Genentech: Publications

July 1, 2012

Multiple antibiotic-resistant Pseudomonas aeruginosa and lung function decline in patients with cystic fibrosis

Journal of Cystic Fibrosis, ISSN: 15691993 18735010

Clement L. Ren; Michael W. Konstan; Ashley Yegin; Lawrence Rasouliyan; Benjamin L. Trzaskoma; Morgan; Warren E. Regelmann

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July 1, 2012

Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC

Nature Immunology, ISSN: 15292908 15292916

Jianming Xie; Johannes B. Huppa; Evan W. Newell; Jun Huang; Peter J. R. Ebert; Qi-Jing Li; Mark M. Davis

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July 1, 2012

Collective action of hematopoietic cell subsets mediates anti-IL10R1 and CpG tumor immunity

Cancer Immunology, Immunotherapy, ISSN: 03407004 14320851

Meng-Yun Chou; Cary D. Austin; Kim

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July 1, 2012

Quantification of antiangiogenic and antivascular drug activity by kinetic analysis of DCE-MRI data

Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535

Gregory Z. Ferl; Ruediger E. Port

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July 1, 2012

Reply to "On the differentiation of mouse IgE + cells"

Nature Immunology, ISSN: 15292908 15292916

Oezcan Talay; Donghong Yan; Hans D. Brightbill; Elizabeth E. M. Straney; Meijuan Zhou; Ena Ladi; Wyne P. Lee; Jackson G. Egen; Cary D. Austin; Min Xu; Lawren C. Wu

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June 29, 2012

The effect of different linkers on target cell catabolism and pharmacokinetics/pharmacodynamics of trastuzumab maytansinoid conjugates

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Hans Erickson; Gail L. Phillips; Douglas Leipold; Carmela A. Provenzano; Elaine Mai; Holly A. Johnson; Bert Gunter; Charlene A. Audette; Manish Gupta; Jan Pinkas; Jay Tibbitts

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June 29, 2012

ERK inhibition overcomes acquired resistance to MEK Inhibitors

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Georgia Hatzivassiliou; Bonnie Liu; Carol O'Brien; Jill M. Spoerke; Klaus P. Hoeflich; Matthias Peter; Robert Soriano; William F. Forrest; Sherry Heldens; Huifen Chen; Toy; Connie Ha; Wei Zhou; Kyung Song; Lori S. Friedman; Lukas Amler; Garret M. Hampton; John Moffat; Marcia Belvin; Lackner

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June 29, 2012

Bystanders Not So Innocent after All

Immunity, ISSN: 10747613 10974180

Marcel Batten; Nico Ghilardi

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June 29, 2012

CD28 costimulation regulates genome-wide effects on alternative splicing

PLoS ONE, ISSN: 19326203

Manish J. Butte; Sun Jung Lee; Jonathan Jesneck; Mary E. Keir; W. Nicholas Haining; Arlene H. Sharpe

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June 29, 2012

Navitoclax (ABT-263) reduces Bcl-x L-mediated chemoresistance in ovarian cancer models

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Maureen Wong; Nguyen Tan; Jiping Zha; Franklin V. Peale Jr.; Peng Yue; Wayne J. Fairbrother; Lisa D. Belmont

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June 28, 2012

Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Janusz J. Kulagowski; Wade S. Blair; Richard J. Bull; Christine Chang; Gauri Deshmukh; Hazel J. Dyke; Eigenbrot; Nico Ghilardi; Paul Gibbons; Trevor K. Harrison; Peter R. Hewitt; Marya Liimatta; Christopher A. Hurley; Adam R. Johnson; Tony Johnson; Jane R. Kenny; Pawan Bir Kohli; Robert J. Maxey; Rohan Mendonca; Kyle Mortara; Jeremy Murray; Raman Narukulla; Steven Shia; Micah Steffek; Savita Ubhayakar; Ultsch; Anne Van Abbema; Stuart I. Ward; Bohdan Waszkowycz; Mark Zak

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June 28, 2012

Discovery of novel PI3-Kinase δ specific inhibitors for the treatment of rheumatoid arthritis: Taming CYP3A4 time-dependent inhibition

