Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8301 - 8350 OF 15613 RESULTS

October 24, 2011

The BOLD effect

Methods in Molecular Biology, ISSN: 10643745

Joan M. Greve

October 21, 2011

Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination

Science, ISSN: 10959203 00368075

Erin C. Dueber; Allyn J. Schoeffler; Andreas Lingel; J. Michael Elliott; Anna V. Fedorova; Anthony M. Giannetti; Zobel; Brigitte Maurer; Eugene Varfolomeev; Ping Wu; Heidi J. A. Wallweber; Sarah G. Hymowitz; Deshayes; Domagoj Vucic; Wayne J. Fairbrother

October 20, 2011

Impaired FcεRI stability, signaling, and effector functions in murine mast cells lacking glycosylphosphatidylinositol-anchored proteins

Blood, ISSN: 15280020 00064971

Wouter L. W. Hazenbos; Ping Wu; Jeffrey Eastham-Anderson; Taroh Kinoshita; Eric J. Brown

October 20, 2011

Neural-specific elongation of 3′ UTRs during Drosophila development

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Valérie Hilgers; Michael W. Perry; David Hendrix; Alexander Stark; Michael Levine; Benjamin Haley

October 19, 2011

Impact of drug conjugation on pharmacokinetics and tissue distribution of Anti-STEAP1 antibody-drug conjugates in rats

Bioconjugate Chemistry, ISSN: 15204812 10431802

C. Andrew Boswell; Eduardo E. Mundo; Crystal Zhang; Daniela Bumbaca; Nicole R. Valle; Katherine R. Kozak; Aimee Fourie-O'Donohue; Josefa Chuh; Neelima Koppada; Ola M. Saad; Herman S. Gill; Shen; Bonnee Rubinfeld; Jay Tibbitts; Surinder Kaur; Frank-Peter Theil; Fielder; Leslie A. Khawli; Kedan Lin

October 18, 2011

Developmental and pathological angiogenesis

Annual review of cell and developmental biology, ISSN: 10810706 15308995

Alicia S Chung; Napoleone Ferrara

October 18, 2011

SpeCond: A method to detect condition-specific gene expression

Genome Biology, ISSN: 14747596 1474760X

Florence M.G. Cavalli; Richard Bourgon; Wolfgang Huber; Juan M. Vaquerizas; Nicholas M. Luscombe

October 18, 2011

Progranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteins

PLoS ONE, ISSN: 19326203

Sandra Almeida; Lijuan Zhou; Fen-Biao Gao

October 17, 2011

Revealing a positive charge patch on a recombinant monoclonal antibody by chemical labeling and mass spectrometry

Analytical Chemistry, ISSN: 00032700

Liangyi Zhang; Wayne G. Lilyestrom; Charlene Li; Thomas M. Scherer; Robert Van Reis; Boyan Zhang

October 17, 2011

Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: Evidence for ipso glutathione addition

Chemical Research in Toxicology, ISSN: 0893228X 15205010

Chenghong Zhang; Jane R. Kenny; Hoa Le; Alan Deese; Kevin A. Ford; Luke K. Lightning; Peter W. Fan; James Driscoll; Jason S Halladay; Cornelis E. Hop; S. Cyrus Khojasteh

October 15, 2011

Trastuzumab emtansine: A unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer

Clinical Cancer Research, ISSN: 10780432 15573265

Patricia M. LoRusso; Denise Weiss; Ellie Guardino; Sandhya Girish; Mark X. Sliwkowski

October 14, 2011

SnapShot: Caspases

Cell, ISSN: 10974172 00928674

Guy S. Salvesen; Avi Ashkenazi

October 13, 2011

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

Nature, ISSN: 00280836 14764687

Hua Tian; Brian Biehs; Søren Warming; Kevin G. Leong; Linda Rangell; Ophir D. Klein; Frederic J. De Sauvage

October 12, 2011

Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q

PLoS ONE, ISSN: 19326203

Svetlana Pidasheva; Sara Trifari; Anne Phillips; Jason A. Hackney; Ma; Ashley Smith; Sue J. Sohn; Hergen Spits; Randall D. Little; Timothy W. Behrens; Lee Honigberg; Nico Ghilardi; Hilary F. Clark

