Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6901 - 6950 OF 15613 RESULTS

Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1
Nature Immunology, ISSN: 15292908 15292916
Chauncey J. Spooner; Justin Lesch; Donghong Yan; Aly A. Khan; Abbas Alexander; Vladimir Ramirez-Carrozzi; Meijuan Zhou; Robert Soriano; Jeffrey Eastham-Anderson; Laurie Diehl; Wyne P. Lee; Zora Modrusan; Rajita Pappu; Min Xu; Jason Devoss; Harinder Singh
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Association of cyp2c9*2 with bosentan-induced liver injury
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Markova; Teresa De Marco; Bendjilali; Kobashigawa; Mefford; Jasleen K. Sodhi; Hoa Le; Chenghong Zhang; Jason S Halladay; Rettie; S. Cyrus Khojasteh; McGlothlin; Wu; Hsueh; Witte; Schwartz; Deanna L. Kroetz
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Systematic evaluation of spliced alignment programs for RNA-seq data
Nature Methods, ISSN: 15487091 15487105
Pär G. Engström; Tamara Steijger; Botond Sipos; Gregory R. Grant; André Kahles; Gunnar Rätsch; Nick Goldman; Tim J. Hubbard; Jennifer Harrow; Roderic Guigó; Paul Bertone; Tyler Alioto; Jonas Behr; Regina Bohnert; Davide Campagna; Carrie A. Davis; Alexander Dobin; Thomas R. Gingeras; Géraldine Jean; Peter Kosarev; Sheng Li; Jinze Liu; Christopher E Mason; Vladimir Molodtsov; Zemin Ning; Hannes Ponstingl; Jan F. Prins; Paolo Ribeca; Igor Seledtsov; Victor Solovyev; Giorgio Valle; Nicola Vitulo; Kai Wang; Thomas D Wu; Georg Zeller
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Assessment of transcript reconstruction methods for RNA-seq
Nature Methods, ISSN: 15487091 15487105
Tamara Steijger; Josep F. Abril; Pär G. Engström; Felix Kokocinski; Martin Akerman; Tyler Alioto; Giovanna Ambrosini; Stylianos E. Antonarakis; Jonas Behr; Paul Bertone; Regina Bohnert; Philipp Bucher; Nicole Cloonan; Thomas Derrien; Sarah Djebali; Jiang Du; Sandrine Dudoit; Mark Gerstein; Thomas R. Gingeras; David Gonzalez; Sean M. Grimmond; Roderic Guigó; Lukas Habegger; Jennifer Harrow; Tim J. Hubbard; Christian Iseli; Géraldine Jean; André Kahles; Julien Lagarde; Jing Leng; Gregory Lefebvre; Suzanna E. Lewis; Ali Mortazavi; Peter Niermann; Gunnar Rätsch; Alexandre Reymond; Paolo Ribeca; Hugues Richard; Jacques Rougemont; Joel Rozowsky; Michael Sammeth; Andrea Sboner; Marcel H. Schulz; Steven M. J. Searle; Naryttza Diaz Solorzano; Victor Solovyev; Mario Stanke; Brian J. Stevenson; Heinz Stockinger; Armand Valsesia; David Weese; Simon White; Barbara J. Wold; Jie Wu; Thomas D Wu; Georg Zeller; Daniel Zerbino; Michael Q. Zhang
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Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse
Developmental Biology, ISSN: 1095564X 00121606
Idella F. Yamben; Rivka A. Rachel; Shalini Shatadal; Neal G. Copeland; Nancy A. Jenkins; Søren Warming; Anne E. Griep
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Use of optimized aminotransferase methods in regulated preclinical studies
Veterinary Clinical Pathology, ISSN: 02756382 1939165X
Jacqueline M. Tarrant; Denny Meyer; Paula Katavolos
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Process lifecycle validation: Applying risk management
BioPharm International, ISSN: 1542166X 19391862
Anurag S. Rathore; Scott Bozzone; A. Hamid Mollah
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Discovery and characterization of a novel dihydroisoxazole class of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiators
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Nandini C. Patel; Jacob B. Schwarz; Xinjun J. Hou; Dennis J. Hoover; Longfei Xie; Anton J. Fliri; Randall J. Gallaschun; John T. Lazzaro; Dianne K. Bryce; William E. Hoffmann; Ashley N. Hanks; Dina F. McGinnis; Eric S. Marr; Justin L. Gazard; Mihály Hajós; Renato J. Scialis; Raymond S. Hurst; Christopher L. Shaffer; Jayvardhan Pandit; Christopher J. O'Donnell
