Scientists / Publications

Publications

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DISPLAYING 7101 - 7150 OF 15612 RESULTS

Quantitative histological assessment of xenobiotic-induced liver enzyme induction and pituitary-thyroid axis stimulation in rats using whole-slide automated image analysis
Journal of Histochemistry and Cytochemistry, ISSN: 00221554
Rosario Garrido; Tanja S. Zabka; Jianhua Tao; Mark Fielden; Adrian J. Fretland; Mudher Albassam
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Oncology comparative effectiveness research:Amultistakeholder perspective on principles for conduct and reporting
Oncologist, ISSN: 10837159 1549490X
Scott D. Ramsey; Sean D. Sullivan; Shelby Reed; Ya-Chen Tina Shih; Ken Schaecher; Rahul Dhanda; Debra Patt; Kelly Pendergrass; Mark S. Walker; Jennifer Malin; Lee S. Schwartzberg; Kurt Neumann; Elaine B. Yu; Arliene Ravelo; Art Small
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Decoding a chain letter for degradation
Structure, ISSN: 18784186 09692126
Christian N. Cunningham; Jacob E. Corn
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Pilot of peer assessment within experiential teaching and learning
Currents in Pharmacy Teaching and Learning, ISSN: 18771297
Craig D. Cox; Michael J. Peeters; Brad L. Stanford; Charles F. Seifert
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Pre-existing biotherapeutic-reactive antibodies: Survey results within the american association of pharmaceutical scientists
AAPS Journal, ISSN: 15507416
Li Xue; Michele Fiscella; Manoj Rajadhyaksha; Jaya Goyal; Claire Holland; Boris Gorovits; Alyssa M. Morimoto
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B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response
PLoS Pathogens, ISSN: 15537366 15537374
Lee Kozakiewicz; Yong Chen; Jiayong Xu; Yanhua Wang; Kyri Dunussi-Joannopoulos; Qinglin Ou; JoAnne L. Flynn; Steven A. Porcelli; William R. Jacobs Jr.; John Chan
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Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: The ITC evidence-based position
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Kalvass; Polli; Bourdet; Bo Feng; Huang; Xingrong Liu; Smith; Zhang; Zamek-Gliszczynski
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Photodegradation of human growth hormone: A novel backbone cleavage between Glu-88 and Pro-89
Molecular Pharmaceutics, ISSN: 15438384 15438392
Daniel Steinmann; Junyan A. Ji; Y. John Wang; Christian Schöneich
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Generation and characterization of a unique reagent that recognizes a panel of recombinant human monoclonal antibody therapeutics in the presence of endogenous human IgG
mAbs, ISSN: 19420862 19420870
Xiangdan Wang; Quarmby; Carl Ng; Anan Chuntharapai; Theresa Shek; Eigenbrot; Robert F. Kelley; Steven Shia; Krista McCutcheon; John Lowe; Cecilia Leddy; Kyle Coachman; Cain; Felix Chu; Isidro Hötzel; Mauricio Maia; Eric Wakshull; Yang
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Assessment of granulation technologies for an API with poor physical properties
Drug Development and Industrial Pharmacy, ISSN: 03639045 15205762
Gena Dalziel; Ewa Nauka; Feng Zhang; Sanjeev Kothari; Minli Xie
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Mechanistic Pharmacokinetic-Pharmacodynamic Modeling of BACE1 Inhibition in Monkeys: Development of a Predictive Model for Amyloid Precursor Protein Processings
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Xingrong Liu; Harvey Wong; Kimberly Scearce-Levie; Ryan J. Watts; Melis Coraggio; Young G. Shin; Kun Peng; Kristin R. Wildsmith; Jasvinder K. Atwal; Jason Mango; Stephen P. Schauer; Kelly Regal; Kevin W. Hunt; Allen A. Thomas; Michael Siu; Joseph P. Lyssikatos; Gauri Deshmukh; Cornelis E. Hop
