Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9051 - 9100 OF 15613 RESULTS

Efficacy and safety of retreatment in patients with rheumatoid arthritis with previous inadequate response to tumor necrosis factor inhibitors: Results from the SUNRISE trial
Journal of Rheumatology, ISSN: 0315162X
Philip J. Mease; Stanley B. Cohen; Norman B. Gaylis; Andrew Chubick; Alan T. Kaell; Maria Greenwald; Sunil Agarwal; Ming Yin; Ariella Kelman
View on Scopus
Signalling lessons from death receptors: The importance of cleavage
Nature Cell Biology, ISSN: 14657392
Vishva M. Dixit
View on Scopus
Detecting low level sequence variants in recombinant monoclonal antibodies
mAbs, ISSN: 19420862
Yi Yang; Alex Strahan; Charlene Li; Amy Shen; Hongbin Liu; Jun Ouyang; Viswanatham Katta; Kathleen Francissen; Boyan Zhang
View on Scopus
Host-detrimental role of Esx-1-mediated inflammasome activation in Mycobacterial infection
PLoS Pathogens, ISSN: 15537366 15537374
Fredric Carlsson; Janice Kim; Calin Dumitru; Kai H. Barck; Richard A. D. Carano; Mei Sun; Laurie Diehl; Eric J. Brown
View on Scopus
A20: From ubiquitin editing to tumour suppression
Nature Reviews Cancer, ISSN: 1474175X 14741768
Sarah G. Hymowitz; Ingrid E. Wertz
View on Scopus
Detection of protein-RNA complexes in Xenopus oocytes
Methods, ISSN: 10462023 10959130
Paul W. Huber; Wei-meng Zhao
View on Scopus
The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans
Molecular and Cellular Biology, ISSN: 02707306
Vernon T. Phan; Vivianne W. Ding; Fenglei Li; Robert J. Chalkley; Alma Burlingame; Frank McCormick
View on Scopus
Vaccinia H5 is a multifunctional protein involved in viral DNA replication, postreplicative gene transcription, and virion morphogenesis
Virology, ISSN: 00426822 10960341
Susan M. D'Costa; Travis W. Bainbridge; Sayuri E. Kato; Cindy Prins; Karen Kelley; Richard C. Condit
View on Scopus
Validation of cell density and viability assays using Cedex automated cell counter
Biologicals, ISSN: 10451056 10958320
Li-Chun Huang; Wendy Lin; Machiko Yagami; Daphne Tseng; Emily Miyashita-Lin; Nitasha Singh; Andy Lin; Shian-Jiun Shih
View on Scopus
Therapeutic antibodies for autoimmunity and inflammation
Nature Reviews Immunology, ISSN: 14741733
Andrew A. Chan; Paul J. Carter
View on Scopus
Prolonged endoplasmic reticulum stress promotes mislocalization of immunoglobulins to the cytoplasm
Molecular Immunology, ISSN: 01615890
Adi Drori; Shahram Misaghi; Joseph Haimovich; Martin Messerle; Boaz Tirosh
View on Scopus
Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis
Nature, ISSN: 00280836 14764687
Sergio E. Baranzini; Joann Mudge; Jennifer C. Van Velkinburgh; Pouya Khankhanian; Irina Khrebtukova; Neil A. Miller; Lu Zhang; Andrew D. Farmer; Callum J. Bell; Ryan W. Kim; Gregory D. May; Jimmy E. Woodward; Stacy J. Caillier; Joseph P. McElroy; Refujia Gomez; Marcelo J. Pando; Leonda E. Clendenen; Elena E. Ganusova; Faye D. Schilkey; Thiruvarangan Ramaraj; Omar A. Khan; Jim J. Huntley; Shujun Luo; Pui-Yan Kwok; Thomas D Wu; Gary P. Schroth; Jorge R. Oksenberg; Stephen L. Hauser; Stephen F. Kingsmore
View on Scopus
Reply to W. Wick et al
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Henry S. Friedman; Michael D. Prados; Patrick Y. Wen; Tom Mikkelsen; David Schiff; Lauren E. Abrey; Alfred Yung; Nina Paleologos; Martin K. Nicholas; Randy Jensen; James Vredenburgh; Jane E. Huang; Maoxia Zheng; Timothy Cloughesy
View on Scopus
