Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8051 - 8100 OF 15613 RESULTS

Handling of tautomerism and stereochemistry in compound registration
Journal of Chemical Information and Modeling, ISSN: 15499596 15205142
Alberto Gobbi; Man-Ling Lee
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Handling of tautomerism and stereochemistry in compound registration
Journal of Chemical Information and Modeling, ISSN: 1549960X 15499596
Alberto Gobbi; Man-Ling Lee
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Genetic models of sensorimotor gating: Relevance to neuropsychiatric disorders
Current Topics in Behavioral Neurosciences, ISSN: 18663389 18663370
Susan Powell; Martin Weber; Mark A. Geyer
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Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Shi-Xiong Tan; Ng; Christopher C. Meoli; Ansu Kumar; Poh-Sim Khoo; Daniel J. Fazakerley; Jagath R. Junutula; Shireen Vali; David E. James; Jacqueline Stöckli
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Effects of resin ligand density on yield and impurity clearance in preparative cation exchange chromatography. I. Mechanistic evaluation
Journal of Chromatography A, ISSN: 00219673 18733778
Jace Fogle; Nina Mohan; Eric Cheung; Josefine Persson
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Effects of resin ligand density on yield and impurity clearance in preparative cation exchange chromatography. II. Process characterization
Journal of Chromatography A, ISSN: 00219673 18733778
Jace Fogle; Josefine Persson
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TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers
Cell, ISSN: 10974172 00928674
Anurag Singh; Michael F. Sweeney; Min Yu; Alexa Burger; Patricia Greninger; Cyril H. Benes; Daniel A. Haber; Jeffrey Settleman
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Engineering upper hinge improves stability and effector function of a human IgG1
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Boxu Yan; Daniel Boyd; Timothy Kaschak; Joni Tsukuda; Amy Shen; Yuwen L. Lin; Shan Chung; Priyanka Gupta; Amrita Kamath; Anne Wong; Jean-Michel Vernes; Meng; Klara Totpal; Gabriele Schaefer; Guoying Jiang; Bartek Nogal; Craig Emery; Vanderlaan; Paul J. Carter; Reed J. Harris; Ashraf Amanullah
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A phase I study evaluating the pharmacokinetics, safety and tolerability of an antibody-based tissue factor antagonist in subjects with acute lung injury or acute respiratory distress syndrome
BMC Pulmonary Medicine, ISSN: 14712466
Peter E. Morris; Jay S. Steingrub; Bee Y. Huang; Shamay Tang; Patrick Liu; Peter R. Rhode; Hing C. Wong
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Exploring racial differences in outcome and treatment for metastatic colorectal cancer: Results from a large prospective observational cohort study (BRiTE)
Cancer, ISSN: 0008543X 10970142
Blase Polite; Amy Sing; Daniel J. Sargent; Grothey; Jordan Berlin; Kozloff; Shibao Feng
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Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Johanna I. Partanen; Topi A. Tervonen; Mikko Myllynen; Essi Lind; Misa Imai; Pekka Katajisto; Gerrit J. P. Dijkgraaf; Panu E. Kovanen; Tomi P. Mäkelä; Zena Wer; Juha Klefström
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Death Receptors DR6 and TROY Regulate Brain Vascular Development
Developmental Cell, ISSN: 15345807 18781551
Stephen Tam; David L. Richmond; Joshua S. Kaminker; Zora Modrusan; Baby Martin-McNulty; Tim C. Cao; Robby M. Weimer; Richard A. D. Carano; Nicholas Vanbruggen; Ryan J. Watts
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Stereochemical and neuroanatomical selectivity of pramipexole effects on sensorimotor gating in rats
Brain Research, ISSN: 00068993 18726240
Wei-Li Chang; Martin Weber; Michelle R. Breier; Richard L. Saint Marie; Samantha R. Hines; Neal R. Swerdlow
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Global kinetic analysis of proteolysis via quantitative targeted proteomics
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Nick Agard; Sami Mahrus; Jonathan C. Trinidad; Aenoch Lynn; Alma Burlingame; James A. Wells
