Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9301 - 9350 OF 15613 RESULTS

The effects of paroxetine on the pharmacokinetics of paliperidone extended-release tablets
Pharmacopsychiatry, ISSN: 01763679 14390795
Berwaerts; Cleton; Herben; I. Van De Vliet; Chang; P. Van Hoek; Eerdekens
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Application of Automation in Ligand-Binding Assays
Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena,
Chris Morrow
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Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double-blind placebo-controlled multicenter trial
Annals of Neurology, ISSN: 03645134 15318249
Kathleen Hawker; Paul O'Connor; Mark S. Freedman; Peter A Calabresi; Jack Antel; Jack Simon; Stephen L. Hauser; Waubant; Timothy Vollmer; Hillel Panitch; Jiameng Zhang; Peter Chin; Craig H. Smith
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The Formulation and Delivery of Monoclonal Antibodies
Therapeutic Monoclonal Antibodies: From Bench to Clinic,
Vikas Sharma; Hung-Wei Chih; Mrsny; Daugherty
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Disposition of GDC-0879, a B-RAF kinase inhibitor in preclinical species Disposition of G-0879 in preclinical species
Xenobiotica, ISSN: 00498254 13665928
Edna F. Choo; James Driscoll; Feng; Bianca M. Liederer; Emile G. Plise; Nikole Randolph; Young G. Shin; Susan C. Wong; Yingqing Ran
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Robo-2 controls the segregation of a portion of basal vomeronasal sensory neuron axons to the posterior region of the accessory olfactory bulb
Journal of Neuroscience, ISSN: 02706474 15292401
Janet E. A. Prince; Hyung Cho Jin; Emilie Dumontier; William Andrews; Tyler Cutforth; Marc Tessier-Lavigne; John Parnavelas; Jean-François Cloutier
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Visualization and identification of IL-7 producing cells in reporter mice
PLoS ONE, ISSN: 19326203
Renata I. Mazzucchelli; Søren Warming; Scott M. Lawrence; Masaru Ishii; Mehrnoosh Abshari; A. Vallance Washington; Lionel Feigenbaum; Andrew C. Warner; Davis J. Sims; Wen Qing Li; Julie A. Hixon; Daniel H.D. Gray; Benjamin E. Rich; Matthew Morrow; Miriam R. Anver; James Cherry; Dieter Naf; Lawrence R. Sternberg; Daniel W. McVicar; Andrew G. Farr; Ronald N. Germain; Keith Rogers; Nancy A. Jenkins; Neal G. Copeland; Scott K. Durum
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Discovering cancer genes by integrating network and functional properties
BMC Medical Genomics, ISSN: 17558794
Li Li; Kangyu Zhang; James Lee; Shaun Cordes; David P. Davis; Zhijun Tang
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Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Lee; Anna V. Fedorova; Zobel; Michelle J. Boyle; Hong Yang; Matthew A. Perugini; Colman; Huang C.S. Huang; Deshayes; Fairlie
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The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis
Science Signaling, ISSN: 19450877 19379145
Amir M. Ashique; Youngshik Choe; Mattias Karlen; Scott R. May; Khanhky Phamluong; Mark J. Solloway; Johan Ericson; Andrew S. Peterson
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Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
John D. Rioux; Philippe Goyette; Timothy J. Vyse; Lennart Hammarström; Michelle M.A. Fernando; Todd Green; Philip L. De Jager; Sylvain Foisy; Joanne Wang; Paul I. W. De Bakker; Stephen Leslie; Gilean McVean; Leonid Padyukov; Lars Alfredsson; Vito Annese; David A. Hafler; Qiang Pan-Hammarström; Ritva Matell; Stephen J. Sawcer; Alastair D. Compston; Bruce A. C. Cree; Daniel B. Mirel; Mark J. Daly; Timothy W. Behrens; Lars Klareskog; Peter K. Gregersen; Jorge R. Oksenberg; Stephen L. Hauser
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Multiproduct high-resolution monoclonal antibody charge variant separations by pH gradient ion-exchange chromatography
Analytical Chemistry, ISSN: 00032700
Dell Farnan; G. Tony Moreno
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Monitoring Ocular Drug Therapy by Analysis of Aqueous Samples
Ophthalmology, ISSN: 01616420
