Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10501 - 10550 OF 15613 RESULTS

The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus
Arthritis Research and Therapy, ISSN: 14786354 14786362
Anthony P. Manderson; Francesco Carlucci; Peter J. Lachmann; Lazarus; Richard J. Festenstein; H. Terence Cook; Mark J. Walport; Marina Botto
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Relapse, rebound, and psoriasis adverse events: An advisory group report
Journal of the American Academy of Dermatology, ISSN: 01909622
Wayne Carey; Scott Glazer; Alice Gottlieb; Mark Lebwohl; Craig Leonardi; Alan Menter; Kim Papp; Amy Chen Rundle; Darryl P. Toth
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The clinical and economic burden of psoriasis
Managed Care Interface, ISSN: 10965645
Elisabeth H. Hazard; Spencer B. Cherry; Deepa Lalla; J. Michael Woolley; Helen Wilfehrt; Chiun-Fang Chiou
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A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery
Development (Cambridge), ISSN: 09501991
David A. Elliott; Mark J. Solloway; Natalie Wise; Christine Biben; Mauro W. Costa; Milena B. Furtado; Martin Lange; Sally Dunwoodie; Richard P. Harvey
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Dickkopf-1, an inhibitor of Wnt signaling, is regulated by progesterone in human endometrial stromal cells
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X 0021972X
Suzana Tulac; Michael T. Overgaard; Amy E. Hamilton; Nelson L'ntshotsholé Jumbe; Ernest Suchanek; Linda C. Giudice
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Depressive symptoms in coronary artery disease patients after hypertension treatment
Annals of Pharmacotherapy, ISSN: 10600280
L. Douglas Ried; Michael J. Tueth; Taylor; Brian C. Sauer; Larry M. Lopez; Carl J. Pepine
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Human T-lymphotropic virus type 1 mitochondrion-localizing protein p13 II is required for viral infectivity in vivo
Journal of Virology, ISSN: 0022538X
Hajime Hiraragi; Seung-Jae Kim; Andrew J. Phipps; Micol Silic-Benussi; Vincenzo Ciminale; Lee Ratner; Patrick L. Green; Michael D. Lairmore
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Efalizumab retreatment in patients with moderate to severe chronic plaque psoriasis
Journal of the American Academy of Dermatology, ISSN: 01909622
Kim Papp; Bruce Miller; Kenneth B. Gordon; Ivor Caro; Paul Kwon; Peter Compton; Craig Leonardi
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Use of drotrecogin alfa (activated) in older patients with severe sepsis
Pharmacotherapy, ISSN: 02770008
Sherri L. Alexander; Frank R. Ernst
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Long-term continuous efalizumab therapy in patients with moderate to severe chronic plaque psoriasis: Updated results from an ongoing trial
Journal of the American Academy of Dermatology, ISSN: 01909622
Alice Gottlieb; Tiffani K. Hamilton; Ivor Caro; Paul Kwon; Peter Compton; Craig Leonardi
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Office-based low-field extremity magnetic resonance imaging: Is the glass half empty or half full?
Arthritis and Rheumatism, ISSN: 00043591
David E. Yocum; Philip G. Conaghan; Ewa Olech; Charles G. Peterfy
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Sinorhizobium meliloti bluB is necessary for production of 5,6-dimethylbenzimidazole, the lower ligand of B12
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Gordon R. O. Campbell; Michiko E. Taga; Kavita Mistry; Javier Lloret; Peter J. Anderson; John R. Roth; Graham C. Walker
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Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Conrad Yap Edosada; Quan; Wiesmann; Thuy Tran; Daniel P. Sutherlin; Mark E. Reynolds; J. Michael Elliott; Helga Raab; Wayne J. Fairbrother; Beni B. Wolf
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Characterization of dual substrate binding sites in the homodimeric structure of Escherichia coli mRNA interferase MazF
Journal of Molecular Biology, ISSN: 00222836
Guang-Yao Li; Yonglong Zhang; Mitchell C.Y. Chan; Tapas K. Mal; Klaus P. Hoeflich; Masayori Inouye; Mitsuhiko Ikura
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Tyrosine plays a dominant functional role in the paratope of a synthetic antibody derived from a four amino acid code
Journal of Molecular Biology, ISSN: 00222836
Frederic A. Fellouse; Pierre A. Barthelemy; Robert F. Kelley; Sachdev S. Sidhu
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Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice
Cancer Research, ISSN: 00085472
Lauren Wallner; Jinlu Dai; June Escara-Wilke; Jian Zhang; Zhi Yao; Yi Lu; Mohit Trikha; Jeffrey A. Nemeth; Mohamed H. Zaki; Evan T. Keller
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CDK2/cyclinA inhibitors: Targeting the cyclinA recruitment site with small molecules derived from peptide leads
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Georgette M. Castanedo; Clark; Shumei Wang; Vickie Tsui; Mengling Wong; John B. Nicholas; Dineli Wickramasinghe; James C. Marsters Jr.; Daniel P. Sutherlin