Ladder polyether synthesis via epoxide-opening cascades directed by a disappearing trimethylsilyl group
Journal of Organic Chemistry, ISSN: 00223263 15206904
Timothy P. Heffron; Graham L. Simpson; Estibaliz Merino; Timothy F. Jamison
View on Scopus
IL-17RC is required for IL-17A- and IL-17F-dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis
Journal of Immunology, ISSN: 00221767 15506606
Yan Hu; Naruhisa Ota; Ivan Peng; Refino; Dimitry Danilenko; Patrick Caplazi; Wenjun Ouyang
View on Scopus
Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Timothy P. Heffron; Megan Berry; Georgette M. Castanedo; Christine Chang; Irina Chuckowree; Jennafer Dotson; Adrian J. Folkes; Janet Gunzner; John Lesnick; Lewis; Simon Mathieu; Jim Nonomiya; Alan G. Olivero; Jodie Pang; David Peterson; Laurent Salphati; Deepak Sampath; Steve Sideris; Daniel P. Sutherlin; Vickie Tsui; Nan Chi Wan; Shumei Wang; Susan C. Wong; Bing-Yan Zhu
View on Scopus
A therapeutic anti-VEGF antibody with increased potency independent of pharmacokinetic half-life
Cancer Research, ISSN: 00085472 15387445
Yik Andy Yeung; Xiumin Wu; Arthur Reyes; Jean-Michel Vernes; Samantha Lien; John Lowe; Mauricio Maia; William F. Forrest; Meng; Lisa A. Damico; Napoleone Ferrara; Henry B. Lowman
View on Scopus
Therapeutic antibody targeting of individual Notch receptors
Nature, ISSN: 00280836 14764687
Yan Wu; Carol Cain-Hom; Lisa Choy; Thijs Hagenbeek; Gladys P. De Leon; Yongmei Chen; David Finkle; Rayna Venook; Xiumin Wu; John B.B. Ridgway; Dorreyah Schahin-Reed; Graham J. Dow; Amy Shelton; Scott Stawicki; Ryan J. Watts; Jeff Zhang; Robert Choy; Peter Howard; Lisa Kadyk; Minhong Yan; Jiping Zha; Christopher Callahan; Sarah G. Hymowitz; Christian W. Siebel
View on Scopus
Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons
Journal of Neuroscience, ISSN: 02706474 15292401
Yanling Wang; Catherine A. Dye; Vikaas Sohal; Jason E. Long; Rosanne C. Estrada; Tomas Roztocil; Thomas Lufkin; Karl Deisseroth; Scott C. Baraban; John L. R. Rubenstein
View on Scopus
Differential effects of divalent manganese and magnesium on the kinase activity of Leucine-Rich Repeat Kinase 2 (LRRK2)
Biochemistry, ISSN: 00062960 15204995
Brian Lovitt; Erica Vanderporten; Zejuan Sheng; Haitao Zhu; Jake Drummond; Yichin Liu
View on Scopus
A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma
Cancer Cell, ISSN: 15356108
Ruihuan Chen; Merry C. Nishimura; Stephanie M. Bumbaca; Samir Kharbanda; William F. Forrest; Ian Kasman; Joan M. Greve; Robert Soriano; Laurie L. Gilmour; Rivers; Zora Modrusan; Serban Nacu; Steve Guerrero; Kyle A. Edgar; Jeffery J. Wallin; Katrin Lamszus; Manfred Westphal; Susanne Heim; C. David James; Scott R. VandenBerg; Joseph F. Costello; Scott Moorefield; Cynthia J. Cowdrey; Michael D. Prados; Phillips
View on Scopus
Cancer therapy reform
Science, ISSN: 00368075 10959203
Levinson
View on Scopus
Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Laetitia Malphettes; Yevgeniy Freyvert; Chang; Pei-Qi Liu; Edmond Chan; Jeffrey C. Miller; Zhe Zhou; Nguyen; Christina Tsai; Andrew Snowden; Trevor N. Collingwood; Philip D. Gregory; Gregory J. Cost
View on Scopus
An intracellular traffic jam: Fc receptor-mediated transport of immunoglobulin G
Current Opinion in Structural Biology, ISSN: 0959440X
Devin B. Tesar; Pamela J. Bjorkman
View on Scopus
The actin-bundling protein L-plastin dissociates CCR7 proximal signaling from CCR7-induced motility
Journal of Immunology, ISSN: 00221767 15506606
