Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8101 - 8150 OF 15613 RESULTS

A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C
PLoS ONE, ISSN: 19326203
Robert Mintzer; Sreemathy Ramaswamy; Kinjalkumar Shah; Rami N. Hannoush; Christine D. Pozniak; Frederick Cohen; Xianrui Zhao; Emile G. Plise; Joe Lewcock; Christopher E. Heise
View on Scopus
Genetic analysis of DSCAM'S role as a netrin-1 receptor in vertebrates
Journal of Neuroscience, ISSN: 02706474 15292401
Elena Palmesino; Patrick C. G. Haddick; Marc Tessier-Lavigne; Artur Kania
View on Scopus
Single electron transfer (SET) activity of the dialkyl-amido sodium zincate [(TMEDA)·Na(μ-TMP)(μ-tBu)Zn(tBu)] towards TEMPO and chalcone
Chemical Communications, ISSN: 1364548X 13597345
Armstrong; Balloch; James J. Crawford; Ben J. Fleming; Hogg; Kennedy; Jan Klett; Mulvey; Charles T. O’Hara; Samantha A. Orr; Robertson
View on Scopus
Single electron transfer (SET) activity of the dialkyl-amido sodium zincate [(TMEDA)·Na(μ-TMP)(μ-tBu)Zn(tBu)] towards TEMPO and chalcone
Chemical Communications, ISSN: 1364548X 13597345
Armstrong; Balloch; James J. Crawford; Ben J. Fleming; Hogg; Alan R. Kennedy; Jan Klett; Mulvey; Charles T. O’Hara; Samantha A. Orr; Robertson
View on Scopus
Safety, pharmacokinetics, and biologic activity of pateclizumab, a novel monoclonal antibody targeting lymphotoxin α: Results of a phase I randomized, placebo-controlled trial
Arthritis Research and Therapy, ISSN: 14786354 14786362
Brinda Emu; Diana Luca; Carolyn Offutt; Jane L. Grogan; Bernadette Rojkovich; Marna Williams; Meina Tao Tang; Jim J. Xiao; June H. Lee; John C. Davis
View on Scopus
Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis
Science, ISSN: 10959203 00368075
Chia-Lin Hsu; Wei Yu Lin; Dhaya Seshasayee; Yunghsiang Chen; Xiao Ding; Zhonghua Lin; Eric Suto; Zhiyu Huang; Wyne P. Lee; Hyunjoo Park; Min Xu; Mei Sun; Linda Rangell; Jeff Lutman; Sheila Ulufatu; Stefanich; Cecile Chalouni; Meredith Sagolla; Laurie Diehl; Fielder; Brian J. Dean; Mercedesz Balazs; Flavius Martin
View on Scopus
Capillary size exclusion chromatography with picogram sensitivity for analysis of monoclonal antibodies purified from harvested cell culture fluid
Journal of Chromatography A, ISSN: 18733778 00219673
Jennifer C. Rea; G. Tony Moreno; Lisa Vampola; Yun Lou; Bjorn Van Haan; Guillaume Tremintin; Laura C. Simmons; Adrian Nava; Yajun Jennifer Wang; Dell Farnan
View on Scopus
The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold
Journal of Molecular Biology, ISSN: 10898638 00222836
Francois Rousseau; Borlan Pan; Wayne J. Fairbrother; J.Fernando Bazan; Andreas Lingel
View on Scopus
Regulation of mitosis and taxane response by Daxx and Rassf1
Oncogene, ISSN: 09509232 14765594
Giovinazzi; Lindsay; Morozov; Escobar-Cabrera; Matthew K. Summers; Han; McIntosh; Ishov
View on Scopus
Rheumatoid arthritis and the incidence of influenza and influenza-related complications: A retrospective cohort study
BMC Musculoskeletal Disorders, ISSN: 14712474
William A. Blumentals; Anna Arreglado; Pavel Napalkov; Stephen Toovey
View on Scopus
An 'all-inclusive' 96-well cytochrome P450 induction method: Measuring enzyme: Activity, mrna levels, protein levels, and cytotoxicity from one well using: Cryopreserved human hepatocytes
Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X 10568719
Jason S Halladay; Susan C. Wong; S. Cyrus Khojasteh; Susan Grepper
View on Scopus
The potential clinical relevance of visible particles in parenteral drugs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Lucette Doessegger; Hanns-Christian Mahler; Piotr Szczesny; Helmut Rockstroh; Georg Kallmeyer; Anja Langenkamp; Joerg Herrmann; Joseph Famulare
