Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9801 - 9850 OF 15613 RESULTS

August 1, 2008

Second Autologous Stem Cell Transplantation for Relapsed Lymphoma after a Prior Autologous Transplant

Biology of Blood and Marrow Transplantation, ISSN: 10838791 15236536

Sonali M. Smith; Koen van Besien; Jeanette Carreras; Asad Bashey; Mitchell S. Cairo; Cesar O. Freytes; Robert Peter Gale; Gregory A. Hale; Brandon Hayes-Lattin; Leona A. Holmberg; Armand Keating; Richard T. Maziarz; McCarthy; Willis H. Navarro; Santiago Pavlovsky; Harry C. Schouten; Matthew Seftel; Peter H. Wiernik; Julie Vose; Hillard M. Lazarus; Parameswaran Hari

August 1, 2008

Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition

Molecular Biology of the Cell, ISSN: 10591524

Wanli Tang; Judy Qiju Wu; Yanxiang Guo; David V. Hansen; Jennifer A. Perry; Christopher D. Freel; Leta Nutt; Peter K Jackson; Sally Kornbluth

August 1, 2008

Application of high-performance tangential flow filtration (HPTFF) to the purification of a human pharmaceutical antibody fragment expressed in Escherichia coli

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Lebreton; Arick Brown; Robert Van Reis

August 1, 2008

Wolman disease/cholesteryl ester storage disease: Efficacy of plant-produced human lysosomal acid lipase in mice

Journal of Lipid Research, ISSN: 00222275 15397262

Hong Du; Terri L. Cameron; Stephen J. Garger; Gregory P. Pogue; Lee A. Hamm; Earl White; Kathleen M. Hanley; Gregory A. Grabowski

July 30, 2008

High-resolution, in vivo magnetic resonance imaging of Drosophila at 18.8 Tesla

PLoS ONE, ISSN: 19326203

Brian Null; Corey W. Liu; Maj Hedehus; Steven Conolly; Ronald W. Davis

July 25, 2008

The Hunt for Cyclin

Cell, ISSN: 00928674

Peter K Jackson

July 25, 2008

Safety of efalizumab therapy in patients with moderate to severe psoriasis: An open-label extension of a phase IIIb trial

Drug Safety, ISSN: 01145916

Tiffani K. Hamilton; Alan Menter; Ivor Caro; Peter Compton; Jeffrey Sobell; Kim Papp

July 20, 2008

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Nature Biotechnology, ISSN: 15461696 10870156

Jagath R. Junutula; Helga Raab; Suzanna Clark; Sunil Bhakta; Douglas Leipold; Sylvia Weir; Chen; Michelle Simpson; Siao Ping Tsai; Dennis; Yanmei Lu; Meng; Carl Ng; Yang; Chien C. Lee; Duenas; Gorrell; Viswanatham Katta; Amy H. Kim; Kevin McDorman; Kelly Flagella; Rayna Venook; Ross; Spencer; Wai Lee Wong; Henry B. Lowman; Richard L. Vandlen; Mark X. Sliwkowski; Richard H. Scheller; Paul G. Polakis; William Mallet

July 15, 2008

A central role for HER3 in HER2-amplified breast cancer: Implications for targeted therapy

Cancer Research, ISSN: 00085472

Si Tuen Lee-Hoeflich; Lisa Crocker; Evelyn Yao; Thinh Q. Pham; Xander Munroe; Klaus P. Hoeflich; Mark X. Sliwkowski; Howard M. Stern

July 15, 2008

Refractoriness to antivascular endothelial growth factor treatment: Role of myeloid cells

Cancer Research, ISSN: 00085472

Farbod Shojaei; Napoleone Ferrara

July 10, 2008

Discovery of novel, potent benzamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model

