Lee; Jie Lv; Christigale Mandapat; Gerard Manning; Marco Mariotti; Robert Mata; Tittu Mathew; Tobias Neumann; Irene Newsham; Dinh N. Ngo; Maria Ninova; Geoffrey Okwuonu; Fiona Ongeri; William J. Palmer; Shobha Patil; Pedro Patraquim; Christopher Pham; Ling-Ling Pu; Nicholas H. Putman; Catherine Rabouille; Olivia Mendivil Ramos; Adelaide C. Rhodes; Helen E. Robertson; Hugh M. Robertson; Matthew Ronshaugen; Julio Rozas; Nehad Saada; Alejandro Sánchez-Gracia; Steven E. Scherer; Andrew M. Schurko; Kenneth W. Siggens; DeNard Simmons; Anna Stief; Eckart Stolle; Maximilian J. Telford; Kristin Tessmar-Raible; Rebecca Thornton; Maurijn van der Zee; Arndt von Haeseler; James M. Williams; Judith H. Willis; Yuanqing Wu; Xiaoyan Zou; Daniel Lawson; Donna M. Muzny; Kim C. Worley; Richard A. Gibbs; Michael Akam; Stephen Richards

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January 1, 2014

New HPLC systems and related products introduced at pittcon 2014: A brief review

LCGC North America, ISSN: 15275949

Michael W. Dong

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January 1, 2014

Discovery and development of DNA methylation-based biomarkers for lung cancer

Epigenomics, ISSN: 1750192X 17501911

Kimberly Walter; Thomas Holcomb; Thomas Januario; Robert Yauch; Pan Du; Richard Bourgon; Somasekar Seshagiri; Lukas Amler; Garret M. Hampton; David S. Shames

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January 1, 2014

A single-arm, open-label, expanded access study of vemurafenib in patients with metastatic melanoma in the United States

Cancer Journal (United States), ISSN: 15289117 1540336X

Lawrence Flaherty; Omid Hamid; Gerald Linette; Lynn Schuchter; Sigrun Hallmeyer; Rene Gonzalez; C. Lance Cowey; Anna Pavlick; Fred Kudrik; Brendan Curti; David Lawson; Paul B. Chapman; Kim Margolin; Antoni Ribas; David McDermott; Keith Flaherty; Lee Cranmer; F. Stephen Hodi; Bann-Mo Day; Rolf Linke; John Hainsworth

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January 1, 2014

Type I interferon is a therapeutic target for virus-induced lethal vascular damage

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Roberto Baccala; Megan J. Welch; Rosana Gonzalez-Quintial; Kevin B. Walsh; John R. Teijaro; Anthony Nguyen; Cherie T. Ng; Brian M. Sullivan; Alessandro Zarpellon; Zaverio M. Ruggeri; Juan Carlos De La Torre; Argyrios N. Theofilopoulos; Michael B.A. Oldstone

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January 1, 2014

Pertuzumab and erlotinib in patients with relapsed non-small cell lung cancer: A phase II study using 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging

Oncologist, ISSN: 1549490X 10837159

Brett Hughes; Linda Mileshkin; Peter Townley; Barbara Gitlitz; Keith Eaton; Paul Mitchell; Rodney Hicks; Katie Wood; Lukas Amler; Bernard M. Fine; David Loecke; Andrea Pirzkall

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January 1, 2014

Targeted erlotinib for first-line treatment of advanced non-small cell lung cancer: A budget impact analysis

Journal of Medical Economics, ISSN: 1941837X 13696998

Preeti S. Bajaj; David L. Veenstra; Hans-Peter Goertz; Josh J. Carlson

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January 1, 2014

Bevacizumab exposure beyond first disease progression in patients with metastatic colorectal cancer: Analyses of the ARIES observational cohort study

Pharmacoepidemiology and Drug Safety, ISSN: 10991557 10538569

Grothey; E. Dawn Flick; Cohn; Bekaii-Saab; Bendell; Kozloff; Roach; Yong Mun; Susan Fish; Herbert Hurwitz

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January 1, 2014

The use of betaine HCL to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria

AAPS Journal, ISSN: 15507416

Marc R. Yago; Adam Frymoyer; Leslie Z. Benet; Gillian S. Smelick; Lynda A. Frassetto; Xiao Ding; Brian J. Dean; Laurent Salphati; Nageshwar Budha; Jin Y. Jin; Mark J. Dresser; Joseph A. Ware

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January 1, 2014

GCMAP: User-friendly connectivity mapping with R

Bioinformatics, ISSN: 13674803 14602059

Thomas Sandmann; Sarah K. Kummerfeld; Robert Gentleman; Richard Bourgon

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January 1, 2014

Enzyme-inducing anticonvulsants increase plasma clearance of dexmedetomidine: A pharmacokinetic and pharmacodynamic study

Anesthesiology, ISSN: 15281175 00033022

Alana M. Flexman; Harvey Wong; K. Wayne Riggs; Tina Shih; Paul A. Garcia; Susana Vacas; Pekka O. Talke

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January 1, 2014

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition

Oncotarget, ISSN: 19492553

Catherine Wilson; Nicholes; Daisy J. Bustos; Eva Lin; Qinghua Song; Jean-Philippe Stephan; Donald S. Kirkpatrick; Jeffrey Settleman

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January 1, 2014

Differential effects of rifampin and ketoconazole on the blood and liver concentration of atorvastatin in wild-type and cyp3a and oatp1a/b knockout mice

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Jae H. Chang; Justin Ly; Emile G. Plise; Xiaolin Zhang; Kirsten Messick; Matthew Wright; Jonathan Cheong

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