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Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells
Development (Cambridge), ISSN: 09501991 14779129
Kelli L. VanDussen; Alexis J. Carulli; Theresa M. Keeley; Sanjeevkumar R. Patel; Brent J. Puthoff; Scott T. Magness; Ivy T. Tran; Ivan Maillard; Christian W. Siebel; Åsa Kolterud; Ann S. Grosse; Deborah L. Gumucio; Stephen A. Ernst; Yu-Hwai Tsai; Peter J. Dempsey; Linda C. Samuelson
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APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1
Nature Cell Biology, ISSN: 14657392 14764679
Nevena V. Dimova; Nathaniel A. Hathaway; Byung-Hoon Lee; Donald S. Kirkpatrick; Marie Lea Berkowitz; Steven P. Gygi; Daniel Finley; Randall W. King
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Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates
Journal of Biomolecular Screening, ISSN: 10870571 1552454X
Yichin Liu; Beresini; Adam R. Johnson; Robert Mintzer; Kinjalkumar Shah; Clark; Stephen Schmidt; Lewis; Marya Liimatta; Linda O. Elliott; Amy Gustafson; Christopher E. Heise
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Characterization of nonrapid virologic response patients infected with HCV genotype 1 who may relapse after standard therapy with peginterferon plus ribavirin
Journal of Viral Hepatitis, ISSN: 13520504 13652893
Reau; Hamzeh; Lentz; Zhou; Donald Jensen
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Monoclonal antibodies: What are the pharmacokinetic and pharmacodynamic considerations for drug development?
Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255 17447607
Rong Deng; Feng Jin; Saileta Prabhu; Suhasini Iyer
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Sudden death related to toxicity in a patient on capecitabine and irinotecan plus bevacizumab intake: Pharmacogenetic implications
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Laetitia Dahan; Joseph Ciccolini; Alexandre Evrard; Litaty Mbatchi; Jay Tibbitts; Pauline Ries; Emmanuelle Norguet; Cedric Mercier; Athanassios Iliadis; L'Houcine Ouafik; Bruno Lacarelle; Jean-Francois Seitz
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Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to at least one tumor necrosis factor inhibitor: Results of a forty-eight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial
Arthritis and Rheumatism, ISSN: 00043591 15290131
Paul P. Tak; Philip J. Mease; Mark C. Genovese; Joel M. Kremer; Haraoui; Tanaka; Bingham; Ashrafzadeh; Travers; Safa-Leathers; Kumar; Wolfgang Dummer
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Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a forty-eight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial
Arthritis and Rheumatism, ISSN: 00043591 15290131
William F. Rigby; Tony; Oelke; Bernard Combe; Laster; Von Muhlen; Fisheleva; Carmen Martin; Travers; Wolfgang Dummer
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Targeting IAP proteins for therapeutic intervention in cancer
Nature Reviews Drug Discovery, ISSN: 14741776 14741784
Fulda; Domagoj Vucic
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Purification and characterization of novel sperm motility-related proteins
Protein Purification,
Gopal C. Majumder; Kaushik Das; Sudipta Saha; Debjani Nath; Arunima Maiti; Sujoy Das; Nabina Dey; Saswati Banerjee; Madhabi Barua; Mahitosh Mandal; Bijay S. Jaiswal; Rupamanjari Biswas; Arpita Bhoumik; Debarun Roy; Souvik Dey; Jharna Som; Debdas Bhattacharyya; Sandhya Rekha Dungdung
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Pharmacokinetic effects of coadministration of lersivirine with raltegravir or maraviroc in healthy subjects
Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596
Manoli Vourvahis; Grant Langdon; Robert R. LaBadie; Gary Layton; Marie-Noella Ndongo; Subhashis Banerjee; John Davis
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Cost, utilization, and patterns of medication use associated with chronic idiopathic urticaria
Annals of Allergy, Asthma and Immunology, ISSN: 10811206 15344436
