Genentech: Publications

January 1, 2014

Population pharmacokinetics of trastuzumab emtansine (T-DM1), a HER2-targeted antibody-drug conjugate, in patients with HER2-positive metastatic breast cancer: Clinical implications of the effect of covariates

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Dan Lu; Sandhya Girish; Yuying Gao; Wang; Joo-Hee Yi; Ellie Guardino; Meghna Samant; Melody A. Cobleigh; Mothaffar F. Rimawi; Pier Franco Conte; Jin Y. Jin

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January 1, 2014

Effects of copper on CHO cells: Insights from gene expression analyses

Biotechnology Progress, ISSN: 15206033 87567938

Inn H. Yuk; Jitao David Zhang; Martin Ebeling; Marco Berrera; Natalia Gomez; Silke Werz; Christoph Meiringer; Zhixin Shao; Jeffrey C. Swanberg; Kelvin H. Lee; Jun Luo; Berthold Szperalski

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January 1, 2014

Elucidating the mechanism of cytochrome p450-mediated pyrimidine ring conversion to pyrazole metabolites with the bace1 inhibitor gne-892 in ratss

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Ryan Takahashi; Shuguang Ma; Alan Deese; Qin Yue; Heasook Kim-Kang; Yijun Yi; Michael Siu; Kevin W. Hunt; Nicholas C. Kallan; Cornelis E. Hop; Xingrong Liu; S. Cyrus Khojasteh

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January 1, 2014

A Neutralizing Anti-gH/gL Monoclonal Antibody Is Protective in the Guinea Pig Model of Congenital CMV Infection

PLoS Pathogens, ISSN: 15537374 15537366

Marcy Auerbach; Donghong Yan; Rajesh Vij; Hongo; Nakamura; Jean-Michel Vernes; Meng; Samantha Lein; Pamela Chan; Ross; Richard A. D. Carano; Rong Deng; Nicholas Lewin-Koh; Min Xu; Becket Feierbach

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January 1, 2014

Chronic GluN2B antagonism disrupts behavior in wild- type mice without protecting against synapse loss or memory impairment in alzheimer's disease mouse models

Journal of Neuroscience, ISSN: 15292401 02706474

Jesse E. Hanson; William J. Meilandt; Alvin Gogineni; Paul Reynen; James Herrington; Robby M. Weimer; Kimberly Scearce-Levie; Qiang Zhou

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January 1, 2014

Phenotypic screening in cancer drug discovery-past, present and future

Nature Reviews Drug Discovery, ISSN: 14741784 14741776

John Moffat; Joachim Rudolph; David Bailey

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January 1, 2014

Personalized drug combinations to overcome trastuzumab resistance in HER2-positive breast cancer

Biochimica et Biophysica Acta - Reviews on Cancer, ISSN: 18792561 0304419X

Thuy Vu; Mark X. Sliwkowski; Francois X. Claret

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January 1, 2014

Lower exposure and faster clearance of bevacizumab in gastric cancer and the impact of patient variables: Analysis of individual data from AVAGAST phase III trial

AAPS Journal, ISSN: 15507416

Kelong Han; Jin Y. Jin; Mauricio Maia; John Lowe; Martina A. Sersch; David E. Allison

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January 1, 2014

Translation of anticancer efficacy from nonclinical models to the clinic

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Mark Stroh; Dan G. Duda; Chris H. Takimoto; Yamazaki; Vicini

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January 1, 2014

25-Hydroxycholesterols in innate and adaptive immunity

Nature Reviews Immunology, ISSN: 14741741 14741733

Jason G. Cyster; Eric V. Dang; Andrea Reboldi; Tangsheng Yi

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January 1, 2014

The Bcl-2 specific BH3 mimetic ABT-199: A promising targeted therapy for t(11;14) multiple myeloma

Leukemia, ISSN: 08876924 14765551

Touzeau; Dousset; Le Gouill; Deepak Sampath; Joel D. Leverson; Andrew J. Souers; Maïga; Béné; Moreau; Pellat-Deceunynck; Amiot

