Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 12651 - 12700 OF 15613 RESULTS

Validation of an HPLC method for the analysis of the charge heterogeneity of the recombinant monoclonal antibody IDEC-C2B8 after papain digestion
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085
Kathy Moorhouse; Wassim Nashabeh; James Deveney; Nancy Bjork; Michael G. Mulkerrin; Thomas C. Ryskamp
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Data handling issues in a gmp environment
FASEB Journal, ISSN: 08926638
Nolan
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Rapid analytical tryptic mapping of a recominant chimeric monoclonal antibody and method validation challenges
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085
Kannan; Michael G. Mulkerrin; Zhang; Gray; Steinharter; Sewerin; Baffi; Reed J. Harris; Karunatilake
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Engineering hyperactive human dnase i with over 4000-fold higher activity in human serum by altering its functional mechan1sm
FASEB Journal, ISSN: 08926638
Clark Q. Pan; Tony H. Dodge; Baker; Sinicropi; Lazarus
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Solution structure of the EGF-1 domain from blood coagulation factor VII by NMR spectroscopy: The effect of O-fucosylation
FASEB Journal, ISSN: 08926638
Yung-Hsiang Kao; Geoffrey F. Lee; Yang Wanga; Robert F. Kelley; Spellman; Laura Lerner
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Fourier-transform infrared spectroscopic analysis of the secondary structure of recombinant humanized immunoglobulin G
Pharmaceutical Sciences, ISSN: 13566881
Henry R. Costantino; Andya; Steven J. Shire; Chung C. Hsu
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The resurgence of analytical ultracentrifugation: An old technique applied to a new technology
Proceedings of SPIE - The International Society for Optical Engineering, ISSN: 0277786X
Steven J. Shire; Jun Liu
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High-dose aldesleukin in renal cell carcinoma: Long-term survival update
Cancer Journal from Scientific American, ISSN: 10814442
Richard I. Fisher; Steven A. Rosenberg; Mario Sznol; David R. Parkinson; Gwendolyn Fyfe
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Mannose phosphorylat10n on secretory glycoproteins
FASEB Journal, ISSN: 08926638
Nase; Nishikawa; Walter Gregory; Akash Nanda; John Frenz; Stuart Kornfeld
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Minimization of a protein binding domain
FASEB Journal, ISSN: 08926638
Andrew Braisted
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Primary B cell development is impaired in mice with defects of the pituitary/thyroid axis
Journal of Immunology, ISSN: 00221767
Encarnacion Montecino-Rodriguez; Ross Clark; Powell-Braxton; Kenneth Dorshkind
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Downregulation of natriuretic peptide C-receptor protein in the hypertrophied ventricle of the aortovenocaval fistula rat
Cardiovascular Research, ISSN: 00086363
Lesley A. Brown; Richard A.D. Rutherford; Derek J.R. Nunez; John Wharton; David G Lowe; Martin R. Wilkins
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Regulation of tissue inhibitor of metalloproteinase-1 in fibroblasts and acute phase proteins in hepatocytes in vitro by mouse oncostatin M, cardiotrophin-1, and IL-6
Journal of Immunology, ISSN: 00221767
Richards; Christine Kerr; Minoru Tanaka; Takahiko Hara; Atsushi Miyajima; Diane Pennica; Fernando Botelho; Langdon
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Deep-lung delivery of therapeutic proteins
CHEMTECH, ISSN: 00092703
John R. Patton
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TNK-tissue plasminogen activator compared with frontloaded tpa in acute myocardial infarction: clinical update
Fibrinolysis and Proteolysis, ISSN: 13690191
Bruce A. Kevt
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Hepatic clearance and metabolism of tnk-tpa, a long half-life variant of rt-PA
Fibrinolysis and Proteolysis, ISSN: 13690191
Geralyn G. Deguzman; Richardson; Keyt; Zioncheck