James L. Zazzali; Michael S. Broder; Eunice Chang; Melvin W. Chiu; Daniel J. Hogan
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Cost-effectiveness of adding rituximab to fludarabine and cyclophosphamide for the treatment of previously untreated chronic lymphocytic leukemia
Leukemia and Lymphoma, ISSN: 10428194 10292403
John Hornberger; Carolina Reyes; Ashwini Shewade; Susan Lerner; Mark Friedmann; Leona Han; Hialy Gutierrez; Sacha Satram-Hoang; Michael J. Keating
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Increased susceptibility to DNA virus infection in mice with a GCN2 mutation
Journal of Virology, ISSN: 0022538X 10985514
Sungyong Won; Celine Eidenschenk; Carrie N. Arnold; Owen M. Siggs; Lei Sun; Katharina Brandl; Tina-Marie Mullen; Glen R. Nemerow; Eva Marie Y. Moresco; Bruce Beutler
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Monocyte tissue factor - Dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin
Journal of Clinical Investigation, ISSN: 00219738 15588238
A. Phillip Owens III; Freda H. Passam; Silvio Antoniak; Stephanie M. Marshall; Allison L. McDaniel; Lawrence Rudel; Julie C. Williams; Brian K. Hubbard; Julie-Ann Dutton; Jian-Guo Wang; Peter S. Tobias; Linda K. Curtiss; Alan Daugherty; Daniel Kirchhofer; James P. Luyendyk; Patrick M. Moriarty; Shanmugam Nagarajan; Barbara C. Furie; Bruce Furie; Douglas G. Johns; Ryan E. Temel; Nigel Mackman
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Recent advances in pathway-targeted cancer drug therapies emerging from cancer genome analysis
Current Opinion in Genetics and Development, ISSN: 0959437X 18790380
Robert Yauch; Jeffrey Settleman
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Efficacy of tocilizumab in patients with moderate to severe active rheumatoid arthritis and a previous inadequate response to disease-modifying antirheumatic drugs: The ROSE study
Annals of the Rheumatic Diseases, ISSN: 00034967 14682060
Yazici; Jeffrey R. Curtis; Ince; Baraf; Raymond L. Malamet; Lichen L. Teng; Arthur Kavanaugh
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A risk-based approach to transferring a mature biopharmaceutical process
BioPharm International, ISSN: 1542166X 19391862
Jean Harms; Purav Dave
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Phosphorylation-dependent activity of the deubiquitinase DUBA
Nature Structural and Molecular Biology, ISSN: 15459993 15459985
Oscar W Huang; Xiaolei Ma; Jianping Yin; Jeremy Flinders; Till Maurer; Nobuhiko Kayagaki; Qui Phung; Ivan Bosanac; David Arnott; Vishva M. Dixit; Sarah G. Hymowitz; Melissa A. Starovasnik; Andrea G Cochran
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Thermodynamics of coupled folding in the interaction of archaeal RNase P proteins RPP21 and RPP29
Biochemistry, ISSN: 00062960 15204995
Yiren Xu; Sri Vidya Oruganti; Venkat Gopalan; Mark P. Foster
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Glutamate receptor subunit GluA1 is necessary for long-term potentiation and synapse unsilencing, but not long-term depression in mouse hippocampus
Brain Research, ISSN: 00068993 18726240
Joel C. Selcher; Weifeng Xu; Jesse E. Hanson; Robert C. Malenka; Daniel V. Madison
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Oncogene addiction
Current Biology, ISSN: 09609822
Jeffrey Settleman
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A guide to rational dosing of monoclonal antibodies
Clinical Pharmacokinetics, ISSN: 03125963 11791926
Shuang Bai; Karin Jorga; Yan Xin; Denise Jin; Zheng; Lisa A. Damico; Manish Gupta; Meina Tao Tang; David E. Allison; Dan Lu; Yi Zhang; Amita Joshi; Mark J. Dresser
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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
Nature Biotechnology, ISSN: 15461696 10870156
Shen; Keyang Xu; Luna Liu; Helga Raab; Sunil Bhakta; Margaret Kenrick; Kathryn Parsons; Janet Y. Tien; Shang-Fan Yu; Elaine Mai; Dongwei Li; Jay Tibbitts; Jakub Baudys; Ola M. Saad; Suzie J. Scales; Paul McDonald; Hass; Eigenbrot; Trung Nguyen; Willy A. Solis; Reina N. Fuji; Kelly Flagella; Darshana Patel; Spencer; Leslie A. Khawli; Allen Ebens; Wai Lee T. Wong; Richard L. Vandlen; Surinder Kaur; Mark X. Sliwkowski; Richard H. Scheller; Paul G. Polakis; Jagath R. Junutula
