Genentech: Publications

January 1, 2011

The pathologist's slide reveals more than meets the eye: Loss of heterozygosity and cancer biology

Veterinary Pathology, ISSN: 03009858 15442217

Suzana Couto

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January 1, 2011

Investigational antibody-drug conjugates for hematological malignancies

Expert Opinion on Investigational Drugs, ISSN: 13543784

Andrew G. Polson; William Y. Ho; Vanitha Ramakrishnan

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January 1, 2011

Evaluation of eml4-alk fusion proteins in non-small cell lung cancer using small molecule inhibitors

Neoplasia (United States), ISSN: 14765586 15228002

Li; Ye; Jinfeng Liu; Jiping Zha; Lin Pei

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January 1, 2011

Quinolones as HCV NS5B polymerase inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Dange V. Kumar; Roopa Rai; Ken A. Brameld; John R. Somoza; Ravi Rajagopalan; James W. Janc; Yu M. Xia; Tony L. Ton; Michael B. Shaghafi; Huiyong Hu; Isabelle Lehoux; Nhat To; Wendy B. Young; Michael J. Green

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January 1, 2011

Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: The IMAGE trial

Annals of the Rheumatic Diseases, ISSN: 00034967 14682060

Paul P. Tak; William F. Rigby; Rubbert-Roth; Charles G. Peterfy; Ronald Van Vollenhoven; Stohl W.; Eva W. Hessey; Annie Chen; Helen Tyrrell; Tim Shaw

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January 1, 2011

Response as a predictor of survival in patients with recurrent glioblastoma treated with bevacizumab

Neuro-Oncology, ISSN: 15228517 15235866

Michael D. Prados; Timothy Cloughesy; Meghna Samant; Liang Fang; Patrick Y. Wen; Tom Mikkelsen; David Schiff; Lauren E. Abrey; Alfred Yung; Nina Paleologos; Martin K. Nicholas; Randy Jensen; James Vredenburgh; Asha Das; Henry S. Friedman

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January 1, 2011

Trastuzumab emtansine (T-DM1): A novel agent for targeting HER2+ breast cancer

Clinical Breast Cancer, ISSN: 19380666 15268209

Howard A. Burris; Jay Tibbitts; Scott N. Holden; Mark X. Sliwkowski; Gail L. Phillips

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January 1, 2011

The societal impact of age-related macular degeneration: Use of social support resources differs by the severity of the impairment

Journal of Visual Impairment and Blindness, ISSN: 0145482X

Mark Brennan; Amy Horowitz; Joann P. Reinhardt; Cynthia Stuen; Roman G. Rubio; Nina Oestreicher

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January 1, 2011

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: What have we learned?

mAbs, ISSN: 19420862 19420870

Rong Deng; Suhasini Iyer; Frank-Peter Theil; Deborah L. Mortensen; Fielder; Saileta Prabhu

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January 1, 2011

Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis

Nature Chemical Biology, ISSN: 15524469 15524450

Julie Di Paolo; Tao Huang; Mercedesz Balazs; Jim Barbosa; Kai H. Barck; Brandon Bravo; Richard A. D. Carano; James Darrow; Douglas R. Davies; Laura DeForge; Laurie Diehl; Ron Ferrando; Steven L. Gallion; Anthony M. Giannetti; Gribling; Vincent Hurez; Sarah G. Hymowitz; Randall Jones; Jeffrey E. Kropf; Wyne P. Lee; Patricia M. MacIejewski; Scott A. Mitchell; Hong Rong; Bart L. Staker; J. Andrew Whitney; Sherry Yeh; Wendy B. Young; Christine Yu; Juan Zhang; Karin Reif; Kevin S. Currie

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January 1, 2011

An observational retrospective subgroup analysis of verteporfin photodynamic therapy-naive and previously treated patients in the focus trial