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January 1, 2014

Discovery and preclinical development of vismodegib

Expert Opinion on Drug Discovery, ISSN: 1746045X 17460441

Stephen Gould; Low; James C. Marsters Jr.; Kirk D. Robarge; Lee L. Rubin; Frederic J. De Sauvage; Daniel P. Sutherlin; Harvey Wong; Robert Yauch

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January 1, 2014

Part VII: GMPs for Small-Molecule Drugs in Early Development—Workshop Summary

Pharmaceutical Technology, ISSN: 21507376 15432521

Chan Li; Jackson D. Pellett; Michael Szulc; Mark D. Trone; Kirby Wong-Moon

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January 1, 2014

Methods for measuring antibody-dependent cell-mediated cytotoxicity in vitro

Methods in Molecular Biology, ISSN: 10643745

Aaron S. Miller; Max L. Tejada; Hélène Gazzano-Santoro

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January 1, 2014

Therapeutic opportunities of the IL-22-IL-22R1 system

Nature Reviews Drug Discovery, ISSN: 14741776 14741784

Robert Sabat; Wenjun Ouyang; Kerstin Wolk

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January 1, 2014

MHC associations with clinical and autoantibody manifestations in European SLE

Genes and Immunity, ISSN: 14765470 14664879

David L. Morris; Michelle M.A. Fernando; Kimberly E. Taylor; Sharon A. Chung; Joanne Nititham; Marta E. Alarcón-Riquelme; Lisa F. Barcellos; Timothy W. Behrens; Chris Cotsapas; Patrick M. Gaffney; Robert R. Graham; Bernardo A. Pons-Estel; Peter K. Gregersen; John B. Harley; Stephen L. Hauser; Geoffrey Hom; Carl D. Langefeld; Janelle A. Noble; John D. Rioux; Michael F. Seldin; Timothy J. Vyse; Lindsey A. Criswell

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January 1, 2014

In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation

mAbs, ISSN: 19420870 19420862

Bing Li; Ashley Fouts; Katharina F. Stengel; Patricia Luhn; Michael Dillon; Wei-Ching Liang; Becket Feierbach; Robert F. Kelley; Isidro Hötzel

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January 1, 2014

Mechanistic pharmacokinetic/pharmacodynamic modeling of in vivo tumor uptake, catabolism, and tumor response of trastuzumab maytansinoid conjugates

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Russell D. Wada; Hans Erickson; Gail L. Phillips; Carmela A. Provenzano; Douglas Leipold; Elaine Mai; Holly A. Johnson; Jay Tibbitts

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January 1, 2014

β-Catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8+ T cells

Journal of Leukocyte Biology, ISSN: 19383673 07415400

Xinjun Liang; Chunmei Fu; Weiguo Cui; Julia L. Ober-Blöbaum; Sonja P. Zahner; Protul A. Shrikant; Björn E. Clausen; Richard A. Flavell; Ira Mellman; Aimin Jiang

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January 1, 2014

Matrix-assisted laser desorption/ionization time-of-flight mass analysis of peptides

Current protocols in protein science / editorial board, John E. Coligan ... [et al.], ISSN: 19343663 19343655

Wendy N. Sandoval

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January 1, 2014

Recommendations for the characterization of immunogenicity response to multiple domain biotherapeutics

Journal of Immunological Methods, ISSN: 18727905 00221759

Boris Gorovits; Eric Wakshull; Renuka Pillutla; Yuanxin Xu; Marta Starcevic Manning; Jaya Goyal

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January 1, 2014

Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th critical assessment of techniques for protein structure prediction experiment CASP10

