Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7451 - 7500 OF 15612 RESULTS

Interferon-gamma-mediated tissue factor expression contributes to T-cell-mediated hepatitis through induction of hypercoagulation in mice
Hepatology, ISSN: 02709139 15273350
Junko Kato; Tomohiro Okamoto; Hiroyuki Motoyama; Ryosuke Uchiyama; Daniel Kirchhofer; Nico Van Rooijen; Hirayuki Enomoto; Shuhei Nishiguchi; Norifumi Kawada; Jiro Fujimoto; Hiroko Tsutsui
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Potential impact of amyloid imaging on diagnosis and intended management in patients with progressive cognitive decline
Alzheimer Disease and Associated Disorders, ISSN: 08930341
Michael Grundman; Michael J. Pontecorvo; Stephen Salloway; P. Murali Doraiswamy; Adam S. Fleisher; Carl H. Sadowsky; Anil K. Nair; Andrew Siderowf; Ming Lu; Anupa K. Arora; Abigail Agbulos; Matthew L. Flitter; Michael J. Krautkramer; Khaled Sarsour; Daniel M. Skovronsky; Mark A. Mintun
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Monoclonal antibodies: From structure to therapeutic application
Pharmaceutical Biotechnology: Fundamentals and Applications, Fourth Edition,
John Davis; Rong Deng; C. Andrew Boswell; Yi Zhang; Jing Li; Fielder; Amita Joshi; Sara Kenkare-Mitra
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The association of rash severity with overall survival: Findings from patients receiving erlotinib for pancreatic cancer in the community setting
Pancreas, ISSN: 08853177 15364828
Edward J. Stepanski; Carolina Reyes; Mark S. Walker; Sacha Satram-Hoang; Larry Leon; Slawomir Wojtowicz-Praga; Paul J. E. Miller; Arthur C. Houts; Lee S. Schwartzberg
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A randomized phase II trial of vismodegib versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer
Clinical Cancer Research, ISSN: 10780432 15573265
Jordan Berlin; Bendell; Lowell Hart; Irfan Firdaus; Ira Gore; Robert Hermann; Mary F. Mulcahy; Mark M. Zalupski; Howard M. Mackey; Robert Yauch; Richard A. Graham; Gordon L. Bray; Low
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The essence of modern HPLC: Advantages, limitations, fundamentals, and opportunities
LCGC North America, ISSN: 15275949
Michael W. Dong
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Daily dosing of vismodegib to steady state does not prolong the qtc interval in healthy volunteers
Journal of Cardiovascular Pharmacology, ISSN: 01602446 15334023
Richard A. Graham; Ilsung Chang; Jin Y. Jin; Wang; Matthew B. Dufek; Jean A. Ayache; Farkad Ezzet; Kenn Zerivitz; Low; Mark J. Dresser
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Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): A randomised phase 3 trial
The Lancet Oncology, ISSN: 14702045 14745488
Bennouna; Sastre; Arnold; Österlund; Greil; Eric Van Cutsem; Von Moos; Vieitez; Bouche; Borg; Steffens; Alonso-Orduna; Schlichting; Reyes-Rivera; Belguendouz Bendahmane; André; Stefan Kubicka
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A sequence-based approach demonstrates that balancing selection in classical human leukocyte antigen (HLA) loci is asymmetric
Human Molecular Genetics, ISSN: 09646906 14602083
Paola G. Bronson; Steven J. Mack; Henry A. Erlich; Montgomery Slatkin
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The genomic and transcriptomic landscape of a hela cell line
G3: Genes, Genomes, Genetics, ISSN: 21601836
Jonathan J.M. Landry; Paul Theodor Pyl; Tobias Rausch; Thomas Zichner; Manu M. Tekkedil; Adrian M. Stütz; Anna Jauch; Raeka S. Aiyar; Gregoire Pau; Nicolas Delhomme; Julien Gagneur; Jan O. Korbel; Wolfgang Huber; Lars M. Steinmetz
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Comparative pharmacokinetics of subcutaneous trastuzumab administered via handheld syringe or proprietary single-use injection device in healthy males
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Chris J. Wynne; Rod B. Ellis-Pegler; Devonie S. Waaka; Christian Schwabe; Michaela Lehle; Dominik Heinzmann; Ranvir Mangat; Chunze Li; Anne E. Dick; Nicola A. Cranshaw; Bert L. Lum
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Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7
