Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8551 - 8600 OF 15613 RESULTS

P85α regulates osteoblast differentiation by cross-talking with the MAPK pathway
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Xiaohua Wu; Shi Chen; Selina A. Orlando; Jin Yuan; Edward T. Kim; Veerendra Munugalavadla; Raghuveer Singh Mali; Reuben Kapur; Feng-Chun Yang
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Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S
Blood, ISSN: 15280020 00064971
Felicity N. E. Gavins; Janice Russell; Elena L. Senchenkova; Lidiana De Almeida Paula; Amílcar S. Damazo; Charles T. Esmon; Daniel Kirchhofer; Robert P. Hebbel; D. Neil Granger
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Genome-wide survey of post-meiotic segregation during yeast recombination
Genome Biology, ISSN: 14747596 1474760X
Eugenio Mancera; Richard Bourgon; Wolfgang Huber; Lars M. Steinmetz
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A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells
Journal of Cell Biology, ISSN: 00219525 00219525
Stephen S. Francis; Jeff Sfakianos; Bryan Lo; Ira Mellman
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Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK Inhibitors in BRAF mutant cancers
Oncotarget, ISSN: 19492553
Ryan B. Corcoran; Jeffrey Settleman; Jeff A. Engelman
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A candidate gene study of the type i interferon pathway implicates IKBKE and IL8 as risk loci for SLE
European Journal of Human Genetics, ISSN: 10184813 14765438
Johanna K. Sandling; Sophie Garnier; Snaevar Sigurdsson; Chuan Wang; Gunnel Nordmark; Iva Gunnarsson; Elisabet Svenungsson; Leonid Padyukov; Gunnar Sturfelt; Andreas Jönsen; Anders A. Bengtsson; Lennart Truedsson; Catharina Eriksson; Solbritt Rantapää-Dahlqvist; Anders Mälarstig; Rona J. Strawbridge; Anders Hamsten; Lindsey A. Criswell; Robert R. Graham; Timothy W. Behrens; Maija-Leena Eloranta; Gunnar Alm; Lars Rönnblom; Ann-Christine Syvänen
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Validation of the functional assessment of chronic illness therapy-fatigue scale in patients with moderately to severely active systemic lupus erythematosus, participating in a clinical trial
Journal of Rheumatology, ISSN: 0315162X 14992752
Jin-Shei Lai; Jennifer L. Beaumont; Sarika Ogale; Paul Brunetta; Cella
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Preclinical absorption, distribution, metabolism, excretion, and pharmacokinetic-pharmacodynamic modelling of N-(4-(3-((3S,4R)-1-ethyl-3- fluoropiperidine-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenyl) -2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxamide, a novel MET kinase inhibitor
Xenobiotica, ISSN: 00498254 13665928
Bianca M. Liederer; Leonid M. Berezhkovskiy; Brian J. Dean; Victoria Dinkel; Jing Peng; Mark Merchant; Emile G. Plise; Harvey Wong; Xingrong Liu
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cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production
Cell Death and Differentiation, ISSN: 13509047 14765403
Nele Vanlangenakker; Vanden Berghe; Bogaert; Bram Laukens; Zobel; Deshayes; Domagoj Vucic; Fulda; Vandenabeele; Mathieu J.M. Bertrand
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A humanized monoclonal antibody targeting the β7 integrin selectively blocks intestinal homing of T lymphocytes
British Journal of Pharmacology, ISSN: 00071188 14765381
Stefanich; Dimitry Danilenko; Hong Wang; Sharon O'Byrne; Erickson; Thomas R. Gelzleichter; Hajime Hiraragi; Chiu; Ivelja; Surinc Er Jeet; Gadkari; Hwang; Franklin Fuh; Looney; Howell; Albert; Mercedesz Balazs; Refino; Sherman Fong; Suhasini Iyer; Marna Williams
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AVAglio: Phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastoma multiforme
Advances in Therapy, ISSN: 0741238X 18658652
Olivier L. Chinot; De La Motte Rouge; Moore; Zeaiter; Asha Das; Phillips; Zora Modrusan; Timothy Cloughesy
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A distinct subset of glioma cell lines with stem cell-like properties reflects the transcriptional phenotype of glioblastomas and overexpresses CXCR4 as therapeutic target
GLIA, ISSN: 08941491 10981136
Alexander Schulte; Hauke S. Günther; Phillips; Dirk Kemming; Tobias Martens; Samir Kharbanda; Robert Soriano; Zora Modrusan; Svenja Zapf; Manfred Westphal; Katrin Lamszus
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Compliance with PET acquisition protocols for therapeutic monitoring of erlotinib therapy in an international trial for patients with non-small cell lung cancer
European Journal of Nuclear Medicine and Molecular Imaging, ISSN: 16197070
David S. Binns; Andrea Pirzkall; Wei Yu; Jason Callahan; Linda Mileshkin; Peter Conti; Andrew M. Scott; David Macfarlane; Bernard M. Fine; Rodney Hicks
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In vitro stability and compatibility of tenecteplase in central venous access devices
Hemodialysis International, ISSN: 14927535 15424758
Yvonne Lentz; Michael Joyce; Lam
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DNA markers linked to eastern filbert blight resistance in "Ratoli" hazelnut (Corylus avellana L.)