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Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Donald S. Kirkpatrick; Daisy J. Bustos; Taner Dogan; Jocelyn Chan; Lilian Phu; Amy Young; Lori S. Friedman; Marcia Belvin; Qinghua Song; Corey Bakalarski; Klaus P. Hoeflich
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A Nobel Prize for membrane traffic: Vesicles find their journey's end
Journal of Cell Biology, ISSN: 00219525 15408140
Ira Mellman; Scott D. Emr
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RASIP1 regulates vertebrate vascular endothelial junction stability through EPAC1-RAP1 signaling
Blood, ISSN: 15280020 00064971
Christopher W. Wilson; Leon Parker; Christopher J. Hall; Tanya Smyczek; Judy Mak; Ailey Crow; George Posthuma; Ann De Mazière; Meredith Sagolla; Cecile Chalouni; Philip Vitorino; Merone Roose-Girma; Søren Warming; Judith Klumperman; Philip S. Crosier; Weilan Ye
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Subcutaneous versus intravenous administration of rituximab: Pharmacokinetics, CD20 target coverage and B-cell depletion in cynomolgus monkeys
PLoS ONE, ISSN: 19326203
Cheng-Ping Mao; Martin R. Brovarney; Karim Dabbagh; Herbert F. Birnböck; Wolfgang F. Richter; Christopher J. Del Nagro
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C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Christian S. Lobsiger; Severine Boillée; Christine Pozniake; Amir M. Khan; Melissa McAlonis-Downes; Joe Lewcock; Don W. Cleveland
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Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer
Journal of Clinical Oncology, ISSN: 15277755
David Spigel; Thomas J. Ervin; Rodryg Ramlau; Davey B Daniel; Jerome H Goldschmidt; George R. Blumenschein; Maciej J Krzakowski; Gilles Robinet; Benoit Godbert; Fabrice Barlesi; Ramaswamy Govindan; Taral Patel; Sergey Orlov; Michael Wertheim; Wei Yu; Jiping Zha; Robert Yauch; Premal Patel; See Phan; Amy Peterson
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Improved crystallographic structures using extensive combinatorial refinement
Structure, ISSN: 09692126 18784186
Jerome C. Nwachukwu; Mark R. Southern; James R. Kiefer; Pavel V. Afonine; Paul D. Adams; Thomas C. Terwilliger; Kendall W. Nettles
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Pharmacokinetics and absorption of the anticancer agents dasatinib and GDC-0941 under various gastric conditions in dogs - Reversing the effect of elevated gastric pH with betaine HCl
Molecular Pharmaceutics, ISSN: 15438384 15438392
Jodie Pang; Gena Dalziel; Brian J. Dean; Joseph A. Ware; Laurent Salphati
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Impact of food and the proton pump inhibitor rabeprazole on the pharmacokinetics of GDC-0941 in healthy volunteers: Bench to bedside investigation of pH-dependent solubility
Molecular Pharmaceutics, ISSN: 15438384 15438392
Joseph A. Ware; Gena Dalziel; Jin Y. Jin; Jackson D. Pellett; Gillian S. Smelick; David A. West; Laurent Salphati; Xiao Ding; Rebecca Sutton; Jane Fridyland; Mark J. Dresser; Glenn Morrisson; Scott N. Holden
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Physical chemical drug-drug interactions from drug discovery to registration: New opportunities for the pharmaceutical scientist to impact drug development
Molecular Pharmaceutics, ISSN: 15438384 15438392
Joseph A. Ware; Gena Dalziel
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Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development