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A versatile platform for nanotechnology based on circular permutation of a chaperonin protein
Nanotechnology, ISSN: 09574484
Paavola; Chan; Li; Mazzarella; McMillan; Trent
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Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin™ Fab
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Fuh; Ping Wu; Wei-Ching Liang; Ultsch; Chingwei V. Lee; Moffat; Wiesmann
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CRIg: A macrophage complement receptor required for phagocytosis of circulating pathogens
Cell, ISSN: 00928674
Karim Y. Helmy; Kenneth J. Katschke Jr.; Nick N. Gorgani; Noelyn Kljavin; J. Michael Elliott; Laurie Diehl; Suzie J. Scales; Nico Ghilardi; Menno Van Lookeren Campagne
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Calorimetric investigation of protein/amino acid interactions in the solid state
International Journal of Pharmaceutics, ISSN: 03785173
Fei Tian; Samir Sane; J. Howard Rytting
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Cryopyrin activates the inflammasome in response to toxins and ATP
Nature, ISSN: 14764687 00280836
Sanjeev Mariathasan; David S. Weiss; Kim Newton; Jacqueline McBride; Karen M. O'Rourke; Merone Roose-Girma; Wyne P. Lee; Yvette Weinrauch; Denise M. Monack; Vishva M. Dixit
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The role of receptor internalization in CD95 signaling
EMBO Journal, ISSN: 02614189 14602075
Kyeong-Hee Lee; Christine Feig; Vladimir Tchikov; Robert Schickel; Cora Hallas; Stefan Schütze; Marcus E. Peter; Andrew A. Chan
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A recombinant 63-kDa form of Bacillus anthracis protective antigen produced in the yeast Saccharomyces cerevisiae provides protection in rabbit and primate inhalational challenge models of anthrax infection
Vaccine, ISSN: 0264410X
Robert W. Hepler; Rosemarie Kelly; Tessie B. McNeely; Hongxia Fan; Maria C. Losada; Hugh George; Andrea Woods; Leslie D. Cope; Alka Bansal; James C. Cook; Gina Zang; Steven L. Cohen; Xiaorong Wei; Paul M. Keller; Elizabeth Leffel; Joseph G. Joyce; Louise Pitt; Loren D. Schultz; Kathrin U. Jansen; Myra Kurtz
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Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly2-Pro1-cleaving specificity
FEBS Letters, ISSN: 00145793
Conrad Yap Edosada; Quan; Thuy Tran; Victoria Pham; Wiesmann; Wayne J. Fairbrother; Beni B. Wolf
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The above letters were referred to genentech, the manufacturer of bevacizumab, which offers the following reply [22]
New England Journal of Medicine, ISSN: 00284793
Hal V. Barron
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Biogenerics at the crossroads
Nature Biotechnology, ISSN: 10870156 15461696
Carole S. Ben-Maimon; Robert L. Garnick
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Large-scale trends in the evolution of gene structures within 11 animal genomes
PLoS Computational Biology, ISSN: 1553734X 15537358
Mark Yandell; Chris J. Mungall; Chris Smith; Simon Prochnik; Joshua S. Kaminker; George Hartzell; Suzanna E. Lewis; Gerald M. Rubin
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Targeting VEGF & EGFR pathways in solid tumors
Journal of Gynecologic Oncology Nursing, ISSN: 15369935
Karen Oleszewski
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The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection
Nature Immunology, ISSN: 15292908 15292916
Dario S. Zamboni; Koichi S. Kobayashi; Tiana Kohlsdorf; Yasunori Ogura; E. Michelle Long; Russell E. Vance; Keisuke Kuida; Sanjeev Mariathasan; Vishva M. Dixit; Richard A. Flavell; William F. Dietrich; Craig R. Roy
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Community-based trial of a triple-combination agent for the treatment of facial melasma
Cutis, ISSN: 00114162
Pearl Grimes; A. Paul Kelly; Helen Torok; Isaac Willis
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Synapse disassembly and formation of new synapses in postnatal muscle upon conditional inactivation of MuSK
Molecular and Cellular Neuroscience, ISSN: 10447431
Boris A. Hesser; Oliver Henschel; Veit Witzemann
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Enantioselective total synthesis of batzelladine F and definition of its structure
Journal of the American Chemical Society, ISSN: 00027863
Frederick Cohen; Larry E. Overman
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Metabolism and excretion of erlotinib, a small molecule inhibitor of epidermal growth factor receptor tyrosine kinase, in healthy male volunteers
Drug Metabolism and Disposition, ISSN: 00909556
Jie Ling; Kim A. Johnson; Zhuang Miao; Ashok Rakhit; Michael P. Pantze; Marta Hamilton; Bert L. Lum; Chandra Prakash
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A rapid method for estimation of baculovirus titer based on viable cell size