Journal of Medicinal Chemistry, ISSN: 00222623

Lisa D. Julian; Zhulun Wang; Tracy Bostick; Seb Caille; Rebekah Choi; Michael DeGraffenreid; Yongmei Di; Xiao He; Randall W. Hungate; Juan C. Jaen; Jinsong Liu; Mario Monshouwer; Dustin McMinn; Yosup Rew; Athena Sudom; Daqing Sun; Hua Tu; Stefania Ursu; Nigel Walker; Xuelei Yan; Qiuping Ye; Jay P. Powers

July 7, 2008

Sγ3 switch sequences function in place of endogenous Sγ1 to mediate antibody class switching

Journal of Experimental Medicine, ISSN: 00221007 00221007

Ali A. Zarrin; Peter H. Goff; Kate Senger; Frederick W. Alt

July 2, 2008

Regenerative growth of corticospinal tract axons via the ventral column after spinal cord injury in mice

Journal of Neuroscience, ISSN: 02706474 02706474

Oswald Steward; Binhai Zheng; Marc Tessier-Lavigne; Maura Hofstadter; Kelli Sharp; Kelly Matsudaira Yee

July 1, 2008

Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer

Cancer Research, ISSN: 00085472

Carol O'Brien; Guy Cavet; Ajay Pandita; Xiaolan Hu; Lauren Haydu; Sankar Mohan; Toy; Rivers; Zora Modrusan; Lukas Amler; Lackner

July 1, 2008

The effects of anesthetic agent and carrier gas on blood glucose and tissue uptake in mice undergoing dynamic FDG-PET Imaging: Sevoflurane and Isoflurane Compared in Air and in Oxygen

Molecular Imaging and Biology, ISSN: 15361632 18602002

Judith E. Flores; Leanne McFarland; Alexander N. Vanderbilt; Annie Ogasawara; Simon P. Williams

July 1, 2008

Molecular imaging in drug development

Nature Reviews Drug Discovery, ISSN: 14741776 14741784

Jürgen K. Willmann; Nicholas Van Bruggen; Ludger M. Dinkelborg; Sanjiv S. Gambhir

July 1, 2008

Synthesis, characterization, and biological evaluation of integrin αvβ3-targeted PAMAM dendrimers

Molecular Pharmaceutics, ISSN: 15438384 15438392

C. Andrew Boswell; Peter K. Eck; Celeste A. S. Regino; Marcelino Bernardo; Karen J. Wong; Diane E. Milenic; Peter Choyke; Martin W. Brechbiel

July 1, 2008

Adaptive resampling algorithms for estimating bootstrap distributions

Journal of Statistical Planning and Inference, ISSN: 03783758

Jiaqiao Hu; Zheng Su

July 1, 2008

Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer

Cancer Research, ISSN: 00085472

Carol O'Brien; Guy Cavet; Ajay Pandita; Hu; Lauren Haydu; Sankar Mohan; Toy; Rivers; Zora Modrusan; Lukas Amler; Lackner

July 1, 2008

Preclinical models of psoriasis

Veterinary Pathology, ISSN: 03009858 15442217

Dimitry Danilenko

July 1, 2008

Metabolism and disposition of dasatinib after oral administration to humans

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Lisa J. Christopher; Donghui Cui; Chiyuan Wu; Roger Luo; James Manning; Samuel J. Bonacorsi; Michael Lago; Alban Allentoff; Francis Y. F. Lee; Betty McCann; Susan Galbraith; Donald P. Reitberg; Kan He; Anthony Barros; Anne Blackwood-Chirchir; W. Griffith Humphreys; Ramaswamy A. Iyer

July 1, 2008

Identification of regions required for apical membrane localization of human multidrug resistance protein 2

Molecular Pharmacology, ISSN: 0026895X 15210111

Paul E. Bandler; Christopher J. Westlake; Caroline E. Grant; Susan P. C. Cole; Roger G. Deeley

July 1, 2008

From the bench to the bedside: Dipeptidyl peptidase IV inhibitors, a new class of oral antihyperglycemic agents

