Genentech: Publications

January 1, 2010

Psychological effects of patient surge in large-scale emergencies: A quality improvement tool for hospital and clinic capacity planning and response

Prehospital and Disaster Medicine, ISSN: 19451938 1049023X

Lisa S. Meredith; James L. Zazzali; Sandra Shields; David P. Eisenman; Halla Alsabagh

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January 1, 2010

A valid equation for the well-stirred perfusion limited physiologically based pharmacokinetic model that consistently accounts for the blood-tissue drug distribution in the organ and the corresponding valid equation for the steady state volume of distribution

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

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January 1, 2010

Cardiovascular events associated with ipratropium bromide in COPD

Chest, ISSN: 19313543 00123692

Sarika S. Ogale; Todd A. Lee; David H. Au; Denise M. Boudreau; Sean D. Sullivan

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January 1, 2010

A mouse knockout library for secreted and transmembrane proteins

Nature Biotechnology, ISSN: 15461696 10870156

Tracy Tzu-Ling Tang; Li Li; Zhijun Tang; Yun Li; Wei Yu Lin; Flavius Martin; Deanna Grant; Mark J. Solloway; Leon Parker; Weilan Ye; William F. Forrest; Nico Ghilardi; Tamás Oravecz; Kenneth A. Platt; Dennis S. Rice; Gwenn M. Hansen; Alejandro Abuin; Derek E. Eberhart; Godowski; Kathleen H. Holt; Andrew S. Peterson; Brian P. Zambrowicz; Frederic J. De Sauvage

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January 1, 2010

Comparative biotransformation of pyrazinone-containing corticotropin- releasing factor receptor-1 antagonists: Minimizing the reactive metabolite formation

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Xiaoliang Zhuo; Richard A. Hartz; Joanne J. Bronson; Harvey Wong; Vijay T. Ahuja; Vivekananda M. Vrudhula; John E. Leet; Stella Huang; John E. Macor; Yue-Zhong Shu

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January 1, 2010

Molecular imaging of the initial inflammatory response in atherosclerosis: Implications for early detection of disease

Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN: 10795642

Beat A. Kaufmann; Chad L. Carr; J. Todd Belcik; Aris Xie; Yue Qi; Scott Chadderdon; Evan S. Caplan; Jaspreet Khangura; Sherron Bullens; Bunting; Jonathan R. Lindner

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January 1, 2010

Longterm safety of patients receiving rituximab in rheumatoid arthritis clinical trials

Journal of Rheumatology, ISSN: 0315162X

Ronald Van Vollenhoven; Paul Emery; Bingham; Edward Keystone; Roy Fleischmann; Daniel E. Furst; Katherine Macey; Marianne Sweetser; Ariella Kelman; Rao Ravi

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January 1, 2010

Specific interactions in high concentration antibody solutions resulting in high viscosity

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Sandeep Yadav; Jun Liu; Steven J. Shire; Devendra S. Kalonia

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January 1, 2010

Safety and efficacy of combining sunitinib with bevacizumab + paclitaxel/carboplatin in non-small cell lung cancer

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Mark A. Socinski; Frank A. Scappaticci; Meghna Samant; Margaret M. Kolb; Kozloff

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January 1, 2010

Secretory Cell Hyperplasia and Defects in Notch Activity in a Mouse Model of Leukocyte Adhesion Deficiency Type II

Gastroenterology, ISSN: 00165085

Christopher C.M. Waterhouse; Steven Johnson; Mia Phillipson; Lori Zbytnuik; Björn Petri; Margaret Kelly; John Lowe; Paul Kubes

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January 1, 2010

Signaling to NF-kappaB: regulation by ubiquitination.