Nature Chemical Biology, ISSN: 15524450 15524469
Yingnan Zhang; Lijuan Zhou; Lionel Rouge; Aaron H. Phillips; Cynthia Lam; Peter S. Liu; Wendy N. Sandoval; Elizabeth Helgason; Jeremy Murray; Ingrid E. Wertz; Jacob E. Corn
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Structural analysis of a therapeutic monoclonal antibody dimer by hydroxyl radical footprinting
mAbs, ISSN: 19420862 19420870
Galahad Deperalta; Melissa Alvarez; Charity Bechtel; Ken Dong; Ross McDonald; Victor Ling
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Material identification by HPLC with charged aerosol detection
LCGC North America, ISSN: 15275949
Brandon Scott; Kelly Zhang; Larry Wigman
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EDSS variability before randomization may limit treatment discovery in primary progressive MS
Multiple Sclerosis Journal, ISSN: 14770970 13524585
Jiameng Zhang; Waubant; Cutter; Wolinsky; Robert Glanzman
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Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation
Neuro-Oncology, ISSN: 15228517 15235866
Sichen Li; Arthur P. Chou; Weidong Chen; Ruihuan Chen; Yuzhong Deng; Phillips; Julia Selfridge; Mira Zurayk; Jerry J. Lou; Richard G. Everson; Kuan-Chung Wu; Kym F. Faull; Timothy Cloughesy; Linda M. Liau; Albert Lai
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Vascular endothelial growth factor a in intraocular vascular disease
Ophthalmology, ISSN: 01616420 15494713
Joan W. Miller; Jennifer Le Couter; Erich C. Strauss; Napoleone Ferrara
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Formulation development of antibody-drug conjugates
Methods in Molecular Biology, ISSN: 10643745
William J. Galush; Aditya A. Wakankar
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Automated dynamic fed-batch process and media optimization for high productivity cell culture process development
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Franklin Lu; Poh Choo Toh; Iain Burnett; Feng Li; Terry Hudson; Ashraf Amanullah; Jincai Li
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Microarray comparison of anterior and posterior drosophila wing imaginal disc cells identifies novel wing genes
G3: Genes, Genomes, Genetics, ISSN: 21601836
Daniel M. Ibrahim; Brian Biehs; Thomas B. Kornberg; Ansgar Klebes
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Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention
Cancer Discovery, ISSN: 21598274 21598290
Shidong Jia; Xueliang Gao; Sang Hyun Lee; Sauveur-Michel Maira; Xiaoqiu Wu; Edward C. Stack; Sabina Signoretti; Massimo Loda; Jean J Zhao; Thomas M. Roberts
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Pharmacokinetics and ADME characterizations of antibody-drug conjugates
Methods in Molecular Biology, ISSN: 10643745
Kedan Lin; Jay Tibbitts; Shen
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A Three-Pronged Template Approach for Rapid HPLC Method Development
LCGC North America, ISSN: 15275949
Michael W. Dong
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Cilia, tubby mice, and obesity
Cilia, ISSN: 20462530
Saikat Mukhopadhyay; Peter K Jackson
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Author reply
Ophthalmology, ISSN: 01616420 15494713
David M. Brown; Quan Dong Nguyen; Jason S. Ehrlich
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Human growth hormone
Pharmaceutical Biotechnology: Fundamentals and Applications, Fourth Edition,
Dao; Barbara M. Lippe; Mike Laird
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Engineering THIOMABs for site-specific conjugation of thiol-reactive linkers
Methods in Molecular Biology, ISSN: 10643745
Sunil Bhakta; Helga Raab; Jagath R. Junutula
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Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice
Journal of Clinical Investigation, ISSN: 15588238 00219738
Tiffany Chang; Kimberly Krisman; Emily Harding Theobald; Jin Xu; Jon Akutagawa; Jennifer O. Lauchle; Scott C. Kogan; Benjamin S. Braun; Kevin Shannon
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Lupus nephritis: Induction therapy in severe lupus nephritis-should MMF be considered the drug of choice?