Proteins: Structure, Function and Bioinformatics, ISSN: 10970134 08873585

Andriy Kryshtafovych; John Moult; Patrick Bales; J.Fernando Bazan; Marco Biasini; Alex Burgin; Chen Chen; Frank V. Cochran; Timothy K. Craig; Rhiju Das; Deborah Fass; Carmela Garcia-Doval; Osnat Herzberg; Donald Lorimer; Hartmut Luecke; Xiaolei Ma; Daniel C. Nelson; Mark J. van Raaij; Forest Rohwer; Anca Segall; Victor Seguritan; Kornelius Zeth; Torsten Schwede

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January 1, 2014

Ubiquitin in inflammation: The right linkage makes all the difference

Nature Structural and Molecular Biology, ISSN: 15459985 15459993

Jacob E. Corn; Domagoj Vucic

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January 1, 2014

Mechanisms of age-related macular degeneration and therapeutic opportunities

Journal of Pathology, ISSN: 00223417 10969896

Menno Van Lookeren Campagne; Jennifer Lecouter; Brian L. Yaspan; Weilan Ye

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January 1, 2014

Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms

Journal of Neuroscience, ISSN: 15292401 02706474

Ali Ertürk; Yuanyuan Wang; Morgan Sheng

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January 1, 2014

Interrogation of in vivo protein-protein interactions using transgenic mouse models and stable isotope labeling

Methods in Molecular Biology, ISSN: 10643745

Anwesha Dey; Jiansheng Wu; Donald S. Kirkpatrick

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January 1, 2014

When assay format matters: A case study on the evaluation of three assay formats to support a clinical pharmacokinetic study

AAPS Journal, ISSN: 15507416

Kun Peng; Baker; Suzanne Brignoli; Janis Cabuhat; Saloumeh Kadkhodayan Fischer

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January 1, 2014

A mechanistic systems pharmacology model for prediction of LDL cholesterol lowering by PCSK9 antagonism in human dyslipidemic populations

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Kapil Gadkar; Nageshwar Budha; Amos Baruch; John Davis; Fielder; Ramanujan

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January 1, 2014

Administration of Anti-CD20 mAb Is Highly Effective in Preventing but Ineffective in Treating Chronic Graft-Versus-Host Disease While Preserving Strong Graft-Versus-Leukemia Effects

Biology of Blood and Marrow Transplantation, ISSN: 15236536 10838791

Heather F. Johnston; Yajing Xu; Jeremy J. Racine; Kaniel Cassady; Xiong Ni; Tao Wu; Andrew A. Chan; Stephen Forman; Defu Zeng

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January 1, 2014

CMRF35-like molecule 1 (CLM-1) regulates eosinophil homeostasis by suppressing cellular chemotaxis

Mucosal Immunology, ISSN: 19353456 19330219

Moshkovits; Shik; Itan; Karo-Atar; Bernshtein; Hershko; Menno Van Lookeren Campagne; Munitz

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January 1, 2014

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

Science, ISSN: 10959203 00368075

Kim Newton; Dugger; Katherine E. Wickliffe; Neeraj Kapoor; Maria Cristina De Almagro; Domagoj Vucic; László Kömüves; Ron Ferrando; French; Webster; Merone Roose-Girma; Søren Warming; Vishva M. Dixit

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January 1, 2014

Phase 2 study of VcR-CVAD with maintenance rituximab for untreated mantle cell lymphoma: An Eastern Cooperative Oncology Group study (E1405)

Blood, ISSN: 15280020 00064971

Julie E. Chang; Hailun Li; Smith; Randy D. Gascoyne; Elisabeth M. Paietta; David T. Yang; Ranjana H. Advani; Sandra J. Horning; Wojciech Jurczak

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January 1, 2014

A phase I study of PRO131921, a novel anti-CD20 monoclonal antibody in patients with relapsed/refractory CD20+ indolent NHL: Correlation between clinical responses and AUC pharmacokinetics

Clinical Immunology, ISSN: 15217035 15216616

Carla Casulo; Julie Vose; William Y. Ho; Wojciech Jurczak; Mark Brunvand; Andre Goy; Yvette Kasamon; Bruce D. Cheson; Jonathan W. Friedberg

