Genentech: Publications

October 1, 2008

In vitro allergen challenge of peripheral blood induces differential gene expression in mononuclear cells of asthmatic patients: Inhibition of cytosolic phospholipase A2α overcomes the asthma-associated response

Clinical and Experimental Allergy, ISSN: 09547894 13652222

Whalen; Legault; Hang; Hill; Kasaian; Donaldson; Bensch; Bensch; Baker; Reddy; Wood; Ramarao; Ellis; Csimma; McKee; Clark; Ryan; Dorner; O'Toole

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October 1, 2008

γ-Glutamyltranspeptidase-mediated degradation of diclofenac-s-acyl- glutathione in vitro and in vivo in rat

Chemical Research in Toxicology, ISSN: 0893228X

Mark P. Grillo; Fengmei Hua; Kristi L. March; Leslie Z. Benet; Charles G. Knutson; Joseph A. Ware

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October 1, 2008

Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis

Gut, ISSN: 00175749

Colin L. Noble; Abbas Alexander; Jennine Cornelius; Charles W. Lees; Gwo-Tzer Ho; Toy; Zora Modrusan; Pal; Fiona Zhong; Sreedevi Chalasani; Hilary F. Clark; Ian D. Arnott; Ian D. Penman; Jack Satsangi; Laurie Diehl

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September 30, 2008

Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction

Science Signaling, ISSN: 19450877 19379145

Marie Evangelista; Tze Yang Lim; James Lee; Leon Parker; Amir M. Ashique; Andrew S. Peterson; Weilan Ye; David P. Davis; Frederic J. De Sauvage

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September 30, 2008

Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Nancy Dumont; Matthew B. Wilson; Yongping Crawford; Paul A. Reynolds; Mahvash Sigaroudinia; Thea D. Tlsty

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September 26, 2008

Robustness of virus removal by protein A chromatography is independent of media lifetime

Journal of Chromatography A, ISSN: 00219673

Scott Lute; Lenore A Norling; Michael Hanson; Rachel Emery; Denise Stinson; Kevin Padua; Gregory S. Blank; Qi Chen; Kurt Brorson

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September 25, 2008

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1- ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

Journal of Medicinal Chemistry, ISSN: 00222623

Adrian J. Folkes; Khatereh Ahmadi; Wendy K. Alderton; Sonia Alix; Stewart Baker; Gary Box; Irina Chuckowree; Paul A. Clarke; Paul Depledge; Suzanne A. Eccles; Lori S. Friedman; Angela Hayes; Timothy Hancox; Arumugam Kugendradas; Letitia Lensun; Pauline Moore; Alan G. Olivero; Jodie Pang; Sonal Patel; Giles H. Pergl-Wilson; Florence I. Raynaud; Anthony Robson; Nahid Saghir; Laurent Salphati; Sukhjit Sohal; Ultsch; Melanie Valenti; Heidi J. A. Wallweber; Chi Wan Nan; Wiesmann; Paul Workman; Alexander Zhyvoloup; Marketa J. Zvelebil; Stephen Shuttleworth

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September 24, 2008

Inducible BRAF Suppression Models for Melanoma Tumorigenesis

Methods in Enzymology, ISSN: 00766879

Klaus P. Hoeflich; Bijay S. Jaiswal; David P. Davis; Somasekar Seshagiri

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September 20, 2008

Two-stage randomization designs in drug development

Statistics in Medicine, ISSN: 02776715 10970258

Marcel Wolbers; Jeffrey D. Helterbrand

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September 19, 2008

Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: A case-control association study of the STAT1-STAT4 region

Arthritis Research and Therapy, ISSN: 14786354 14786362

Aya Kawasaki; Ikue Ito; Koki Hikami; Jun Ohashi; Taichi Hayashi; Daisuke Goto; Isao Matsumoto; Satoshi Ito; Akito Tsutsumi; Minori Koga; Tadao Arinami; Robert R. Graham; Geoffrey Hom; Yoshinari Takasaki; Hiroshi Hashimoto; Timothy W. Behrens; Takayuki Sumida; Naoyuki Tsuchiya