Peter A. Campochiaro; David F. Choy; Diana V. Do; Gulnar Hafiz; Syed Mahmood Shah; Quan Dong Nguyen; Roman G. Rubio; Joseph R. Arron
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Pegylated Kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis
Cancer Research, ISSN: 00085472 15387445
Wei Li; Bu-Er Wang; Paul Moran; Michael T. Lipari; Rajkumar Ganesan; Corpuz; Mary J. C. Ludlam; Alvin Gogineni; Koeppen; Bunting; Gao; Daniel Kirchhofer
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A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
Nature Genetics, ISSN: 10614036 15461718
Vesela Gateva; Johanna K. Sandling; Geoffrey Hom; Kimberly E. Taylor; Sharon A. Chung; Xin Sun; Ward Ortmann; Kosoy; Ricardo C. Ferreira; Gunnel Nordmark; Iva Gunnarsson; Elisabet Svenungsson; Leonid Padyukov; Gunnar Sturfelt; Andreas Jönsen; Anders A. Bengtsson; Solbritt Rantapää-Dahlqvist; Emily C. Baechler; Elizabeth E. Brown; Graciela S. Alarcõn; Jeffrey C. Edberg; Robert P. Kimberly; Gerald McGwin; John D. Reveille; Luis M. Vilá; Robert P. Kimberly; Manzi; Michelle Petri; Annette T. Lee; Peter K. Gregersen; Michael F. Seldin; Lars Rönnblom; Lindsey A. Criswell; Ann-Christine Syvänen; Timothy W. Behrens; Robert R. Graham
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Recent asthma exacerbations predict future exacerbations in children with severe or difficult-to-treat asthma
Journal of Allergy and Clinical Immunology, ISSN: 00916749
Tmirah Haselkorn; Robert S. Zeiger; Bradley E. Chipps; David R. Mink; Stanley J. Szefler; F. Estelle R. Simons; Marc Massanari; James E. Fish
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Comparison of asthma exacerbations in pediatric and adult patients with severe or difficult-to-treat asthma
Journal of Allergy and Clinical Immunology, ISSN: 00916749
Robert S. Zeiger; Bradley E. Chipps; Tmirah Haselkorn; Lawrence Rasouliyan; F. Estelle R. Simons; James E. Fish
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Oral bioavailability of polychlorinated dibenzo-p-dioxins/dibenzofurans in industrial soils
Human and Ecological Risk Assessment, ISSN: 10807039 15497860
Brent Finley; Kurt Fehling; John Warmerdam; Eric Morinello
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Economic outcomes in patients diagnosed with systemic lupus erythematosus with versus without nephritis: Results from an analysis of data from a US claims database
Clinical Therapeutics, ISSN: 01492918 1879114X
Elise M. Pelletier; Sarika Ogale; Elaine B. Yu; Paul Brunetta; Jay Garg
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Combined effects of chronic nicotine and acute virus exposure on neurotrophin expression in rat lung
Pediatric Pulmonology, ISSN: 87556863 10990496
Fernando Urrego; Mario Scuri; Alexander Auais; Lida Mohtasham; Giovanni Piedimonte
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Targeting inhibitor of apoptosis proteins for therapeutic intervention
Future Medicinal Chemistry, ISSN: 17568919
Chudi O. Ndubaku; Frederick Cohen; Eugene Varfolomeev; Domagoj Vucic
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Human immunodeficiency virus type 1 protease-correlated cleavage site mutations enhance inhibitor resistance
Journal of Virology, ISSN: 0022538X
Madhavi Kolli; Eric Stawiski; Colombe Chappey; Celia A. Schiffer
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Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4- (methylsulfonyl)benzamide), an orally bioavailable systemic hedgehog signalling pathway inhibitor
Xenobiotica, ISSN: 00498254 13665928
Harvey Wong; Jacob Z. Chen; Bilin Chou; Jason S Halladay; Jane R. Kenny; Hank La; James C. Marsters Jr.; Emile G. Plise; Patrick J. Rudewicz; Kirk D. Robarge; Young G. Shin; Susan C. Wong; Chenghong Zhang; S. Cyrus Khojasteh
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Human monomeric antibody fragments to TRAIL-R1 and TRAIL-R2 that display potent in vitro agonism
mAbs, ISSN: 19420862
Claire L. Dobson; Sarah Main; Philip Newton; Matthieu Chodorge; Karen Cadwallader; Robin Humphreys; Albert; Tristan J. Vaughan; Ralph R. Minter; Bryan M. Edwards