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January 1, 2014

Bevacizumab and cyclosphosphamide, doxorubicin, vincristine and prednisone in combination for patients with peripheral T-cell or natural killer cell neoplasms: An Eastern Cooperative Oncology Group study (E2404)

Leukemia and Lymphoma, ISSN: 10292403 10428194

Kristen Ganjoo; Fangxin Hong; Sandra J. Horning; Randy D. Gascoyne; Yasodha Natkunam; Lode J. Swinnen; Thomas M. Habermann; Wojciech Jurczak; Ranjana H. Advani

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January 1, 2014

A20-a bipartite ubiquitin editing enzyme with immunoregulatory potential

Advances in Experimental Medicine and Biology, ISSN: 22148019 00652598

Ingrid E. Wertz; Vishva M. Dixit

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January 1, 2014

Guidance on the implementation and reporting of a drug safety Bayesian network meta-analysis

Pharmaceutical Statistics, ISSN: 15391604

David Ohlssen; Karen L. Price; Hong Amy Xia; Hwanhee Hong; Jouni Kerman; Haoda Fu; George Quartey; Cory R. Heilmann; Haijun Ma; Bradley P. Carlin

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January 1, 2014

Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013

The Lancet, ISSN: 1474547X 01406736

Christopher J.L. Murray; Katrina F. Ortblad; Caterina Guinovart; Stephen Lim; Timothy M. Wolock; David Allen Roberts; Emily Dansereau; Nicholas Graetz; Ryan M. Barber; Jonathan Brown; Haidong Wang; Herbert Duber; Mohsen Naghavi; Daniel Dicker; Lalit Dandona; Joshua A. Salomon; Kyle R. Heuton; Kyle J. Foreman; David Phillips; Thomas Fleming; Abraham Flaxman; Bryan Phillips; Elizabeth K. Johnson; Megan Coggeshall; Foad Abd-Allah; Semaw F. Abera; Jerry P. Abraham; Ibrahim Abubakar; Laith J. Abu-Raddad; Niveen M.E. Abu-Rmeileh; Tom Achoki; Austine Olufemi Adeyemo; Arsène K. Adou; Josef C. Adsuar; Emilie E. Agardh; Dickens Akena; Mazin J. Al Kahbouri; Deena Alasfoor; Mohammed I. Albittar; Alcalá-Cerra; Miguel A. Alegretti; Zewdie A. Alemu; Rafael Alfonso-Cristancho; Samia Alhabib; Raghib Ali; Francois Alla; Peter J. Allen; Ubai Alsharif; Elena Alvarez; Nelson Alvis-Guzman; Adansi A. Amankwaa; Azmeraw T. Amare; Heresh Amini; Walid Ammar; Benjamin O. Anderson; Carl Abelardo T. Antonio; Palwasha Anwari; Johan Arnlov; Valentina S. Arsic Arsenijevic; Al Artaman; Rana J. Asghar; Reza Assadi; Lydia S. Atkins; Alaa Badawi; Kalpana Balakrishnan; Amitava Banerjee; Sanjay Basu; Justin Beardsley; Tolesa Bekele; Michelle L. Bell; Eduardo Bernabe; Tariku J. Beyene; Neeraj Bhala; Ashish Bhalla; Zulfiqar Bhutta; Aref