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Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies
Clinical Cancer Research, ISSN: 10780432 15573265
Matthew J. Brauer; Guanglei Zhuang; Maike Schmidt; Jenny Yao; Xiumin Wu; Joshua S. Kaminker; Stefanie S. Jurinka; Ganesh Kolumam; Alicia S Chung; Adrian M. Jubb; Zora Modrusan; Tomoko Ozawa; C. David James; Phillips; Benjamin Haley; Rachel Tam; Anne C. Clermont; Jason H. Cheng; Sherry X. Yang; Sandra M. Swain; Daniel S. Chen; Stefan J. Scherer; Koeppen; Ru-Fang Yeh; Peng Yue; Jean-Philippe Stephan; Priti Hegde; Napoleone Ferrara; Mallika Singh; Carlos Bais
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Developing Therapeutic Antibodies for Neurodegenerative Disease
Neurotherapeutics, ISSN: 19337213 18787479
Y. Joy Yu; Ryan J. Watts
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A novel visuospatial priming task for rats with relevance to Tourette syndrome and modulation of dopamine levels
Neuroscience and Biobehavioral Reviews, ISSN: 01497634 18737528
Nurith Amitai; Martin Weber; Neal R. Swerdlow; Richard F. Sharp; Michelle R. Breier; Adam L. Halberstadt; Jared W. Young
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Challenges of trial design for extended drug delivery: A virtual round table with industry
Retina Today, ISSN: 18250572
Ken Green; Yehia Hashad; Roman G. Rubio
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Estimating the survival functions for right-censored and interval-censored data with piecewise constant hazard functions
Contemporary Clinical Trials, ISSN: 15517144 15592030
Pei He; George Kong; Zheng Su
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Theoretical considerations and practical approaches to address the effect of anti-drug antibody (ADA) on quantification of biotherapeutics in circulation
AAPS Journal, ISSN: 15507416
Marian Kelley; Ago Ahene; Boris Gorovits; John Kamerud; Lindsay King; Thomas McIntosh; Yang
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Calcineurin inhibitor-free mycophenolate mofetil/sirolimus maintenance in liver transplantation: The randomized spare-the-nephron trial
Liver Transplantation, ISSN: 15276465 15276473
Lewis Teperman; Dilip Moonka; Anthony Sebastian; Linda Sher; Paul Marotta; Christopher Marsh; Baburao Koneru; John Goss; Dennis Preston; John P. Roberts
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Fibroblast growth factor receptor 3 is a rational therapeutic target in bladder cancer
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Kilian M. Gust; David J. McConkey; Shannon Awrey; Paul K. Hegarty; Jing Qing; Jolanta Bondaruk; Avi Ashkenazi; Bogdan Czerniak; Colin P. Dinney; Peter C. Black
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Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: The ITC evidence-based position
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Kalvass; Polli; Bourdet; Bo Feng; Huang; Liu; Smith; Zhang; Zamek-Gliszczynski
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At scale analysis and optimization of a cell culture harvest process-mitigating risk and optimizing performance
American Pharmaceutical Review, ISSN: 10998012
Michael Pohlscheidt; Goetz Lieser; Bjoern-Erec Bertermann; Horst Eberhardt; Stefan Herter; Hermann Tebbe
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DCDT2980S, an anti-CD22-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for non-hodgkin lymphoma
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Dongwei Li; Kirsten Achilles Poon; Shang-Fan Yu; Randall Dere; MaryAnn Go; Jeffrey Lau; Bing Zheng; Kristi Elkins; Dimitry Danilenko; Katherine R. Kozak; Pamela Chan; Josefa Chuh; Xiaoyan Shi; Denise Nazzal; Franklin Fuh; Jacqueline McBride; Vanitha Ramakrishnan; Ruth De Tute; Andy Rawstron; Andrew S. Jack; Rong Deng; Yu-Waye Chu; David Dornan; Marna Williams; William Y. Ho; Allen Ebens; Saileta Prabhu; Andrew G. Polson