Clinical Journal of the American Society of Nephrology, ISSN: 1555905X 15559041
Brad H. Rovin; Samir V. Parikh; Lee A. Hebert; Tak Mao Chan; Chi Chiu Mok; Ellen M. Ginzler; Lai Seong Hooi; Paul Brunetta; Romeo MacIuca; Neil Solomons
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Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models
Cancer Cell, ISSN: 18783686 15356108
Ryan B. Corcoran; Katherine A. Cheng; Aaron N. Hata; Anthony C. Faber; Hiromichi Ebi; Erin M. Coffee; Patricia Greninger; Ronald D. Brown; Jason T. Godfrey; Travis J. Cohoon; Youngchul Song; Eugene Lifshits; Kenneth E. Hung; Toshi Shioda; Dora Dias-Santagata; Anurag Singh; Jeffrey Settleman; Cyril H. Benes; Mari Mino-Kenudson; Kwok-Kin Wong; Jeff A. Engelman
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Dual targeting of EGFR and HER3 with MEHD7945A overcomes acquired resistance to EGFR inhibitors and radiation
Cancer Research, ISSN: 15387445 00085472
Shyhmin Huang; Chunrong Li; Eric A. Armstrong; Chimera R. Peet; Jarob Saker; Lukas Amler; Mark X. Sliwkowski; Paul M. Harari
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Alkylsulfanyl-1,2,4-triazoles, a New Class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Paolo Polucci; Paola Magnaghi; Mauro Angiolini; Daniela Asa; Nilla Avanzi; Alessandra Badari; Jay Bertrand; Elena Casale; Silvia Cauteruccio; Alessandra Cirla; Liviana Cozzi; Arturo Galvani; Peter K Jackson; Yichin Liu; Steven Magnuson; Beatrice Malgesini; Stefano Nuvoloni; Christian Orrenius; Federico Riccardi Sirtori; Laura Riceputi; Simona Rizzi; Beatrice Trucchi; Thomas O'Brien; Antonella Isacchi; Daniele Donati; Roberto D'Alessio
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Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma
Blood, ISSN: 15280020 00064971
James L. Rubenstein; Jing Li; Lingjing Chen; Ranjana H. Advani; Jan Drappatz; Elizabeth Gerstner; Tracy Batchelor; Hendrikus Krouwer; James Hwang; Glenna Auerback; Cigall Kadoch; Clifford Lowell; Pamela N. Münster; Soonmee Cha; Shuman; Lloyd E. Damon
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Examination of the follicular lymphoma international prognostic index (FLIPI) in the national lymphocare study (NLCS): A prospective US patient cohort treated predominantly in community practices
Annals of Oncology, ISSN: 15698041 09237534
Nooka; Chadi Nabhan; Zhou; Taylor; Michelle Byrtek; Thomas P. Miller; Jonathan W. Friedberg; Zelenetz; Brian K. Link; James R. Cerhan; Dillon; Sinha; Shenoy; Levy; Keith Dawson; Jamie Hirata; Christopher R. Flowers
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Prediction of drug terminal half-life and terminal volume of distribution after intravenous dosing based on drug clearance, steady-state volume of distribution, and physiological parameters of the body
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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An alternative approach for quantitative bioanalysis using diluted blood to profile oral exposure of small molecule anticancer drugs in mice
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Bianca M. Liederer; Leonid M. Berezhkovskiy; Savita Ubhayakar; Yuzhong Deng
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CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States
American Journal of Ophthalmology, ISSN: 18791891 00029394
Louis R. Pasquale; Stephanie J. Loomis; Jae H. Kang; Brian L. Yaspan; Wael Abdrabou; Donald L. Budenz; Teresa C. Chen; Elizabeth Delbono; Friedman; Douglas Gaasterland; Terry Gaasterland; Cynthia L. Grosskreutz; Richard K. Lee; Paul R. Lichter; Yutao Liu; Catherine A. McCarty; Sayoko E. Moroi; Olson; Tony Realini; Douglas J. Rhee; Schuman; Kuldev Singh; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; R. Rand Allingham; Brian W. Kunkle; Robert N. Weinreb; Kang Zhang; Michael A. Hauser; Julia E. Richards; Jonathan L. Haines; Janey L. Wiggs
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Compatibility and stability of pertuzumab and trastuzumab admixtures in i.v. infusion bags for coadministration
