Genentech: Publications

February 1, 2010

Association of methotrexate and tumour necrosis factor antagonists with risk of infectious outcomes including opportunistic infections in the CORRONA registry

Annals of the Rheumatic Diseases, ISSN: 00034967 14682060

Greenberg; Reed; Joel M. Kremer; Tindall; Arthur Kavanaugh; Zheng; Bishai; Hochberg

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February 1, 2010

Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors

Cancer Research, ISSN: 00085472 15387445

Kyle A. Edgar; Jeffery J. Wallin; Megan Berry; Leslie Lee; Wei Wei Prior; Deepak Sampath; Lori S. Friedman; Marcia Belvin

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January 29, 2010

Understanding and mitigating conductivity transitions in weak cation exchange chromatography

Journal of Chromatography A, ISSN: 00219673

Jace Fogle; Jenny Hsiung

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January 25, 2010

Dynamics of the bacterial intermediate filament crescentin in vitroand in vivo

PLoS ONE, ISSN: 19326203

Osigwe Esue; Laura Rupprecht; Sean X. Sun; Denis Wirtz

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January 22, 2010

Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development

Cell, ISSN: 00928674

Beate M. Lichtenberger; Poi Kiang Tan; Heide Niederleithner; Napoleone Ferrara; Peter Petzelbauer; Maria Sibilia

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January 19, 2010

Utilization of lysozyme charge ladders to examine the effects of protein surface charge distribution on binding affinity in ion exchange systems

Langmuir, ISSN: 07437463

Wai Keen Chung; Steven T. Evans; Alexander S. Freed; James J. Keba; Zachary C. Baer; Kaushal Rege; Steven M. Cramer

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January 19, 2010

β1 Integrin Establishes Endothelial Cell Polarity and Arteriolar Lumen Formation via a Par3-Dependent Mechanism

Developmental Cell, ISSN: 15345807

Ann C. Zovein; Alfonso Luque; Kirsten A. Turlo; Jennifer J. Hofmann; Kathleen M. Yee; Michael S. Becker; Reinhard Fässler; Ira Mellman; Timothy F. Lane; M. Luisa Iruela-Arispe

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January 19, 2010

Stromal cell-derived factor-1/CXCL12 contributes to MMTV-Wnt1 tumor growth involving Gr1+CD11b+ cells

PLoS ONE, ISSN: 19326203

Bob Y. Liu; Soloviev; Peter Chang; John Lee; Xiaodong Huang; Cuiling Zhong; Napoleone Ferrara; Paul G. Polakis; Sakanaka

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January 19, 2010

Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo

Developmental Cell, ISSN: 15345807

Eric Camerer; Adrian Barker; Daniel N. Duong; Rajkumar Ganesan; Hiroshi Kataoka; Ivo Cornelissen; Molly R. Darragh; Arif Hussain; Yao-Wu Zheng; Yoga Srinivasan; Christopher Brown; Shan-Mei Xu; Jean B. Regard; Chen-Yong Lin; Charles S. Craik; Daniel Kirchhofer; Shaun R. Coughlin

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January 18, 2010

Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1

Journal of Experimental Medicine, ISSN: 00221007 15409538

Hongkang Xi; Kenneth J. Katschke Jr.; Karim Y. Helmy; Paige A. Wark; Noelyn Kljavin; Hilary F. Clark; Jeffrey Eastham-Anderson; Theresa Shek; Merone Roose-Girma; Nico Ghilardi; Menno Van Lookeren Campagne

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January 15, 2010

Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis

Journal of Immunology, ISSN: 00221767 15506606

Nadine Kassner; Manuela Krueger; Hideo Yagita; Andrzej Dzionek; Andreas Hutloff; Richard Kroczek; Alexander Scheffold; Sascha Rutz

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January 15, 2010

Reversing HOXA9 oncogene activation by PI3K inhibition: Epigenetic mechanism and prognostic significance in human glioblastoma

Cancer Research, ISSN: 00085472 15387445

Bruno M. Costa; Justin S. Smith; Ying Chen; Justin Chen; Phillips; Kenneth D. Aldape; Giuseppe Zardo; Janice M. Nigro; C. David James; Jane Fridlyand; Rui M. Reis; Joseph F. Costello