View on Scopus
Key findings and clinical implications from the Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Bradley E. Chipps; Robert S. Zeiger; Larry Borish; Sally E. Wenzel; Ashley Yegin; Mary Lou Hayden; Dave P. Miller; Eugene R. Bleecker; F. Estelle R. Simons; Stanley J. Szefler; Weiss; Tmirah Haselkorn
View on Scopus
Mechanisms of acquired resistance to targeted cancer therapies
Future Oncology, ISSN: 17448301 14796694
Lackner; Wilson; Jeffrey Settleman
View on Scopus
Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models
Journal of Pathology, ISSN: 10969896 00223417
Mallika Singh; Suzana Couto; William F. Forrest; Anthony Lima; Jason H. Cheng; Rafael Molina; Jason E. Long; Patricia Hamilton; Angela McNutt; Ian Kasman; Michelle Nannini; Hani Bou-Reslan; Tim C. Cao; Calvin Ho; Kai H. Barck; Richard A. D. Carano; Oded Foreman; Jeffrey Eastham-Anderson; Adrian M. Jubb; Napoleone Ferrara; Leisa Johnson
View on Scopus
The power of FDG PET to detect treatment effects is increased by glucose correction using a Michaelis constant
EJNMMI Research, ISSN: 2191219X
Simon P. Williams; Judith E. Flores; Andreas R. Baudy; Ruediger E. Port; Thomas Bengtsson
View on Scopus
Quantitation of glucose uptake in tumors by dynamic FDG-PET has less glucose bias and lower variability when adjusted for partial saturation of glucose transport
EJNMMI Research, ISSN: 2191219X
Simon P. Williams; Judith E. Flores; Ruediger E. Port; Thomas Bengtsson
View on Scopus
FDG-PET is a good biomarker of both early response and acquired resistance in BRAFV600 mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973
EJNMMI Research, ISSN: 2191219X
Andreas R. Baudy; Taner Dogan; Judith E. Flores; Klaus P. Hoeflich; Fei Su; Nicholas Van Bruggen; Simon P. Williams
View on Scopus
Symptom burden & quality of life among patients receiving second-line treatment of metastatic colorectal cancer
BMC Research Notes, ISSN: 17560500
Mark S. Walker; Elaine B. Yu; Jiandong Kerr; Yeun Mi Yim; Edward J. Stepanski; Lee S. Schwartzberg
View on Scopus
On the accuracy of determination of unbound drug fraction in tissue using diluted tissue homogenate
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
View on Scopus
Phase II study of eribulin mesylate (E7389) in patients with metastatic castration-resistant prostate cancer stratified by prior taxane therapy
Annals of Oncology, ISSN: 15698041 09237534
De Bono; Molife; Guru Sonpavde; Pablo Maroto; Calvo; Cartwright; Loesch; Feit; Asha Das; Zang; Wanders; Agoulnik; Petrylak
View on Scopus
Contribution of a single host genetic locus to mouse adenovirus type 1 infection and encephalitis
mBio, ISSN: 21507511
Tien-Huei Hsu; Irene W. Althaus; Oded Foreman; Katherine R. Spindlera
View on Scopus
Applying Nonexperimental Study Approach to Analyze Historical Batch Data
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Yong Cui; Xiling Song; King Chuang; Minli Xie
View on Scopus
Preclinical molecular imaging of the translocator protein (TSPO) in a metastases model based on breast cancer xenografts propagated in the murine brain
Current Molecular Medicine, ISSN: 18755666 15665240
Shelby K. Wyatt; H. Charles Manning; Mingfeng Bai; Moneeb Ehtesham; Khubaib Y. Mapara; Reid C. Thompson; Darryl J. Bornhop
View on Scopus
Synapses and Alzheimer's disease
Cold Spring Harbor Perspectives in Biology, ISSN: 19430264
Morgan Sheng; Bernardo L Sabatini; Thomas C. Südhof
View on Scopus
Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma