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Redesigning antibodies
FASEB Journal, ISSN: 08926638
Presta
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Pharmacokinetics and dynamics of longer half-life and pai-1 resistant tissue plasminogen activator mutants: slow clearing molecules are not rapidly inhibited
Fibrinolysis and Proteolysis, ISSN: 13690191
Bruce A. Kevtt; Lea Berleau; Hung V. Nguyen; Stephen Epplerf; Nishit Modif
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Evaluation of ABRF-96SEQ: A sequence assignment exercise
Techniques in Protein Chemistry, ISSN: 10808914
Joseph Fernandez; Arie Admon; Karen De Jongh; Greg Grant; William J. Henzel; William Lane; Kathryn Stone; Barbara Merrill
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A novel receptor for Apo2L/TRAIL contains a truncated death domain
Current Biology, ISSN: 09609822
Scot A. Marsters; James P. Sheridan; Pitti; Arthur Huang; Skubatch; Daryl T. Baldwin; Jean Q. Yuan; Austin L. Gurney; Goddard; Godowski; Avi Ashkenazi
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Metabolic labeling for monitoring sialylation of recombinant proteins in growing chinese hamster ovary cell cultures
FASEB Journal, ISSN: 08926638
Santeli; Ryll Twang; Jane Gunson; Warner
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Native fluorescence detection of recombinant human growth hormone resolve from E. coli cell paste extract by capillary zone electrophoresls
FASEB Journal, ISSN: 08926638
McNerney; Robert L. Bridenbaugh
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Identification of components of the cell death pathway
Fibrinolysis and Proteolysis, ISSN: 13690191
Vishva M. Dixit
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Engineering hyperactive human DNASE I with over 4000-fold higher activity in human serum
Protein Engineering, ISSN: 02692139
Pan; Tony H. Dodge; Baker; Sinicropi; Lazarus
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RhDNase I is a well characterized protein
Pharmaceutical Sciences, ISSN: 13566881
Quan; Cacia; John Frenz; O'Connor
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Hemodynamic effects of scatter factor in conscious rats
Journal of Cardiovascular Pharmacology, ISSN: 01602446
Renhui Yang; Bunting; Annie Ko; Ralph H. Schwall; Hongkui Jin
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Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
American Journal of Pathology, ISSN: 00029440
Alicia M. Viloria Petit; Janusz Rak; Mien-Chie Hung; Patricia Rockwell; Neil Goldstein; Brian M. Fendly; Robert S. Kerbel
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Inhibition of angiogenesis by blocking vegf action: mutational analysis of vegf:receptor binding and epitope mapping of neutralizing antibodies
Fibrinolysis and Proteolysis, ISSN: 13690191
Keyt
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Intravenous infusion of vascular endothelial growth factor (VEGF) substantially attenuates its hemodynamic effects
FASEB Journal, ISSN: 08926638
Renhui Yang; Bunting; Annie Ko; Keyt; Napoleone Ferrara; Hongkui Jin
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How integrins are activated
Nature, ISSN: 00280836
Lasky
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Potent biflnctional anticoagulants: kunitz domain - tissue factor fusion proteins
FASEB Journal, ISSN: 08926638
Geoffrey F. Lee
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ErbB3 is required for normal cerebellar and cardiac development: A comparison with ErbB2- and heregulin-deficient mice
Development (Cambridge), ISSN: 09501991
Sharon Erickson; Sue O'Shea; Nazli Ghaboosi; Linda Loverro; Gretchen D. Frantz; Michele Bauer; Lucy Lu; Mark Moore
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Hemodynamic effects of scatter factor in conscious rats
FASEB Journal, ISSN: 08926638
Hongkui Jin; Renhui Yang; Annie Ko; Ralph H. Schwall; Bunting
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Engineered receptor cytoplasmic domains with fixed signal output: Probing mechanism with design
FASEB Journal, ISSN: 08926638
Andrea G Cochran