Molecular Pharmaceutics, ISSN: 15438384 15438392
Gillian S. Smelick; Timothy P. Heffron; Laura Chu; Brian J. Dean; David A. West; Scott L. Duvall; Bert L. Lum; Nageshwar Budha; Scott N. Holden; Leslie Z. Benet; Adam Frymoyer; Mark J. Dresser; Joseph A. Ware
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Investigation of the rat model for preclinical evaluation of pH-dependent oral absorption in humans
Molecular Pharmaceutics, ISSN: 15438384 15438392
Joseph W. Lubach; Jacob Z. Chen; Jonathan Hau; Jose Imperio; Melis Coraggio; Lichuan Liu; Harvey Wong
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Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria
Molecular Pharmaceutics, ISSN: 15438384 15438392
Marc R. Yago; Adam Frymoyer; Gillian S. Smelick; Lynda A. Frassetto; Nageshwar Budha; Mark J. Dresser; Joseph A. Ware; Leslie Z. Benet
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Absolute bioavailability and effect of formulation change, food, or elevated pH with rabeprazole on cobimetinib absorption in healthy subjects
Molecular Pharmaceutics, ISSN: 15438384 15438392
Luna Musib; Edna F. Choo; Yuzhong Deng; Stephen M. Eppler; Isabelle Rooney; Iris Chan; Mark J. Dresser
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Characterization of a water-solid interaction in a partially ordered system
Molecular Pharmaceutics, ISSN: 15438384 15438392
Paroma Chakravarty; Joseph W. Lubach
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Systemic concentrations can limit the oral absorption of poorly soluble drugs: An investigation of non-sink permeation using physiologically based pharmacokinetic modeling
Molecular Pharmaceutics, ISSN: 15438384 15438392
Po-Chang Chiang; Hank La; Haiming Zhang; Harvey Wong
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Two-dimensional HPLC in pharmaceutical analysis
American Pharmaceutical Review, ISSN: 10998012
Kelly Zhang; Jennifer Wang; Midco Tsang; Larry Wigman; Nik P. Chetwyn
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Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences
Nature Neuroscience, ISSN: 10976256 15461726
David V. Hansen; Jan H. Lui; Pierre Flandin; Kazuaki Yoshikawa; John L. R. Rubenstein; Arturo Alvarez-Buylla; Arnold R. Kriegstein
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More myths in ultrahigh-pressure liquid chromatography
LC-GC Europe, ISSN: 14716577
Michael W. Dong
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Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
Journal of Experimental Medicine, ISSN: 00221007 15409538
Omar Abdel-Wahab; Jie Gao; Mazhar Adli; Anwesha Dey; Thomas Trimarchi; Young Rock Chung; Cem Kuscu; Todd Hricik; Delphine Ndiaye-Lobry; Lindsay M. LaFave; Richard Koche; Alan H. Shih; Olga A. Guryanova; Eunhee Kim; Sheng Li; Suveg Pandey; Joseph Y. Shin; Leon Telis; Jinfeng Liu; Parva K. Bhatt; Sebastien Monette; Xinyang Zhao; Christopher E Mason; Christopher Y. Park; Bradley E. Bernstein; Iannis Aifantis; Ross L. Levine
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Vehicle selection for nonclinical oral safety studies
Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255 17447607
Evan A Thackaberry
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Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Sharada Labadie; Kathy Barrett; Wade S. Blair; Christine Chang; Gauri Deshmukh; Eigenbrot; Paul Gibbons; Adam R. Johnson; Jane R. Kenny; Pawan Bir Kohli; Marya Liimatta; Patrick J. Lupardus; Steven Shia; Micah Steffek; Savita Ubhayakar; Anne Van Abbema; Mark Zak
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Purification of antibodies by precipitating impurities using Polyethylene Glycol to enable a two chromatography step process
