Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8351 - 8400 OF 15613 RESULTS

USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma
Cell, ISSN: 10974172 00928674
Samuel A. Williams; Heather Maecker; French; Jinfeng Liu; Andrew Gregg; Leah B. Silverstein; Tim C. Cao; Richard A. D. Carano; Vishva M. Dixit
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Pyrazolopyridine inhibitors of B-Raf V600E. Part 2: Structure-activity relationships
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Steve Wenglowsky; Kateri Ahrendt; Alexandre J. Buckmelter; Bainian Feng; Susan L. Gloor; Stefan Gradl; Jonas Grina; Joshua D. Hansen; Ellen R. Laird; Paul Lunghofer; Simon Mathieu; David Moreno; Bradley J. Newhouse; Li Ren; Tyler Risom; Joachim Rudolph; Jeongbeob Seo; Hillary L. Sturgis; Walter C. Voegtli; Zhaoyang Wen
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A simple assay for 3-deoxy-D-manno-octulosonate cytidylyltransferase and its use as a pathway screen
Analytical Biochemistry, ISSN: 10960309 00032697
Li Yi; Melvin S. Velasquez; Tod P. Holler; Ronald W. Woodard
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The tumor suppressor tuberin regulates mitotic onset through the cellular localization of cyclin B1
Cell Cycle, ISSN: 15514005 15384101
Elizabeth Fidalgo Da Silva; Shora B. Ansari; Jiamila Maimaiti; Elizabeth A. Barnes; Monica Kong-Beltran; Daniel J. Donoghue; Lisa A. Porter
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Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration
Human Molecular Genetics, ISSN: 14602083 09646906
Yi Yu; Tushar Bhangale; Jesen Fagerness; Stephan Ripke; Gudmar Thorleifsson; Perciliz L. Tan; Eric H. Souied; Andrea J. Richardson; Joanna E. Merriam; Gabriëlle H.S. Buitendijk; Robyn Reynolds; Soumya Raychaudhuri; Kimberly A. Chin; Lucia Sobrin; Evangelos Evangelou; Phil H Lee; Aaron Y. Lee; Nicolas Leveziel; Donald J. Zack; Betsy Campochiaro; Peter A. Campochiaro; R. Theodore Smith; Gaetano R. Barile; Robyn H. Guymer; Ruth E. Hogg; Usha Chakravarthy; Luba D. Robman; Omar Gustafsson; Haraldur Sigurdsson; Ward Ortmann; Timothy W. Behrens; Kari Stefansson; André G. Uitterlinden; Cornelia M. Van Duijn; Johannes R. Vingerling; Caroline C.W. Klaver; Rando Allikmets; Milam A. Brantley Jr.; Paul N. Baird; Nicholas Katsanis; Unnur Thorsteinsdottir; John P.A. Ioannidis; Mark J. Daly; Robert R. Graham; Johanna M. Seddon
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Access to saturated fused pyrimidine derivatives via a flexible N -vinyl tertiary enamide synthesis
Synlett, ISSN: 09365214 14372096
Anthony A. Estrada; Joseph P. Lyssikatos; Frederic St-Jean; Philippe Bergeron
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Phage display of tissue inhibitor of metalloproteinases-2 (TIMP-2): Identification of selective inhibitors of collagenase-1 (metalloproteinase 1 (MMP-1))
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Harinath Bahudhanapati; Yingnan Zhang; Sachdev S. Sidhu; Keith Brew
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Purification Process Design and the Influence of Product and Technology Platforms
Comprehensive Biotechnology, Second Edition,
Chris Dowd; Kelley
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Disposable Bioreactors
Comprehensive Biotechnology, Second Edition,
Oosterhuis; Terry Hudson; D'Avino; Zijlstra; Ashraf Amanullah
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Process Validation
Comprehensive Biotechnology, Second Edition,
David H. Reifsnyder; Nathan McKnight; Kelley
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DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity
Journal of Cell Biology, ISSN: 00219525 15408140
Arundhati Sengupta Ghosh; Bei Wang; Christine D. Pozniak; Mark Chen; Ryan J. Watts; Joe Lewcock
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The interleukin-17 cytokine family: Critical players in host defence and inflammatory diseases
Immunology, ISSN: 00192805 13652567