Cold Spring Harbor Perspectives in Biology, ISSN: 19430264

Ingrid E. Wertz; Vishva M. Dixit

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January 1, 2010

Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the hedgehog pathway inhibitor GDC-0449 in dogs: An investigation using preclinical studies and physiologically based pharmacokinetic modeling

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Harvey Wong; Frank-Peter Theil; Yong Cui; James C. Marsters Jr.; S. Cyrus Khojasteh; Laurent Vernillet; Hank La; Xiling Song; Hong Wang; Eric Morinello; Yuzhong Deng; Cornelis E. Hop

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January 1, 2010

On the influence of protein binding on pharmacological activity of drugs

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

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January 1, 2010

Vision-Related Function after Ranibizumab Treatment by Better- or Worse-Seeing Eye. Clinical Trial Results from MARINA and ANCHOR

Ophthalmology, ISSN: 01616420

Neil M. Bressler; Tom S. Chang; Ivan J. Suñer; Jennifer T. Fine; Chantal M. Dolan; James Ward; Tsontcho Ianchulev

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January 1, 2010

PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth

Cell, ISSN: 00928674

Carlos Bais; Xiumin Wu; Jenny Yao; Suya Yang; Yongping Crawford; Krista McCutcheon; Christine Tan; Ganesh Kolumam; Jean-Michel Vernes; Jeffrey Eastham-Anderson; Peter Haughney; Marcin Kowanetz; Thijs Hagenbeek; Ian Kasman; Hani Bou-Reslan; Ross; Nicholas Van Bruggen; Richard A. D. Carano; Yu-Ju Gloria Meng; Hongo; Jean-Philippe Stephan; Masabumi Shibuya; Napoleone Ferrara

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January 1, 2010

Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors

American Journal of Pathology, ISSN: 15252191 00029440

Seth B. Coffelt; Claire E. Lewis; Luigi Naldini; J. Martin Brown; Napoleone Ferrara; Michele De Palma

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January 1, 2010

Vibrational spectroscopy and chemometrics to characterize and quantitate trehalose crystallization

Analytical Biochemistry, ISSN: 10960309 00032697

Brian D. Connolly; Thomas W. Patapoff; Y. John Wang; Jamie M. R. Moore; Tim J. Kamerzell

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January 1, 2010

Ricinus communis agglutinin I leads to rapid down-regulation of VEGFR-2 and endothelial cell apoptosis in tumor blood vessels

American Journal of Pathology, ISSN: 15252191 00029440

Weon-Kyoo You; Ian Kasman; Dana D. Hu-Lowe; Donald M. McDonald

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January 1, 2010

Functions of type II pneumocyte-derived vascular endothelial growth factor in alveolar structure, acute inflammation, and vascular permeability

American Journal of Pathology, ISSN: 15252191 00029440

Marco Mura; Matthew Binnie; Bing Han; Chengjin Li; Cristiano F. Andrade; Atsushi Shiozaki; Yu Zhang; Napoleone Ferrara; David Hwang; Thomas K. Waddell; Shaf Keshavjee; Mingyao Liu

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January 1, 2010

Co-expression of ferrochelatase allows for complete heme incorporation into recombinant proteins produced in E. coli

Protein Expression and Purification, ISSN: 10465928

Jawahar Sudhamsu; Mariam Kabir; Michael V. Airola; Bhumit A. Patel; Syun-Ru Yeh; Denis L. Rousseau; Brian R. Crane

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January 1, 2010

On developing a process for conducting extractable-leachable assessment of components used for storage of biopharmaceuticals

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Aditya A. Wakankar; Y. John Wang; Eleanor Canova-Davis; Stacey Ma; Dieter Schmalzing; Josh Grieco; Terry Milby; Theresa Reynolds; Mazzarella; Ed Hoff; Stephen Gomez; Sheryl Martin-Moe

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January 1, 2010

Two lab tests help clinicians diagnose and predict ischemic stroke.