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Brian S. Safina; Stewart Baker; Matthew Baumgardner; Paul M. Blaney; Bryan K. Chan; Yunghsiang Chen; Matthew W. Cartwright; Georgette M. Castanedo; Christine Chabot; Arnaud J. Cheguillaume; Paul Goldsmith; David M. Goldstein; Bindu Goyal; Timothy Hancox; Raj K. Handa; Pravin S Iyer; Jasmit Kaur; Rama Kondru; Jane R. Kenny; Sussie L. Krintel; Jun Li; John Lesnick; Matthew C. Lucas; Lewis; Sophie Mukadam; Jeremy Murray; Alan J. Nadin; Jim Nonomiya; Fernando Padilla; Wylie S. Palmer; Jodie Pang; Neil Pegg; Steve Price; Karin Reif; Laurent Salphati; Pascal P. A. Savy; Eileen Seward; Stephen Shuttleworth; Sukhjit Sohal; Zachary K. Sweeney; Suzanne Tay; Parcharee Tivitmahaisoon; Bohdan Waszkowycz; Binqing Wei; Qin Yue; Chenghong Zhang; Daniel P. Sutherlin

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June 26, 2012

Temporal resolution of autophosphorylation for normal and oncogenic forms of EGFR and differential effects of gefitinib

Biochemistry, ISSN: 00062960 15204995

Youngjoo Kim; Zhimin Li; Mihaela Apetri; Beibei Luo; Jeffrey Settleman; Karen S. Anderson

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June 22, 2012

DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina

Cell, ISSN: 10974172 00928674

Joseph M. Zullo; Ignacio A. Demarco; Roger Piqué-Regi; Daniel J. Gaffney; Charles B. Epstein; Chauncey J. Spooner; Teresa R. Luperchio; Bradley E. Bernstein; Jonathan K. Pritchard; Karen L. Reddy; Harinder Singh

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June 21, 2012

Clinical trial considerations on male contraception and collection of pregnancy information from female partners

Journal of Translational Medicine, ISSN: 14795876

Maria L. Banholzer; Heinrich Buergin; Christoph Wandel; Georg Schmitt; Elmar Gocke; Richard Peck; Thomas Singer; Theresa Reynolds; Marie Mannino; Jonathan Deutsch; Lucette Doessegger

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June 20, 2012

Pharmacokinetic models for FcRn-mediated IgG disposition

Journal of Biomedicine and Biotechnology, ISSN: 11107243 11107251

Jim J. Xiao

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June 19, 2012

Charge heterogeneity of monoclonal antibodies by multiplexed imaged capillary isoelectric focusing immunoassay with chemiluminescence detection

Analytical Chemistry, ISSN: 00032700

David A. Michels; Andrea W. Tu; Will McElroy; David Voehringer; Oscar Salas-Solano

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June 15, 2012

Analysis of Fcγ receptor IIIa and IIa polymorphisms: Lack of correlation with outcome in trastuzumab-treated breast cancer patients

Clinical Cancer Research, ISSN: 10780432 15573265

Sara A. Hurvitz; David J. Betting; Howard M. Stern; Emmanuel Quinaux; Stinson; Somasekar Seshagiri; Ying Zhao; Marc Buyse; John Mackey; Adrian Driga; Sambasivarao Damaraju; Mark X. Sliwkowski; Nicholas J. Robert; Vicente Valero; John Crown; Carla Falkson; Adam Brufsky; Tadeusz Pienkowski; Wolfgang Eiermann; Miguel Martín; Valerie Bée; Omkar Marathe; Dennis J. Slamon; John M. Timmerman

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June 14, 2012

Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Huifen Chen; Bryan K. Chan; Jason H. Drummond; Anthony A. Estrada; Janet Gunzner; Xingrong Liu; Yichin Liu; John Moffat; Daniel G. Shore; Zachary K. Sweeney; Thuy Tran; Shumei Wang; Guiling Zhao; Haitao Zhu; Burdick

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June 14, 2012

Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

Blood, ISSN: 15280020 00064971

Delphine Mérino; Seong Lin Khaw; Stefan P. Glaser; Daniel J Anderson; Lisa D. Belmont; Wong; Peng Yue; Mikara Robati; Belinda Phipson; Fairlie; Lee; Kirsteen J. Campbell; Cassandra J. Vandenberg; Suzanne Cory; Andrew W. Roberts; Mary J. C. Ludlam; David C.S. Huang; Bouillet

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June 13, 2012

Drugging Wnt signalling in cancer

EMBO Journal, ISSN: 14602075 02614189

Paul G. Polakis

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June 13, 2012

IL-17-Induced Act1-Mediated signaling is critical for cuprizone-induced demyelination

Journal of Neuroscience, ISSN: 02706474 15292401

Zizhen Kang; Liping Liu; Roo Spangler; Charles Spear; Chenhui Wang; Muhammet Fatih Gulen; Mike Veenstra; Wenjun Ouyang; Richard M. Ransohoff; Xiaoxia Li

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June 13, 2012

Monoclonal antibodies to the V2 domain of MN-rgp120: Fine mapping of epitopes and inhibition of α4β7 binding