Thorax, ISSN: 14683296 00406376
Claire A. Butler; Stephen McQuaid; Cliff C. Taggart; Sinead Weldon; Richard Carter; Grzegorz Skibinski; Timothy J. Warke; David F. Choy; Lorcan P. McGarvey; Peter Bradding; Joseph R. Arron; Liam G. Heaney
View on Scopus
Phase transformation in thiamine hydrochloride tablets: Influence on tablet microstructure, physical properties, and performance
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Paroma Chakravarty; Raj Suryanarayanan; Ramprakash Govindarajan
View on Scopus
Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C
Gastroenterology, ISSN: 15280012 00165085
Tom W. Chu; Rohit Kulkarni; Edward J. Gane; Stuart K. Roberts; Catherine Stedman; Peter Angus; Brett Ritchie; Xiao-Yu Lu; David Ipe; Uri Lopatin; Søren Germer; Victor A. Iglesias; Robert Elston; Patrick F. Smith; Nancy Shulman
View on Scopus
Escherichia coli Serotype O55:H7 Diversity Supports Parallel Acquisition of Bacteriophage at Shiga Toxin Phage Insertion Sites during evolution of the O157:H7 lineage
Journal of Bacteriology, ISSN: 10985530 00219193
Jennifer L. Kyle; Craig A. Cummings; Craig T. Parker; Beatriz Quiñones; Paolo Vatta; Elizabeth Newton; Steven Huynh; Michelle Swimley; Lovorka Degoricija; Melissa Barker; Samar Fontanoz; Kimberly Nguyen; Ronak Patel; Rixun Fang; Robert Tebbs; Olga Petrauskene; Manohar Furtado; Robert E. Mandrell
View on Scopus
Pooled analysis of cardiac safety in patients with cancer treated with pertuzumab
Annals of Oncology, ISSN: 15698041 09237534
Lenihan; Suter; Melissa Brammer; Neate; Graham Ross; Baselga
View on Scopus
Influenza a virus infection of human primary dendritic cells impairs their ability to cross-present antigen to CD8 T cells
PLoS Pathogens, ISSN: 15537374 15537366
Anna Smed-Sörensen; Cecile Chalouni; Bithi Chatterjee; Lillian Cohn; Peter Blattmann; Norihiro Nakamura; Lélia Delamarre; Ira Mellman
View on Scopus
Viscosity behavior of high-concentration protein mixtures
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
William J. Galush; Lan N. Le; Jamie M. R. Moore
View on Scopus
Transforming the untransformable: Application of direct transformation to manipulate genetically Staphylococcus aureus and Staphylococcus epidermidis
mBio, ISSN: 21507511
Ian R. Monk; Ishita M. Shah; Min Xu; Man-Wah Tan; Timothy J. Foster
View on Scopus
Viscosity behavior of high-concentration monoclonal antibody solutions: Correlation with interaction parameter and electroviscous effects
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Sandeep Yadav; Steven J. Shire; Devendra S. Kalonia
View on Scopus
DEGAS: Sharing and tracking target compound ideas with external collaborators
Journal of Chemical Information and Modeling, ISSN: 15205142 15499596
Man-Ling Lee; Ignacio Aliagas; Jennafer Dotson; Jianwen A. Feng; Alberto Gobbi; Timothy P. Heffron
View on Scopus
Evaluation of the National Heart, Lung, and Blood Institute guidelines impairment domain for classifying asthma control and predicting asthma exacerbations
Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206
Robert S. Zeiger; Ashley Yegin; F. Estelle R. Simons; Tmirah Haselkorn; Lawrence Rasouliyan; Stanley J. Szefler; Bradley E. Chipps
View on Scopus
Signaling: An oxysterol ligand for Smoothened
Nature Chemical Biology, ISSN: 15524469 15524450
Hayley J. Sharpe; Frederic J. De Sauvage
View on Scopus
The Yin and Yang of Immunomodulatory Biologics: Assessing the Delicate Balance between Benefit and Risk
Toxicologic Pathology, ISSN: 15331601 01926233
Dimitry Danilenko; Hong Wang
View on Scopus