Managed Care, ISSN: 10623388

Thomas Morrow

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January 1, 2010

Asthma and the prospective risk of anaphylactic shock and other allergy diagnoses in a large integrated health care delivery system

Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206

Carlos Iribarren; Irina V. Tolstykh; Mary K. Miller; Mark D. Eisner

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January 1, 2010

An automated method for nonparametric kinetic analysis of clinical DCE-MRI data: Application to glioblastoma treated with bevacizumab

Magnetic Resonance in Medicine, ISSN: 15222594 07403194

Gregory Z. Ferl; Lu Xu; Michel Friesenhahn; Lisa J. Bernstein; Daniel P. Barboriak; Ruediger E. Port

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January 1, 2010

Manipulation of host cell death pathways during microbial infections

Cell Host and Microbe, ISSN: 19346069 19313128

Lamkanfi; Vishva M. Dixit

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January 1, 2010

Vessel imaging with viable tumor analysis for quantification of tumor angiogenesis

Magnetic Resonance in Medicine, ISSN: 15222594 07403194

Sharon E. Ungersma; Glenn Pacheco; Calvin Ho; Sharon Fong Yee; Ross; Nicholas Van Bruggen; Franklin V. Peale Jr.; Ross; Richard A. D. Carano

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January 1, 2010

Ranibizumab for Macular Edema following Branch Retinal Vein Occlusion. Six-Month Primary End Point Results of a Phase III Study

Ophthalmology, ISSN: 01616420

Peter A. Campochiaro; Jeffrey S. Heier; Leonard Feiner; Sarah Gray; Namrata Saroj; Amy Chen Rundle; Wendy Yee Murahashi; Roman G. Rubio

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January 1, 2010

Early menstrual characteristics associated with subsequent diagnosis of endometriosis

American Journal of Obstetrics and Gynecology, ISSN: 00029378

Susan A. Treloar; Tanya A. Bell; Christina M. Nagle; David M. Purdie; Adèle C. Green

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January 1, 2010

Ranibizumab for Macular Edema following Central Retinal Vein Occlusion. Six-Month Primary End Point Results of a Phase III Study

Ophthalmology, ISSN: 01616420

David M. Brown; Peter A. Campochiaro; Rishi Singh; Zhengrong Li; Sarah Gray; Namrata Saroj; Amy Chen Rundle; Roman G. Rubio; Wendy Yee Murahashi

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January 1, 2010

Incidence of New Choroidal Neovascularization in Fellow Eyes of Patients Treated in the MARINA and ANCHOR Trials

American Journal of Ophthalmology, ISSN: 00029394

Irene Barbazetto; Namrata Saroj; Howard Shapiro; Pamela Wong; Allen C. Ho; K. Bailey Freund

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January 1, 2010

O-fucose modulates notch-controlled blood lineage commitment

American Journal of Pathology, ISSN: 15252191 00029440

Quanjian Yan; David Yao; Lebing L. Wei; Yuanshuai Huang; Jay Myers; Lihua Zhang; Wei Xin; Jeongsup Shim; Yunfang Man; Bronislawa Petryniak; Stanton Gerson; John Lowe; Lan Zhou

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January 1, 2010

The chemical toolbox for monitoring protein fatty acylation and prenylation

Nature Chemical Biology, ISSN: 15524469 15524450

Rami N. Hannoush; Jinglucy Sun

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January 1, 2010

Molecular dynamics simulations of hydrotropic solubilization and self-aggregation of nicotinamide

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Yong Cui; Chenyue Xing; Yingqing Ran

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January 1, 2010

Vascular endothelial growth factor and age-related macular degeneration: From basic science to therapy

Nature Medicine, ISSN: 1546170X 10788956

Napoleone Ferrara

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January 1, 2010

Noncompartmental kinetic analysis of DCE-MRI data from malignant tumors: Application to glioblastoma treated with bevacizumab

Magnetic Resonance in Medicine, ISSN: 15222594 07403194

Ruediger E. Port; Lisa J. Bernstein; Daniel P. Barboriak; Lu Xu; Timothy P.L. Roberts; Nicholas Van Bruggen

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January 1, 2010

RTM3, which controls long-distance movement of potyviruses, is a member of a new plant gene family encoding a meprin and TRAF homology domain-containing protein

Plant Physiology, ISSN: 15322548 00320889

Patrick Cosson; Luc Sofer; Quang Hien Le; Valérie Léger; Valérie Schurdi-Levraud; Steven A. Whitham; Miki L. Yamamoto; Suresh Gopalan; Olivier le Gall; Thierry Candresse; James C. Carrington; Frédéric Revers

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January 1, 2010

Characterization of a nutrient feed precipitate from an E. coli fermentation process.