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Therapeutic monoclonal as the treatment of allergic disease
Proceedings of the Western Pharmacology Society, ISSN: 00838969
Paula Jardieu
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IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL- 1 signaling
Science, ISSN: 00368075
Marta Muzio; Jian Ni; Ping Feng; Vishva M. Dixit
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Crystal structure at 1.7 Å resolution f VEGF in complex with domain 2 of the Fit-1 receptor
Cell, ISSN: 00928674
Wiesmann; Fuh; Hans W. Christinger; Eigenbrot; James A. Wells; De Vos
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Interaction of human IgE with soluble forms of IgE high affinity receptors
Pharmaceutical Research, ISSN: 07248741
Jun Liu; Jane Ruppel; Steven J. Shire
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Caspases: Intracellular signaling by proteolysis
Cell, ISSN: 00928674
Guy S. Salvesen; Vishva M. Dixit
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Hepatocyte-derived cell lines express a functional receptor for cardiotrophin-1
European Cytokine Network, ISSN: 11485493
Olivier Robledo; Catherine Guillet; Sylvie Chevalier; Maryvonne Fourcin; Josy Froger; Annick Pouplard-Barthelaix; Diane Pennica; Hugues Gascan
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A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand Ephrin-A5/AL-1
Cell and Tissue Research, ISSN: 0302766X
Caras
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Structural plasticity in a remodeled protein-protein interface
Science, ISSN: 00368075
Shane Atwell; Ultsch; De Vos; James A. Wells
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The use of sequential high-performance liquid chromatography and capillary zone electrophoresis to separate the glycosylated peptides from recombinant tissue plasminogen activator to a detailed level of microheterogeneity
Analytical Biochemistry, ISSN: 00032697
Shiaw-Lin Wu
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Capillary electrophoresis based immunoassays: A critical review
Electrophoresis, ISSN: 01730835
Dieter Schmalzing; Wassim Nashabeh
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The effect of inhaling a dry powder of sodium chloride on the airways of asthmatic subjects
European Respiratory Journal, ISSN: 09031936
Anderson; Spring; Moore; Rodwell; Spalding; Gonda; Chan; Andrew J. Walsh; Clark
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Potent α4β1 peptide antagonists as potential anti-inflammatory agents
Journal of Medicinal Chemistry, ISSN: 00222623
Jackson; Quan; Dean R. Artis; Thomas E. Rawson; Brent Blackburn; Martin Struble; Geraldine Fitzgerald; Kathryn S. Chan; Sheldon Mullins; Burnier; Wayne J. Fairbrother; Clark; Maureen Berisini; Henry Chui; Renz; Susan Jones; Fong
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Potent α4β1 peptide antagonists as potential anti-inflammatory agents
Journal of Medicinal Chemistry, ISSN: 00222623
Jackson; Quan; Dean R. Artis; Thomas E. Rawson; Brent Blackburn; Martin Struble; Geraldine Fitzgerald; Kathryn S. Chan; Sheldon Mullins; Burnier; Wayne J. Fairbrother; Clark; Maureen Berisini; Henry Chui; Renz; Susan Jones; Sherman Fong
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Single step method for the accurate concentration determination of polysorbate 80
Journal of Chromatography A, ISSN: 00219673
Travis H. Tani; Jamie M. R. Moore; Thomas W. Patapoff
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Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines
Circulation, ISSN: 00097322
Eric Van Belle; Alain Rivard; Donghui Chen; Marcy Silver; Bunting; Napoleone Ferrara; James F. Symes; Christophe Bauters; Jeffrey M. Isner
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A p47-phox pseudogene carries the most common mutation causing p47- phox-deficient chronic granulomatous disease
Journal of Clinical Investigation, ISSN: 00219738
Agnes Görlach; Pauline L. Lee; Joachim Roesler; Penelope J. Hopkins; Barbara Christensen; Eric D. Green; Stephen J. Chanock; John T. Curnutte
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