October 12, 2011

Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6

Structure, ISSN: 09692126 18784186

Eric Bourhis; Weiru Wang; Christine Tam; Jiyoung Hwang; Yingnan Zhang; Didier Spittler; Oscar W Huang; Yan Gong; Alberto Estevez; Inna Zilberleyb; Lionel Rouge; Cecilia Chiu; Yan Wu; Michael Costa; Rami N. Hannoush; Yvonne Franke; Andrea G Cochran

October 3, 2011

Accelerating drug discovery for Alzheimer's disease: Best practices for preclinical animal studies

Alzheimer's Research and Therapy, ISSN: 17589193

Diana W Shineman; Guriqbal S Basi; Jennifer L Bizon; Carol A Colton; Barry D Greenberg; Beth A Hollister; John Lincecum; Gabrielle G Leblanc; Linda H. Lee; Feng Luo; Dave Morgan; Iva Morse; Lorenzo M Refolo; David R Riddell; Kimberly Scearce-Levie; Patrick Sweeney; Juha Yrjänheikki; Howard Fillit

October 1, 2011

Peptoids: Synthesis, characterization, and nanostructures

Comprehensive Biomaterials,

Seo; Lee; Zuckermann

October 1, 2011

Inferring disease and gene set associations with rank coherence in networks

Bioinformatics, ISSN: 13674803 14602059

Tae Hyun Hwang; Wei Zhang; Maoqiang Xie; Jinfeng Liu; Rui Kuang

October 1, 2011

An observational study to validate the Satisfaction Measure of the Injection of Growth Hormone Therapy (SMIGHTy) questionnaire

Current Medical Research and Opinion, ISSN: 03007995 14734877

Rubin; Peyrot; Catherine P. Metzinger; Yaping Xu; Barbara M. Lippe; Leah McCormack; Daniel Aaron Davis

October 1, 2011

The Ect2 Rho Guanine Nucleotide Exchange Factor Is Essential for Early Mouse Development and Normal Cell Cytokinesis and Migration

Genes and Cancer, ISSN: 19476019 19476027

Danielle R. Cook; Patricia A. Solski; Scott J. Bultman; Gunther Kauselmann; Michael Schoor; Ralf Kuehn; Lori S. Friedman; Dale O. Cowley; Terry van Dyke; Jen Jen Yeh; Leisa Johnson; Channing J. Der

October 1, 2011

Mutator suppression and escape from replication error-induced extinction in yeast

PLoS Genetics, ISSN: 15537390 15537404

Alan J. Herr; Masanori Ogawa; Nicole A. Lawrence; Lindsey N. Williams; Julie M. Eggington; Mallika Singh; Robert A. Smith; Bradley D. Preston

October 1, 2011

High-pressure refolding of human vascular endothelial growth factor (VEGF) recombinantly expressed in bacterial inclusion bodies: Refolding optimization, and feasibility assessment

Biotechnology Progress, ISSN: 87567938 15206033

Amber Cothran; Rick St. John; Charles H. Schmelzer; Shelly A. Pizarro

October 1, 2011

The two-component sensor kinase KdpD is required for Salmonella typhimurium colonization of Caenorhabditis elegans and survival in macrophages

Cellular Microbiology, ISSN: 14625814 14625822

Rosanna A. Alegado; Chui-Yoke Chin; Denise M. Monack; Man-Wah Tan

October 1, 2011

IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium

Nature Immunology, ISSN: 15292908 15292916

Naruhisa Ota; Kit Wong; Patricia A. Valdez; Yan Zheng; Natasha K Crellin; Laurie Diehl; Wenjun Ouyang

October 1, 2011

Potential errors in the volume of distribution estimation of therapeutic proteins composed of differently cleared components

Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 1567567X 15738744

Wolfgang F. Richter; Hans Peter Grimm; Frank-Peter Theil

October 1, 2011

Site-specific tryptophan oxidation induced by autocatalytic reaction of polysorbate 20 in protein formulation