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September 18, 2008

A paracrine requirement for hedgehog signalling in cancer

Nature, ISSN: 00280836 14764679

Robert Yauch; Stephen Gould; Suzie J. Scales; Tracy Tzu-Ling Tang; Hua Tian; Christina Ahn; Derek Marshall; Ling Fu; Thomas Januario; Dara Y. Kallop; Michelle Nannini; Karen Kotkow; James C. Marsters Jr.; Lee L. Rubin; Frederic J. De Sauvage

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September 15, 2008

Gene expression profile and angiogenic marker correlates with response to neoadjuvant bevacizumab followed by bevacizumab plus chemotherapy in breast cancer

Clinical Cancer Research, ISSN: 10780432

Sherry X. Yang; Seth M. Steinberg; Dat Nguyen; Thomas D Wu; Zora Modrusan; Sandra M. Swain

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September 5, 2008

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB activation

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Eugene Varfolomeev; Tatiana Goncharov; Anna V. Fedorova; Jasmin N. Dynek; Zobel; Deshayes; Wayne J. Fairbrother; Domagoj Vucic

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September 1, 2008

A specificity map for the PDZ domain family

PLoS Biology, ISSN: 15449173 15457885

Raffi Tonikian; Yingnan Zhang; Stephen L. Sazinsky; Bridget Currell; Jung-Hua Yeh; Boris Reva; Heike A. Held; Brent A. Appleton; Marie Evangelista; Yan Wu; Xiaofeng Xin; Andrew A. Chan; Somasekar Seshagiri; Lasky; Chris Sander; Charles Boone; Gary D. Bader; Sachdev S. Sidhu

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September 1, 2008

Reduced insulin secretion and content in VEGF-A deficient mouse pancreatic islets

Experimental and Clinical Endocrinology and Diabetes, ISSN: 09477349

Normund Jabs; Franklin; Brenner; Gromada; Napoleone Ferrara; Wollheim; Eckhard Lammert

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September 1, 2008

Argatroban anticoagulation in intensive care patients: Effects of heart failure and multiple organ system failure

Journal of Intensive Care Medicine, ISSN: 08850666 15251489

Susan M. Begelman; Sarkis B. Baghdasarian; Inder M. Singh; Michael A. Militello; Marcie J. Hursting; John R. Bartholomew

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September 1, 2008

Effect of Rhesus D incompatibility on schizophrenia depends on offspring sex

Schizophrenia Research, ISSN: 09209964

Christina G.S. Palmer; Erin Mallery; Joni A. Turunen; Hsin-Ju Hsieh; Leena Peltonen; Jouko Lonnqvist; J. Arthur Woodward; Janet S. Sinsheimer

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September 1, 2008

Health-related quality of life impact of bevacizumab when combined with irinotecan, 5-fluorouracil, and leucovorin or 5-fluorouracil and leucovorin for metastatic colorectal cancer

Oncologist, ISSN: 10837159 1549490X

Fairooz F. Kabbinavar; Joel F. Wallace; Holmgren; Jing Yi; Cella; Yost; Herbert Hurwitz

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September 1, 2008

Ocrelizumab, a humanized anti-CD20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I/II randomized, blinded, placebo-controlled, dose-ranging study

Arthritis and Rheumatism, ISSN: 00043591

Mark C. Genovese; Jeffrey Kaine; Mitchell B. Lowenstein; José Del Giudice; Andrew Baldassare; Joy Schechtman; Edward Fudman; Michael Kohen; Gujrathi; Robert G. Trapp; Nadera J. Sweiss; Spaniolo; Wolfgang Dummer

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September 1, 2008

T cell-independent development and induction of somatic hypermutation in human IgM+IgD+CD27+ B cells

Journal of Experimental Medicine, ISSN: 00221007 00221007

Ferenc A. Scheeren; Maho Nagasawa; Kees Weijer; Tom Cupedo; Jörg Kirberg; Nicolas Legrand; Hergen Spits