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Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cell
Biotechnology Progress, ISSN: 87567938 15206033
Zhilan Hu; Donglin Guo; Shirley S. M. Yip; Dejin Zhan; Shahram Misaghi; John C. Joly; Snedecor; Amy Shen
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Optimization of drug-drug interaction study design: Comparison of minimal physiologically based pharmacokinetic models on prediction of CYP3A inhibition by ketoconazole
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Bing Han; Jialin Mao; Jenny Y. Chien; Stephen D. Hall
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Use of an anti-apoptotic CHO cell line for transient gene expression
Biotechnology Progress, ISSN: 87567938 15206033
Nichole F. Macaraeg; Dorothea Reilly; Athena W. Wong
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BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor
Nature Cell Biology, ISSN: 14657392 14764679
Brian Biehs; Jimmy Kuang-Hsien Hu; Nicolas B. Strauli; Eugenio Sangiorgi; Heekyung Jung; Ralf-Peter Heber; Sunita Ho; Alice F. Goodwin; Jeremy S. Dasen; Mario R. Capecchi; Ophir D. Klein
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Reading speed improvements in retinal vein occlusion after ranibizumab treatment
JAMA Ophthalmology, ISSN: 21686165
Ivan J. Suñer; Neil M. Bressler; Rohit Varma; Paul P. Lee; Chantal M. Dolan; James Ward; Shoshana Colman; Roman G. Rubio
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In situ validation of an intestinal stem cell signature in colorectal cancer
Gut, ISSN: 00175749 14683288
Jennifer L. Ziskin; Debra Dunlap; Murat Yaylaoglu; Imola K. Fodor; William F. Forrest; Rajesh Patel; Nianfeng Ge; Gordon G. Hutchins; James K. Pine; Philip Quirke; Koeppen; Adrian M. Jubb
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Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactionss
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Harma Ellens; Shibing Deng; Joann Coleman; Joe Bentz; Mitchell E. Taub; Isabelle Ragueneau-Majlessi; Sophie P. Chung; Krisztina Herédi-Szabó; Sibylle Neuhoff; Johan Palm; Praveen Balimane; Lei Zhang; Masoud Jamei; Imad Hanna; Michael O'connor; Dallas Bednarczyk; Malin Forsgard; Xiaoyan Chu; Christoph Funk; Ailan Guo; Kathleen M. Hillgren; Libin Li; Anne Y. Pak; Elke S. Perloff; Ganesh Rajaraman; Laurent Salphati; Jan-Shiang Taur; Dietmar Weitz; Heleen M. Wortelboer; Cindy Q. Xia; Guangqing Xiao; Tetsuo Yamagata; Caroline A. Lee
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Authors' Response to Letter to the Editor on "Image Cytometry Protocols"
Journal of Histochemistry and Cytochemistry, ISSN: 00221554
Rosario Garrido; Tanja S. Zabka; Jianhua Tao; Mark Fielden; Adrian J. Fretland; Mudher Albassam
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T Cell Receptor (TCR) and Transforming Growth Factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Chaoran Li; Peter J. R. Ebert; Qi-Jing Li
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AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes
Nature, ISSN: 00280836 14764687
Ritu Kumar; Lauren Dimenna; Nadine Schrode; Ting-Chun Liu; Philipp Franck; Silvia Muñoz-Descalzo; Anna-Katerina Hadjantonakis; Ali A. Zarrin; Jayanta Chaudhuri; Olivier Elemento; Todd Evans
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Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Xiaozhang Zheng; Paul Bauer; Timm Baumeister; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Jian Lin; Dominic J. Reynolds; Geeta Sharma; Chase C. Smith; Zhongguo Wang; Peter Dragovich; Angela Oh; Weiru Wang; Mark Zak; Janet Gunzner; Guiling Zhao; Po-Wai Yuen; Kenneth W. Bair