Pharmaceutical Research, ISSN: 07248741 1573904X

Lam; William G. Lai; Edwin K. Chan; Victor Ling; Chung C. Hsu

October 1, 2011

Effects of cell culture conditions on antibody N-linked glycosylation-what affects high mannose 5 glycoform

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Efren Pacis; Marcella Yu; Jennifer Autsen; Robert Bayer; Feng Li

October 1, 2011

Evaluation of dried blood spot sampling following cassette dosing in drug discovery

Bioanalysis, ISSN: 17576180 17576199

Xiaorong Liang; Lulu Yang; Leonid M. Berezhkovskiy; Bianca M. Liederer; Trung Nguyen; Wei Jia; Michelle G. Schweiger; Brian J. Dean; Yuzhong Deng

October 1, 2011

Intracranial hypertension in pediatric patients treated with recombinant human growth hormone: Data from 25 years of the genentech National Cooperative Growth Study

Journal of Pediatric Endocrinology and Metabolism, ISSN: 0334018X 21910251

Richard Noto; Thomas J. Maneatis; James W. Frane; Kimberly Alexander; Barbara M. Lippe; Daniel A. Davis

October 1, 2011

Sustained benefits from ranibizumab for macular edema following central retinal vein occlusion: Twelve-month outcomes of a phase III study

Ophthalmology, ISSN: 01616420 15494713

Peter A. Campochiaro; David M. Brown; Carl C. Awh; S. Young Lee; Sarah Gray; Namrata Saroj; Wendy Yee Murahashi; Roman G. Rubio

October 1, 2011

Healthcare costs associated with bevacizumab and cetuximab in second-line treatment of metastatic colorectal cancer

Journal of Medical Economics, ISSN: 13696998 1941837X

Hongbo Yang; Andrew P. Yu; Eric Q. Wu; Yeun Mi Yim; Elaine B. Yu

October 1, 2011

Erratum: A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal Fc receptor (FcRn) (Annals of Biomedical Engineering (2005) 33:11 (1640-1652) DOI: 10.1007/s10439-005-7410-3)

Annals of Biomedical Engineering, ISSN: 00906964 15739686

Gregory Z. Ferl; Anna H. Wu; Joseph J. Distefano III

October 1, 2011

Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Lichuan Liu; Jason S Halladay; Young G. Shin; Susan C. Wong; Melis Coraggio; Hank La; Matthew Baumgardner; Hoa Le; Sashi Gopaul; Jason Boggs; Peter Kuebler; John C. Davis; X. Charlene Liao; Joseph W. Lubach; Alan Deese; C. Gregory Sowell; Kevin S. Currie; Wendy B. Young; S. Cyrus Khojasteh; Cornelis E. Hop; Harvey Wong

October 1, 2011

Gut-derived factors promote neurogenesis of CNS-neural stem cells and nudge their differentiation to an enteric-like neuronal phenotype

American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN: 01931857 15221547

Subhash Kulkarni; Bende Zou; Jesse E. Hanson; Maria-Adelaide Micci; Gunjan Tiwari; Laren Becker; Martin Kaiser; Xinmin Xie; Pankaj Jay Pasricha

October 1, 2011

Overcoming challenges in WAVE bioreactors without feedback controls for pH and dissolved oxygen

Biotechnology Progress, ISSN: 87567938 15206033

Inn H. Yuk; Dinesh Baskar; Philip H. Duffy; Jenny Hsiung; Susan Leung; Andy Lin

October 1, 2011

Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model

American Journal of Pathology, ISSN: 00029440 15252191

Abbas Alexander; Janet Jackman; Sherron L. Bullens; Sarah M. Davis; David F. Choy; Grazyna Fedorowicz; Martha Tan; Bao-Tran Truong; Meng; Laurie Diehl; Lisa A. Miller; Edward S. Schelegle; Dallas M. Hyde; Hilary F. Clark; Zora Modrusan; Joseph R. Arron; Lawren C. Wu