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September 1, 2008

Growth hormone responsiveness: Peak stimulated growth hormone levels and other variables in idiopathic short stature (ISS): Data from the national cooperative growth study

Pediatric Endocrinology Reviews, ISSN: 15654753

Wayne V. Moore; Ken Dana; James W. Frane; Barbara M. Lippe

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September 1, 2008

Shifting patterns of inhaled antibiotic use in cystic fibrosis

Pediatric Pulmonology, ISSN: 87556863 10990496

Samuel M. Moskowitz; Stefanie J. Silva; Nicole Mayer-Hamblett; David J. Pasta; David R. Mink; Jenny A. Mabie; Michael W. Konstan; Wagener

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September 1, 2008

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

Nature Genetics, ISSN: 10614036 15461718

Stacy L. Musone; Kimberly E. Taylor; Timothy T. Lu; Joanne Nititham; Ricardo C. Ferreira; Ward Ortmann; Nataliya Shifrin; Michelle Petri; M. Ilyas Kamboh; Manzi; Michael F. Seldin; Peter K. Gregersen; Timothy W. Behrens; Averil Ma; Pui-Yan Kwok; Lindsey A. Criswell

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September 1, 2008

The effect of age and gender on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase

Journal of Clinical Pharmacology, ISSN: 00912700 15524604

Reza Khosravan; Michael J. Kukulka; Jing-Tao Wu; Nancy Joseph-Ridge; Laurent Vernillet

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September 1, 2008

Whole body physiologically-based pharmacokinetic models: Their use in clinical drug development

Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255

Andrea N. Edginton; Frank-Peter Theil; Walter Schmitt; Stefan Willmann

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September 1, 2008

Comparative clinical and economic outcomes of treatments for refractory non-small cell lung cancer (NSCLC)

Lung Cancer, ISSN: 01695002

Josh J. Carlson; Carolina Reyes; Nina Oestreicher; Deborah Lubeck; Scott D. Ramsey; David L. Veenstra

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September 1, 2008

Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis

Molecular Medicine, ISSN: 10761551

Chunyu Liu; Franak Batliwalla; Wentian Li; Annette T. Lee; Ronenn Roubenoff; Evan Beckman; Houman Khalili; Aarti Damle; Marlena Kern; Richard A. Furie; Najaf Amin; Robert M. Plenge; Marieke J.H. Coenen; Timothy W. Behrens; John P. Carulli; Peter K. Gregersen

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September 1, 2008

Hospitalized cardiovascular diseases in neovascular age-related macular degeneration

Archives of Ophthalmology, ISSN: 00039950 00039950

Bao-Anh Nguyen-Khoa; Earl L. Goehring; Winifred Werther; Emily W. Gower; Diana V. Do; Judith K. Jones

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August 29, 2008

IL-22 in mucosal immunity

Mucosal Immunology, ISSN: 19330219

Wenjun Ouyang; Patricia A. Valdez

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August 29, 2008

A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein-Protein Interfaces

Journal of Molecular Biology, ISSN: 00222836

Ryan N. Gilbreth; Kaori Esaki; Akiko Koide; Sachdev S. Sidhu; Shohei Koide

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August 28, 2008

On the edge of validation - Cancer protease fibroblast activation protein

Mini-Reviews in Medicinal Chemistry, ISSN: 13895575

Beni B. Wolf; Quan; Thuy Tran; Wiesmann; Daniel P. Sutherlin

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August 25, 2008

TGFβ induces SIK to negatively regulate type I receptor kinase signaling

Journal of Cell Biology, ISSN: 00219525 00219525

Marcin Kowanetz; Peter Lönn; Michael Vanlandewijck; Katarzyna Kowanetz; Carl-Henrik Heldin; Aristidis Moustakas

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August 22, 2008

The Unique N Terminus of the UbcH10 E2 Enzyme Controls the Threshold for APC Activation and Enhances Checkpoint Regulation of the APC

