Genentech: Publications

January 1, 2012

Monitoring phosphoproteomic response to targeted kinase inhibitors using reverse-phase protein microarrays

Methods in Molecular Biology, ISSN: 10643745

Gabriela Lavezzari; Lackner

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January 1, 2012

The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether

Protein Science, ISSN: 09618368 1469896X

Ping Liu; Samuel Bouyain; Eigenbrot; Daniel J. Leahy

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January 1, 2012

Profiling cellular myristoylation and palmitoylation using ω-alkynyl fatty acids

Methods in Molecular Biology, ISSN: 10643745

Rami N. Hannoush

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January 1, 2012

Costs and clinical outcomes among patients with second-line non-small cell lung cancer in the outpatient community setting

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Eric Nadler; Michael Forsyth; Sacha Satram-Hoang; Carolina Reyes

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January 1, 2012

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Jun Luo; Natarajan Vijayasankaran; Jennifer Autsen; Rodell Santuray; Terry Hudson; Ashraf Amanullah; Feng Li

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January 1, 2012

The authors' reply

American Journal of Clinical Pathology, ISSN: 00029173 19437722

Mark H. Stoler; Teresa L. Wright

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January 1, 2012

Internet and print resources to facilitate pathology analysis when phenotyping genetically engineered rodents

Veterinary Pathology, ISSN: 03009858 15442217

Brad Bolon; Suzana Couto; Laurence Fiette; la Perle

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January 1, 2012

An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription

Nucleic Acids Research, ISSN: 03051048 13624962

Emily C. Knouf; Kavita Garg; Jason D. Arroyo; Yesenia Correa; Deepayan Sarkar; Rachael K. Parkin; Kaitlyn Wurz; Kathy C. O'Briant; Andrew K. Godwin; Nicole D. Urban; Walter L. Ruzzo; Robert Gentleman; Charles W. Drescher; Elizabeth M. Swisher; Muneesh Tewari

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January 1, 2012

High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency

PLoS Genetics, ISSN: 15537390 15537404

Ricardo C. Ferreira; Qiang Pan-Hammarström; Robert R. Graham; Gumersindo Fontán; Annette T. Lee; Ward Ortmann; Ning Wang; Elena Urcelay; Miguel Fernández-Arquero; Concepción Núñez; Gudmundur Jorgensen; Björn R. Ludviksson; Sinikka Koskinen; Katri Haimila; Leonid Padyukov; Peter K. Gregersen; Lennart Hammarström; Timothy W. Behrens

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January 1, 2012

Neuropilin-1 expression in cancer and development

Journal of Pathology, ISSN: 00223417 10969896

Adrian M. Jubb; Laura A. Strickland; Scot D. Liu; Judy Mak; Maike Schmidt; Koeppen

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January 1, 2012

Differentiation programs in development and cancer

Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing,

Hosein Kouros-Mehr

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January 1, 2012

Tenecteplase for the improvement of blood flow rate in dysfunctional hemodialysis catheters

Clinical Nephrology, ISSN: 03010430

Jesse Goldman; Steven Fishbane; Matthew J. Oliver; Martha Blaney; Joan R. Jacobs; Susan M. Begelman

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January 1, 2012

Erratum: Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres (Bioorganic and Medicinal Chemistry Letters (2010) 20 (2229-2233))

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Frederick Cohen; Michael F. T. Koehler; Philippe Bergeron; Linda O. Elliott; Flygare; Matthew C Franklin; Lewis Gazzard; Stephen F. Keteltas; Kevin Lau; Cuong Q. Ly; Vickie Tsui; Wayne J. Fairbrother

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January 1, 2012

Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials

Pancreatology, ISSN: 14243911 14243903

Rebecca J. Brais; Susan E. Davies; Maria O'Donovan; Ben W. Simpson; Natalie Cook; Darbonne; Sian Chilcott; Martijn P. Lolkema; Albrecht Neesse; Michelle Lockley; Pippa G. Corrie; Duncan I. Jodrell; Raaj K. Praseedom; Emmanuel L. Huguet; Asif Jah; Neville V. Jamieson; Frederic J. De Sauvage; David Tuveson; Nicholas R. Carroll

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January 1, 2012

Dectin-1-dependent interleukin-22 contributes to early innate lung defense against aspergillus fumigatus

Infection and Immunity, ISSN: 00199567 10985522

Melissa A. Gessner; Jessica L. Werner; Lauren M. Lilly; Michael P. Nelson; Allison E. Metz; Chad W. Dunaway; Yvonne R. Chan; Wenjun Ouyang; Gordon D. Brown; Casey T. Weaver; Chad Steele

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January 1, 2012

Evaluating the minimally important difference of the urticaria activity score and other measures of disease activity in patients with chronic idiopathic urticaria

Annals of Allergy, Asthma and Immunology, ISSN: 10811206 15344436

Susan D. Mathias; Ross D. Crosby; James L. Zazzali; Marcus Maurer; Sarbjit S. Saini