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232 1873376X
Glen Giese; Adam Myrold; Gorrell; Josefine Persson
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Exposure-response analysis of pertuzumab in HER2-positive metastatic breast cancer: Absence of effect on QTc prolongation and other ECG parameters
Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843
Amit Garg; Jing Li; Emma Clark; Adam Knott; Timothy J. Carrothers; Jean-François Marier; Javier Cortés; Michael Brewster; Jennifer Visich; Bert L. Lum
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ATLAS: Randomized, double-blind, placebo-controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib, after completion of chemotherapy, with bevacizumab for first-line treatment of advanced non-small-cell lung cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Bruce E. Johnson; Fairooz F. Kabbinavar; Louis Fehrenbacher; John Hainsworth; Saifuddin Kasubhai; Bruce Kressel; Chin-Yu Lin; Thomas Marsland; Taral Patel; Jonathan Polikoff; Mark Rubin; Leonard White; James Chih-Hsin Yang; Chris J. Bowden; Vincent A. Miller
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Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration
Journal of Experimental Medicine, ISSN: 00221007 15409538
Christine D. Pozniak; Arundhati Sengupta Ghosh; Alvin Gogineni; Jesse E. Hanson; Seung-Hye Lee; Jessica L. Larson; Hilda Solanoy; Daisy J. Bustos; Hong Li; Hai Ngu; Adrian M. Jubb; Gai Ayalon; Jiansheng Wu; Kimberly Scearce-Levie; Qiang Zhou; Robby M. Weimer; Donald S. Kirkpatrick; Joe Lewcock
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Maximizing kinetic performance in supercritical fluid chromatography using state-of-the-art instruments
Journal of Chromatography A, ISSN: 18733778 00219673
Alexandre Grand-Guillaume Perrenoud; Chris Hamman; Meenakshi Goel; Jean-Luc Veuthey; Davy Guillarme; Szabolcs Fekete
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Porcine circovirus (PCV) removal by Q sepharose fast flow chromatography
Biotechnology Progress, ISSN: 87567938 15206033
Bin Yang; Hua Wang; Cintia Ho; Philip M. Lester; Qi Chen; Florian Neske; Sally A. Baylis; Johannes Blümel
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Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells
Acta Neuropathologica, ISSN: 00016322 14320533
Annegret Kathagen; Alexander Schulte; Gerd Balcke; Phillips; Tobias Martens; Jakob Matschke; Hauke S. Günther; Robert Soriano; Zora Modrusan; Thomas Sandmann; Carsten Kuhl; Alain Tissier; Mareike Holz; Lutz A. Krawinkel; Markus Glatzel; Manfred Westphal; Katrin Lamszus
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Absence of pharmacokinetic drug-drug interaction of pertuzumab with trastuzumab and docetaxel
Anti-Cancer Drugs, ISSN: 09594973 14735741
Javier Cortés; Sandra M. Swain; Iveta Kudaba; Maik Hauschild; Taral Patel; Elza Grincuka; Norikazu Masuda; Virginia McNally; Graham Ross; Michael Brewster; Jean-François Marier; My My Trinh; Amit Garg; Ihsan Nijem; Jennifer Visich; Bert L. Lum; Baselga
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Sample size and threshold estimation for clinical trials with predictive biomarkers
Contemporary Clinical Trials, ISSN: 15517144 15592030
Howard M. Mackey; Thomas Bengtsson
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Population pharmacokinetic analysis from phase i and phase ii studies of the humanized monovalent antibody, onartuzumab (metmab), in patients with advanced solid tumors
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Yan Xin; Denise Jin; Stephen M. Eppler; Lisa A. Damico; Amita Joshi; John Davis; Surinder Kaur; Ihsan Nijem; John Bothos; Amy Peterson; Premal Patel; Shuang Bai