PLoS ONE, ISSN: 19326203

Nakamura; Dora P. A. J. Fonseca; Sara M. O'Rourke; Aaron L. Vollrath; Berman

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June 12, 2012

Role of apolipoprotein A-II in the structure and remodeling of human high-density lipoprotein (HDL): Protein conformational ensemble on HDL

Biochemistry, ISSN: 00062960 15204995

Xuan Gao; Shujun Yuan; Shobini Jayaraman; Olga Gursky

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June 12, 2012

Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Xiaolei Ma; Elizabeth Helgason; Qui Phung; Quan; Rekha S. Iyer; Michelle W. Lee; Krista K. Bowman; Melissa A. Starovasnik; Erin C. Dueber

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June 10, 2012

OCEANS: A randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Carol Aghajanian; Stephanie V. Blank; Barbara Goff; Patricia L. Judson; Michael G. Teneriello; Amreen Husain; Mika A. Sovak; Jing Yi; Lawrence R. Nycum

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June 7, 2012

Efficacy and safety of vismodegib in advanced basal-cell carcinoma

New England Journal of Medicine, ISSN: 15334406 00284793

Aleksandar Sekulic; Michael R. Migden; Anthony E. Oro; Luc Dirix; Karl Lewis; John Hainsworth; James A. Solomon; Simon Yoo; Sarah T. Arron; Philip A. Friedlander; Ellen Marmur; Charles M. Rudin; Anne Lynn S. Chang; Low; Howard M. Mackey; Robert Yauch; Richard A. Graham; Josina C. Reddy; Axel Hauschild

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June 7, 2012

Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome

New England Journal of Medicine, ISSN: 15334406 00284793

Jean Y. Tang; Julian M. Mackay-Wiggan; Michelle Aszterbaum; Robert Yauch; Joselyn Lindgren; Kris Chang; Carol Coppola; Anita M. Chanana; Jackleen Marji; David R. Bickers; Ervin H. Epstein Jr.

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June 7, 2012

Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

Nature, ISSN: 00280836 14764687

Jian Payandeh; Tamer M. Gamal El-Din; Todd Scheuer; Ning Zheng; William A. Catterall

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June 7, 2012

Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer

Blood, ISSN: 15280020 00064971

Jian-Guo Wang; Julia E. Geddings; Maria M. Aleman; Jessica C. Cardenas; Pichika Chantrathammachart; Julie C. Williams; Daniel Kirchhofer; Vladimir Y. Bogdanov; Ronald R. Bach; Janusz Rak; Frank C. Church; Alisa S. Wolberg; Rafal Pawlinski; Nigel S. Key; Jen Jen Yeh; Nigel Mackman

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June 6, 2012

Structural and functional analysis of HtrA1 and its subdomains

Structure, ISSN: 09692126 18784186

Eigenbrot; Ultsch; Michael T. Lipari; Paul Moran; S. Jack Lin; Rajkumar Ganesan; Quan; Jeffrey Tom; Wendy N. Sandoval; Menno Van Lookeren Campagne; Daniel Kirchhofer

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June 5, 2012

MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Jessica K. Ma; Mia Y. Platt; Jeffrey Eastham-Anderson; Jeoung-Sook Shin; Ira Mellman

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June 5, 2012

Impact of low-dose ritonavir on danoprevir pharmacokinetics: Results of computer-based simulations and a clinical drug-drug interaction study

Clinical Pharmacokinetics, ISSN: 03125963 11791926

Micaela B. Reddy; Yuan Chen; Joshua Haznedar; Jennifer Fretland; Steven Blotner; Patrick F. Smith; Jonathan Q. Tran

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June 4, 2012

In vivo human apolipoprotein E isoform fractional turnover rates in the CNS

PLoS ONE, ISSN: 19326203

Kristin R. Wildsmith; Jacob M. Basak; Bruce W. Patterson; Yuriy Pyatkivskyy; Jungsu Kim; Kevin E. Yarasheski; Jennifer X. Wang; Kwasi G. Mawuenyega; Hong Jiang; Maia Parsadanian; Hyejin Yoon; Tom Kasten; Wendy C. Sigurdson; Chengjie Xiong; Alison M. Goate; David M. Holtzman; Randall J. Bateman

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June 1, 2012

Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A biomarker evaluation from the AVAGAST randomized phase III trial

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Eric Van Cutsem; Sanne De Haas; Yoon-Koo Kang; Atsushi Ohtsu; Niall C. Tebbutt; Jian M. Xu; Wei Peng Yong; Bernd Langer; Paul Delmar; Stefan J. Scherer; Manish A. Shah