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January 1, 2012

Treatment of HER2-positive breast cancer: Current status and future perspectives

Nature Reviews Clinical Oncology, ISSN: 17594774 17594782

Carlos L. Arteaga; Mark X. Sliwkowski; C.Kent Osborne; Edith A. Perez; Fabio Puglisi; Luca Gianni

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January 1, 2012

Assessing and improving asymmetric flow field-flow fractionation of therapeutic proteins

Field-Flow Fractionation in Biopolymer Analysis,

Jun Liu; Qing Zhu; Steven J. Shire; Barthélemy Demeule

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January 1, 2012

Editorial

Contemporary Clinical Trials, ISSN: 15517144 15592030

Zheng Su

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January 1, 2012

Hybridization of conditional and predictive power for futility assessment in sequential clinical trials with time-to-event outcomes: A resampling approach

Contemporary Clinical Trials, ISSN: 15517144 15592030

Jing Yi; Liang Fang; Zheng Su

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January 1, 2012

BEAM: A randomized phase II study evaluating the activity of bevacizumab in combination with carboplatin plus paclitaxel in patients with previously untreated advanced melanoma

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Kevin B. Kim; Jeffrey A. Sosman; John P. Fruehauf; Gerald Linette; Svetomir N. Markovic; David McDermott; Jeffrey S. Weber; Hoa Nguyen; Peter Cheverton; Daniel S. Chen; Amy Peterson; William E. Carson III; Steven J. O'Day

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January 1, 2012

Thioredoxin 1 is responsible for antibody disulfide reduction in CHO cell culture

Journal of Biotechnology, ISSN: 01681656 18734863

Kristen L. Koterba; Trissa Borgschulte; Mike Laird

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January 1, 2012

3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymerase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Dange V. Kumar; Roopa Rai; Ken A. Brameld; Jennifer Riggs; John R. Somoza; Ravi Rajagopalan; James W. Janc; Yu M. Xia; Tony L. Ton; Huiyong Hu; Isabelle Lehoux; Joseph D. Ho; Wendy B. Young; Barry Hart; Michael J. Green

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January 1, 2012

Carbon-deuterium rotational-echo double-resonance NMR spectroscopy of lyophilized aspartame formulations

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Suman A. Luthra; Marcel Utz; Eric M. Gorman; Michael J. Pikal; Eric Munson; Joseph W. Lubach

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January 1, 2012

Characterization of the isomerization products of aspartate residues at two different sites in a monoclonal antibody

Pharmaceutical Research, ISSN: 07248741 1573904X

Alavattam Sreedhara; Cordoba; Qing Zhu; Jeanne Kwong; Jun Liu

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January 1, 2012

Effect of sulfobutyl ether beta-cyclodextrin modifier on selectivity of reversed phase hplc separations

Journal of Liquid Chromatography and Related Technologies, ISSN: 10826076 1520572X

Kenley K. Ngim; Qiqing Zhong; Kavita Mistry; Nik P. Chetwyn

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January 1, 2012

Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice

mAbs, ISSN: 19420862 19420870

Rong Deng; Meng; Kwame Hoyte; Jeff Lutman; Yanmei Lu; Suhasini Iyer; Laura DeForge; Frank-Peter Theil; Fielder; Saileta Prabhu

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January 1, 2012

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

mAbs, ISSN: 19420870 19420862

Zheng; Devin B. Tesar; Lisa Benincosa; Herbert F. Birnböck; C. Andrew Boswell; Daniela Bumbaca; Kyra J. Cowan; Dimitry Danilenko; Daugherty; Fielder; Hans Peter Grimm; Amita Joshi; Nicole Justies; Gerry Kolaitis; Nicholas Lewin-Koh; Jing Li; Sami McVay; Jennifer O'Mahony; Michael Otteneder; Michael P. Pantze; Wendy Putnam; Zhihua Julia Qiu; Jane Ruppel; Thomas Singer; Oliver B. Stauch; Frank-Peter Theil; Jennifer Visich; Yang; Yong Ying; Leslie A. Khawli; Wolfgang F. Richter

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January 1, 2012

Transferrin antibodies into the brain

Neuropsychopharmacology, ISSN: 0893133X 1740634X

Dennis; Ryan J. Watts

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January 1, 2012

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

Nature Cell Biology, ISSN: 14657392 14764679

Ben Chih; Peter S. Liu; Yvonne Chinn; Cecile Chalouni; László Kömüves; Hass; Wendy N. Sandoval; Andrew S. Peterson

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January 1, 2012

In vitro-in vivo extrapolation of clearance: Modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing calculation methods

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Patrick Poulin; Jane R. Kenny; Cornelis E. Hop; Sami Haddad

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January 1, 2012

Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

David F. Choy; Daniel K. Hsu; Dhaya Seshasayee; Maxwell A. Fung; Zora Modrusan; Flavius Martin; Fu-Tong Liu; Joseph R. Arron

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January 1, 2012

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.

