Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10601 - 10650 OF 15613 RESULTS

December 27, 2005

Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Michelle A. Lowes; Francesca Chamian; Maria V. Abello; Judilyn Fuentes-Duculan; Shao-Lee Lin; Rachel Nussbaum; Inna Novitskaya; Henrietta Carbonaro; Irma Cardinale; Toyoko Kikuchi; Patricia Gilleaudeau; Mary Sullivan-Whalen; Knut Wittkowski; Kim Papp; Marvin Garovoy; Wolfgang Dummer; Ralph M. Steinman; James G. Krueger

December 24, 2005

Identification of the minimal protein domain required for priming activity of munc13-1

Current Biology, ISSN: 09609822

David R. Stevens; Zheng-Xing Wu; Ulf Matti; Harald Junge; Claudia Schirra; Ute Becherer; Sonja M. Wojcik; Nils Brose; Jens Rettig

December 15, 2005

Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients

Clinical Cancer Research, ISSN: 10780432

Robert Yauch; Thomas Januario; Eberhard; Guy Cavet; Wenjing Zhu; Ling Fu; Thinh Q. Pham; Robert Soriano; Stinson; Somasekar Seshagiri; Zora Modrusan; Chin-Yu Lin; Vincent O'Neill; Lukas Amler

December 15, 2005

Angiogenesis as a therapeutic target

Nature, ISSN: 00280836 14764679

Napoleone Ferrara; Robert S. Kerbel

December 14, 2005

MORT1/FADD is involved in liver regeneration

World Journal of Gastroenterology, ISSN: 10079327

Marcus Schuchmann; Felix Rückert; Jose F. Garcia-Lazaro; Andrea Karg; Jürgen Burg; Natalia Knorr; Jürgen Siebler; Eugene Varfolomeev; David Wallach; Wolfgang Schreiber; Ansgar W. Lohse; Peter R. Galle

December 13, 2005

Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Cary D. Austin; Xiaohui Wen; Lewis Gazzard; Nelson; Richard H. Scheller; Suzie J. Scales

December 12, 2005

Interspecies exchange mutagenesis of the first epidermal growth factor-like domain of human factor VII

Journal of Thrombosis and Haemostasis, ISSN: 15387933 15387836

Williamson; Pyke; Sampath Sridhara; Robert F. Kelley; Morris A. Blajchman; Bryan J. Clarke

December 9, 2005

Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Eugene Varfolomeev; Heather Maecker; Darcie Sharp; David Lawrence; Renz; Domagoj Vucic; Avi Ashkenazi

December 8, 2005

A smooth operator for LPS responses

Nature Immunology, ISSN: 15292908 15292916

Godowski

December 8, 2005

P63 is an essential proapoptotic protein during neural development

Neuron, ISSN: 08966273

W. Bradley Jacobs; Gregory Govoni; Daniel Ho; Jasvinder K. Atwal; Fanie Barnabe-Heider; William M. Keyes; Alea A. Mills; Freda D. Miller; David R. Kaplan

December 2, 2005

TWEAK attenuates the transition from innate to adaptive immunity

Cell, ISSN: 00928674

Heather Maecker; Eugene Varfolomeev; Frank C. Kischkel; David Lawrence; Heidi LeBlanc; Wyne P. Lee; Stephen D. Hurst; Dimitry Danilenko; Jun Li; Ellen H. Filvaroff; Becky Yang; Dylan Daniel; Avi Ashkenazi

December 1, 2005

Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer

Journal of Clinical Oncology, ISSN: 0732183X

David B. Agus; Michael S. Gordon; Charles Taylor; Ronald B. Natale; Beth Karlan; David Mendelson; Michael F. Press; David E. Allison; Mark X. Sliwkowski; Grade Lieberman; Stephen Kelsey; Gwendolyn Fyfe

December 1, 2005

Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib

Journal of Clinical Oncology, ISSN: 0732183X

Eberhard; Bruce E. Johnson; Lukas Amler; Goddard; Sherry Heldens; Roy S. Herbst; William Ince; Pasi A. Jänne; Thomas Januario; David H. Johnson; Pam Klein; Vincent A. Miller; Michael Ostland; David A. Ramies; Dragan Sebisanovic; Stinson; Zhang; Somasekar Seshagiri; Kenneth J. Hillan

December 1, 2005

UV microscopy at 280 nm is effective in screening for the growth of protein microcrystals

Journal of Applied Crystallography, ISSN: 00218898 16005767

Christopher S. Lunde; Shahab Rouhani; Jonathan P. Remis; Steven E. Ruzin; James A. Ernst; Robert M. Glaeser

December 1, 2005

Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer

Journal of Clinical Oncology, ISSN: 0732183X

Kathy Miller; Linnea I. Chap; Frankie Ann Holmes; Melody A. Cobleigh; P. Kelly Marcom; Louis Fehrenbacher; Maura N. Dickler; Beth A. Overmoyer; Reimann; Amy Sing; Virginia K. Langmuir; Hope S. Rugo

