Genentech: Publications

August 1, 2010

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia

Nature Immunology, ISSN: 15292908 15292916

Daniel J. Hodson; Michelle L. Janas; Alison Galloway; Sarah E. Bell; Simon Andrews; Cheuk M. Li; Richard Pannell; Christian W. Siebel; H. Robson MacDonald; Kim De Keersmaecker; Adolfo A. Ferrando; Gerald Grutz; Martin Turner

View on Scopus

August 1, 2010

Effects of anti-VEGF treatment duration on tumor growth, tumor regrowth, and treatment efficacy

Clinical Cancer Research, ISSN: 10780432 15573265

Anil Bagri; Berry; Bert Gunter; Mallika Singh; Ian Kasman; Lisa A. Damico; Hong Xiang; Maike Schmidt; Fuh; Beth A Hollister; Oliver Rosen; Greg D. Plowman

View on Scopus

August 1, 2010

Enhancement of DNA uptake in FUT8-deleted CHO cells for transient production of afucosylated antibodies

Biotechnology and Bioengineering, ISSN: 10970290 00063592

Athena W. Wong; Tomasz K. Baginski; Dorothea Reilly

View on Scopus

August 1, 2010

A plate-based assay to measure cellular ERK substrate phosphorylation: Utility for drug discovery of the MAPK-signaling cascade

Assay and Drug Development Technologies, ISSN: 1540658X

Sreemathy Ramaswamy; Ivana Yen; Steve Sideris; Shiva Malek; Christopher E. Heise

View on Scopus

August 1, 2010

Neural RNA-Binding Protein Musashi1 Controls Midline Crossing of Precerebellar Neurons through Posttranscriptional Regulation of Robo3/Rig-1 Expression

Neuron, ISSN: 08966273

Ken-ichiro Kuwako; Kyoko Kakumoto; Takao Imai; Mana Igarashi; Takao Hamakubo; Shin-ichi Sakakibara; Marc Tessier-Lavigne; Hirotaka James Okano; Hideyuki Okano

View on Scopus

August 1, 2010

The lytic transcriptome of Kaposi's sarcoma-associated herpesvirus reveals extensive transcription of noncoding regions, including regions antisense to important genes

Journal of Virology, ISSN: 0022538X 10985514

Sanjay Chandriani; Yiyang Xu; Don Ganem

View on Scopus

August 1, 2010

The Type 1 Diabetes PhysioLab® Platform: A validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse

Clinical and Experimental Immunology, ISSN: 00099104 13652249

Shoda; Kreuwel; Kapil Gadkar; Zheng; Whiting; Mark Atkinson; Jeffrey A. Bluestone; Mathis; Young; Ramanujan

View on Scopus

August 1, 2010

A chemosensitization screen identifies TP53RK, a kinase that restrains apoptosis after mitotic stress

Cancer Research, ISSN: 00085472 15387445

David Peterson; James Lee; Xingye Lei; William F. Forrest; David P. Davis; Peter K Jackson; Lisa D. Belmont

View on Scopus

August 1, 2010

K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody

Molecular Cell, ISSN: 10972765

Marissa L. Matsumoto; Katherine E. Wickliffe; Ken Dong; Christine Yu; Ivan Bosanac; Daisy J. Bustos; Lilian Phu; Donald S. Kirkpatrick; Sarah G. Hymowitz; Michael Rape; Robert F. Kelley; Vishva M. Dixit

View on Scopus

August 1, 2010

Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas

Modern Pathology, ISSN: 08933952 15300285

Xingxing Zang; Peggy S. Sullivan; Robert A. Soslow; Rebecca Waitz; Victor E. Reuter; Andrew Wilton; Howard T. Thaler; Manonmani Arul; Susan F. Slovin; Joyce Wei; David R. Spriggs; Jakob Dupont; James P. Allison

View on Scopus

August 1, 2010

Distal regions of the human IFNG locus direct cell type-specific expression

Journal of Immunology, ISSN: 00221767 15506606

Patrick L. Collins; Shaojing Chang; Melodie Henderson; Mohammed Soutto; Georgia M. Davis; Allyson G. McLoed; Michael J. Townsend; Laurie H. Glimcher; Douglas P. Mortlock; Aune