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Design of synthetic autonomous VH domain libraries and structural analysis of a VH domain bound to vascular endothelial growth factor
Journal of Molecular Biology, ISSN: 10898638 00222836
Xiaolei Ma; Pierre A. Barthelemy; Lionel Rouge; Wiesmann; Sachdev S. Sidhu
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Role of Helicase-Like Transcription Factor (Hltf) in the G2/M Transition and Apoptosis in Brain
PLoS ONE, ISSN: 19326203
Rebecca A. Helmer; Oded Foreman; Janet S. Dertien; Marlyn Panchoo; Suhani M. Bhakta; Beverly S. Chilton
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Therapeutic protein drug-drug interactions: Navigating the knowledge gaps-highlights from the 2012 AAPS NBC roundtable and IQ Consortium/FDA workshop
AAPS Journal, ISSN: 15507416
Jane R. Kenny; Maggie M. Liu; Andrew T. Chow; Justin C. Earp; Raymond Evers; J. Greg Slatter; Diane D. Wang; Lei Zhang; Honghui Zhou
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Characterization of the guinea pig CMV gH/gL/GP129/GP131/GP133 complex in infection and spread
Virology, ISSN: 00426822 10960341
Marcy Auerbach; Donghong Yan; Ashley Fouts; Min Xu; Alberto Estevez; Cary D. Austin; Fernando Bazan; Becket Feierbach
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Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1
eLife, ISSN: 2050084X
Ling Luo; Hironori Uehara; Xiaohui Zhang; Subrata K. Das; Thomas Olsen; Derick Holt; Jacquelyn M. Simonis; Kyle Jackman; Nirbhai Singh; Tadashi R. Miya; Wei Huang; Faisal Ahmed; Ana Bastos-Carvalho; Yun Zheng Le; Christina Mamalis; Vince A. Chiodo; William W. Hauswirth; Judit Z. Baffi; Pedro M. Lacal; Angela Orecchia; Napoleone Ferrara; Guangping Gao; Kim Young-hee; Yingbin Fu; Leah Owen; Romulo J. C. Albuquerque; Wolfgang Baehr; Kirk Thomas; Dean Y. Li; Kakarla V. Chalam; Masabumi Shibuya; Salvatore Grisanti; David J. Wilson; Jayakrishna Ambati; Balamurali K. Ambati
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Adherence to dornase alfa treatment among commercially insured patients with cystic fibrosis
Journal of Medical Economics, ISSN: 13696998 1941837X
Samya Z. Nasr; Will Chou; Kathleen F. Villa; Eunice Chang; Michael S. Broder
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Population pharmacokinetics of cyclosporine in transplant recipients
AAPS Journal, ISSN: 15507416
Kelong Han; Venkateswaran C. Pillai; Raman Venkataramanan
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Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Janet Gunzner; Guiling Zhao; Paul Bauer; Timm Baumeister; Alexandre J. Buckmelter; Maureen Caligiuri; Karl H. Clodfelter; Bang Fu; Bingsong Han; Yen-Ching Ho; Nikolai Kley; Xiaorong Liang; Bianca M. Liederer; Jian Lin; Sophie Mukadam; Thomas O'Brien; Angela Oh; Dominic J. Reynolds; Geeta Sharma; Nicholas J. Skelton; Chase C. Smith; Jasleen K. Sodhi; Weiru Wang; Zhongguo Wang; Yang Xiao; Po-Wai Yuen; Mark Zak; Lei Zhang; Xiaozhang Zheng; Kenneth W. Bair; Peter Dragovich
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Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells
Cancer Research, ISSN: 00085472 15387445
Luis E. Arias-Romero; Olga Villamar-Cruz; Min Huang; Klaus P. Hoeflich; Jonathan Chernoff
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Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Christopher A. Hurley; Wade S. Blair; Richard J. Bull; Christine Chang; Peter H. Crackett; Gauri Deshmukh; Hazel J. Dyke; Rina Fong; Nico Ghilardi; Paul Gibbons; Peter R. Hewitt; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Pawan Bir Kohli; Janusz J. Kulagowski; Marya Liimatta; Patrick J. Lupardus; Robert J. Maxey; Rohan Mendonca; Raman Narukulla; Rebecca Pulk; Savita Ubhayakar; Anne Van Abbema; Stuart I. Ward; Bohdan Waszkowycz; Mark Zak