Rajita Pappu; Vladimir Ramirez-Carrozzi; Arivazhagan Sambandam
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Conference report: The AAPS national biotechnology conference
Therapeutic Delivery, ISSN: 20415990 20416008
Margaret Kenrick
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Bounds for an estimate of the optimal backward error for linear least squares problems
International Journal of Computer Mathematics, ISSN: 00207160 10290265
Zheng Su
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2011 White paper on recent issues in bioanalysis and regulatory findings from audits and inspections
Bioanalysis, ISSN: 17576180 17576199
Fabio Garofolo; Mario Rocci; Isabelle Dumont; Suzanne Martinez; Steve Lowes; Eric Woolf; Peter Van Amsterdam; Surendra Bansal; Ariadna Cristina Gomes Barra; Ronald Bauer; Brian Booth; Montserrat Carrasco-Triguero; Binodh DeSilva; John Dunn; Keith Gallicano; Dominique Gouty; Stacy Ho; Richard Hucker; Mohammed Jemal; Noriko Katori; Olivier Le Blaye; Jean W. Lee; Wenkui Li; Steve Michael; Corey Nehls; Robert Nicholson; Eric Ormsby; Daniel Tang; Viswanathan; Russell Weiner; Graeme Young
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PPM1H Is a p27 phosphatase implicated in trastuzumab resistance
Cancer Discovery, ISSN: 21598274 21598290
Si Tuen Lee-Hoeflich; Thinh Q. Pham; Dowbenko; Xander Munroe; James Lee; Li Li; Wei Zhou; Matthias Peter; Kanan Pujara; Stinson; Sara M. Chan; Jeffrey Eastham-Anderson; Ajay Pandita; Somasekar Seshagiri; Klaus P. Hoeflich; Gulisa Turashvili; Karen A. Gelmon; Samuel A. Aparicio; David P. Davis; Mark X. Sliwkowski; Howard M. Stern
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The science of project management: Project controls systems integration
Pharmaceutical Engineering, ISSN: 02738139
Frederick Cramer; Susanne Keller; Christopher Law; Thomas Shih; Britton L. Wolf
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A hybrid approach to predicting events in clinical trials with time-to-event outcomes
Contemporary Clinical Trials, ISSN: 15517144 15592030
Liang Fang; Zheng Su
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Randomized, placebo-controlled clinical trial of an aerosolized β2-agonist for treatment of acute lung injury
American Journal of Respiratory and Critical Care Medicine, ISSN: 1073449X 15354970
Michael A. Matthay; Roy G. Brower; Shannon Carson; Ivor S. Douglas; Mark D. Eisner; Duncan Hite; Steven Holets; Richard H. Kallet; Kathleen D. Liu; Neil MacIntyre; Marc Moss; David Schoenfeld; Jay S. Steingrub; B. Taylor Thompson
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Dextran sieving test for characterization of virus filtration membranes
Journal of Membrane Science, ISSN: 03767388 18733123
Meisam Bakhshayeshi; Dharmesh M. Kanani; Amit Mehta; Robert Van Reis; Ralf Kuriyel; Nigel B. Jackson; Andrew Zydney
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Cross talk between ubiquitination and demethylation
Molecular and Cellular Biology, ISSN: 02707306 10985549
Xiaodong Huang; Vishva M. Dixit
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Magnetic resonance imaging in rheumatoid arthritis clinical trials: Emerging patterns based on recent experience
Journal of Rheumatology, ISSN: 0315162X 14992752
Charles G. Peterfy; Peter Countryman; Annarita Gabriele; Tim Shaw; Andrew Anisfeld; Wayne Tsuji; Ewa Olech; Norman B. Gaylis; Philip G. Conaghan; Vibeke Strand; Julie DiCarlo
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Evaluation of homogenization techniques for the preparation of mouse tissue samples to support drug discovery
Bioanalysis, ISSN: 17576180 17576199
Xiaorong Liang; Savita Ubhayakar; Bianca M. Liederer; Brian J. Dean; Ann R. Qin; Sheerin Shahidi-Latham; Yuzhong Deng
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A note on importance resampling for multi-dimensional statistics
Communications in Statistics: Simulation and Computation, ISSN: 03610918 15324141
Zheng Su