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January 15, 2010

Corrigendum to "GDC-0449-A potent inhibitor of the hedgehog pathway" [Bioorg. Med. Chem. Lett. 19 (2009) 5576] (DOI:10.1016/j.bmcl.2009.08.049)

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Kirk D. Robarge; Shirley A. Brunton; Georgette M. Castanedo; Yong Cui; Dina; Richard Goldsmith; Stephen Gould; Oivin Guichert; Janet Gunzner; Jason S Halladay; Wei Jia; S. Cyrus Khojasteh; Michael F. T. Koehler; Karen Kotkow; Hank La; Rebecca L. LaLonde; Kevin Lau; Leslie Lee; Derek Marshall; James C. Marsters Jr.; Lesley J. Murray; Changgeng Qian; Lee L. Rubin; Laurent Salphati; Mark S. Stanley; John H.A. Stibbard; Daniel P. Sutherlin; Savita Ubhayakar; Shumei Wang; Susan C. Wong; Minli Xie

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January 11, 2010

Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3

Journal of Cell Biology, ISSN: 00219525 00219525

Yunling Xu; Li Yuan; Judy Mak; Luc Pardanaud; Maresa Caunt; Ian Kasman; Bruno Larrivee; Raquel del Toro; Steven Suchting; Alexander Medvinsky; Jillian Silva; Jian Yang; Jean-Léon Thomas; Alexander W. Koch; Kari Alitalo; Anne Eichmann; Anil Bagri

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January 8, 2010

Industrial case study: Evaluation of a mixed-mode resin for selective capture of a human growth factor recombinantly expressed in E. coli

Journal of Chromatography A, ISSN: 00219673

Kimberly A. Kaleas; Charles H. Schmelzer; Shelly A. Pizarro

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January 8, 2010

Four-component synthesis of fully substituted 1,2,4-triazoles

Angewandte Chemie - International Edition, ISSN: 14337851

Steven T. Staben; Nicole Blaquiere

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January 7, 2010

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

Nature, ISSN: 00280836 14764687

Martin Schwickart; Xiaodong Huang; Jennie R. Lill; Jinfeng Liu; Ron Ferrando; French; Heather Maecker; Karen M. O'Rourke; J.Fernando Bazan; Jeffrey Eastham-Anderson; Peng Yue; David Dornan; David C.S. Huang; Vishva M. Dixit

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January 1, 2010

Targeting inhibitor of apoptosis (IAP) proteins in cancer

Apoptosis: Modern Insights into Disease from Molecules to Man,

Eugene Varfolomeev; Domagoj Vucic

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January 1, 2010

Statistical techniques to construct assays for identifying likely responders to a treatment under evaluation from cell line genomic data.

BMC Cancer, ISSN: 14712407

Erich P. Huang; Jane Fridlyand; Nicholas Lewin-Koh; Peng Yue; Xiaoyan Shi; David Dornan; Bart Burington

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January 1, 2010

Pharmaceutical Medical Information Contact Centers: Results of Three Benchmarking Surveys

Therapeutic Innovation and Regulatory Science, ISSN: 21684790

Pete Guillot; Stacey M. Fung

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January 1, 2010

Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging model

British Journal of Dermatology, ISSN: 13652133 00070963

Wang; Fujita; Prado; Tousson; Hsu; Arndt J Schottelius; Kelly; Yang; Wu; Chen; Xu; Elmets; Mountz; Edwards Iii

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January 1, 2010

Single-use technology and its carbon and water footprints, part 2: "Bioreactors - To be or not to be: That is the question"

American Pharmaceutical Review, ISSN: 10998012

Lindsay Leveen

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January 1, 2010

An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Satish K. Singh; Nataliya Afonina; Michel Awwad; Karoline Bechtold-Peters; Jeffrey T. Blue; Danny Chou; Cromwell; Hans-Juergen Krause; Hanns-Christian Mahler; Brian K. Meyer; Linda O. Narhi; Doug P. Nesta; Thomas Spitznagel

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January 1, 2010

A generic headspace GC method for residual solvents in pharmaceuticals: Benefits, rationale, and adaptations for new chemical entities

