Genentech: Publications

November 1, 2006

CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway

Cellular Signalling, ISSN: 08986568

Simon Rousseau; Ignacio Dolado; Victoria Beardmore; Natalia Shpiro; Rodolfo Marquez; Angel R. Nebreda; J. Simon C. Arthur; Lauren C Case; Marc Tessier-Lavigne; Matthias Gaestel; Ana Cuenda; Philip Cohen

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November 1, 2006

Preclinical pharmacokinetics and metabolism of 6-(4- (2,5-Difluorophenyl)oxazol-5-yk)-3-isopropyl-[1,2,4]-triazolo[4,3- a]pyridine, a novel and selective p38α inhibitor: Identification of an active metaboline in preclinical species and human liver microsomes

Biopharmaceutics and Drug Disposition, ISSN: 01422782 1099081X

Amit S. Kalgutkar; Heather L. Hatch; Frederick Kosea; Hang T. Nguyen; Edna F. Choo; Kim F. McClure; Timothy J. Taylor; Kirk R. Henne; Alexander V. Kuperman; Mark A. Dombroski; Michael A. Letavic

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November 1, 2006

Magnetic resonance angiography reveals therapeutic enlargement of collateral vessels induced by VEGF in a murine model of peripheral arterial disease

Journal of Magnetic Resonance Imaging, ISSN: 10531807 15222586

Joan M. Greve; Chico; Hope Goldman; Bunting; Franklin V. Peale Jr.; Daugherty; Nicholas Van Bruggen; Simon P. Williams

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November 1, 2006

Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis

Molecular and Cellular Biology, ISSN: 02707306

Zhaoyu Jin; Wafik S. El-Deiry

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November 1, 2006

Rapid redistribution of synaptic PSD-95 in the neocortex in vivo

PLoS Biology, ISSN: 15457885 15457885

Noah W. Gray; Robby M. Weimer; Ingrid Bureau; Karel Svoboda

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November 1, 2006

Human immunodeficiency virus persistence and production in T-cell development

Clinical and Vaccine Immunology, ISSN: 15566811

Kevin B. Gurney; Christel H. Uittenbogaart

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November 1, 2006

Inhibitory effect of carboxylic acid group on hERG binding

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Bing-Yan Zhu; Zhaozhong J. Jia; Penglie Zhang; Ting Su; Wenrong Huang; Erick Goldman; Daniel B. Tumas; Vic Kadambi; Priya Eddy; Uma Sinha; Robert M. Scarborough; Yonghong Song

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November 1, 2006

Allowing for missing data at highly polymorphic genes when testing for maternal, offspring and maternal-fetal genotype incompatibility effects

Human Heredity, ISSN: 00015652

Hsin-Ju Hsieh; Christina G.S. Palmer; Janet S. Sinsheimer

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November 1, 2006

Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration: Year 1 results of the FOCUS study

Archives of Ophthalmology, ISSN: 00039950 00039950

Jeffrey S. Heier; David S. Boyer; Thomas A. Ciulla; Philip J. Ferrone; J. Michael Jumper; Ronald C. Gentile; Debbie Kotlovker; Carol Y. Chung; Robert Kim

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October 26, 2006

Corneal avascularity is due to soluble VEGF receptor-1

Nature, ISSN: 14764687 00280836

Balamurali K. Ambati; Miho Nozaki; Nirbhai Singh; Atsunobu Takeda; Pooja D. Jani; Tushar Suthar; Romulo J. C. Albuquerque; Elizabeth Richter; Eiji Sakurai; Michael T. Newcomb; Mark E. Kleinman; Ruth Caldwell; Qing Lin; Yuichiro Ogura; Angela Orecchia; Don A. Samuelson; Dalen W. Agnew; Judy St. Leger; W. Richard Green; Parameshwar J. Mahasreshti; David T. Curiel; Donna Kwan; Helene Marsh; Sakae Ikeda; Lucy J. Leiper; J. Martin Collinson; Sasha Bogdanovich; Tejvir S. Khurana; Masabumi Shibuya; Megan E. Baldwin; Napoleone Ferrara; Hans-Peter Gerber; Sandro De Falco; Jassir Witta; Judit Z. Baffi; Brian J. Raisler; Jayakrishna Ambati