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Proteolytic activation of pro-macrophage-stimulating protein by hepsin
Molecular Cancer Research, ISSN: 15417786 15573125
Rajkumar Ganesan; Ganesh Kolumam; S. Jack Lin; Xie; Santell; Thomas D Wu; Lazarus; Amitabha Chaudhuri; Daniel Kirchhofer
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Integrated safety in tocilizumab clinical trials
Arthritis Research and Therapy, ISSN: 14786354 14786362
Michael H. Schiff; Joel M. Kremer; Angelika Jahreis; Emma Vernon; John D. Isaacs; Ronald Van Vollenhoven
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An Audit Strategy for Progression-Free Survival
Biometrics, ISSN: 15410420 0006341X
Lori E. Dodd; Edward L. Korn; Boris Freidlin; Robert Gray; Suman Bhattacharya
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Decision Making for a Companion Diagnostic in an Oncology Clinical Development Program
Drug Information Journal, ISSN: 00928615
Lee D. Kaiser; Claus Becker; Sharad Kukreti; Bernard M. Fine
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Uniting small molecule and biologic drug perspectives: Analytical characterization and regulatory considerations for antibody-drug conjugates
BioProcess International, ISSN: 15426319
Jon Harris; Fred Jacobson; Claudia Jochheim; Godfrey Amphlett; Kathleen Francissen; Lorna McLeod
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Use of confocal scanning laser microscopy to study virus retention during virus filtration
Journal of Membrane Science, ISSN: 03767388 18733123
Meisam Bakhshayeshi; Nigel B. Jackson; Ralf Kuriyel; Amit Mehta; Robert Van Reis; Andrew Zydney
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Pharmacokinetic dose-scheduling study of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors
Clinical Cancer Research, ISSN: 10780432 15573265
Patricia M. LoRusso; Antonio Jimeno; Grace Dy; Alex Adjei; Jordan Berlin; Lawrence Leichman; Low; Dawn Colburn; Ilsung Chang; Sravanthi Cheeti; Jin Y. Jin; Richard A. Graham
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Stems to gems: Impact of stem cell technology on engineered animal models
Veterinary Pathology, ISSN: 03009858 15442217
Wendy Halpern; Mark McArthur; Elizabeth Galbreath; Elizabeth Uhl; Wayne Buck; Elizabeth Whitley
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A20 edits ubiquitin and autoimmune paradigms
Nature Genetics, ISSN: 10614036 15461718
Flavius Martin; Vishva M. Dixit
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AAPS workshop report: Strategies to address therapeutic protein-drug interactions during clinical development
AAPS Journal, ISSN: 15507416
Sandhya Girish; Steven W Martin; Mark C Peterson; Lei K. Zhang; Hong Zhao; Joseph P. Balthasar; Raymond Evers; Honghui Zhou; Min Zhu; Lewis Klunk; Chao Han; Eva Gil Berglund; Huang; Amita Joshi
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Efficient production of antibodies against a mammalian integral membrane protein by phage display
Protein Engineering, Design and Selection, ISSN: 17410126 17410134
Isidro Hötzel; Vicki Chiang; Jingyu Diao; Homer Pantua; Henry R. Maun; Sharookh B. Kapadia
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Lyp breakdown and autoimmunity
Nature Genetics, ISSN: 10614036 15461718
Timothy W. Behrens
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Asthma in the elderly: Current understanding and future research needs - A report of a National Institute on Aging (NIA) workshop
Journal of Allergy and Clinical Immunology, ISSN: 00916749 10976825
Nicola A. Hanania; Monroe J. King; Sidney S. Braman; Carol Saltoun; Robert A. Wise; Paul Enright; Ann R. Falsey; Sameer K. Mathur; Joe W. Ramsdell; Linda Rogers; David A. Stempel; John Lima; James E. Fish; Sandra R. Wilson; Cynthia Boyd; Kushang V. Patel; Charles G. Irvin; Barbara P. Yawn; Ethan A. Halm; Stephen I. Wasserman; Mark F. Sands; William B. Ershler; Dennis Ledford