Retina, ISSN: 0275004X

Rajendra S. Apte; Sherri L. Alexander; Erin C. Henry; Pamela Wong; Lisa Tuomi

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January 1, 2011

Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development

Molecular and Cellular Neuroscience, ISSN: 10447431

Viola Maier; Christine Jolicoeur; Helen Rayburn; Noriko Takegahara; Atsushi Kumanogoh; Hitoshi Kikutani; Marc Tessier-Lavigne; Wolfgang Wurst; Roland H. Friedel

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January 1, 2011

Pregnancy outcomes after maternal exposure to rituximab

Blood, ISSN: 15280020 00064971

Eliza F. Chakravarty; Elaine R. Murray; Ariella Kelman; Pamela Farmer

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January 1, 2011

The corrected traditional equations for calculation of hepatic clearance that account for the difference in drug ionization in extracellular and intracellular tissue water and the corresponding corrected PBPK equation

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

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January 1, 2011

Erratum: Vessel imaging with viable tumor analysis for quantification of tumor angiogenesis (Magnetic Resonance in Medicine (2010) 63 (1637-1647))

Magnetic Resonance in Medicine, ISSN: 15222594 07403194

Sharon E. Ungersma; Glenn Pacheco; Calvin Ho; Sharon Fong Yee; Ross; Nicholas Van Bruggen; Franklin V. Peale Jr.; Ross; Richard A. D. Carano

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January 1, 2011

American College of Rheumatology/European League Against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials

Annals of the Rheumatic Diseases, ISSN: 14682060 00034967

David T. Felson; Josef S. Smolen; George Wells; Bin Zhang; Lilian H.D. Van Tuyl; Julia Funovits; Daniel Aletaha; Allaart; Joan Bathon; Stefano Bombardieri; Peter Brooks; Andrew Brown; Marco Matucci-Cerinic; Hyon Choi; Bernard Combe; Maarten De Wit; Maxime Dougados; Paul Emery; Daniel E. Furst; Juan Gomez-Reino; Gillian Hawker; Edward Keystone; Dinesh Khanna; John Kirwan; Tore K. Kvien; Robert Landewé; Joachim Listing; Kaleb Michaud; Emilio Martin-Mola; Pamela Montie; Theodore Pincus; Pamela Richards; Jeffrey N. Siegel; Lee S. Simon; Tuulikki Sokka; Vibeke Strand; Peter Tugwell; Alan Tyndall; Desirée Van Der Heijde; Suzan Verstappen; Barbara White; Frederick Wolfe; Angela Zink; Maarten Boers

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January 1, 2011

Analytical methods for physicochemical characterization of antibody drug conjugates

mAbs, ISSN: 19420870 19420862

Aditya A. Wakankar; Yan Chen; Yatin Gokarn; Fred Jacobson

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January 1, 2011

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening

Cancer Cell, ISSN: 18783686 15356108

Eric T. Sawey; Maia Chanrion; Chunlin Cai; Guanming Wu; Jianping Zhang; Lars Zender; Alice Zhao; Ronald W. Busuttil; Herman Yee; Lincoln Stein; French; Richard S. Finn; Scott W. Lowe; Scott Powers

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January 1, 2011

From eperimental design to validated hits: A comprehensive walk-through of fragment lead identification using surface plasmon resonance

Methods in Enzymology, ISSN: 00766879

Anthony M. Giannetti

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January 1, 2011

Advancing fragment binders to lead-like compounds using ligand and protein-based NMR spectroscopy

Methods in Enzymology, ISSN: 00766879

Till Maurer

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January 1, 2011

Slit2 activity in the migration of guidepost neurons shapes thalamic projections during development and evolution

Neuron, ISSN: 10974199 08966273

Franck Bielle; Paula Marcos-Mondéjar; Maryama Keita; Caroline Mailhes; Catherine Verney; Kim T. Nguyen-Ba-Charvet; Marc Tessier-Lavigne; Guillermina López-Bendito; Sonia Garel

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January 1, 2011

Mycophenolate mofetil-based immunosuppression with sirolimus in renal transplantation: A randomized, controlled Spare-the-Nephron trial