Journal of Virological Methods, ISSN: 01660934
Vasantharajan Janakiraman; William F. Forrest; Bernard Chow; Somasekar Seshagiri
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Evaluation of the absolute oral bioavailability and bioequivalence of erlotinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in a randomized, crossover study in healthy subjects
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Paul Frohna; Jian-Feng Lu; Stephen M. Eppler; Marta Hamilton; Julie Wolf; Ashok Rakhit; Jie Ling; Sara Kenkare-Mitra; Bert L. Lum
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Effect of overexpression of a soluble pyridine nucleotide transhydrogenase (UdhA) on the production of poly(3-hydroxybutyrate) in Escherichia coli
Biotechnology Progress, ISSN: 87567938
Ailen M. Sánchez; Jared Andrews; Insiya Hussein; George N. Bennett; Ka-Yiu San
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Mitochondrial localization of CNP2 is regulated by phosphorylation of the N-terminal targeting signal by PKC: Implications of a mitochondrial function for CNP2 in glial and non-glial cells
Molecular and Cellular Neuroscience, ISSN: 10447431
John Lee; Ryan C. O'Neill; Min Woo Park; Michel Gravel; Peter E. Braun
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Vascular endothelial growth factor A signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival
Journal of the American Society of Nephrology, ISSN: 10466673
Vera Eremina; Shiying Cui; Hans-Peter Gerber; Napoleone Ferrara; Jody Haigh; Andras Nagy; Masatsugu Ema; Janet Rossant; Serge Jothy; Jeffrey H. Miner; Susan E. Quaggin
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The vascular basement membrane: A niche for insulin gene expression and β cell proliferation
Developmental Cell, ISSN: 15345807
Ganka Nikolova; Normund Jabs; Irena Konstantinova; Anna Domogatskaya; Karl Tryggvason; Lydia Sorokin; Reinhard Fässler; Guoqiang Gu; Hans-Peter Gerber; Napoleone Ferrara; Douglas A. Melton; Eckhard Lammert
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Altered patterns of transcription of the septin gene, SEPT9, in ovarian tumorigenesis
International Journal of Cancer, ISSN: 00207136 10970215
Michael Scott; W. Glenn McCluggage; Kenneth J. Hillan; Peter A. Hall; S. E. Hilary Russell
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Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis
Development (Cambridge), ISSN: 09501991
Phyllis Strickland; Grace C. Shin; Andrew Plump; Marc Tessier-Lavigne; Hinck
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Compaction agent protection of nucleic acids during mechanical lysis
Biotechnology Progress, ISSN: 87567938
Jason C. Murphy; Tony Cano; George E. Fox; Richard C. Willson
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Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit: Differences in structure and function relative to unliganded UL44
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Brent A. Appleton; Justin Brooks; Arianna Loregian; David J. Filman; Donald M. Coen; James M. Hogle
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Cutting edge: Novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods
Journal of Immunology, ISSN: 00221767
Pisabarro; Beatrice Leung; Mandy Kwong; Corpuz; Gretchen D. Frantz; Nancy Y. Chiang; Richard L. Vandlen; Laurie Diehl; Nicholas J. Skelton; Hok Seon Kim; Dan L. Eaton; Kerstin N. Schmidt
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Dr. Mastrianni's letter was referred to Genentech, the manufacturer of trastuzumab, which offers the following reply [9]
New England Journal of Medicine, ISSN: 00284793 15334406
Hal V. Barron
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New neurons follow the flow of cerebrospinal fluid in the adult brain
Science, ISSN: 00368075 10959203
Kazunobu Sawamoto; Hynek Wichterle; Oscar Gonzalez-Perez; Jeremy A. Cholfin; Masayuki Yamada; Nathalie Spassky; Noel S. Murcia; Jose Manuel Garcia-Verdugo; Oscar Marín; John L. R. Rubenstein; Marc Tessier-Lavigne; Hideyuki Okano; Arturo Alvarez-Buylla
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Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma
Cancer, ISSN: 0008543X 10970142
Brian I. Rini; Vivian Weinberg; Sarah Dunlap; Alexandra Elchinoff; Nancy Yu; Robert Bok; Jeffery Simko; Small
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Identification and immunotherapeutic targeting of antigens induced by chemotherapy
Nature Biotechnology, ISSN: 10870156 15461696
Bonnee Rubinfeld; Archana Upadhyay; Suzanna Clark; Fong; Victoria Smith; Koeppen; Ross; Paul G. Polakis
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Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the αl subunit of lymphocyte function-associated antigen-1
Protein Science, ISSN: 09618368 1469896X
Keating; Clark; Lisa D. Stefanich; Arellano; Caroline P. Edwards; Bodary; Steven A. Spencer; Thomas Gadek; James C. Marsters Jr.; Beresini
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