LCGC North America, ISSN: 15275949

Lulu Dai; Amanda C. Quiroga; Kelly Zhang; Heather B. Runes; Derrick T. Yazzie; Kavita Mistry; Nik P. Chetwyn; Michael W. Dong

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January 1, 2010

Cancer: MiRNA addiction - Depending on life's little things

Current Biology, ISSN: 09609822

David Dornan; Jeffrey Settleman

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January 1, 2010

Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia

Journal of Immunology, ISSN: 15506606 00221767

Lamkanfi; Anasuya Sarkar; Vande Walle; Alberto C. Vitari; Amal O. Amer; Mark D. Wewers; Kevin J. Tracey; Thirumala-Devi Kanneganti; Vishva M. Dixit

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January 1, 2010

The conserved bardet-biedl syndrome proteins assemble a coat that traffics membrane proteins to Cilia

Cell, ISSN: 00928674

Hua Jin; Susan Roehl White; Toshinobu Shida; Stefan Schulz; Mike Aguiar; Steven P. Gygi; J.Fernando Bazan; Maxence V. Nachury

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January 1, 2010

B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity

Annals of Neurology, ISSN: 15318249 03645134

Martin Weber; Thomas Prod'homme; Juan C. Patarroyo; Nicolas Molnarfi; Tara Karnezis; Klaus Lehmann-Horn; Dimitry Danilenko; Jeffrey Eastham-Anderson; Anthony J. Slavin; Christopher Linington; Claude C.A. Bernard; Flavius Martin; Scott S. Zamvil

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January 1, 2010

A two-stage algorithm for designing phase I cancer clinical trials for two new molecular entities

Contemporary Clinical Trials, ISSN: 15517144

Zheng Su

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January 1, 2010

Immunization responses in rheumatoid arthritis patients treated with rituximab: Results from a controlled clinical trial

Arthritis and Rheumatism, ISSN: 00043591 15290131

Bingham; R. John Looney; Deodhar; Neal Halsey; Maria Greenwald; Christine Codding; Benjamin L. Trzaskoma; Flavius Martin; Sunil Agarwal; Ariella Kelman

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January 1, 2010

Phase 1 study of aflibercept administered subcutaneously to patients with advanced solid tumors

Clinical Cancer Research, ISSN: 10780432

William P. Tew; Michael S. Gordon; John Murren; Jakob Dupont; Sandra Pezzulli; Carol Aghajanian; Paul Sabbatini; David Mendelson; Lawrence Schwartz; Scott Gettinger; Amanda Psyrri; Jesse M. Cedarbaum; David R. Spriggs

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January 1, 2010

Guidelines for reporting the use of capillary electrophoresis in proteomics

Nature Biotechnology, ISSN: 15461696 10870156

Paula J. Domann; Satoko Akashi; Coral Barbas; Lihua Huang; Wendy Lau; Cristina Legido-Quigley; Stephen McClean; Christian Neusü; David Perrett; Milena Quaglia; Erdmann Rapp; Lance Smallshaw; Norman W. Smith; W Franklin Smyth; Chris Taylor

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January 1, 2010

Cell culture monitoring via an auto-sampler and an integrated multi-functional off-line analyzer

Biotechnology Progress, ISSN: 87567938 15206033

Gayle E. Derfus; Daniel Abramzon; Meg Tung; David Chang; Robert Kiss; Ashraf Amanullah

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January 1, 2010

Prospects for personalized medicine with inhibitors targeting the RAS and PI3K pathways

Expert Review of Molecular Diagnostics, ISSN: 14737159 17448352

Lackner

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January 1, 2010

Mechanism-based receptor-binding model to describe the pharmacokinetic and pharmacodynamic of an anti-α5β1 integrin monoclonal antibody (volociximab) in cancer patients

Cancer Chemotherapy and Pharmacology, ISSN: 03445704

Chee Ng; Shuang Bai; Takimoto; Meina Tao Tang; Anthony W. Tolcher

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January 1, 2010

Structural characterization of intact antibodies by high-resolution LTQ Orbitrap mass spectrometry

Journal of Mass Spectrometry, ISSN: 10765174 10969888

Jennifer Zhang; Hongbin Liu; Viswanatham Katta

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January 1, 2010

Local tissue distribution and cellular fate of vascular endothelial growth factor (VEGF) following intramuscular injection