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October 15, 2006

A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo

Clinical Cancer Research, ISSN: 10780432

Tobias Martens; Nils-Ole Schmidt; Carmen Eckerich; Regina Filibrandt; Mark Merchant; Ralph H. Schwall; Manfred Westphal; Katrin Lamszus

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October 15, 2006

The Hedgehog signaling pathway in cancer

Clinical Cancer Research, ISSN: 10780432

Marie Evangelista; Hua Tian; Frederic J. De Sauvage

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October 15, 2006

Polyclonal resistance in gastrointestinal stromal tumor treated with sequential kinase inhibitors [3]

Clinical Cancer Research, ISSN: 10780432

Loughrey; Waring; Dobrovic; George Demetri; Kovalenko; McArthur

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October 13, 2006

2005 AAPS Biotechnology Conference Open Forum on Aggregation of Protein Therapeutics - Panel discussion June 5-8, 2005 San Francisco, CA

AAPS Journal, ISSN: 15507416

Steven J. Shire

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October 13, 2006

Pro-urokinase-type plasminogen activator is a substrate for hepsin

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Paul Moran; Wei Li; Bin Fan; Rajesh Vij; Eigenbrot; Daniel Kirchhofer

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October 5, 2006

Ranibizumab for neovascular age-related macular degeneration

New England Journal of Medicine, ISSN: 00284793 15334406

Philip J. Rosenfeld; David M. Brown; Jeffrey S. Heier; David S. Boyer; Peter K. Kaiser; Carol Chung; Robert Kim

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October 5, 2006

Ranibizumab versus verteporfin for neovascular age-related macular degeneration

New England Journal of Medicine, ISSN: 00284793 15334406

David M. Brown; Peter K. Kaiser; Mark Michels; Gisele Soubrane; Jeffrey S. Heier; Robert Kim; Judy P. Sy; Susan Schneider

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October 5, 2006

Ranibizumab versus Verteporfin Photodynamic Therapy for Neovascular Age-Related Macular Degeneration: Two-Year Results of the ANCHOR Study

Ophthalmology, ISSN: 01616420

David M. Brown; Mark Michels; Peter K. Kaiser; Jeffrey S. Heier; Judy P. Sy; Tsontcho Ianchulev

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October 5, 2006

Ranibizumab for neovascular age-related macular degeneration

New England Journal of Medicine, ISSN: 00284793 15334406

Philip J. Rosenfeld; David M. Brown; Jeffrey S. Heier; David S. Boyer; Peter K. Kaiser; Carol Y. Chung; Robert Kim

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October 3, 2006

Structure of SAP18: A ubiquitin fold in histone deacetylase complex assembly

Biochemistry, ISSN: 00062960

Scott A. McCallum; J.Fernando Bazan; Mark Merchant; Jianping Yin; Borlan Pan; Frederic J. De Sauvage; Wayne J. Fairbrother

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October 2, 2006

Imaging tumor angiogenesis

Journal of Clinical Investigation, ISSN: 00219738 15588238

Kristy Red-Horse; Napoleone Ferrara

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October 1, 2006

A review of malignancies observed during efalizumab (Raptiva®) clinical trials for plaque psoriasis

Dermatology, ISSN: 10188665

Craig Leonardi; Darryl P. Toth; Jennifer C. Cather; Richard G. B. Langley; Winifred Werther; Peter Compton; Paul Kwon; Graham Wetherill; Francois Curtin; Alan Menter

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October 1, 2006

The lack of cardiotrophin-1 alters expression of interleukin-6 and leukemia inhibitory factor mRNA but does not impair cardiac injury response

