Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4951 - 5000 OF 15701 RESULTS

January 1, 2017

From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Jun Liang; Sharada Labadie; Birong Zhang; Daniel F. Ortwine; Snahel Patel; Maia Vinogradova; James R. Kiefer; Till Mauer; Victor S Gehling; Jean-Christophe Harmange; Richard T Cummings; Tommy Lai; Jiangpeng Liao; Xiaoping Zheng; Yichin Liu; Amy Gustafson; Erica Vanderporten; Weifeng Mao; Bianca M. Liederer; Gauri Deshmukh; Le An; Yingqing Ran; Marie Classon; Patrick Trojer; Peter Dragovich; Lesley J. Murray

January 1, 2017

The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target

Retina, ISSN: 15392864 0275004X

David S. Boyer; Ursula Schmidt-Erfurth; Menno Van Lookeren Campagne; Erin C. Henry; Christopher Brittain

January 1, 2017

TREM2, Microglia, and Neurodegenerative Diseases

Trends in Molecular Medicine, ISSN: 14714914

Felix L. Yeh; David V. Hansen; Morgan Sheng

January 1, 2017

A fully integrated, three-dimensional fluorescence to electron microscopy correlative workflow

Methods in Cell Biology, ISSN: 0091679X

Claudia S. López; Cedric Bouchet-Marquis; Christopher P. Arthur; Jessica L. Riesterer; Gregor Heiss; Guillaume Thibault; Lee Pullan; Sunjong Kwon; Joe W. Gray

January 1, 2017

Expression of MET in circulating tumor cells correlates with expression in tumor tissue from advanced-stage lung cancer patients

Oncotarget, ISSN: 19492553

Marius Ilie; Edith Szafer-Glusman; Véronique Hofman; Elodie Long-Mira; Rebecca Suttmann; Darbonne; Catherine Butori; Salomé Lalvée; Julien Fayada; Eric Selva; Wei Yu; Charles-Hugo Marquette; David S. Shames; Elizabeth A. Punnoose; Paul Hofman

January 1, 2017

Elements of cancer immunity and the cancer-immune set point

Nature, ISSN: 14764687 00280836

Daniel S. Chen; Ira Mellman

January 1, 2017

Anti-CD22 and anti-CD79b antibody-drug conjugates preferentially target proliferating B cells

British Journal of Pharmacology, ISSN: 14765381 00071188

Franklin Fuh; Looney; Dongwei Li; Kirsten Achilles Poon; Randall Dere; Dimitry Danilenko; Jacqueline McBride; Chae Reed; Shan Chung; Bing Zheng; W Rodney Mathews; Andrew G. Polson; Saileta Prabhu; Marna Williams

January 1, 2017

Ultrasensitive HIV-1 p24 assay detects single infected cells and differences in reservoir induction by latency reversal agents

Journal of Virology, ISSN: 10985514 0022538X

Caroline Pereira Bittencourt Passaes; Timothée Bruel; Jérémie Decalf; Annie David; Mathieu Angin; Valerie Monceaux; Michaela Muller-Trutwin; Nicolas Noel; Katia Bourdic; Olivier Lambotte; Matthew L. Albert; Darragh Duffy; Olivier Schwartz; Asier Sáez-Cirión; Christine Rouzioux; Brigitte Autran; Monsef Benkirane; Jeremie Guedj; Laurent Hocqueloux; Christine Katlama; Roger Legrand; Laurence Meyer; Hugo Mouquet; Michaela Müller-Trutwin; Anne- Marie Taburet; Carine Van Lint

January 1, 2017

A protective role for interleukin-1 signaling during mouse adenovirus type 1-induced encephalitis

Journal of Virology, ISSN: 10985514 0022538X

Luiza A. Castro-Jorge; Carla D. Pretto; Asa B. Smith; Oded Foreman; Kelly E. Carnahan; Katherine R. Spindler

January 1, 2017

NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus

American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN: 15221547 01931857

Elise S. Demitrack; Gail B. Gifford; Theresa M. Keeley; Nobukatsu Horita; Andrea Todisco; Kim Turgeon; Christian W. Siebel; Linda C. Samuelson

January 1, 2017

Differences in health care use and costs among patients with cancer receiving intravenous chemotherapy in physician offices versus in hospital outpatient settings

Journal of Oncology Practice, ISSN: 1935469X 15547477

Maxine D. Fisher; Rajeshwari Punekar; Yeun Mi Yim; Art Small; Joseph R. Singer; Jay Schukman; Barbara L. McAneny; Rakesh Luthra; Jennifer Malin