Molecular Cell, ISSN: 10972765

Matthew K. Summers; Borlan Pan; Kiran Mukhyala; Peter K Jackson

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August 22, 2008

Ubiquitin Chain Editing Revealed by Polyubiquitin Linkage-Specific Antibodies

Cell, ISSN: 00928674

Kim Newton; Marissa L. Matsumoto; Ingrid E. Wertz; Donald S. Kirkpatrick; Jennie R. Lill; Jenille Tan; Dugger; Nathaniel C. Gordon; Sachdev S. Sidhu; Frederic A. Fellouse; László Kömüves; French; Ron Ferrando; Cynthia Lam; Deanne M. Compaan; Christine Yu; Ivan Bosanac; Sarah G. Hymowitz; Robert F. Kelley; Vishva M. Dixit

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August 15, 2008

Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg

Blood, ISSN: 15280020 00064971

David D. Kim; Takashi Miwa; Yuko Kimura; Retoa Schwendener; Menno Van Lookeren Campagne; Wen-Chao Song

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August 15, 2008

Antibody Purification: Drivers of Change

Process Scale Purification of Antibodies,

Narahari Pujar; Duncan Low; O'Leary

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August 15, 2008

Potent and selective pyrazole-based inhibitors of B-Raf kinase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Joshua D. Hansen; Jonas Grina; Bradley J. Newhouse; Michael Welch; George Topalov; Nicole Littman; Michele Callejo; Susan L. Gloor; Matthew Martinson; Ellen R. Laird; Barbara J. Brandhuber; Guy Vigers; Tony Morales; Richard D. Woessner; Nikole Randolph; Joseph P. Lyssikatos; Alan G. Olivero

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August 15, 2008

Bootstrap quantile estimation via importance resampling

Computational Statistics and Data Analysis, ISSN: 01679473

Jiaqiao Hu; Zheng Su

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August 15, 2008

Downstream Processing of Monoclonal Antibodies: Current Practices and Future Opportunities

Process Scale Purification of Antibodies,

Kelley; Gregory S. Blank; Ann L. Lee

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August 15, 2008

Advances in Technology and Process Development for Industrial-Scale Monoclonal Antibody Purification

Process Scale Purification of Antibodies,

Nuno Fontes; Robert Van Reis

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August 14, 2008

A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability

Journal of Medicinal Chemistry, ISSN: 00222623

Thomas E. Rawson; Matthias Rüth; Elizabeth M. Blackwood; Burdick; Laura B. Corson; Jennafer Dotson; Jason H. Drummond; Carter Fields; Guy J. Georges; Bernhard Goller; Jason S Halladay; Thomas Hunsaker; Tracy L. Kleinheinz; Hans-Willi Krell; Jun Li; Jun Liang; Anja Limberg; Angela McNutt; John Moffat; Gail L. Phillips; Yingqing Ran; Brian S. Safina; Ultsch; Leslie Walker; Wiesmann; Birong Zhang; Aihe Zhou; Bing-Yan Zhu; Petra Rüger; Andrea G Cochran

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August 13, 2008

Liposomal packaging generates Wnt protein with in vivo biological activity

PLoS ONE, ISSN: 19326203

Nathan T. Morrell; Philipp Leucht; Ludan Zhao; Jae-Beom Kim; Derk ten Berge; Karthik Ponnusamy; A. Lyonel Carre; Henryk Dudek; Marie Zachlederova; Michael McElhaney; Shirley A. Brunton; Janet Gunzner; Marinella G. Callow; Paul G. Polakis; Michael Costa; Xiaoyan M. Zhang; Jill A. Helms; Roel Nusse

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August 12, 2008

FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development

Neural Development, ISSN: 17498104

Ugo Borello; Inma Cobos; Jason E. Long; Cornelis Murre; John L. R. Rubenstein

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August 1, 2008

Cognitive impairment after breast cancer treatment

Clinical journal of oncology nursing, ISSN: 10921095 1538067X

Tamsin Mulrooney

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August 1, 2008