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Previous myocardial infarction as a risk factor for in-hospital cardiovascular outcomes (from the National Registry of Myocardial Infarction 4 and 5)
American Journal of Cardiology, ISSN: 00029149 18791913
Quang T. Bui; Vanessa S. Reddy; Joan R. Jacobs; Susan M. Begelman; Paul D. Frederick; Dave P. Miller; William J. French
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Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria
New England Journal of Medicine, ISSN: 15334406 00284793
Marcus Maurer; Karin Rosén; Hsin-Ju Hsieh; Sarbjit S. Saini; Clive E. Grattan; Ana Gimenéz-Arnau; Sunil Agarwal; Ramona Doyle; Janice Canvin; Allen P. Kaplan; Thomas B. Casale
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Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Mark Zak; Christopher A. Hurley; Stuart I. Ward; Philippe Bergeron; Kathy Barrett; Mercedesz Balazs; Wade S. Blair; Richard J. Bull; Paroma Chakravarty; Christine Chang; Peter H. Crackett; Gauri Deshmukh; Jason Devoss; Peter Dragovich; Eigenbrot; Charles Ellwood; Simon Gaines; Nico Ghilardi; Paul Gibbons; Stefan Gradl; Gribling; Chris Hamman; Eric Harstad; Peter R. Hewitt; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Michael F. T. Koehler; Pawan Bir Kohli; Sharada Labadie; Wyne P. Lee; Jiangpeng Liao; Marya Liimatta; Rohan Mendonca; Raman Narukulla; Rebecca Pulk; Austin Reeve; Scott Savage; Steven Shia; Micah Steffek; Savita Ubhayakar; Anne Van Abbema; Ignacio Aliagas; Barbara Avitabile-Woo; Yisong Xiao; Jing Yang; Janusz J. Kulagowski
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Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d ][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2- methylpropanamide (GDC-0032): A β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Chudi O. Ndubaku; Timothy P. Heffron; Steven T. Staben; Matthew Baumgardner; Nicole Blaquiere; Erin K. Bradley; Richard J. Bull; Steven Do; Jennafer Dotson; Danette Dudley; Kyle A. Edgar; Lori S. Friedman; Richard Goldsmith; Robert Heald; Aleksandr Kolesnikov; Leslie Lee; Lewis; Michelle Nannini; Jim Nonomiya; Jodie Pang; Steve Price; Wei Wei Prior; Laurent Salphati; Steve Sideris; Jeffery J. Wallin; Lan Wang; Binqing Wei; Deepak Sampath; Alan G. Olivero
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Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Jun Liang; Anne Van Abbema; Mercedesz Balazs; Kathy Barrett; Leo Berezhkovsky; Wade S. Blair; Christine Chang; Donnie Delarosa; Jason Devoss; James Driscoll; Eigenbrot; Nico Ghilardi; Paul Gibbons; Jason S Halladay; Adam R. Johnson; Pawan Bir Kohli; Yingjie Lai; Yanzhou Liu; Joseph P. Lyssikatos; Priscilla Mantik; Kapil Menghrajani; Jeremy Murray; Ivan Peng; Amy Sambrone; Steven Shia; Young G. Shin; Jan Smith; Sue J. Sohn; Vickie Tsui; Ultsch; Lawren C. Wu; Yisong Xiao; Wenqian Yang; Judy Young; Birong Zhang; Bing-Yan Zhu; Steven Magnuson
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Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies
Journal of Molecular Biology, ISSN: 10898638 00222836
Homer Pantua; Jingyu Diao; Ultsch; Meredith Hazen; Mary Mathieu; Krista McCutcheon; Kentaro Takeda; Shailesh V. Date; Tommy K. Cheung; Qui Phung; Hass; David Arnott; Hongo; Matthews; Alex Brown; Arvind H. Patel; Robert F. Kelley; Eigenbrot; Sharookh B. Kapadia
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miR-221/222 Targets Adiponectin Receptor 1 to Promote the Epithelial-to-Mesenchymal Transition in Breast Cancer
PLoS ONE, ISSN: 19326203
Michael S. Hwang; Nancy Yu; Susanna Y. Stinson; Peng Yue; Robert J. Newman; Bernard B. Allan; David Dornan
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