Sharon Celeste Morley; Chen Wang; Wan-Lin Lo; Chan-Wang J. Lio; Bernd H. Zinselmeyer; Mark J. Miller; Eric J. Brown; Paul M. Allen
View on Scopus
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
Nature Cell Biology, ISSN: 14657392
Yaron Pereg; Bob Y. Liu; Karen M. O'Rourke; Meredith Sagolla; Anwesha Dey; László Kömüves; French; Vishva M. Dixit
View on Scopus
Characteristics of rhVEGF release from topical hydrogel formulations
Pharmaceutical Research, ISSN: 07248741 1573904X
Junyan A. Ji; Jun Liu; Steven J. Shire; Tim J. Kamerzell; Sung Hong; Karen L Billeci; Ye Shen; Y. John Wang
View on Scopus
A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice
Developmental Biology, ISSN: 1095564X 00121606
Setsu Endoh-Yamagami; Kameel M. Karkar; Scott R. May; Inma Cobos; Myo T. Thwin; Jason E. Long; Amir M. Ashique; Konstantinos Zarbalis; John L. R. Rubenstein; Andrew S. Peterson
View on Scopus
Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Frederick Cohen; Michael F. T. Koehler; Philippe Bergeron; Linda O. Elliott; Flygare; Matthew C Franklin; Lewis Gazzard; Stephen F. Keteltas; Kevin Lau; Cuong Q. Ly; Vickie Tsui; Wayne J. Fairbrother
View on Scopus
Novel method for genotyping hepatitis B virus on the basis of taqMan real-time PCR
Journal of Clinical Microbiology, ISSN: 00951137
Sebastian Malmström; Ida Enquist; Magnus Lindh
View on Scopus
Cytosol as battleground: Ubiquitin as a weapon for both host and pathogen
Trends in Cell Biology, ISSN: 09628924
Cathleen A. Collins; Eric J. Brown
View on Scopus
Estimating duration in partnership studies: Issues, methods and examples
Sexually Transmitted Infections, ISSN: 13684973 14723263
Bart Burington; James P. Hughes; William L. H. Whittington; Brad Stoner; Geoff Garnett; Sevgi O. Aral; King K. Holmes
View on Scopus
Site-specifically 89Zr-labeled monoclonal antibodies for ImmunoPET
Nuclear Medicine and Biology, ISSN: 09698051
Jeff N. Tinianow; Herman S. Gill; Annie Ogasawara; Judith E. Flores; Alexander N. Vanderbilt; Luis; Richard L. Vandlen; Martine Darwish; Jagath R. Junutula; Simon P. Williams; Jan Marik
View on Scopus
Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?
Annals of Neurology, ISSN: 03645134 15318249
Amit Bar-Or; Lama Fawaz; Boli Fan; Peter J. Darlington; Aja Rieger; Christine Ghorayeb; Peter A Calabresi; Waubant; Stephen L. Hauser; Jiameng Zhang; Craig H. Smith
View on Scopus
Spatial control of EGF receptor activation by reversible dimerization on living cells
Nature, ISSN: 00280836 14764687
Inhee Chung; Robert W. Akita; Richard L. Vandlen; Derek Toomre; Schlessinger; Ira Mellman
View on Scopus
Cross-species comparison of the metabolism and excretion of zoniporide: Contribution of aldehyde oxidase to interspecies differences
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Deepak Dalvie; Chenghong Zhang; Weichao Chen; Teresa Smolarek; R. Scott Obach; Cho-Ming Loi
View on Scopus
Glembatumumab vedotin, a conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin e for the treatment of melanoma and breast cancer
Current Opinion in Molecular Therapeutics, ISSN: 14648431
Louie Naumovski; Jagath R. Junutula
View on Scopus
A phase III, randomized, double-blind, placebo-controlled study of tenecteplase for improvement of hemodialysis catheter function: TROPICS 3
Clinical Journal of the American Society of Nephrology, ISSN: 15559041 1555905X
James Tumlin; Jesse Goldman; David M. Spiegel; David Roer; K. Adu Ntoso; Martha Blaney; Joan R. Jacobs; Barbara S. Gillespie; Susan M. Begelman