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Using registries to identify adverse events in rheumatic diseases
Pediatrics, ISSN: 00314005 10984275
Geraldina Lionetti; Yukiko Kimura; Laura E. Schanberg; Timothy Beukelman; Carol A. Wallace; Norman T. Ilowite; Jane Winsor; Kathleen Fox; Marc Natter; John S. Sundy; Eric Brodsky; Jeffrey R. Curtis; Vincent Del Gaizo; Solomon Iyasu; Angelika Jahreis; Ann Meeker-O'connell; Barbara B. Mittleman; Bernard M. Murphy; Eric D. Peterson; Sandra C. Raymond; Soko Setoguchi; Jeffrey N. Siegel; Rachel E. Sobel; Daniel Solomon; Taunton R. Southwood; Richard Vesely; Patience H. White; Nico M. Wulffraat; Christy I. Sandborg
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A two-stage Bayesian design with sample size reestimation and subgroup analysis for phase II binary response trials
Contemporary Clinical Trials, ISSN: 15517144 15592030
Wei Zhong; Joseph S. Koopmeiners; Bradley P. Carlin
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Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Bradley J. Newhouse; Steve Wenglowsky; Jonas Grina; Ellen R. Laird; Walter C. Voegtli; Li Ren; Kateri Ahrendt; Alexandre J. Buckmelter; Susan L. Gloor; Nathalie Klopfenstein; Joachim Rudolph; Zhaoyang Wen; Xianfeng Li; Bainian Feng
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Age distribution of patients with advanced non-melanoma skin cancer in the United States
Archives of Dermatological Research, ISSN: 03403696 1432069X
Stacey Dacosta Byfield; Diana M. Chen; Yeun Mi Yim; Carolina Reyes
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A randomised study of the effect of danoprevir/ritonavir or ritonavir on substrates of cytochrome P450 (CYP) 3A and 2C9 in chronic hepatitis C patients using a drug cocktail
European Journal of Clinical Pharmacology, ISSN: 00316970 14321041
Peter N. Morcos; Linda Chang; Rohit Kulkarni; Mylene Giraudon; Nancy Shulman; Barbara J. Brennan; Patrick F. Smith; Jonathan Q. Tran
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Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct
Developmental Dynamics, ISSN: 10588388 10970177
Yoko Inès Nozawa; Erica Yao; Chuwen Lin; Jehn-Hsiahn Yang; Christopher W. Wilson; Rhodora Gacayan; Pao-Tien Chuang
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Erratum: Increased glucocerebrosidase (GBA) 2 activity in GBA1 deficient mice brains and in Gaucher leucocytes (Journal of Inherited Metabolic Disease DOI: 10.1007/s10545-012-9561-3)
Journal of Inherited Metabolic Disease, ISSN: 01418955 15732665
Derek G. Burke; Ahad A. Rahim; Simon N. Waddington; Stefan Karlsson; Ida Enquist; Kailash Bhatia; Atul Mehta; Ashok Vellodi; Simon Heales
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Clinical applications of palifermin: Amelioration of oral mucositis and other potential indications
Journal of Cellular and Molecular Medicine, ISSN: 15821838
Saroj Vadhan-Raj; Jenna D. Goldberg; Miguel-Angel Perales; Dietmar P. Berger; Marcel R.M. van den Brink
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Strategy for selecting disposable bags for cell culture media applications based on a root-cause investigation
Biotechnology Progress, ISSN: 87567938 15206033
Joseph Wood; Ekta Mahajan; Masaru Shiratori
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IL-2 Immunotherapy Reveals Potential for Innate Beta Cell Regeneration in the Non-Obese Diabetic Mouse Model of Autoimmune Diabetes
PLoS ONE, ISSN: 19326203
Yaiza Diaz-de-Durana; Janet Lau; Deborah Knee; Christophe Filippi; Marco Londei; Peter McNamara; Marc Nasoff; Michael Didonato; Richard Glynne; Ann E. Herman
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