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Zephania Kwong Glover; Lynn Gennaro; Sandeep Yadav; Barthélemy Demeule; Wong; Alavattam Sreedhara
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Effect of baseline rheumatoid factor and anticitrullinated peptide antibody serotype on rituximab clinical response: A meta-analysis
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
John D. Isaacs; Stanley B. Cohen; Paul Emery; Paul P. Tak; Jianmei Wang; Guiyuan Lei; Sarah Williams; Preeti Lal; Simon J. Read
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Avoiding pitfalls during technology transfer of cell culture manufacturing processes in the pharmaceutical industry - Mitigating risk and optimizing performance
Pharmaceutical Outsourcing, ISSN: 19453337
Michael Pohlscheidt; Mahalia Corrales; Salim Charanyia; Eric Fallon; Manfred Bruch; Marco Jenzsch; Christian Sieblist
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The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: The next therapeutic frontier)
Alzheimer's and Dementia, ISSN: 15525279 15525260
Adam L. Boxer; Michael Gold; Edward Huey; William T. Hu; Howard J. Rosen; Joel H. Kramer; Fen-Biao Gao; Edward A. Burton; Tiffany Chow; Aimee Kao; Blair R. Leavitt; Bruce Lamb; Megan Grether; David Knopman; Nigel J. Cairns; Ian R. Mackenzie; Laura Mitic; Erik D. Roberson; Daniel Van Kammen; Marc Cantillon; Kathleen Zahs; George Jackson; Stephen Salloway; John C. Morris; Gary Tong; Howard Feldman; Howard Fillit; Susan Dickinson; Zaven S. Khachaturian; Margaret Sutherland; Susan Abushakra; Joe Lewcock; Robert Farese; Robert O. Kenet; Frank Laferla; Steve Perrin; Steve Whitaker; Lawrence S. Honig; Marsel M. Mesulam; Brad Boeve; Murray Grossman; Bruce L. Miller; Jeffrey L. Cummings
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Response
Chest, ISSN: 19313543 00123692
Nareg Roubinian; Paul D. Blanc; Hubert Chen
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Redefining approaches to asthma: Developing targeted biologic therapies
Advances in Pharmacology, ISSN: 15578925 10543589
Joseph R. Arron; Heleen Scheerens; Matthews
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Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): A randomised, double-blind, controlled phase 4 trial
The Lancet, ISSN: 1474547X 01406736
Cem Gabay; Paul Emery; Ronald Van Vollenhoven; Ara Dikranian; Rieke Alten; Karel Pavelka; Micki Klearman; David Musselman; Sunil Agarwal; Jennifer Green; Arthur Kavanaugh
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Polar solvents decrease the viscosity of high concentration IgG1 solutions through hydrophobic solvation and interaction: Formulation and biocompatibility considerations
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Tim J. Kamerzell; Amanda L. Pace; Megan Li; Dimitry Danilenko; Michelle Mcdowell; Yatin Gokarn; Y. John Wang
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Use of Animal Models of Human Disease for Nonclinical Safety Assessment of Novel Pharmaceuticals
Toxicologic Pathology, ISSN: 15331601 01926233
Sherry J. Morgan; Chandikumar S. Elangbam; Shawn Berens; Evan B. Janovitz; Allison Vitsky; Tanja S. Zabka; Laura Conour
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Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery
EMBO Reports, ISSN: 14693178 1469221X
Dong Yun Lee; David Arnott; Eric J. Brown
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The cost burden of multiple sclerosis in the United States: A systematic review of the literature
Journal of Medical Economics, ISSN: 1941837X 13696998
Gabriel Adelman; Stanley G. Rane; Kathleen F. Villa
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NMDA receptors in nervous system diseases
Neuropharmacology, ISSN: 18737064 00283908
Qiang Zhou; Morgan Sheng
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Sensitivity and specificity of diagnostic accuracy in alzheimer's disease: A synthesis of existing evidence
American Journal of Alzheimer's Disease and other Dementias, ISSN: 19382731 15333175
Joseph E. Gaugler; Robert L. Kane; Joseph A. Johnston; Khaled Sarsour
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