Tree Genetics and Genomes, ISSN: 16142942 16142950
Sathuvalli; Chen; Mehlenbacher; Smith
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Genetic and molecular analysis of nematode-microbe interactions
Cellular Microbiology, ISSN: 14625814 14625822
Man-Wah Tan; Michael Shapira
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Improving prescribing safety in patients with renal insufficiency in the ambulatory setting: The Drug Renal Alert Pharmacy (DRAP) program
Pharmacotherapy, ISSN: 02770008
Bharati Bhardwaja; Nikki M. Carroll; Marsha A. Raebel; Elizabeth A. Chester; Korner; Bob E. Rocho; David W. Brand; David J. Magid
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International consensus for a definition of disease flare in lupus
Lupus, ISSN: 09612033
Nicolino Ruperto; Hanrahan; Graciela S. Alarcõn; Belmont; Brey; Paul Brunetta; Jill P. Buyon; Costner; Cronin; Dooley; Filocamo; Fiorentino; Fortin; Franks; Gary S. Gilkeson; Ginzler; Gordon; Grossman; Hahn; David A. Isenberg; Kenneth C. Kalunian; Michelle Petri; Sammaritano; Sánchez-Guerrero; Sontheimer; Vibeke Strand; Urowitz; Von Feldt; Werth; Merrill
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Do cilia put brakes on the cell cycle?
Nature Cell Biology, ISSN: 14657392
Peter K Jackson
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Functional characterization of putative cilia genes by high-content analysis
Molecular Biology of the Cell, ISSN: 10591524 19394586
Cary K. Lai; Nidhi Gupta; Xiaohui Wen; Linda Rangell; Ben Chih; Andrew S. Peterson; J.Fernando Bazan; Li Li; Suzie J. Scales
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NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling
Cell, ISSN: 00928674
Sharon Biton; Avi Ashkenazi
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Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocytespecific deletion of JAK2
Journal of Clinical Investigation, ISSN: 15588238 00219738
Brandon C. Sos; Charles Harris; Sarah M. Nordstrom; Jennifer L. Tran; Mercedesz Balazs; Patrick Caplazi; Maria Febbraio; Milana A. B. Applegate; Kay-Uwe Wagner; Ethan J. Weiss
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Integrated cytogenetic and high-resolution array CGH analysis of genomic alterations associated with MYCN amplification
Cytogenetic and Genome Research, ISSN: 14248581
Ajay Pandita; Bayani; Paderova; Marrano; Graham; Barrett; Prasad; Zielenska; Squire
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BioBeat: ICBE explores biology at the molecular level
Chemical Engineering Progress, ISSN: 03607275
Deshayes
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A humanized monoclonal antibody targeting the β7 integrin selectively blocks intestinal homing of T lymphocytes
British Journal of Pharmacology, ISSN: 00071188 14765381
Stefanich; Dimitry Danilenko; Hong Wang; Sharon O'Byrne; Erickson; Thomas R. Gelzleichter; Hajime Hiraragi; Chiu; Ivelja; Surinc Er Jeet; Gadkari; Hwang; Franklin Fuh; Looney; Howell; Albert; Mercedesz Balazs; Refino; Fong; Suhasini Iyer; Marna Williams
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An observational study of outcomes after initial infused therapy in Medicare patients diagnosed with chronic lymphocytic leukemia
Blood, ISSN: 15280020 00064971
Mark Danese; Robert I. Griffiths; Michelle Gleeson; Sacha Satram-Hoang; Kevin Knopf; Joseph Mikhael; Carolina Reyes
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A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice
Science Translational Medicine, ISSN: 19466234 19466242
Natalya Lyubynska; Matthew F. Gorman; Jennifer O. Lauchle; Wan Xing Hong; Jon Akutagawa; Kevin Shannon; Benjamin S. Braun
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Advancing translational research
Science, ISSN: 10959203 00368075