Cytokine, ISSN: 10434666

Kurt Gritman; Donna M. Van Winkle; Christina U. Lorentz; Diane Pennica; Beth A. Habecker

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October 1, 2006

Ophthalmological and otological problems in Turner syndrome

International Congress Series, ISSN: 05315131

Saenger; Nussbaum; Barbara M. Lippe

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October 1, 2006

Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration

Retina, ISSN: 0275004X

Napoleone Ferrara; Lisa A. Damico; Naveed Shams; Henry B. Lowman; Robert Kim

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October 1, 2006

Early coronary revascularization diminishes the risk of ischemic stroke with acute myocardial infarction

Stroke, ISSN: 00392499

Eric Van De Graaff; Monisha Dutta; Pranab Das; Eric A. Shry; Paul D. Frederick; Martha Blaney; David J. Pasta; Steven R. Steinhubl

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September 29, 2006

The inhibitor of apoptosis protein fusion c-IAP2·MALT1 stimulates NF-κB activation independently of TRAF1 and TRAF2

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Eugene Varfolomeev; Sarah M. Wayson; Vishva M. Dixit; Wayne J. Fairbrother; Domagoj Vucic

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September 22, 2006

A critical review of analytical ultracentrifugation and field flow fractionation methods for measuring protein aggregation

AAPS Journal, ISSN: 15507416

Jun Liu; Andya; Steven J. Shire

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September 22, 2006

Monopolar Attachment of Sister Kinetochores at Meiosis I Requires Casein Kinase 1

Cell, ISSN: 00928674

Mark Petronczki; Joao Matos; Saori Mori; Juraj Gregan; Aliona Bogdanova; Martin Schwickart; Karl Mechtler; Katsuhiko Shirahige; Wolfgang Zachariae; Kim Nasmyth

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September 19, 2006

SNAREs - Engines for membrane fusion

Nature Reviews Molecular Cell Biology, ISSN: 14710072 14710080

Reinhard Jahn; Richard H. Scheller

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September 15, 2006

Protein aggregation and bioprocessing

AAPS Journal, ISSN: 15507416

Cromwell; Eric Hilario; Fred Jacobson

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September 15, 2006

Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Hui Li; John Tatlock; Angelica Linton; Javier Gonzalez; Allen Borchardt; Peter Dragovich; Tanya Jewell; Tom Prins; Ru Zhou; Julie Blazel; Hans Parge; Robert Love; Michael Hickey; Chau Doan; Stephanie Shi; Rohit Duggal; Lewis; Shella Fuhrman

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September 15, 2006

HATH1 expression in mucinous cancers of the colorectum and related lesions

Clinical Cancer Research, ISSN: 10780432

Eun Taek Park; Hee Kyung Oh; James R. Gum Jr.; Suzanne C. Crawley; Sanjay Kakar; Juan Engel; Ching Ching Leow; Gao; Young S. Kim

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September 15, 2006

Optimization and validation of a quantitative capillary electrophoresis sodium dodecyl sulfate method for quality control and stability monitoring of monoclonal antibodies

Analytical Chemistry, ISSN: 00032700

Oscar Salas-Solano; Brandon Tomlinson; Sarah Du; Monica Parker; Alex Strahan; Stacey Ma

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September 15, 2006

Using genetically engineered mouse models of cancer to aid drug development: An industry perspective

Clinical Cancer Research, ISSN: 10780432

Mallika Singh; Leisa Johnson

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September 11, 2006

Mouse Emi2 is required to enter meiosis II by reestablishing cyclin B1 during interkinesis

Journal of Cell Biology, ISSN: 00219525 00219525

Suzanne Madgwick; David V. Hansen; Mark Levasseur; Peter K Jackson; Keith T. Jones

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September 5, 2006

A biosynthetic pathway for anandamide

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Jie Liu; Lei Wang; Judith Harvey-White; Douglas Osei-Hyiaman; Raj Razdan; Qian Gong; Andrew A. Chan; Zhifeng Zhou; Bill X. Huang; Hee-Yong Kim; George Kunos