Consistency of the novel equations for determination of hepatic clearance and drug time course in liver that account for the difference in drug ionization in extracellular and intracellular tissue water
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy; Ning Liu; Jason S Halladay
View on Scopus
Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization
Nature Chemical Biology, ISSN: 15524469 15524450
Karen Stanger; Micah Steffek; Lijuan Zhou; Christine D. Pozniak; Quan; Yvonne Franke; Jeffrey Tom; Christine Tam; J. Michael Elliott; Joe Lewcock; Yingnan Zhang; Jeremy Murray; Rami N. Hannoush
View on Scopus
Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney
Toxicological Sciences, ISSN: 10960929 10966080
Dolores Diaz; Krishna P. Allamneni; Jacqueline M. Tarrant; Sock-Cheng Lewin-Koh; Rama Pai; Preeti Dhawan; Cain; Cleopatra Kozlowski; Hajime Hiraragi; Nghi La; Dylan P. Hartley; Xiao Ding; Brian J. Dean; Sheila Bheddah; Donna M. Dambach
View on Scopus
Virologic escape during danoprevir (ITMN-191/RG7227) monotherapy is hepatitis C virus subtype dependent and associated with R155K substitution
Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596
Sharlene R. Lim; Xiaoli Qin; Simone Susser; John B. Nicholas; Christian Lange; Eva Herrmann; Jin Hong; Ann Elizabeth Arfsten; Lisa Hooi; Williamson Bradford; Nájera; Patrick F. Smith; Stefan Zeuzem; Karl Kossen; Christophe Sarrazin; Scott D. Seiwert
View on Scopus
Stability of IgG1 monoclonal antibodies in intravenous infusion bags under clinical in-use conditions
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Alavattam Sreedhara; Zephania Kwong Glover; Nicole Piros; Nina Xiao; Ankit Patel; Bruce Kabakoff
View on Scopus
Culture temperature modulates aggregation of recombinant antibody in cho cells
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Natalia Gomez; Jayashree Subramanian; Jun Ouyang; Mary D. H. Nguyen; Matthew Hutchinson; Vikas Sharma; Andy Lin; Inn H. Yuk
View on Scopus
Interdependence of drug substance physical properties and corresponding quality control strategy
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Yong Cui; Xiling Song; Mark E. Reynolds; King Chuang; Minli Xie
View on Scopus
The Role of Pharmaceutical Medical Information in Promotional Review: Three Benchmarking Surveys
Drug Information Journal, ISSN: 00928615
Lisa Bonk; Madhuri Kothari; Alyson Sous Andrikanich; Ellen Yang
View on Scopus
Intermittent administration of MEK inhibitor GDC-0973 plus pi3k inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition
Cancer Research, ISSN: 00085472 15387445
Klaus P. Hoeflich; Mark Merchant; Christine Orr; Jocelyn Chan; Doug Den Otter; Berry; Ian Kasman; Koeppen; Ken Rice; Nai-Ying Yang; Stefan Engst; Stuart H. Johnston; Lori S. Friedman; Marcia Belvin
View on Scopus
Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Aarti Shikotra; David F. Choy; Chandra M. Ohri; Emma Doran; Claire A. Butler; Beverley Hargadon; Maria Shelley; Abbas Alexander; Cary D. Austin; Janet Jackman; Lawren C. Wu; Liam G. Heaney; Joseph R. Arron; Peter Bradding
View on Scopus
Impact of baseline virologic, immunologic, and demographic characteristics on virologic responses in the Gemini study
HIV Clinical Trials, ISSN: 15284336 19455771
Anchalee Avihingsanon; Kiat Ruxrungtham; Harold Katner; Carol Jean Guittari; Sharon Walmsley
View on Scopus
Severity of asthma score predicts clinical outcomes in patients with moderate to severe persistent asthma
Chest, ISSN: 19313543 00123692
Mark D. Eisner; Ashley Yegin; Benjamin L. Trzaskoma
View on Scopus
© 2025 Genentech, Inc. All rights reserved. This site is intended for US residents only.