View on Scopus

August 1, 2010

High-yield expression of human vascular endothelial growth factor VEGF 165 in Escherichia coli and purification for therapeutic applications

Protein Expression and Purification, ISSN: 10465928

Shelly A. Pizarro; Jane Gunson; Field; Rachel Dinges; Stefanie Khoo; Milind Dalal; Michael Lee; Kimberly A. Kaleas; Kathryn Moiseff; Susan Garnick; Dorothea Reilly; Mike Laird; Charles H. Schmelzer

View on Scopus

August 1, 2010

Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Hanbiao Yang; Robert T. Hendricks; Nidhi Arora; Dov Nitzan; Calvin Yee; Matthew C. Lucas; Yanli Yang; Amy Fung; Sonal Rajyaguru; Seth F. Harris; Vincent J.P. Leveque; Julie Qi Hang; Sophie Le Pogam; Deborah Reuter; Gisele A. Tavares

View on Scopus

August 1, 2010

Subset analysis of patients experiencing clinical events of a potentially immunogenic nature in the pivotal clinical trials of tocilizumab for rheumatoid arthritis: Evaluation of an antidrug antibody ELISA using clinical adverse event-driven immunogenicity testing

Clinical Therapeutics, ISSN: 01492918 1879114X

Kay Stubenrauch; Uwe Wessels; Herbert Birnboeck; Francisco Ramirez; Angelika Jahreis; Julia Schleypen

View on Scopus

August 1, 2010

Effect of trastuzumab on health-related quality of life in patients with HER2-positive metastatic breast cancer: Data from three clinical trials

Clinical Breast Cancer, ISSN: 15268209

Hope S. Rugo; Melissa Brammer; Fan Zhang; Deepa Lalla

View on Scopus

August 1, 2010

Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer

Biological Chemistry, ISSN: 14316730 14374315

Henry R. Maun; Daniel Kirchhofer; Lazarus

View on Scopus

July 29, 2010

Managing Successful Product Portfolio Creation and R&D Pipelines

Pharmaceutical and Biomedical Project Management in a Changing Global Environment,

Sue E. Steven

View on Scopus

July 29, 2010

Vertebrate Hedgehog signaling: Cilia rule

BMC Biology, ISSN: 17417007

Christopher W. Wilson; Didier Y. R. Stainier

View on Scopus

July 28, 2010

Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin

Journal of Neuroscience, ISSN: 02706474 15292401

Ozlem Bozdagi; Xiaobin Wang; Jessica S. Nikitczuk; Tonya R. Anderson; Erik B. Bloss; Glenn L. Radice; Qiang Zhou; Deanna L. Benson; George W. Huntley

View on Scopus

July 21, 2010

Preparation and separation of antimicrobial agents derived from capreomycin

Tetrahedron Letters, ISSN: 00404039

D. David Hennings; Daniel J. Watson; Joseph P. Lyssikatos; Andrew Allen

View on Scopus

July 20, 2010

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Lee Honigberg; Ashley Smith; Mint Sirisawad; Erik Verner; David Loury; Betty Chang; Shyr Li; Zhengying Pan; Douglas H. Thamm; Richard A. Miller; Joseph J. Buggy

View on Scopus

July 16, 2010

Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Faye Martin; Padmamalini Baskaran; Xiaolei Ma; Pete W. Dunten; Martina Schaefer; Johannes-Peter Stasch; Annie Beuve; Focco Van Den Akker

View on Scopus

July 15, 2010

Rituximab versus cyclophosphamide for ANCA-associated vasculitis

New England Journal of Medicine, ISSN: 15334406 00284793

John H. Stone; Merkel; Spiera; Seo; Langford; Hoffman; Cees Kallenberg; St.clair; Anthony Turkiewicz; Tchao; Lisa Webber; Linna Ding; Lourdes P. Sejismundo; Kathleen Mieras; David Weitzenkamp; Iklé; Vicki Seyfert-Margolis; Mark Mueller; Paul Brunetta; Allen; Fervenza; Duvuru Geetha; Keogh; Kissin; Monach; Peikert; Stegeman; Steven R. Ytterberg; Specks