December 1, 2005

Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer

Journal of Clinical Oncology, ISSN: 0732183X

Fairooz F. Kabbinavar; Julie Hambleton; Robert Mass; Herbert Hurwitz; Emily Bergsland; Somnath Sarkar

December 1, 2005

Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial

Journal of Clinical Oncology, ISSN: 0732183X

Fairooz F. Kabbinavar; Joseph Schulz; Michael McCleod; Taral Patel; John T. Hamm; Joel Randolph Hecht; Robert Mass; Brent Perrou; Betty Nelson; Novotny

December 1, 2005

Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib

Journal of Clinical Oncology, ISSN: 0732183X

Eberhard; Bruce E. Johnson; Lukas Amler; Goddard; Sherry Heldens; Roy S. Herbst; William L. Ince; Pasi A. Jänne; Thomas Januario; David H. Johnson; Pam Klein; Vincent A. Miller; Michael Ostland; David A. Ramies; Dragan Sebisanovic; Stinson; Zhang; Somasekar Seshagiri; Kenneth J. Hillan

December 1, 2005

Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer

Journal of Clinical Oncology, ISSN: 0732183X

Agus; Michael S. Gordon; Charles Taylor; Ronald B. Natale; Beth Karlan; David Mendelson; Michael F. Press; David E. Allison; Mark X. Sliwkowski; Grade Lieberman; Stephen Kelsey; Gwendolyn Fyfe

December 1, 2005

Inhibition of collagen gene expression in systemic sclerosis dermal fibroblasts by mithramycin

Annals of the Rheumatic Diseases, ISSN: 00034967

Sandorfi; Louneva; Hitraya; Hajnoczky; Saitta; Sergio A. Jimenez

December 1, 2005

Predicting clinical benefit in non-small-cell lung cancer patients treated with epidermal growth factor tyrosine kinase inhibitors

Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451

Lukas Amler; Goddard; Kenneth J. Hillan

December 1, 2005

Minimally important differences were estimated for the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) instrument using a combination of distribution- and anchor-based approaches

Journal of Clinical Epidemiology, ISSN: 08954356

Yost; Cella; Chawla; Holmgren; Eton; Ayanian; West

December 1, 2005

Symptom control and improved functioning: The effect of omalizumab on Asthma-Related Quality of Life (ARQL)

Journal of Asthma, ISSN: 02770903 15324303

Allan T. Luskin; Mark Kosinski; Bresnahan; Ashby; Dennis A. Wong

December 1, 2005

Safety of efalizumab in patients with moderate to severe chronic plaque psoriasis: Review of clinical data. Part II

Journal of Cutaneous Medicine and Surgery, ISSN: 12034754

Kim Papp; Charles Camisa; Stephen P. Stone; Ivor Caro; Xiaolin Wang; Peter Compton; Patricia Walicke; Alice Gottlieb

December 1, 2005

Clinical efficacy of efalizumab in patients with chronic plaque psoriasis: Results from three randomized placebo-controlled phase III trials: Part I

Journal of Cutaneous Medicine and Surgery, ISSN: 12034754

David M. Pariser; Kenneth B. Gordon; Kim Papp; Craig Leonardi; Paul Kwon; Peter Compton; Amy Chen Rundle; Patricia Walicke; Mark Lebwohl

December 1, 2005

Strategies for developing a successful electronic submission

American Pharmaceutical Review, ISSN: 10998012

Pawson

December 1, 2005

Impaired skin barrier function in dermatologic disease and repair with moisturization

Cutis, ISSN: 00114162

Mark Lebwohl; Lisa G. Herrmann

December 1, 2005

Efficacy of a long-acting growth hormone (GH) preparation in patients with adult GH deficiency

Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X 0021972X

Andrew R. Hoffman; Beverly M. K. Biller; David Cook; Joyce Baptista; Bernard L. Silverman; Dao; Kenneth M. Attie; Fielder; Thomas J. Maneatis; Barbara M. Lippe

December 1, 2005

Proteomics

Methods in Enzymology, ISSN: 00766879

Stults; David Arnott

December 1, 2005

Isolation and culture of hair cell progenitors from postnatal rat cochleae

Journal of Neurobiology, ISSN: 00223034

Suo-qiang Zhai; Li Shi; Bu-Er Wang; Gui-liang Zheng; Wei Song; Yin-yan Hu; Gao

December 1, 2005

Heterogeneity of recombinant antibodies: Linking structure to function

Developments in Biologicals, ISSN: 14246074

Reed J. Harris

December 1, 2005

Agreement in histologic assessments of the pituitary pars intermedia in aged horses

American Journal of Veterinary Research, ISSN: 00029645

Dianne McFarlane; Lisa M. Miller; Linden E. Craig; Noel Dybdal; Perry L. Habecker; Margaret A. Miller; Jon S. Patterson; Alastair E. Cribb

December 1, 2005

Class I FIPs, Rab11-binding proteins that regulate endocytic sorting and recycling