View on Scopus
Kinetics of Hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation
Molecular and Cellular Biology, ISSN: 02707306
Xiaohui Wen; Cary K. Lai; Marie Evangelista; Hongo; Frederic J. De Sauvage; Suzie J. Scales
View on Scopus
Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-α antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Rong Deng; Kelly M. Loyet; Samantha Lien; Suhasini Iyer; Laura DeForge; Frank-Peter Theil; Henry B. Lowman; Fielder; Saileta Prabhu
View on Scopus
Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions
Nature Methods, ISSN: 15487091 15491676
Anita A. Koshy; Ashley Fouts; Melissa B. Lodoen; Ozan Alkan; Helen M. Blau; John C. Boothroyd
View on Scopus
Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Jin I. Lee; Damien M. O'Halloran; Jeffrey Eastham-Anderson; Bi-Tzen Juang; Julia A. Kaye; O. Scott Hamilton; Bluma Lesch; Andrei Goga; Noelle D. L'Etoile
View on Scopus
Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Desiree H. Fong; Christopher T. Lemke; Jiyoung Hwang; Bing Xiong; Albert M. Berghuis
View on Scopus
Reconstitution of a Frizzled8·Wnt3a·LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Eric Bourhis; Christine Tam; Yvonne Franke; J.Fernando Bazan; James A. Ernst; Jiyoung Hwang; Michael Costa; Andrea G Cochran; Rami N. Hannoush
View on Scopus
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Nature, ISSN: 00280836 14764687
Georgia Hatzivassiliou; Kyung Song; Ivana Yen; Barbara J. Brandhuber; Daniel J Anderson; Ryan Alvarado; Mary J. C. Ludlam; David Stokoe; Susan L. Gloor; Guy Vigers; Tony Morales; Ignacio Aliagas; Bonnie Liu; Steve Sideris; Klaus P. Hoeflich; Bijay S. Jaiswal; Somasekar Seshagiri; Koeppen; Marcia Belvin; Lori S. Friedman; Shiva Malek
View on Scopus
The tripartite motif protein MADD-2 functions with the receptor UNC-40 (DCC) in netrin-mediated axon attraction and branching
Developmental Cell, ISSN: 18781551 15345807
Joe C. Hao; Carolyn E. Adler; Leslie Mebane; Frank B. Gertler; Cornelia I. Bargmann; Marc Tessier-Lavigne
View on Scopus
Regulation of actin polymerization and adhesion-dependent cell edge protrusion by the abl-related gene (Arg) tyrosine kinase and N-WASp
Biochemistry, ISSN: 00062960 15204995
Matthew M. Miller; Stefanie Lapetina; Stacey M. MacGrath; Mindan K. Sfakianos; Thomas D. Pollard; Anthony J. Koleske
View on Scopus
Phase 1 pharmacokinetic and drug-interaction study of dasatinib in patients with advanced solid tumors
Cancer, ISSN: 0008543X 10970142
Faye M. Johnson; Shruti Agrawal; Howard A. Burris; Lee Rosen; Navneet Dhillon; David Hong; Anne Blackwood-Chirchir; Feng R. Luo; Oumar Sy; Sanjeev Kaul; Alberto A. Chiappori
View on Scopus
Using precipitation by polyamines as an alternative to chromatographic separation in antibody purification processes
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232
Junfen Ma; Hai Hoang; Thomas Myint; Thanmaya Peram; Fahrner; Judy H. Chou
View on Scopus
Determination of GDC-0449, a small-molecule inhibitor of the Hedgehog signaling pathway, in human plasma by solid phase extraction-liquid chromatographic-tandem mass spectrometry
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232
Xiao Ding; Bilin Chou; Richard A. Graham; Sravanthi Cheeti; Percey; Matassa; Reuschel; Meng; Liu; Voelker; Bert L. Lum; Patrick J. Rudewicz; Cornelis E. Hop
View on Scopus
© 2025 Genentech, Inc. All rights reserved. This site is intended for US residents only.