View on Scopus

July 15, 2010

Predictive biomarkers of sensitivity to the phosphatidylinositol 3′ kinase inhibitor GDC-0941 in breast cancer preclinical models

Clinical Cancer Research, ISSN: 10780432 15573265

Carol O'Brien; Jeffery J. Wallin; Deepak Sampath; Debraj GuhaThakurta; Heidi Savage; Elizabeth A. Punnoose; Zhengyu Guan; Berry; Wei Wei Prior; Lukas Amler; Marcia Belvin; Lori S. Friedman; Lackner

View on Scopus

July 15, 2010

IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail

Journal of Immunology, ISSN: 00221767 15506606

Allen W. Ho; Fang Shen; Heather R. Conti; Nayan Patel; Erin E. Childs; Alanna C. Peterson; Nydiaris Herna´ndez-Santos; Jay K. Kolls; Lawrence P. Kane; Wenjun Ouyang; Sarah L. Gaffen

View on Scopus

July 14, 2010

Collaborative and specialized functions of Robo1 and Robo2 in spinal commissural axon guidance

Journal of Neuroscience, ISSN: 02706474 15292401

Alexander Jaworski; Hua Long; Marc Tessier-Lavigne

View on Scopus

July 8, 2010

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity

Nature, ISSN: 00280836 14764687

Ira Surolia; Stephan P. Pirnie; Vasant Chellappa; Kendra N. Taylor; Annaiah Cariappa; Jesse Moya; Haoyuan Liu; Daphne W. Bell; David R. Driscoll; Sven Diederichs; Khaleda Haider; Ilka Netravali; Sheila Le; Roberto Elia; Ethan Dow; Annette T. Lee; Jan Freudenberg; Philip L. De Jager; Yves Chretien; Ajit Varki; Marcy E. MacDonald; Tammy Gillis; Timothy W. Behrens; Donald Bloch; Deborah Collier; Joshua Korzenik; Daniel K. Podolsky; David A. Hafler; Mandakolathur Murali; Bruce Sands; John H. Stone; Peter K. Gregersen; Shiv Pillai

View on Scopus

July 2, 2010

Response

Science, ISSN: 10959203 00368075

Levinson

View on Scopus

July 2, 2010

Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Janet Jackman; Yongmei Chen; Arthur Huang; Moffat; Justin M. Scheer; Leong; Wyne P. Lee; Juan Zhang; Navneet Sharma; Yanmei Lu; Suhasini Iyer; Robert L. Shields; Nancy Y. Chiang; Michele Bauer; Diana Jakubiak; Merone Roose-Girma; Richard L. Vandlen; Yansura; Yan Wu; Lawren C. Wu

View on Scopus

July 1, 2010

Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II

Nature Immunology, ISSN: 15292908 15292916

Hyota Takamatsu; Noriko Takegahara; Yukinobu Nakagawa; Michio Tomura; Masahiko Taniguchi; Roland H. Friedel; Helen Rayburn; Marc Tessier-Lavigne; Yutaka Yoshida; Tatsusada Okuno; Masayuki Mizui; Sujin Kang; Satoshi Nojima; Tohru Tsujimura; Yuji Nakatsuji; Ichiro Katayama; Toshihiko Toyofuku; Hitoshi Kikutani; Atsushi Kumanogoh

View on Scopus

July 1, 2010

Pre-sterilized, single use filling systems for liquid bio-pharmaceuticals

American Pharmaceutical Review, ISSN: 10998012

Lindsay Leveen

View on Scopus

July 1, 2010

The adaptor protein Sh2d3c is critical for marginal zone B cell development and function

Journal of Immunology, ISSN: 00221767 15506606

Amin Al-Shami; Carrie Wilkins; Jeannette Crisostomo; Dhaya Seshasayee; Flavius Martin; Nianhua Xu; Adisak Suwanichkul; Stephen J. Anderson; Tamás Oravecz

View on Scopus

July 1, 2010

Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens

Journal of Immunology, ISSN: 15506606 00221767

Sheela Ramanathan; Stephanie Dubois; Julien Gagnon; Chantal Leblanc; Sanjeev Mariathasan; Gerardo Ferbeyre; Robert Rottapel; Pamela S. Ohashi; Subburaj Ilangumaran