Current Opinion in Drug Discovery and Development, ISSN: 13676733

Zhonghua Pei

July 1, 2008

Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating β-catenin signaling

Cancer Research, ISSN: 00085472

Rama Pai; Debra Dunlap; Jing Qing; Iman Mohtashemi; Kathy Hötzel; French

July 1, 2008

Bioactivation of Flutamide Metabolites by Human Liver Microsomes

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Ping Kang; Deepak Dalvie; Evan Smith; Sue Zhou; Alan Deese; James A. Nieman

June 30, 2008

3D micro-CT imaging of the postmortem brain

Journal of Neuroscience Methods, ISSN: 01650270

De Crespigny; Hani Bou-Reslan; Merry C. Nishimura; Phillips; Richard A. D. Carano; Helen D'Arceuil

June 27, 2008

DSCAM Is a Netrin Receptor that Collaborates with DCC in Mediating Turning Responses to Netrin-1

Cell, ISSN: 00928674

Alice Ly; Anatoly Nikolaev; Geetha Suresh; Yufang Zheng; Marc Tessier-Lavigne; Elke Stein

June 23, 2008

Aurora A: Target Invalidated?

Chemistry and Biology, ISSN: 10745521

Andrea G Cochran

June 18, 2008

Molecular mechanisms controlling midline crossing by precerebellar neurons

Journal of Neuroscience, ISSN: 02706474 02706474

Thomas Di Meglio; Kim T. Nguyen-Ba-Charvet; Marc Tessier-Lavigne; Constantino Sotelo; Alain Chedotal

June 17, 2008

DEAF-1 regulates immunity gene expression in Drosophila

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Darien E. Reed; Xinhua M. Huang; James A. Wohlschlegel; Michael Levine; Kate Senger

June 15, 2008

Improvement in patient-reported outcomes in a rituximab trial in patients with severe rheumatoid arthritis refractory to anti-tumor necrosis factor therapy

Arthritis Care and Research, ISSN: 21514658

Edward Keystone; Gerd R. Burmester; Richard A. Furie; James E. Loveless; Paul Emery; Joel M. Kremer; Paul P. Tak; Michael S. Broder; Elaine B. Yu; Matthew W. Cravets; Fabio Magrini; Jost

June 15, 2008

Final survival and safety results from a multicenter, open-label, phase 3b trial of erlotinib in patients with advanced nonsmall cell lung cancer

Cancer, ISSN: 0008543X 10970142

David Spigel; Ming Lin; Vincent O'Neill; John Hainsworth

June 13, 2008

Systems analysis of quantitative shRNA-library screens identifies regulators of cell adhesion

BMC Systems Biology, ISSN: 17520509

Xiaodong Huang; Jean Y.J. Wang; Xin Lu

June 13, 2008

Bridging Toll-like- and B Cell-Receptor Signaling: Meet Me at the Autophagosome

Immunity, ISSN: 10747613

John G. Monroe; Mary E. Keir

June 11, 2008

Genomic analysis of Drosophila neuronal remodeling: A role for the RNA-binding protein boule as a negative regulator of axon pruning

Journal of Neuroscience, ISSN: 02706474 02706474

Eric D. Hoopfer; Andrea Penton; Ryan J. Watts; Liqun Luo

June 10, 2008

Dual-specificity phosphatases in the hypo-osmotic stress response of keratin-defective epithelial cell lines

Experimental Cell Research, ISSN: 00144827

Mirjana Liovic; Brian B. Lee; Marjana Tomic-Canic; Mariella D'Alessandro; Viacheslav N. Bolshakov; E. Birgitte Lane

June 10, 2008

Dual-specificity phosphatases in the hypo-osmotic stress response of keratin-defective epithelial cell lines

Experimental Cell Research, ISSN: 00144827

Mirjana Liovic; Brian Lee; Marjana Tomic-Canic; Mariella D'Alessandro; Viacheslav N. Bolshakov; E. Birgitte Lane

June 3, 2008

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Li-Chung Hsu; Syed R. Ali; Shauna McGillivray; Ping-Hui Tseng; Sanjeev Mariathasan; Eric W. Humke; Lars Eckmann; Jonathan J. Powell; Victor Nizet; Vishva M. Dixit; Michael Karin