Bin Abdulhak; Agnes Binagwaho; Jed D. Blore; Berrak Bora Basara; Dipan Bose; Michael Brainin; Nicholas J.K. Breitborde; Carlos A. Castaneda-Orjuela; Ferran Catala-Lopez; Vineet K. Chadha; Jung-Chen Chang; Peggy P. Chiang; Pablo M. Lavados; Mercedes Colomar; Christian Kieling; Cyrus Cooper; Karen Courville; Benjamin C. Cowie; Michael H. Criqui; Rakhi Dandona; Anand Dayama; Diego De Leo; Louisa Degenhardt; Borja Del Pozo-Cruz; Kebede Deribe; Don C. Des Jarlais; Muluken Dessalegn; Samath D. Dharmaratne; Uur Dilmen; Eric L. Ding; Tim R. Driscoll; Adnan M. Durrani; Richard G. Ellenbogen; Sergey P. Ermakov; Alireza Esteghamati; Emerito Jose A. Faraon; Farshad Farzadfar; Seyed-Mohammad Fereshtehnejad; Daniel Obadare Fijabi; Mohammad H. Forouzanfar; Urbano Fra. Paleo; Lynne Gaffikin; Amiran Gamkrelidze; Fortune G. Gankpe; Johanna M. Geleijnse; Bradford D. Gessner; Katherine B. Gibney; Ibrahim A. Ginawi; Elizabeth L. Glaser; Philimon Gona; Atsushi Goto; Hebe N. Gouda; Harish C. Gugnani; Rajeev Gupta; Rahul Gupta; Nima Hafezi-Nejad; Randah R. Hamadeh; Mouhanad Hammami; Graeme J. Hankey; Hilda L. Harb; Josep Maria Haro; Rasmus Havmoeller; Simon Hay; Mohammad T. Hedayati; Ileana B. Heredia Pi; Hans W. Hoek; John Hornberger; Francis A. Mhimbira; Peter J. Hotez; Damian G. Hoy; John J. Huang; Kim M. Iburg; Bulat T. Idrisov; Kaire Innos; Kathryn H. Jacobsen; Panniyammakal Jeemon; Paul N. Jensen; Vivekanand Jha; Guohong Jiang; Jost B. Jonas; Knud Juel; Haidong Kan; Ida Kankindi; Karam; Andre Karch; Corine Kakizi Karema; Anil Kaul; Norito Kawakami; Dhruv S. Kazi; Andrew H. Kemp; Andre P. Kengne; Andre Keren; Maia Kereselidze; Yousef S. Khader; Shams Eldin A.H. Khalifa; Ejaz A. Khan; Young-Ho Khang; Irma Khonelidze; Yohannes Kinfu; Jonas M. Kinge; Luke Knibbs; Yoshihiro Kokubo; Soewarta Kosen; Barthelemy Kuate Defo; Veena S. Kulkarni; Chanda Kulkarni; Kaushalendra Kumar; Ravi B. Kumar; G Anil Kumar; Gene F. Kwan; Taavi Lai; Arjun Lakshmana Balaji; Hilton Lam; Qing Lan; Van C. Lansingh; Heidi Larson; Anders Larsson; Jong-Tae Lee; James Leigh; Mall Leinsalu; Ricky Leung; Yichong Li; Yongmei Li; Graça Maria Ferreira De Lima; Hsien-Ho Lin; Steven E. Lipshultz; Shiwei Liu; Yang Liu; Belinda K. Lloyd; Paulo A. Lotufo; Vasco Manuel Pedro Machado; Jennifer H. MacLachlan; Carlos Magis-Rodriguez; Marek Majdan; Christopher C. Mapoma; Wagner Marcenes; Melvin B. Marzan; Joseph R. Masci; Mohammad Taufiq Mashal; Amanda J. Mason-Jones; Bongani M. Mayosi; Tasara T. Mazorodze; Abigail C. McKay; Peter A. Meaney; Man Mohan Mehndiratta; Fabiola Mejia-Rodriguez; Yohannes