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Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer
Nature Medicine, ISSN: 1546170X 10788956
Clara Montagut; Alba Dalmases; Beatriz Bellosillo; Marta Crespo; Silvia Pairet; Mar Iglesias; Marta Salido; Manuel Gallen; Scot A. Marsters; Siao Ping Tsai; André Minoche; Somasekar Seshagiri; Sergi Serrano; Heinz Himmelbauer; Joaquim Bellmunt; Ana Rovira; Jeffrey Settleman; Francesc Bosch; Joan Albanell
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Heteroarylation of azine N-oxides
Organic Letters, ISSN: 15237052 15237060
Francis Gosselin; Scott Savage; Nicole Blaquiere; Steven T. Staben
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DUX4 Activates Germline Genes, Retroelements, and Immune Mediators: Implications for Facioscapulohumeral Dystrophy
Developmental Cell, ISSN: 15345807 18781551
Linda N. Geng; Zizhen Yao; Lauren Snider; Abraham P. Fong; Jennifer N. Cech; Janet M. Young; Silvere M. vanderMaarel; Walter L. Ruzzo; Robert Gentleman; Rabi Tawil; Stephen J. Tapscott
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Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: A radiographic study in 358 de novo human glioblastomas
NeuroImage, ISSN: 10538119 10959572
Benjamin M. Ellingson; Timothy Cloughesy; Whitney B. Pope; Taryar M. Zaw; Phillips; Shadi Lalezari; Phioanh L. Nghiemphu; Hassana Ibrahim; Kourosh M. Naeini; Robert J. Harris; Albert Lai
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NMDA receptors and BAX are essential for Aβ impairment of LTP
Scientific Reports, ISSN: 20452322
Kimberly Moore Olsen; Morgan Sheng
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Androgen deprivation causes epithelial-mesenchymal transition in the prostate: Implications for androgen- deprivation therapy
Cancer Research, ISSN: 00085472 15387445
Yuting Sun; Bu-Er Wang; Kevin G. Leong; Peng Yue; Li Li; Suchit Jhunjhunwala; Darrell Chen; Kyounghee Seo; Zora Modrusan; Gao; Jeffrey Settleman; Leisa Johnson
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Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf V600E kinase with favorable physicochemical and pharmacokinetic properties
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Li Ren; Ellen R. Laird; Alexandre J. Buckmelter; Victoria Dinkel; Susan L. Gloor; Jonas Grina; Bradley J. Newhouse; Kevin Rasor; Gregg Hastings; Stefan Gradl; Joachim Rudolph
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Pyrazolopyridine inhibitors of B-Raf V600E. Part 3: An increase in aqueous solubility via the disruption of crystal packing
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Steve Wenglowsky; David Moreno; Joachim Rudolph; Yingqing Ran; Kateri Ahrendt; Alisha Arrigo; Ben Colson; Susan L. Gloor; Gregg Hastings
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Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
New England Journal of Medicine, ISSN: 15334406 00284793
Baselga; Javier Cortés; Sung-Bae Kim; Seock-Ah Im; Roberto Hegg; Im; Laslo Roman; José Luiz Pedrini; Tadeusz Pienkowski; Adam Knott; Emma Clark; Benyunes; Graham Ross; Sandra M. Swain
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A secreted protein microarray platform for extracellular protein interaction discovery
Analytical Biochemistry, ISSN: 10960309 00032697
Sree R. Ramani; Irene Tom; Nicholas Lewin-Koh; Bernd Wranik; Laura DePalatis; Jianjun Zhang; Dan L. Eaton; Lino C. Gonzalez Jr.
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Transarterial chemoembolization plus or minus intravenous bevacizumab in the treatment of hepatocellular cancer: A pilot study
BMC Cancer, ISSN: 14712407
Carolyn D. Britten; Antoinette S. Gomes; Zev A. Wainberg; David Elashoff; Rafael Amado; Yan Xin; Ronald W. Busuttil; Dennis J. Slamon; Richard S. Finn
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Separation-Based Analytical Methods for Measuring Protein Aggregation
Analysis of Aggregates and Particles in Protein Pharmaceuticals,
Jun Liu; Barthélemy Demeule; Steven J. Shire
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