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AAPS workshop report: Strategies to address therapeutic protein-drug interactions during clinical development
AAPS Journal, ISSN: 15507416
Sandhya Girish; Steven W Martin; Mark C Peterson; Zhang; Hong Zhao; Joseph P. Balthasar; Raymond Evers; Honghui Zhou; Min Zhu; Lewis Klunk; Chao Han; Eva Gil Berglund; Huang; Amita Joshi
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Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b
Journal of Experimental Medicine, ISSN: 00221007 15409538
Niko Föger; André Jenckel; Zane Orinska; Kyeong-Hee Lee; Andrew A. Chan; Silvia Bulfone-Paus
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Switchable Proteins and Channels
Molecular Switches, Second Edition,
Matthew Volgraf; Matthew Banghart; Dirk Trauner
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CCBE1 Is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-c in vivo
Circulation Research, ISSN: 00097330 15244571
Frank L. Bos; Maresa Caunt; Josi Peterson-Maduro; Lara Planas-Paz; Joe Kowalski; Terhi Karpanen; Andreas Van Impel; Raymond K. Tong; James A. Ernst; Jeroen Korving; Johan H. Van Es; Eckhard Lammert; Henricus J. Duckers; Stefan Schulte-Merker
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The notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development
Blood, ISSN: 15280020 00064971
Kyle Niessen; Gu Zhang; John B.B. Ridgway; Hao Chen; Ganesh Kolumam; Christian W. Siebel; Minhong Yan
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Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex
EMBO Journal, ISSN: 02614189 14602075
Matthew L Bentley; Jacob E. Corn; Ken Dong; Qui Phung; Tommy K. Cheung; Andrea G Cochran
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miR-221/222 targeting of trichorh inophalangeal 1 (TRPS1) promotes epithelial-to-mesenchymal transition in breast cancer
Science Signaling, ISSN: 19450877 19379145
Susanna Y. Stinson; Lackner; Alex T. Adai; Nancy Yu; Hyo-Jin Kim; Carol O'Brien; Jill M. Spoerke; Suchit Jhunjhunwala; Zachary Boyd; Thomas Januario; Robert J. Newman; Peng Yue; Richard Bourgon; Zora Modrusan; Howard M. Stern; Søren Warming; Frederic J. De Sauvage; Lukas Amler; Ru-Fang Yeh; David Dornan
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Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdala
Journal of Comparative Neurology, ISSN: 00219967 10969861
Bei Wang; Thomas Lufkin; John L. R. Rubenstein
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Antiviral activity of danoprevir (ITMN-191/RG7227) in combination with pegylated interferon α-2a and ribavirin in patients with hepatitis C
Journal of Infectious Diseases, ISSN: 00221899
Nicole Forestier; Dominique Larrey; Marcellin; Dominique Guyader; Alain Patat; Régine Rouzier; Patrick F. Smith; Xiaoli Qin; Sharlene R. Lim; Williamson Bradford; Steven Porter; Scott D. Seiwert; Stefan Zeuzem
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Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics
PLoS ONE, ISSN: 19326203
Daniel J Anderson; Jenni K. Durieux; Kyung Song; Ryan Alvarado; Peter K Jackson; Georgia Hatzivassiliou; Mary J. C. Ludlam
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Preparation of distinct ubiquitin chain reagents of high purity and yield
Structure, ISSN: 09692126 18784186
Ken Dong; Elizabeth Helgason; Christine Yu; Lilian Phu; David Arnott; Ivan Bosanac; Deanne M. Compaan; Oscar W Huang; Anna V. Fedorova; Donald S. Kirkpatrick; Sarah G. Hymowitz; Erin C. Dueber
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Isolation and characterization of therapeutic antibody charge variants using cation exchange displacement chromatography
Journal of Chromatography A, ISSN: 00219673 18733778
Taylor Zhang; Justin Bourret; Tony Cano
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Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes
FEBS Letters, ISSN: 00145793 18733468
Xinxin Gao; Natalia Arenas-Ramirez; Suzie J. Scales; Rami N. Hannoush
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