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September 1, 2006

CEPharm 2005

Chromatographia, ISSN: 00095893 16121112

Stacey Ma; Kevin D. Altria

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September 1, 2006

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

Nature Immunology, ISSN: 15292908 15292916

Marcel Batten; Ji Li; Sothy Yi; Noelyn Kljavin; Dimitry Danilenko; Sophie Lucas; James Lee; Frederic J. De Sauvage; Nico Ghilardi

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September 1, 2006

Concerning Lewis acid promoted, directing-group-free epoxide-ring-opening cascades

Synlett, ISSN: 09365214

Timothy P. Heffron; Timothy F. Jamison

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September 1, 2006

Role of Vascular Endothelial Growth Factor in Ocular Angiogenesis

Ophthalmology Clinics of North America, ISSN: 08961549

Naveed Shams; Tsontcho Ianchulev

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September 1, 2006

Vascular endothelial growth factor signaling pathways: Therapeutic perspective

Clinical Cancer Research, ISSN: 10780432

Marcin Kowanetz; Napoleone Ferrara

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September 1, 2006

Comparison of costs associated with the use of etanercept, infliximab, and adalimumab for the treatment of rheumatoid arthritis

Managed Care Interface, ISSN: 10965645

Michael F. Bullano; Brian J. McNeeley; Yanni F. Yu; Ralph Quimbo; Lauren P. Burawski; Elaine B. Yu; J. Michael Woolley

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September 1, 2006

Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor

Genes and Development, ISSN: 08909369 15495477

Julie J. Miller; Matthew K. Summers; David V. Hansen; Maxence V. Nachury; Norman L. Lehman; Alexander V. Loktev; Peter K Jackson

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September 1, 2006

A series of collaborations between various pharmaceutical companies and regulatory authorities concerning the analysis of biomolecules using capillary electrophoresis

Chromatographia, ISSN: 00095893 16121112

Brian Nunnally; Park; Ketaki Patel; Mingfang Hong; Xinfeng Zhang; Shao-Xiong Wang; Brenda Rener; Angelia Reed-Bogan; Oscar Salas-Solano; Wendy Lau; Michel Girard; Heather Carnegie; Virginia Garcia-Cañas; Cheng; Ming Zeng; Margaret Ruesch; Ronald Frazier; Claudia Jochheim; Kshama Natarajan; K. Michael Jessop; Mansoor Saeed; Frank Moffatt; Seth Madren; Serigne Thiam; Kevin D. Altria

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September 1, 2006

Experience and scale and scope economies: Trade-offs and performance in development

Strategic Management Journal, ISSN: 01432095 10970266

Jeffrey T. Macher; Christopher S. Boerner

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September 1, 2006

Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia

International Immunology, ISSN: 09538178 14602377

Andrew G. Polson; Bing Zheng; Kristi Elkins; Wesley S. Chang; Du; Patrick Dowd; Lulu Yen; Christine Tan; Hongo; Koeppen; Allen Ebens

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September 1, 2006

Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum

Molecular Microbiology, ISSN: 0950382X 13652958

Katerina Artavanis-Tsakonas; Shahram Misaghi; Christy A. Comeaux; André Catic; Eric Spooner; Manoj T. Duraisingh; Hidde L. Ploegh

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August 25, 2006

ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage

Science, ISSN: 00368075 10959203

David Dornan; Harumi Shimizu; Angie Mah; Tanay Dudhela; Mike Eby; Karen M. O'Rourke; Somasekar Seshagiri; Vishva M. Dixit

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August 24, 2006

Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates

British Journal of Pharmacology, ISSN: 14765381 00071188

Kelley; Thomas R. Gelzleichter; Dong Xie; Wyne P. Lee; Darbonne; Ferhan Qureshi; Kim Kissler; Ezogelin Oflazoglu; Iqbal S. Grewal

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