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June 1, 2012

Synaptic structure and function

Current Opinion in Neurobiology, ISSN: 09594388 18736882

Antoine Triller; Morgan Sheng

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June 1, 2012

Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

John I. Trujillo; James R. Kiefer; Wei Huang; Jacqueline E. Day; Joseph Moon; Gina M. Jerome; Christine P. Bono; Christine M. Kornmeier; Melanie L. Williams; Cyrille Kuhn; Glen R. Rennie; Thomas A. Wynn; Christopher P. Carron; Atli Thorarensen

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June 1, 2012

Erythropoietin-coated ZP-microneedle transdermal system: Preclinical formulation, stability, and delivery

Pharmaceutical Research, ISSN: 07248741 1573904X

Elaine E. Peters; Mahmoud Ameri; Xiaomei Wang; Maa; Peter E. Daddona

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June 1, 2012

HORIZON: An open-label extension trial of ranibizumab for choroidal neovascularization secondary to age-related macular degeneration

Ophthalmology, ISSN: 01616420 15494713

Michael Singer; Carl C. Awh; Srinivas Sadda; William R. Freeman; Andrew N. Antoszyk; Pamela Wong; Lisa Tuomi

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June 1, 2012

Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention

Genes and Development, ISSN: 08909369 15495477

Karen Yap; Zhao Qin Lim; Piyush Khandelia; Brad A. Friedman; Eugene V. Makeyev

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June 1, 2012

Developmental genetics of secretory vesicle acidification during caenorhabditis Elegans spermatogenesis

Genetics, ISSN: 00166731 19432631

Elizabeth J. Gleason; Paul D. Hartley; Melissa Henderson; Katherine L. Hill-Harfe; Paul W. Price; Robby M. Weimer; Tim L. Kroft; Guang-dan Zhu; Suzanne Cordovado; Steven W. L'Hernault

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June 1, 2012

Genetically engineered mouse models: Closing the gap between preclinical data and trial outcomes

Cancer Research, ISSN: 00085472 15387445

Mallika Singh; Christopher L. Murriel; Leisa Johnson

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June 1, 2012

Issues and challenges of subvisible and submicron particulate analysis in protein solutions

AAPS Journal, ISSN: 15507416

Thomas M. Scherer; Stephenie Leung; Laura Owyang; Steven J. Shire

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June 1, 2012

Fc gamma receptor 3a genotype predicts overall survival in follicular lymphoma patients treated on SWOG trials with combined monoclonal antibody plus chemotherapy but not chemotherapy alone

Haematologica, ISSN: 03906078 15928721

Daniel O. Persky; David Dornan; Bryan H. Goldman; Rita M. Braziel; Richard I. Fisher; Michael LeBlanc; David G. Maloney; Oliver W. Press; Thomas P. Miller; Lisa M. Rimsza

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June 1, 2012

Evaluation of drug load and polymer by using a 96-well plate vacuum dry system for amorphous solid dispersion drug delivery

AAPS PharmSciTech, ISSN: 15309932

Po-Chang Chiang; Yingqing Ran; Kang-Jye Chou; Yong Cui; Amy Sambrone; Connie Chan; Ryan Hart

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June 1, 2012

Relationship of obesity with respiratory symptoms and decreased functional capacity in adults without established COPD

Primary Care Respiratory Journal, ISSN: 14714418 14751534

Moshe Zutler; Jonathan P. Singera; Theodore A. Omachia; Mark D. Eisner; Carlos Iribarren; Patricia Katz; Paul D. Blanc

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June 1, 2012

Induction of Bv8 Expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: Key role of Stat3 signaling

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Xueping Qu; Guanglei Zhuang; Lanlan Yu; Meng; Napoleone Ferrara

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June 1, 2012

Bridging the gap between preclinical and clinical studies using pharmacokinetic-pharmacodynamic modeling: An analysis of GDC-0973, a MEK inhibitor

Clinical Cancer Research, ISSN: 10780432 15573265

Harvey Wong; Laurent Vernillet; Amy Peterson; Joseph A. Ware; Lillian Lee; Jean-Francois Martini; Peiwen Yu; Congfen Li; Geoffrey Del Rosario; Edna F. Choo; Klaus P. Hoeflich; Yongchang Shi; Blake T. Aftab; Ron Aoyama; Sanh Tan Lam; Marcia Belvin; John Prescott

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June 1, 2012

The cost-effectiveness of primary stroke centers for acute stroke care

Stroke, ISSN: 00392499 15244628

Gregory F. Guzauskas; Denise M. Boudreau; Kathleen F. Villa; Steven R. Levine; David L. Veenstra

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June 1, 2012

Capillary electrophoresis-mass spectrometry methods for tryptic peptide mapping of therapeutic antibodies

Electrophoresis, ISSN: 01730835 15222683

Colin D. Whitmore; Lynn Gennaro

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