View on Scopus

July 1, 2010

Increasing parvovirus filter throughput of monoclonal antibodies using ion exchange membrane adsorptive pre-filtration

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Arick Brown; Charity Bechtel; Jerome Bill; Hui F. Liu; Jun Liu; Daniel J. McDonald; Satyan Pai; Asha Radhamohan; Ryan Renslow; Brooke Thayer; Stefan T. Yohe; Chris Dowd

View on Scopus

July 1, 2010

Increased targeting of donor switch region and IgE in Sγ1-deficient B cells

Journal of Immunology, ISSN: 00221767 15506606

Shahram Misaghi; Christopher Garris; Yonglian Sun; Allen Nguyen; Juan Zhang; Andrew Sebrell; Kate Senger; Donghong Yan; Maria N. Lorenzo; Sherry Heldens; Wyne P. Lee; Min Xu; Jiansheng Wu; Laura DeForge; Tao Sai; Vishva M. Dixit; Ali A. Zarrin

View on Scopus

July 1, 2010

SEC assay for polyvinylsulfonic impurities in 2-(N-morpholino) ethanesulfonic acid using a charged aerosol detector

Chromatographia, ISSN: 00095893 16121112

Taylor Zhang; Daniel Hewitt; Kao

View on Scopus

July 1, 2010

Quantitative modeling of viable cell density, cell size, intracellular conductivity, and membrane capacitance in batch and fed-batch CHO processes using dielectric spectroscopy

Biotechnology Progress, ISSN: 87567938 15206033

Cary F. Opel; Jincai Li; Ashraf Amanullah

View on Scopus

July 1, 2010

Process transfer to contract manufacturing organizations: A case study on process development support past regulatory approval

Pharmaceutical Engineering, ISSN: 02738139

Amy Webb; David H. Reifsnyder; Bender

View on Scopus

July 1, 2010

PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice

Journal of Clinical Investigation, ISSN: 00219738 15588238

Scott N. Mueller; Vijay K. Vanguri; Sang-Jun Ha; Erin E. West; Mary E. Keir; Jonathan N. Glickman; Arlene H. Sharpe; Rafi Ahmed

View on Scopus

July 1, 2010

Modulation of inflammasome activity for the treatment of auto-inflammatory disorders

Journal of Clinical Immunology, ISSN: 02719142 15732592

Naik; Vishva M. Dixit

View on Scopus

July 1, 2010

Inline ultrafiltration

Biotechnology Progress, ISSN: 87567938 15206033

Christopher A. Teske; Lebreton

View on Scopus

July 1, 2010

Use of disposable reactors to generate inoculum cultures for E. coli production fermentations

Biotechnology Progress, ISSN: 87567938 15206033

Ekta Mahajan; Timothy Matthews; Ryan Hamilton; Mike Laird

View on Scopus

July 1, 2010

Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells

Journal of Clinical Investigation, ISSN: 00219738 15588238

Sheng Cao; Usman Yaqoob; Amitava Das; Uday Shergill; Kumaravelu Jagavelu; Robert C. Huebert; Chittaranjan Routray; Soha Abdelmoneim; Meher Vasdev; Edward Leof; Michael R. Charlton; Ryan J. Watts; Debabrata Mukhopadhyay; Vijay H. Shah

View on Scopus

July 1, 2010

New neurons clear the path of astrocytic processes for their rapid migration in the adult brain

Neuron, ISSN: 08966273

Naoko Kaneko; Oscar Marín; Masato Koike; Yuki Hirota; Yasuo Uchiyama; Jane Y. Wu; Qiang Lu; Marc Tessier-Lavigne; Arturo Alvarez-Buylla; Hideyuki Okano; John L. R. Rubenstein; Kazunobu Sawamoto

View on Scopus

July 1, 2010

Cost analysis review of stroke centers, telestroke, and rt-PA

American Journal of Managed Care, ISSN: 10880224

Bart M. Demaerschalk; Ha-Mill Hwang; Grace Leung

View on Scopus

July 1, 2010

The role of the hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment

Clinical Cancer Research, ISSN: 10780432 15573265

Ivor Caro; Low

View on Scopus

July 1, 2010