Brad Bolon; Bruce Altrock; Stephen W. Barthold; Nicole Baumgarth; David Besselsen; Gregory Boivin; Kelli L. Boyd; Cory Brayton; Robert D. Cardiff; Suzana Couto; Kathryn A. Eaton; Oded Foreman; Stephen M. Griffey; la Perle; Michael D. Lairmore; Chen Liu; David K. Meyerholz; Alexander Yu. Nikitin; Trenton R. Schoeb; Denise Schwahn; Rani Sellers; John P. Sundberg; Ravi Tolwani; Victor E. Valli; M. Christine Zink
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Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Brad E Sleebs; Czabotar; Wayne J. Fairbrother; Fairlie; Flygare; David C.S. Huang; Wilhelmus J A Kersten; Michael F. T. Koehler; Guillaume Lessene; Kym N Lowes; John P Parisot; Brian J. Smith; Morey L. Smith; Andrew J. Souers; Ian P Street; Hong Yang; Jonathan B Baell
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FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways
PLoS ONE, ISSN: 19326203
Ai-Luen Wu; Sally Coulter; Christopher Liddle; Anne Wong; Jeffrey Eastham-Anderson; French; Andrew S. Peterson; Junichiro Sonoda
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Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cell
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Stephanie M. Stanford; Divya Krishnamurthy; Matthew D. Falk; Rossella Messina; Bikash Debnath; Sheng Li; Tong Liu; Roza Kazemi; Russell Dahl; Yantao He; Xiao Yu; Andrew A. Chan; Zhong-Yin Zhang; Amy M. Barrios; Virgil L. Woods Jr.; Nouri Neamati; Nunzio Bottini
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Matrix metalloproteinase-9 predicts pulmonary status declines in α1-antitrypsin deficiency
Respiratory Research, ISSN: 1465993X 14659921
Theodore A. Omachi; Mark D. Eisner; Alexis Rames; Lada Markovtsova; Paul D. Blanc
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Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes
PLoS ONE, ISSN: 19326203
Rezaul Karim; Craig Meyers; Claude Backendorf; Kristina Ludigs; Rienk Offringa; Gert-Jan B. van Ommen; Cornelis J. M. Melief; Sjoerd H. van der Burg; Judith M. Boer
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Effects of anti-VEGF on predicted antibody biodistribution: Roles of vascular volume, interstitial volume, and blood flow
PLoS ONE, ISSN: 19326203
C. Andrew Boswell; Gregory Z. Ferl; Eduardo E. Mundo; Daniela Bumbaca; Michelle G. Schweiger; Frank-Peter Theil; Fielder; Leslie A. Khawli
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CD40 pathway activation status predicts response to CD40 therapy in diffuse large B cell lymphoma
Science Translational Medicine, ISSN: 19466234 19466242
Bart Burington; Peng Yue; Xiaoyan Shi; Ranjana H. Advani; Jeffrey Lau; Jenille Tan; Susanna Y. Stinson; Stinson; Thomas Januario; Sven De Vos; Stephen Ansell; Andres Forero; Grazyna Fedorowicz; Teddy T. C. Yang; Kristi Elkins; Du; Sankar Mohan; Nancy Yu; Zora Modrusan; Somasekar Seshagiri; Shang-Fan Yu; Ajay Pandita; Koeppen; French; Andrew G. Polson; Rienk Offringa; Nancy Whiting; Allen Ebens; David Dornan
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Remote functionalisation via sodium alkylamidozincate intermediates: Access to unusual fluorenone and pyridyl ketone reactivity patterns
Chemical Communications, ISSN: 1364548X 13597345
James J. Crawford; Ben J. Fleming; Kennedy; Charles T. O’Hara; Samantha A. Orr
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Navitoclax enhances the efficacy of taxanes in non-small cell lung cancer models
Clinical Cancer Research, ISSN: 10780432 15573265
Nguyen Tan; Mehnaz Malek; Jiping Zha; Peng Yue; Robert Kassees; Berry; Wayne J. Fairbrother; Deepak Sampath; Lisa D. Belmont
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Identification of isomerization and racemization of aspartate in the Asp-Asp motifs of a therapeutic protein
Analytical Biochemistry, ISSN: 10960309 00032697
Jennifer Zhang; Holly Yip; Viswanatham Katta
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Effect of CC chemokine receptor 2 CCR2 blockade on serum C-reactive protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte chemoattractant protein-1 promoter region