Biotechnology Progress, ISSN: 15206033

Lauren Speciner; Erin Mallon; Susan Leung; Mike Laird; Osigwe Esue

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January 1, 2010

Anti-CD22-MCC-DM1: An antibody-drug conjugate with a stable linker for the treatment of non-Hodgkin's lymphoma

Leukemia, ISSN: 14765551 08876924

Andrew G. Polson; Marna Williams; Gray; Reina N. Fuji; Kirsten Achilles Poon; Jacqueline McBride; Helga Raab; Thomas Januario; MaryAnn Go; Jeffrey Lau; Shang-Fan Yu; Du; Franklin Fuh; Christine Tan; Yan Wu; Wei-Ching Liang; Saileta Prabhu; Jean-Philippe Stephan; Hongo; Randall Dere; Rong Deng; Cullen; Ruth De Tute; Bennett; Andy Rawstron; Andrew S. Jack; Allen Ebens

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January 1, 2010

Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency

Nature Genetics, ISSN: 15461718 10614036

Ricardo C. Ferreira; Qiang Pan-Hammarström; Robert R. Graham; Vesela Gateva; Gumersindo Fontán; Annette T. Lee; Ward Ortmann; Elena Urcelay; Miguel Fernández-Arquero; Concepción Núñez; Gudmundur Jorgensen; Björn R. Ludviksson; Sinikka Koskinen; Katri Haimila; Hilary F. Clark; Lars Klareskog; Peter K. Gregersen; Timothy W. Behrens; Lennart Hammarström

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January 1, 2010

Treatment outcomes by tumor histology in eastern cooperative group study E4599 of bevacizumab with paclitaxel/carboplatin for advanced non-small cell lung cancer

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Alan Sandler; Jing Yi; Suzanne Dahlberg; Margaret M. Kolb; Lisa I. Wang; Julie Hambleton; Joan H. Schiller; David H. Johnson

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January 1, 2010

Monoclonal antibody purification using cationic polyelectrolytes: an alternative to column chromatography.

Biotechnology Progress, ISSN: 15206033

Thanmaya Peram; Paul McDonald; Jayme N. Carter-Franklin; Fahrner

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January 1, 2010

Effect of temperature, pH, dissolved oxygen, and hydrolysate on the formation of triple light chain antibodies in cell culture.

Biotechnology Progress, ISSN: 15206033

Natalia Gomez; Jun Ouyang; Mary D. H. Nguyen; Abigail R Vinson; Andy Lin; Inn H. Yuk

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January 1, 2010

Structure of the Complex between HER2 and an Antibody Paratope Formed by Side Chains from Tryptophan and Serine

Journal of Molecular Biology, ISSN: 00222836

Robert D. Fisher; Ultsch; Andreas Lingel; Gabriele Schaefer; Lily Shao; Sara Birtalan; Sachdev S. Sidhu; Eigenbrot

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January 1, 2010

Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER study year 2

American Journal of Ophthalmology, ISSN: 00029394

Prema Abraham; Huibin Yue; Laura J. Wilson

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January 1, 2010

On the possibility of self-induction of drug protein binding

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

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January 1, 2010

Questions about coverage accompany new fully implantable hearing system

Managed Care, ISSN: 10623388

Thomas Morrow

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January 1, 2010

Molecular biomarker analyses using circulating tumor cells

PLoS ONE, ISSN: 19326203

Elizabeth A. Punnoose; Siminder Atwal; Jill M. Spoerke; Heidi Savage; Ajay Pandita; Ru-Fang Yeh; Andrea Pirzkall; Bernard M. Fine; Lukas Amler; Daniel S. Chen; Lackner

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January 1, 2010

Cell biology redux.

Molecular Biology of the Cell, ISSN: 19394586

Ira Mellman

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January 1, 2010

Molecular mechanisms of regulatory T cell development and suppressive function

Progress in Molecular Biology and Translational Science, ISSN: 18771173

Kim

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January 1, 2010