Kidney International, ISSN: 15231755 00852538

Matthew R. Weir; Shamkant Mulgaonkar; Laurence Chan; Hamid Shidban; Thomas H. Waid; Dennis Preston; Roberto N. Kalil; Thomas C. Pearson

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January 1, 2011

The relative rate of immunoglobulin gamma 1 fragmentation

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Tim J. Kamerzell; Megan Li; Shaily Arora; Junyan A. Ji; Y. John Wang

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January 1, 2011

Multiple Effects of Angiopoietin-2 Blockade on Tumors

Cancer Cell, ISSN: 18783686 15356108

Claire E. Lewis; Napoleone Ferrara

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January 1, 2011

Biomarkers of immunotoxicity for environmental and public health research

International Journal of Environmental Research and Public Health, ISSN: 16604601

Paurene Duramad; Nina T. Holland

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January 1, 2011

Fatty acid and water-soluble polymer-based controlled release drug delivery system

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Divyakant Desai; Sanjeev Kothari; Wei Chen; Jennifer Wang; Ming Huang; Laxmikant Sharma

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January 1, 2011

Omalizumab in severe allergic asthma inadequately controlled with standard therapy: A randomized trial

Annals of Internal Medicine, ISSN: 15393704 00034819

Nicola A. Hanania; Oral Alpan; Daniel L. Hamilos; John Condemi; Reyes-Rivera; Jin Zhu; Karin Rosén; Mark D. Eisner; Dennis A. Wong; William W. Busse

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January 1, 2011

Introduction to current and future protein therapeutics: A protein engineering perspective

Experimental Cell Research, ISSN: 10902422 00144827

Paul J. Carter

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January 1, 2011

Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): A double-blind, placebo-controlled, phase 3 trial

The Lancet, ISSN: 1474547X 01406736

Roy S. Herbst; Rafat Ansari; Frederique Bustin; Patrick J. Flynn; Lowell Hart; Gregory A Otterson; Gordana Vlahovic; Chang-Heok Soh; Paula O'Connor; John Hainsworth

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January 1, 2011

Perspective of clinical research in follicular NHL: Interaction between science and industry

Best Practice and Research: Clinical Haematology, ISSN: 15321924 15216926

Gregg D. Fine; Sandra J. Horning

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January 1, 2011

On the accuracy of estimation of basic pharmacokinetic parameters by the traditional noncompartmental equations and the prediction of the steady-state volume of distribution in obese patients based upon data derived from normal subjects

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

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January 1, 2011

P21-activated kinase 1: PAK'ed with potential

Oncotarget, ISSN: 19492553

Christy C. Ong; Adrian M. Jubb; Wei Zhou; Matthias Peter; Adrian L. Harris; Marcia Belvin; Lori S. Friedman; Koeppen; Klaus P. Hoeflich

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January 1, 2011

New imaging paradigms in drug development: The PET imaging approach

Drug Discovery Today: Technologies, ISSN: 17406749

Jan Marik; Sandra M. Sanabria-Bohorquez; Simon P. Williams; Nicholas Van Bruggen

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January 1, 2011

Using molecular simulations to probe pharmaceutical materials

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Yong Cui

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January 1, 2011

Mechanisms and molecules of neuronal wiring: A primer

Cold Spring Harbor Perspectives in Biology, ISSN: 19430264

Alex L. Kolodkin; Marc Tessier-Lavigne

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January 1, 2011

Identification of amino acid residues responsible for the release of free drug from an antibody-drug conjugate utilizing lysine-succinimidyl ester chemistry

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Hung-Wei Chih; Benson Gikanga; Yi Yang; Boyan Zhang

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January 1, 2011

Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4

mAbs, ISSN: 19420870 19420862

Daniela Bumbaca; Anne Wong; Elizabeth Drake; Arthur Reyes; Benjamin C. Lin; Jean-Philippe Stephan; Luc Desnoyers; Shen; Dennis