American Journal of Cardiology, ISSN: 00029149
Jim Gilbert; Julie Lekstrom-Himes; Debra Donaldson; Yih Lee; Mingxiu Hu; Jing Xu; Tim Wyant; Michael Davidson
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Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells
Cancer Research, ISSN: 00085472 15387445
Yong-Yu Liu; Gauri A. Patwardhan; Kaustubh Bhinge; Vineet Gupta; Xin Gu; S. Michal Jazwinski
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Remote functionalisation via sodium alkylamidozincate intermediates: Access to unusual fluorenone and pyridyl ketone reactivity patterns
Chemical Communications, ISSN: 1364548X 13597345
James J. Crawford; Ben J. Fleming; Alan R. Kennedy; Charles T. O’Hara; Samantha A. Orr
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Mitochondrial reactive oxygen species drive proinflammatory cytokine production
Journal of Experimental Medicine, ISSN: 00221007 15409538
Naik; Vishva M. Dixit
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Impact of β2 integrin deficiency on mouse natural killer cell development and function
Blood, ISSN: 15280020 00064971
Karine Crozat; Celine Eidenschenk; Baptiste N. Jaeger; Philippe Krebs; Sophie Guia; Bruce Beutler; Eric Vivier; Sophie Ugolini
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Development of a multi-product leached protein A assay for bioprocess samples containing recombinant human monoclonal antibodies
Journal of Immunological Methods, ISSN: 00221759
Diya Ren; Maria R. Darlucio; Judy H. Chou
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Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
Nature, ISSN: 00280836 14764687
Ingrid E. Wertz; Saritha Kusam; Cynthia Lam; Toru Okamoto; Wendy N. Sandoval; Daniel J Anderson; Elizabeth Helgason; James A. Ernst; Mike Eby; Jinfeng Liu; Lisa D. Belmont; Joshua S. Kaminker; Karen M. O'Rourke; Kanan Pujara; Pawan Bir Kohli; Adam R. Johnson; Mark L. Chiu; Jennie R. Lill; Peter K Jackson; Wayne J. Fairbrother; Somasekar Seshagiri; Mary J. C. Ludlam; Kevin G. Leong; Erin C. Dueber; Heather Maecker; David C.S. Huang; Vishva M. Dixit
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Dense mapping of IL18 shows no association in SLE
Human Molecular Genetics, ISSN: 09646906 14602083
Sandra G. Guerra; David L. Morris; Vesela Gateva; Robert R. Graham; Timothy J. Vyse; Deborah S. Cunninghame Graham
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Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production
PLoS Genetics, ISSN: 15537390 15537404
Sharon A. Chung; Kimberly E. Taylor; Robert R. Graham; Joanne Nititham; Annette T. Lee; Ward Ortmann; Chaim O. Jacob; Marta E. Alarcón-Riquelme; Betty P. Tsao; John B. Harley; Patrick M. Gaffney; Kathy L. Moser; Michelle Petri; F. Yesim Demirci; M. Ilyas Kamboh; Manzi; Peter K. Gregersen; Carl D. Langefeld; Timothy W. Behrens; Criswell
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DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression
Neuro-Oncology, ISSN: 15228517 15235866
Shichun Zheng; E. Andres Houseman; Zachary Morrison; Margaret R. Wrensch; Joseph S. Patoka; Christian Ramos; Daphne A. Haas-Kogan; Sean McBride; Carmen J. Marsit; Brock C. Christensen; Heather H. Nelson; David Stokoe; Joseph L. Wiemels; Susan Chang; Michael D. Prados; Tarik Tihan; Scott R. VandenBerg; Karl T. Kelsey; Mitchel S. Berger; John K. Wiencke
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The minimum L2 distance estimator for Poisson mixture models
Journal of Statistical Planning and Inference, ISSN: 03783758
Ian R. Harris; Shuyi Shen
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Challenges in developing bioanalytical assays for characterization of antibody-drug conjugates
Bioanalysis, ISSN: 17576180 17576199
Jean-Philippe Stephan; Katherine R. Kozak; Wai Lee T. Wong
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