A. Melaku; Ziad A. Memish; Walter Mendoza; Ted R. Miller; Edward J. Mills; Karzan A. Mohammad; Ali H. Mokdad; Glen L. Mola; Lorenzo Monasta; Marcella Montico; Ami R. Moore; Rintaro Mori; Wilkister N. Moturi; Mitsuru Mukaigawara; Kinnari S. Murthy; Aliya Naheed; Kovin S. Naidoo; Luigi Naldi; Vinay Nangia; K.M. Venkat Narayan; Denis Nash; Chakib Nejjari; Robert G. Nelson; Sudan P. Neupane; Charles R. Newton; Marie Ng; Muhammad I. Nisar; Sandra Nolte; Ole F. Norheim; Vincent Nowaseb; Luke Nyakarahuka; In Hwan Oh; Takayoshi Ohkubo; Bolajoko O. Olusanya; Saad B. Omer; John Nelson Opio; Orish Ebere Orisakwe; Jeyaraj D. Pandian; Christina Papachristou; Angel J. Paternina Caicedo; Scott B. Patten; Vinod K. Paul; Boris I. Pavlin; Neil Pearce; David M. Pereira; Aslam Pervaiz; Konrad Pesudovs; Max Petzold; Farshad Pourmalek; Dima Qato; Amado D. Quezada; Quistberg; Anwar Rafay; Kazem Rahimi; Vafa Rahimi-Movaghar; Sajjad Ur Rahman; Murugesan Raju; Saleem M. Rana; Homie Razavi; Robert Quentin Reilly; Giuseppe Remuzzi; Jan Hendrik Richardus; Luca Ronfani; Nobhojit Roy; Nsanzimana Sabin; Mohammad Yahya Saeedi; Mohammad Ali Sahraian; Genesis May J. Samonte; Monika Sawhney; Ione J.C. Schneider; David C. Schwebel; Soraya Seedat; Sadaf G. Sepanlou; Edson E. Servan-Mori; Sara Sheikhbahaei; Kenji Shibuya; Hwashin Hyun Shin; Ivy Shiue; Rupak Shivakoti; Inga D. Sigfusdottir; Donald H. Silberberg; Andrea P. Silva; Edgar P. Simard; Jasvinder A. Singh; Vegard Skirbekk; Karen Sliwa; Samir Soneji; Sergey S. Soshnikov; Chandrashekhar T. Sreeramareddy; Vasiliki Kalliopi Stathopoulou; Konstantinos Stroumpoulis; Soumya Swaminathan; Bryan L. Sykes; Karen M. Tabb; Roberto Tchio Talongwa; Eric Yeboah Tenkorang; Abdullah Sulieman Terkawi; Alan J. Thomson; Andrew L. Thorne-Lyman; Charles D.A. Wolfe; Jefferson Traebert; Bach X. Tran; Zacharie Tsala Dimbuene; Miltiadis K. Tsilimbaris; Uche S. Uchendu; Kingsley N. Ukwaja; Selen B. Uzun; Andrew J. Vallely; Tommi J. Vasankari; Narayanaswamy Venketasubramanian; Francesco S. Violante; Vasiliy Victorovich Vlassov; Stein Emil Vollset; Stephen Waller; Mitchell T. Wallin; Linhong Wang; XiaoRong Wang; Yanping Wang; Scott Weichenthal; Elisabete Weiderpass; Robert G. Weintraub; Ronny Westerman; Richard A. White; James D. Wilkinson; Thomas N. Williams; Solomon M. Woldeyohannes; John Q. Wong; Gelin Xu; Yang C. Yang; Yuichiro Yano; Gokalp K. Yentur; Paul Yip; Naohiro Yonemoto; Seok-Jun Yoon; Mustafa Younis; Chuanhua Yu; Kim Yun Jin; Maysaa El Sayed Zaki; Yong Zhao; Yingfeng Zheng; Maigeng Zhou; Jun Zhu; Xiao Nong Zou; Alan D. Lopez; Theo Vos