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January 1, 2011

Economic burden of impairment in children with severe or difficult-to-treat asthma

Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206

Stanley J. Szefler; Robert S. Zeiger; Tmirah Haselkorn; David R. Mink; Tripthi V. Kamath; James E. Fish; Bradley E. Chipps

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January 1, 2011

Phase 2 trial of linifanib (ABT-869) in patients with advanced non-small cell lung cancer

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Eng-Huat Tan; Glenwood D. Goss; Ravi Salgia; Benjamin Besse; David R. Gandara; Nasser H. Hanna; James Chih-Hsin Yang; Raymond Thertulien; Michael Wertheim; Julien Mazieres; Thomas Hensing; Christa Lee; Neeraj Gupta; Rajendra Pradhan; Jiang Qian; Qin Qin; Frank A. Scappaticci; Justin L. Ricker; Dawn M. Carlson; Ross A. Soo

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January 1, 2011

Solubilities and transfer free energies of hydrophobic amino acids in polyol solutions: Importance of the hydrophobicity of polyols

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Shermeen A. Abbas; Vikas Sharma; Thomas W. Patapoff; Devendra S. Kalonia

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January 1, 2011

Analysis of 2,2'-Azobis (2-amidinopropane) dihydrochloride degradation and hydrolysis in aqueous solutions

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Jay Werber; Y. John Wang; Michael Milligan; Xiaohua Li; Junyan A. Ji

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January 1, 2011

A new roadmap for biopharmaceutical drug product development: Integrating development, validation, and quality by design

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Sheryl Martin-Moe; Fred Lim; Wong; Alavattam Sreedhara; Jagannathan Sundaram; Samir Sane

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January 1, 2011

Neuregulin-1-Mediated Autocrine Signaling Underlies Sensitivity to HER2 Kinase Inhibitors in a Subset of Human Cancers

Cancer Cell, ISSN: 18783686 15356108

Wilson; Diana Y. Lee; Berry; David S. Shames; Jeffrey Settleman

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January 1, 2011

A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine-refractory chronic idiopathic urticaria

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Sarbjit S. Saini; Karin Rosén; Hsin-Ju Hsieh; Dennis A. Wong; Edward Conner; Allen P. Kaplan; Sheldon Spector; Marcus Maurer

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January 1, 2011

Development of the Asthma Control Composite outcome measure to predict omalizumab response

Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206

Harris; Dennis A. Wong; Amy V. Kapp

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January 1, 2011

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis

Neoplasia (United States), ISSN: 14765586 15228002

Bram Laukens; Claudia Jennewein; Barbara Schenk; Nele Vanlangenakker; Alexander Schier; Cristofanon; Zobel; Deshayes; Domagoj Vucic; Irmela Jeremias; Mathieu J.M. Bertrand; Vandenabeele; Fulda

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January 1, 2011

Overview of SLC22A and SLCO families of drug uptake transporters in the context of cancer treatments

Current Drug Metabolism, ISSN: 18755453 13892002

Murray J. Cutler; Edna F. Choo

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January 1, 2011

DATforDCEMRI: An R package for deconvolution analysis and visualization of DCE-MRI data

Journal of Statistical Software, ISSN: 15487660

Gregory Z. Ferl

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January 1, 2011

A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies

Cancer Cell, ISSN: 18783686 15356108

Gabriele Schaefer; Lauric Haber; Lisa Crocker; Steven Shia; Lily Shao; Dowbenko; Klara Totpal; Anne Wong; Chingwei V. Lee; Scott Stawicki; Robyn Clark; Carter Fields; Gail L. Phillips; Prell; Dimitry Danilenko; Yvonne Franke; Jean-Philippe Stephan; Jiyoung Hwang; Yan Wu; Jenny Bostrom; Mark X. Sliwkowski; Fuh; Eigenbrot

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January 1, 2011

The influence of hepatic transport on the distribution volumes and mean residence time of drug in the body and the accuracy of estimating these parameters by the traditional pharmacokinetic calculations

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

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