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Multivariate analysis of the sequence dependence of asparagine deamidation rates in peptides
Pharmaceutical Research, ISSN: 07248741 1573904X
Andrew Kosky; Vasumathi Dharmavaram; Gayathri Ratnaswamy; Mark C. Manning
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Carboxylate-dependent gelation of a monoclonal antibody
Pharmaceutical Research, ISSN: 07248741 1573904X
Osigwe Esue; Sonoko Kanai; Jun Liu; Thomas W. Patapoff; Steven J. Shire
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Charge-based analysis of antibodies with engineered cysteines: From multiple peaks to a single main peak
mAbs, ISSN: 19420862
Xiaoying Chen; Mary D. H. Nguyen; Fred Jacobson; Jun Ouyang
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Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: Insights from imaging
Clinical Cancer Research, ISSN: 10780432
James P.B. O'Connor; Richard A. D. Carano; Andrew R. Clamp; Ross; Calvin Ho; Alan Jackson; Geoff J. M. Parker; Chris J. Rose; Franklin V. Peale Jr.; Michel Friesenhahn; Claire L. Mitchell; Yvonne Watson; Caleb Roberts; Lynn Hope; Sue Cheung; Hani Bou-Reslan; MaryAnn Go; Glenn Pacheco; Xiumin Wu; Tim C. Cao; Ross; Giovanni A. Buonaccorsi; Karen Davies; Jurjees Hasan; Paula Thornton; Olivia Del Puerto; Napoleone Ferrara; Nicholas Van Bruggen; Gordon C. Jayson
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A novel alginate hollow fiber bioreactor process for cellular therapy applications
Biotechnology Progress, ISSN: 87567938
Corinne A. Hoesli; Minh Luu; James M. Piret
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Retinoic Acid from the Meninges Regulates Cortical Neuron Generation
Cell, ISSN: 00928674
Julie A. Siegenthaler; Amir M. Ashique; Konstantinos Zarbalis; Katelin P. Patterson; Jonathan H. Hecht; Maureen A. Kane; Alexandra E. Folias; Youngshik Choe; Scott R. May; Tsutomu Kume; Joseph L. Napoli; Andrew S. Peterson; Samuel J. Pleasure
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Azaindole hydroxamic acids are potent HIV-1 integrase inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623
Michael B. Plewe; Scott L. Butler; Klaus R. Dress; Qiyue Hu; Ted W. Johnson; Jon E. Kuehler; Atsuo Kuki; Hieu Lam; Wen Liu; Dawn Nowlin; Qinghai Peng; Sadayappan V. Rahavendran; Steven P. Tanis; Khanh T. Tran; Hai Wang; Anle Yang; Junhu Zhang
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Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes
Journal of Experimental Medicine, ISSN: 00221007 15409538
David K. Finlay; Linda V. Sinclair; Carmen Feijoo; Caryll M. Waugh; Thijs Hagenbeek; Hergen Spits; Doreen A. Cantrell
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Masking MALT1: The paracaspase's potential for cancer therapy
Journal of Experimental Medicine, ISSN: 00221007 15409538
Domagoj Vucic; Vishva M. Dixit
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Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma
Science, ISSN: 00368075 10959203
Robert Yauch; Gerrit J. P. Dijkgraaf; Bruno Alicke; Thomas Januario; Christina Ahn; Thomas Holcomb; Kanan Pujara; Stinson; Christopher Callahan; Tracy Tzu-Ling Tang; J.Fernando Bazan; Zhengyan Kan; Somasekar Seshagiri; Christine L. Hann; Stephen Gould; Low; Charles M. Rudin; Frederic J. De Sauvage
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The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Richard G. Jenner; Michael J. Townsend; Ian Jackson; Kaiming Sun; Russell D. Bouwman; Richard A. Young; Laurie H. Glimcher; Graham M. Lord
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A Role for C. elegans Eph RTK Signaling in PTEN Regulation
Developmental Cell, ISSN: 15345807
Sarah Brisbin; Jun Liu; Jeff Boudreau; Jimmy Peng; Marie Evangelista; Ian Chin-Sang
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The Molecular Basis of Vascular Lumen Formation in the Developing Mouse Aorta
Developmental Cell, ISSN: 15345807
Boris Strilić; Tomáš Kučera; Jan Eglinger; Michael R. Hughes; Kelly M. McNagny; Sachiko Tsukita; Elisabetta Dejana; Napoleone Ferrara; Eckhard Lammert
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Promising bone-related therapeutic targets for rheumatoid arthritis