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January 1, 2014

Nonclinical Safety Biomarkers of Drug-induced Vascular Injury:Current Status and Blueprint for the Future

Toxicologic Pathology, ISSN: 15331601 01926233

Igor Mikaelian; Mark Cameron; Deidre A. Dalmas; Bradley E. Enerson; Raymond J. Gonzalez; Silvia Guionaud; Peter K. Hoffmann; Nicholas M. P. King; Michael P. Lawton; Marshall S. Scicchitano; Holly W. Smith; Roberta A. Thomas; James L. Weaver; Tanja S. Zabka; Daniel Morton; Lindsay Tomlinson

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January 1, 2014

Evaluation of a multimodal resin for selective capture of CHO-derived monoclonal antibodies directly from harvested cell culture fluid

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232

Kimberly A. Kaleas; Margaret Tripodi; Scott Revelli; Vikas Sharma; Shelly A. Pizarro

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January 1, 2014

Sleeping our Alzheimer's risk away

Journal of Experimental Medicine, ISSN: 15409538 00221007

Ryan J. Watts

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January 1, 2014

Change notifications for single use components: Criteria from an end user perspective

Pharmaceutical Engineering, ISSN: 02738139

Sally Kline; Ekta Mahajan; Darrell Morrow; Bob Steininger; Nancy Sweeney; Russell Wong

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January 1, 2014

Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: Metabolite structure, kinetics, inducibility, and interindividual variability

Endocrinology, ISSN: 19457170 00137227

Zhican Wang; Timothy Wong; Takanori Hashizume; Leslie Dickmann; Michele Scian; Nicholas J. Koszewski; Jesse P. Goff; Ronald L. Horst; Amarjit S. Chaudhry; Erin G. Schuetz; Kenneth E. Thummel

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January 1, 2014

New FDA draft guidance on immunogenicity

AAPS Journal, ISSN: 15507416

Ashwin Parenky; Heather Myler; Lakshmi Amaravadi; Karoline Bechtold-Peters; Amy Rosenberg; Susan Kirshner; Quarmby

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January 1, 2014

Byproducts of commonly used coupling reagents: Origin, toxicological evaluation and methods for determination

American Pharmaceutical Review, ISSN: 10998012

Larry Wigman; Travis Remarchuk; Stephen Gomez; Archana Kumar; Michael W. Dong; Colin D. Medley; Nik P. Chetwyn

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January 1, 2014

Model-based meta-analysis for quantifying paclitaxel dose response in cancer patients

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Dan Lu; Amita Joshi; Li; Nancy Zhang; Melanie Ren; Yuying Gao; Russell D. Wada; Jin Y. Jin

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January 1, 2014

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2

Nature Structural and Molecular Biology, ISSN: 15459985 15459993

Heidi J. A. Wallweber; Christine Tam; Yvonne Franke; Melissa A. Starovasnik; Patrick J. Lupardus

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January 1, 2014

Multiplexed ion beam imaging of human breast tumors

Nature Medicine, ISSN: 1546170X 10788956

Michael Angelo; Sean C. Bendall; Rachel Finck; Matthew B. Hale; Chuck Hitzman; Alexander D. Borowsky; Richard M. Levenson; John Lowe; Scot D. Liu; Shuchun Zhao; Yasodha Natkunam; Garry P. Nolan

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January 1, 2014

Etrolizumab as induction therapy for ulcerative colitis: A randomised, controlled, phase 2 trial

The Lancet, ISSN: 1474547X 01406736

Séverine Vermeire; Sharon O'Byrne; Mary E. Keir; Marna Williams; Timothy T. Lu; John C Mansfield; Christopher A. Lamb; Brian G. Feagan; Julián Panés; Azucena Salas; Daniel C. Baumgart; Stefan Schreiber; Iris Dotan; William J. Sandborn; Tew; Diana Luca; Meina Tao Tang; Laurie Diehl; Jeffrey Eastham-Anderson; Gert De Hertogh; Clementine Perrier; Jackson G. Egen; John A. Kirby; Gert Van Assche; Paul J. Rutgeerts

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January 1, 2014

Reference standards for therapeutic proteins

BioProcess International, ISSN: 15426319

Mire-Sluis; Nadine Ritter; Barry Cherney; Dieter Schmalzing; Markus Blümel

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January 1, 2014

Reference standards for therapeutic proteins

BioProcess International, ISSN: 15426319

Mire-Sluis; Nadine Ritter; Barry Cherney; Dieter Schmalzing; Markus Blümel

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