June 2, 2008

To kill a tumor cell: The potential of proapoptotic receptor agonists

Journal of Clinical Investigation, ISSN: 00219738 15588238

Avi Ashkenazi; Roy S. Herbst

June 1, 2008

PCSK9 function and physiology

Journal of Lipid Research, ISSN: 00222275 15397262

Andrew S. Peterson; Loren G. Fong; Stephen G. Young

June 1, 2008

A golden era of opportunity in immunotherapy discovery and development

Immunological Reviews, ISSN: 01052896 1600065X

Andrew A. Chan

June 1, 2008

Vascular endothelial growth factors in pulmonary edema: An update

Journal of Thrombosis and Thrombolysis, ISSN: 09295305

Ioanna Kosmidou; Dimitrios Karmpaliotis; Ajay J. Kirtane; Hal V. Barron; C.Michael Gibson

June 1, 2008

Design opportunities for actively targeted nanoparticle vaccines

Nanomedicine, ISSN: 17435889

Tarek M. Fahmy; Stacey L. Demento; Michael J. Caplan; Ira Mellman; W. Mark Saltzman

June 1, 2008

High-resolution genomic and expression analyses of copy number alterations in breast tumors

Genes Chromosomes and Cancer, ISSN: 10452257 10982264

Matthias Peter; Jane Fridlyand; Li Li; Gad Getz; Rameen Beroukhim; Scott Lohr; Thomas D Wu; Guy Cavet; Zemin Zhang; John Chant

June 1, 2008

Dendritic cells: Driving the differentiation programme of T cells in viral infections

Immunology and Cell Biology, ISSN: 08189641 14401711

Frederick Masson; Adele Mount; Nicholas S. Wilson; Gabrielle T Belz

June 1, 2008

Quantitative determination of humanized monoclonal antibody rhuMAb2H7 in cynomolgus monkey serum using a Generic Immunoglobulin Pharmacokinetic (GRIP) assay

Journal of Immunological Methods, ISSN: 00221759

Yang; Carl Ng; Henry B. Lowman; Chestnut; Cheryl A. Schofield; Bryan Sandlund; James A. Ernst; Bennett; Quarmby

June 1, 2008

Ubiquitin-mediated regulation of TNFR1 signaling

Cytokine and Growth Factor Reviews, ISSN: 13596101

Ingrid E. Wertz; Vishva M. Dixit

June 1, 2008

Multiple sclerosis risk after optic neuritis: Final optic neuritis treatment trial follow-up

Archives of Neurology, ISSN: 00039942 15383687

Michael Brodsky; Sarkis Nazarian; Silvia Orengo-Nania; George J. Hutton; Edward G. Buckley; E. Wayne Massey; M. Tariq Bhatti; Melvin Greer; James Goodwin; Michael Wall; Peter J. Savino; Thomas Leist; Neil R. Miller; David Irani; Jonathan D. Trobe; Wayne Cornblath; David I. Kaufman; Eric Eggenberger; Mark J. Kupersmith; William T. Shults; Leslie McAllister; Steve Hamilton; Roy W. Beck; Mariya Dontchev; Robin L. Gal; Craig Kollman; John L. Keltner; Craig H. Smith

June 1, 2008

(Un)expected roles of c-IAPs in apoptotic and NFκB signaling pathways

Cell Cycle, ISSN: 15514005 15384101

Eugene Varfolomeev; Domagoj Vucic

June 1, 2008

MetMAb, the one-armed 5d5 anti-c-met antibody, inhibits orthotopic pancreatic tumor growth and improves survival

Cancer Research, ISSN: 00085472

Hongkui Jin; Renhui Yang; Zhong Zheng; Mally Romero; Ross; Hani Bou-Reslan; Richard A. D. Carano; Ian Kasman; Elaine Mai; Judy Young; Jiping Zha; Zemin Zhang; Ross; Ralph H. Schwall; Gail T. Colbern; Mark Merchant

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