Methods in Enzymology, ISSN: 00766879

Elizabeth Tarbutton; Andrew A. Peden; Jagath R. Junutula; Rytis Prekeris

December 1, 2005

Requirement for the SnoN oncoprotein in transforming growth factor β-induced oncogenic transformation of fibroblast cells

Molecular and Cellular Biology, ISSN: 02707306

Qingwei Zhu; Sonia Pearson-White; Kunxin Luo

December 1, 2005

Targeted therapy: Wave of the future

Journal of Clinical Oncology, ISSN: 0732183X

Pegram; Pietras; Alex Bajamonde; Pam Klein; Gwendolyn Fyfe

December 1, 2005

Development and the boundaries of the firm: A knowledge-based examination in drug development

Academy of Management 2005 Annual Meeting: A New Vision of Management in the 21st Century, AOM 2005,

Jeffrey T. Macher; Christopher S. Boerner

December 1, 2005

Rituximab in combination with fludarabine chemotherapy in low-grade or follicular lymphoma

Journal of Clinical Oncology, ISSN: 0732183X

Myron S. Czuczman; Koryzna; Mohr; Stewart; Donohue; Blumenson; Bernstein; McCarthy; Alam; Hernandez-Ilizaliturri; Skipper; Brown; Chanan-Khan; Klippenstein; Loud; Mike K Rock; Benyunes; Grillo-Lopez; Bernstein

December 1, 2005

Expression of HIF-1α in human tumours [5]

Journal of Clinical Pathology, ISSN: 00219746

Adrian M. Jubb; Kenneth J. Hillan

December 1, 2005

Quantitative structure-activity relationships of methotrexate and methotrexate analogues transported by the rat multispecific resistance- associated protein 2 (rMrp2)

European Journal of Pharmaceutical Sciences, ISSN: 09280987

Chee Ng; Yun-De Xiao; Bert L. Lum; Yong-Hae Han

December 1, 2005

Analysis of protein therapeutics by capillary electrophoresis: Applications and challenges

Developments in Biologicals, ISSN: 14246074

Stacey Ma

December 1, 2005

Salutary effects of combining early very low-dose systemic estradiol with growth hormone therapy in girls with Turner syndrome

Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X 0021972X

Rosenfield; Nancy Devine; Joanne Julius Hunold; Nelly Mauras; Thomas Moshang Jr.; Allen W. Root

November 25, 2005

Attenuating lymphocyte activity: The crystal structure of the BTLA-HVEM complex

Journal of Biological Chemistry, ISSN: 00219258

Deanne M. Compaan; Lino C. Gonzalez Jr.; Irene Tom; Kelly M. Loyet; Dan L. Eaton; Sarah G. Hymowitz

November 22, 2005

Isolation and characterization of the B-cell marker CD20

Biochemistry, ISSN: 00062960

James A. Ernst; Hong Li; Hok Seon Kim; Nakamura; Yansura; Richard L. Vandlen

November 21, 2005

Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation

Journal of Experimental Medicine, ISSN: 00221007 00221007

Honglin Zhou; Denise M. Monack; Nobuhiko Kayagaki; Ingrid E. Wertz; Jianping Yin; Beni B. Wolf; Vishva M. Dixit

November 15, 2005

Immune thrombocytopenia associated with efalizumab therapy for psoriasis [7]

Annals of Internal Medicine, ISSN: 00034819

Theodore E. Warkentin; Paul Kwon

November 15, 2005

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

Developmental Biology, ISSN: 00121606

Scott R. May; Amir M. Ashique; Mattias Karlen; Baolin Wang; Yiguo Shen; Konstantinos Zarbalis; Jeremy Reiter; Johan Ericson; Andrew S. Peterson

November 11, 2005

Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking

Journal of Biological Chemistry, ISSN: 00219258

Mark Larance; Georg Ramm; Jacqueline Stöckli; Ellen M. Van Dam; Stephanie Winata; Valerie Wasinger; Fiona Simpson; Michael Graham; Jagath R. Junutula; Michael Guilhaus; David E. James

November 9, 2005

Concomitant administration of bevacizumab, irinotecan, 5-fluorouracil, and leucovorin: Nonclinical safety and pharmacokinetics

International Journal of Toxicology, ISSN: 10915818 1092874X

Jacques Gaudreault; Vanessa Shiu; Ann Bricarello; Brian J. Christian; Christina L. Zuch; Barbara Mounho

November 1, 2005

Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes

Molecular Biology of the Cell, ISSN: 10591524

Alexander C. Theos; Danièle Tenza; José A. Martina; Ilse Hurbain; Andrew A. Peden; Elena V. Sviderskaya; Abigail Stewart; Margaret S. Robinson; Dorothy C. Bennett; Daniel F. Cutler; Juan S. Bonifacino; Michael S. Marks; Graça Raposo

November 1, 2005

Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers

Cancer Research, ISSN: 00085472

Daniel C. Gray; Adrian M. Jubb; Deborah A. Hogue; Patrick Dowd; Noelyn Kljavin; Sothy Yi; Wei Bai; Gretchen D. Frantz; Zemin Zhang; Koeppen; Frederic J. De Sauvage; David P. Davis

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