Nature Reviews Rheumatology, ISSN: 17594790 17594804
Yongwon Choi; Joseph R. Arron; Michael J. Townsend
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TSPAN12 Regulates Retinal Vascular Development by Promoting Norrin- but Not Wnt-Induced FZD4/β-Catenin Signaling
Cell, ISSN: 00928674
Harald Junge; Stacey Yang; Jeremy B. Burton; Kim Paes; Xiao Shu; French; Michael Costa; Dennis S. Rice; Weilan Ye
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Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y+, proopiomelanocortin+, and tyrosine hydroxylase+ neurons in neonatal and adult mice
Journal of Comparative Neurology, ISSN: 00219967 10969861
Cindy Yee; Yanling Wang; Stewart Anderson; Marc Ekker; John L. R. Rubenstein
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Revving the throttle on an oncogene: CDK8 takes the driver seat
Cancer Research, ISSN: 00085472 15387445
Ron Firestein; William C. Hahn
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Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors-Insight into Heterotrimeric IL-1 Signaling Complexes
Structure, ISSN: 09692126
Andreas Lingel; Thomas M. Weiss; Marc Niebuhr; Borlan Pan; Brent A. Appleton; Wiesmann; J.Fernando Bazan; Wayne J. Fairbrother
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Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: A validation study
Arthritis and Rheumatism, ISSN: 00043591 15290131
Jason W. Bauer; Michelle Petri; Franak Batliwalla; Thearith Koeuth; Joseph Wilson; Catherine A. Slattery; Angela Panoskaltsis-Mortari; Peter K. Gregersen; Timothy W. Behrens; Emily C. Baechler
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Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells
PLoS ONE, ISSN: 19326203
Junichi Soh; Naoki Okumura; William W. Lockwood; Hiromasa Yamamoto; Hisayuki Shigematsu; Wei Zhang; Raj Chari; David S. Shames; Ximing Tang; Calum MacAulay; Marileila Varella-Garcia; Tõnu Vooder; Ignacio I. Wistuba; Stephen Lam; Rolf Brekken; Shinichi Toyooka; Minna; Wan L. Lam; Adi Gazdar
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Engineering surfaces for substrate-mediated gene delivery using recombinant proteins
Biomacromolecules, ISSN: 15257797
Jennifer C. Rea; Romie F. Gibly; Nicolynn E. Davis; Annelise E. Barron; Lonnie D. Shea
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DNA spike studies for demonstrating improved clearance on chromatographic media
Journal of Chromatography A, ISSN: 00219673
Michelle D. Butler; Brian Kluck; Tracy Bentley
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Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
Journal of Cell Biology, ISSN: 00219525 00219525
Lamkanfi; James L. Mueller; Alberto C. Vitari; Shahram Misaghi; Anna V. Fedorova; Deshayes; Wyne P. Lee; Hal M. Hoffman; Vishva M. Dixit
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Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus
Lupus, ISSN: 09612033
Michelle Petri; Singh; Tesfasyone; Russell L Dedrick; Fry; Preeti Lal; Williams; Jason W. Bauer; Peter K. Gregersen; Timothy W. Behrens; Emily C. Baechler
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Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins
PLoS Biology, ISSN: 15449173 15457885
Raffi Tonikian; Xiaofeng Xin; Christopher P. Toret; David Gfeller; Christiane Landgraf; Simona Panni; Serena Paoluzi; Luisa Castagnoli; Bridget Currell; Somasekar Seshagiri; Haiyuan Yu; Barbara Winsor; Marc Vidal; Mark Gerstein; Gary D. Bader; Rudolf Volkmer; Gianni Cesareni; Drubin; Philip M. Kim; Sachdev S. Sidhu; Charles Boone
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High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions
PLoS Genetics, ISSN: 15537390 15537404
Lisa F. Barcellos; Suzanne L. May; Ramsay; Hong L. Quach; Lane; Joanne Nititham; Janelle A. Noble; Kimberly E. Taylor; Diana L. Quach; Sharon A. Chung; Jennifer A. Kelly; Kathy L. Moser; Timothy W. Behrens; Michael F. Seldin; Glenys Thomson; John B. Harley; Patrick M. Gaffney; Lindsey A. Criswell
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