Journal of Drug Targeting, ISSN: 1061186X 10292330

Daugherty; Mrsny

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January 1, 2010

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist

British Journal of Pharmacology, ISSN: 14765381 00071188

Joel R. Gever; Rothschild Soto; Robert A. Henningsen; Renee S. Martin; David Hackos; Sandip Panicker; Rubas; Ian B. Oglesby; Michael P. Dillon; Marcos E. Milla; Geoffrey Burnstock; Anthony P. D. W. Ford

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January 1, 2010

Purification and characterization of a motility initiating protein from caprine epididymal plasma

Journal of Cellular Physiology, ISSN: 00219541

Bijay S. Jaiswal; Kaushik Das; Sudipta Saha; Sandhya Rekha Dungdung; Gopal C. Majumder

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January 1, 2010

Poor disease control among insured users of high-dose combination therapy for asthma

Allergy and Asthma Proceedings, ISSN: 10885412 15396304

Michael S. Broder; Eunice Chang; Tripthi V. Kamath; Sandhya Sapra

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January 1, 2010

Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells

Trends in Molecular Medicine, ISSN: 14714914

Liyun Sang; James M. Roberts; Hilary A. Coller

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January 1, 2010

Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial

Arthritis and Rheumatism, ISSN: 00043591 15290131

Merrill; C. Michael Neuwelt; Daniel J. Wallace; Joseph C. Shanahan; Latinis; James C. Oates; Tammy O. Utset; Gordon; David A. Isenberg; Hsin-Ju Hsieh; David Zhang; Paul Brunetta

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January 1, 2010

Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: Insights into rational drug design and activity regulation

Chemical Biology and Drug Design, ISSN: 17470285 17470277

Alan K. Kutach; Armando G. Villaseñor; Diana Lam; Charles Belunis; Cheryl Janson; Stephen Lok; Li-Na Hong; Chao-Min Liu; Jerome Deval; Thomas J. Novak; Jim W. Barnett; Wei Chu; David Shaw; Andreas Kuglstatter

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January 1, 2010

Regulation of death receptor signaling by the ubiquitin system

Cell Death and Differentiation, ISSN: 13509047 14765403

Ingrid E. Wertz; Vishva M. Dixit

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January 1, 2010

Long-term safety of recombinant human growth hormone in children

Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X 0021972X

Jennifer J. Bell; Parker; Rita D. Swinford; Andrew R. Hoffman; Thomas J. Maneatis; Barbara M. Lippe

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January 1, 2010

Therapeutic strategies within the ubiquitin proteasome system

Cell Death and Differentiation, ISSN: 13509047 14765403

Adam G. Eldridge; Thomas O'Brien

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January 1, 2010

Bevacizumab safety in patients with central nervous system metastases

Clinical Cancer Research, ISSN: 10780432

Benjamin Besse; Susan F. Lasserre; Peter Compton; Jane E. Huang; Stella Augustus; Ulrich-Peter Rohr

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January 1, 2010

Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

Cancer Cell, ISSN: 15356108

Jian-Bin Wang; Jon W. Erickson; Reina N. Fuji; Sekar Ramachandran; Ping Gao; Ramani Dinavahi; Kristin F. Wilson; Andre L.B. Ambrosio; Sandra M.G. Dias; Chi V. Dang; Richard A. Cerione

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January 1, 2010

Cold denaturation of monoclonal antibodies

mAbs, ISSN: 19420862

Kristi L. Lazar; Thomas W. Patapoff; Vikas Sharma

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January 1, 2010

A multigene predictor of outcome in glioblastoma

Neuro-Oncology, ISSN: 15228517 15235866

Howard Colman; Li Zhang; Erik P. Sulman; J. Matthew McDonald; Nasrin Latif Shooshtari; Andreana Rivera; Sonya Popoff; Catherine L. Nutt; David N. Louis; J. Gregory Cairncross; Mark R. Gilbert; Phillips; Minesh P. Mehta; Arnab Chakravarti; Christopher E. Pelloski; Krishna P.L. Bhat; Burt G. Feuerstein; Robert B. Jenkins; Kenneth D. Aldape

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