Science Translational Medicine, ISSN: 19466242

Zejuan Sheng; Shuo Zhang; Daisy J. Bustos; Tracy L. Kleinheinz; Claire E. Le Pichon; Sara L. Dominguez; Hilda Solanoy; Jason H. Drummond; Xiaolin Zhang; Xiao Ding; Fang Cai; Qinghua Song; Xianting Li; Zhenyu Yue; Marcel P Van Der Brug; Burdick; Janet Gunzner; Huifen Chen; Xingrong Liu; Anthony A. Estrada; Zachary K. Sweeney; Kimberly Scearce-Levie; John Moffat; Donald S. Kirkpatrick; Haitao Zhu

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January 1, 2012

Targeting a cystic fibrosis mutation opens door for personalized treatment.

Managed Care, ISSN: 10623388

Thomas Morrow

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January 1, 2012

Influence of the compound selection process on the performance of human clearance prediction methods

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Harvey Wong; Sock-Cheng Lewin-Koh; Frank-Peter Theil; Cornelis E. Hop

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January 1, 2012

A very short history of structure-based design: How did we get here and where do we need to go?

Journal of Computer-Aided Molecular Design, ISSN: 0920654X 15734951

Jeff Blaney

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January 1, 2012

Pioneers of oncology nursing.

ONS connect, ISSN: 19351623

Bertie Ford

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January 1, 2012

A very short history of structure-based design: How did we get here and where do we need to go?

Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X

Jeff Blaney

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January 1, 2012

Evaluation of time-dependent cytochrome P450 inhibition in a high-throughput, automated assay: Introducing a novel area under the curve shift approach

Drug Metabolism Letters, ISSN: 18723128

Sophie Mukadam; Suzanne Tay; Daniel Tran; Leslie Wang; Erlie Marie Delarosa; S. Cyrus Khojasteh; Jason S Halladay; Jane R. Kenny

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January 1, 2012

Phase i clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma

Investigational New Drugs, ISSN: 15730646 01676997

Jason Konner; Rachel N. Grisham; Jae Park; Owen A. O'Connor; Gillian Cropp; Robert Johnson; Alison L. Hannah; Martee L. Hensley; Paul Sabbatini; Svetlana Miranov; Samuel Danishefsky; David Hyman; David R. Spriggs; Jakob Dupont; Carol Aghajanian

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January 1, 2012

Investigating high-concentration monoclonal antibody powder suspension in nonaqueous suspension vehicles for subcutaneous injection

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Mayumi Bowen; Nick Armstrong; Maa

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January 1, 2012

Variable selection in multivariate modeling of drug product formula and manufacturing process

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Yong Cui; Xiling Song; King Chuang; Venkatramani; Sueanne Lee; Gregory Gallegos; Thirunellai Venkateshwaran; Minli Xie

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January 1, 2012

Conceptual underestimation of the total body clearance by the sum of clearances of individual organs in physiologically based pharmacokinetics

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

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January 1, 2012

Erratum:Ungersma et al., vessel imaging with viable tumor analysis for quantification of tumor angiogenesis.(Magnetic Resonance in Medicine 2010 63 (1637-1647))

Magnetic Resonance in Medicine, ISSN: 15222594 07403194

Sharon E. Ungersma; Glenn Pacheco; Calvin Ho; Sharon Fong Yee; Ross; Nicholas Van Bruggen; Franklin V. Peale Jr.; Ross; Richard A. D. Carano

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January 1, 2012

Bevacizumab maintenance in patients with advanced non-small-cell lung cancer, clinical patterns, and outcomes in the eastern cooperative oncology group 4599 study: Results of an exploratory analysis

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Ariel Lopez-Chavez; Todd Young; Sophie Fages; Larry Leon; Joan H. Schiller; Afshin Dowlati; Julie Brahmer; David H. Johnson; Alan Sandler

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January 1, 2012

Comparative assessment of In Vitro-In Vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Patrick Poulin; Cornelis E. Hop; Quynh Ho; Jason S Halladay; Sami Haddad; Jane R. Kenny

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January 1, 2012

Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Ozan S. Kumru; Jun Liu; Junyan A. Ji; Wilson Cheng; Y. John Wang; Tingting Wang; Sangeeta B. Joshi; C. Russell Middaugh; David B. Volkin

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January 1, 2012

A phase i study of erlotinib and hydroxychloroquine in advanced non-small-cell lung cancer

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Sarah B. Goldberg; Jeffrey G. Supko; Joel W. Neal; Alona Muzikansky; Subba Digumarthy; Panos Fidias; Jennifer S. Temel; Rebecca S. Heist; Alice T. Shaw; Patricia O. McCarthy; Thomas J. Lynch; Sreenath Sharma; Jeffrey Settleman; Lecia V. Sequist

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January 1, 2012

Determination of hepatic clearance with the account of drug-protein binding kinetics

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

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January 1, 2012

Effects of commercial air travel on patients with pulmonary hypertension

Chest, ISSN: 19313543 00123692

Nareg Roubinian; C. Gregory Elliott; Christopher F. Barnett; Paul D. Blanc; Joan Chen; Teresa De Marco; Hubert Chen

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