October 1, 2011

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus

PLoS Genetics, ISSN: 15537390 15537404

Deborah S. Cunninghame Graham; David L. Morris; Tushar Bhangale; Lindsey A. Criswell; Ann-Christine Syvänen; Lars Rönnblom; Timothy W. Behrens; Robert R. Graham; Timothy J. Vyse

October 1, 2011

Regulation of interleukin-10 and interleukin-22 expression in T helper cells

Current Opinion in Immunology, ISSN: 09527915 18790372

Sascha Rutz; Wenjun Ouyang

October 1, 2011

Detection and identification of a serine to arginine sequence variant in a therapeutic monoclonal antibody

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232 1873376X

Diya Ren; Jian Zhang; Ross Pritchett; Hongbin Liu; Jennifer Kyauk; Jun Luo; Ashraf Amanullah

October 1, 2011

Introductory perspective

Seminars in Immunology, ISSN: 10445323 10963618

Harinder Singh

October 1, 2011

Development of tools and processes to improve treatment times in patients with febrile neutropenia

Clinical journal of oncology nursing, ISSN: 10921095 1538067X

Erika L. Hawley; Molly Loney; Michelle Wiece

October 1, 2011

An observational study to validate the Satisfaction Measure of the Injection of Growth Hormone Therapy (SMIGHTy) questionnaire

Current Medical Research and Opinion, ISSN: 03007995 14734877

Richard R. Rubin; Peyrot; Catherine P. Metzinger; Yaping Xu; Barbara M. Lippe; Leah McCormack; Daniel Aaron Davis

September 30, 2011

Regioselective synthesis of β-iodo-enamides and β-yn-enamides

Tetrahedron, ISSN: 00404020 14645416

Adele E. Pasqua; Lynne H. Thomas; James J. Crawford; Rodolfo Marquez

September 28, 2011

Exploration of overloaded cation exchange chromatography for monoclonal antibody purification

Journal of Chromatography A, ISSN: 00219673 18733778

Hui F. Liu; Beth McCooey; Tiago Duarte; Deanna E. Myers; Terry Hudson; Ashraf Amanullah; Robert Van Reis; Kelley

September 23, 2011

Immunoglobulin E receptor signaling and asthma

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Lawren C. Wu

September 22, 2011

Lebrikizumab treatment in adults with asthma

New England Journal of Medicine, ISSN: 15334406 00284793

Jonathan Corren; Robert F. Lemanske Jr.; Nicola A. Hanania; Phillip Korenblat; Merdad V. Parsey; Joseph R. Arron; Harris; Heleen Scheerens; Lawren C. Wu; Zheng Su; Mosesova; Mark D. Eisner; Sean P. Bohen; Matthews

September 21, 2011

A plasmablast biomarker for nonresponse to antibody therapy to CD20 in rheumatoid arthritis

Science Translational Medicine, ISSN: 19466234 19466242

Kasia Owczarczyk; Preeti Lal; Abbas Alexander; Kristen Wolslegel; Cécile T.J. Holweg; Wolfgang Dummer; Ariella Kelman; Paul Brunetta; Nicholas Lewin-Koh; Marco Sorani; Diane Leong; Fielder; David E. Yocum; Carole Ho; Ward Ortmann; Michael J. Townsend; Timothy W. Behrens

September 21, 2011

Patterns of biologic agent utilization among patients with rheumatoid arthritis: A retrospective cohort study

BMC Musculoskeletal Disorders, ISSN: 14712474

Sarika Ogale; Hitraya; Henry J. Henk

September 19, 2011

High-throughput, 384-well, LC-MS/MS CYP inhibition assay using automation, cassette-analysis technique and streamlined data analysis

Drug Metabolism Letters, ISSN: 18723128

Jason S Halladay; Erlie Marie Delarosa; Daniel Tran; Leslie Wang; Susan C. Wong; S. Cyrus Khojasteh

September 16, 2011

Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Amitabha Chaudhuri; Xie; Becky Yang; Kaushiki Mahapatra; Jinfeng Liu; Scot A. Marsters; Sweta Bodepudi; Avi Ashkenazi

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