January 1, 2017

A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains

Journal of Alzheimer's Disease, ISSN: 18758908 13872877

Patrick C. G. Haddick; Jessica L. Larson; Nisha Rathore; Tushar Bhangale; Qui Phung; Karpagam Srinivasan; David V. Hansen; Jennie R. Lill; Brian W. Kunkle; Jonathan L. Haines; Lindsay A. Farrer; John S.K. Kauwe; Gerard D. Schellenberg; Paul K. Crane; Alison M. Goate; Timothy W. Behrens; Ryan J. Watts; Robert R. Graham; Joshua S. Kaminker; Marcel P Van Der Brug

January 1, 2017

Assessing sex differences in the risk of cardiovascular disease and mortality per increment in systolic blood pressure: A systematic review and meta-analysis of follow-up studies in the United States

PLoS ONE, ISSN: 19326203

Yu-Chung Wei; Nysia I. George; Ching-Wei Chang; Karen A. Hicks

January 1, 2017

Bruton's tyrosine kinase small molecule inhibitors induce a distinct pancreatic toxicity in rats

Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565

Rebecca Erickson; Leah Schutt; Jacqueline M. Tarrant; Michelle Mcdowell; Lichuan Liu; Adam R. Johnson; Sock-Cheng Lewin-Koh; Maj Hedehus; Ross; Richard A. D. Carano; Karin Staflin; Fiona Zhong; James J. Crawford; Shelly Zhong; Karin Reif; Arna Katewa; Harvey Wong; Wendy B. Young; Donna M. Dambach; Misner

January 1, 2017

Mass cytometry panel optimization through the designed distribution of signal interference

Cytometry Part A, ISSN: 15524930 15524922

Chikara Takahashi; Amelia Au-Yeung; Franklin Fuh; Teresa Ramirez-Montagut; Christopher R. Bolen; W Rodney Mathews; William E. O'Gorman

January 1, 2017

IL-22R ligands IL-20, IL-22, and IL-24 promote wound healing in diabetic db/db mice

PLoS ONE, ISSN: 19326203

Ganesh Kolumam; Xiumin Wu; Wyne P. Lee; Jason A. Hackney; Jose Zavala-Solorio; Vineela D. Gandham; Dimitry Danilenko; Puneet Arora; Xiaoting Wang; Wenjun Ouyang

January 1, 2017

Preclinical efficacy of an antibody-drug conjugate targeting mesothelin correlates with quantitative89 Zr-ImmunoPET

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Anton G. T. Van Terwisscha Scheltinga; Annie Ogasawara; Glenn Pacheco; Alexander N. Vanderbilt; Jeff N. Tinianow; Nidhi Gupta; Dongwei Li; Ron Firestein; Jan Marik; Suzie J. Scales; Simon P. Williams

January 1, 2017

Building proteomic tool boxes to monitor MHC class I and class II peptides

Proteomics, ISSN: 16159861 16159853

Frances-Rose Schumacher; Lélia Delamarre; Suchit Jhunjhunwala; Zora Modrusan; Qui Phung; Joshua E. Elias; Jennie R. Lill

January 1, 2017

A first-in-human phase I study of the ATP-competitive AKT inhibitor Ipatasertib demonstrates Robust and safe targeting of AKT in patients with solid tumors

Cancer Discovery, ISSN: 21598290 21598274

Saura; Desamparados Roda; Susana Roselló; Oliveira; Teresa Macarulla; José Alejandro Pérez-Fidalgo; Rafael Morales-Barrera; Juan Manuel Sanchis-García; Luna Musib; Nageshwar Budha; Jin Zhu; Michelle Nannini; Wai Y. Chan; Sandra M. Sanabria-Bohorquez; Raymond D. Meng; Kui Lin; Yibing Yan; Premal Patel; Baselga; Tabernero; Andrés Cervantes

January 1, 2017

Efficacy and Safety Results From a Phase II, Placebo-Controlled Study of Onartuzumab Plus First-Line Platinum-Doublet Chemotherapy for Advanced Squamous Cell Non–Small-Cell Lung Cancer

Clinical Lung Cancer, ISSN: 19380690 15257304

Fred R. Hirsch; Ramaswamy Govindan; Zanete Zvirbule; Fadi S. Braiteh; Achim Rittmeyer; Cristóbal Belda-Iniesta; Dolores Isla; Thomas Cosgriff; Michelle Boyer; Masamichi Ueda; See Phan; David R. Gandara

January 1, 2017

Genotype-phenotype correlations in pathology caused by collagen type IV alpha 1 and 2 mutations

Matrix Biology, ISSN: 15691802 0945053X

Marion Jeanne; Douglas B. Gould

January 1, 2017

Quantitative proteomics reveals fundamental regulatory differences in oncogenic hras and isocitrate dehydrogenase (IDH1) driven astrocytoma

Molecular and Cellular Proteomics, ISSN: 15359484 15359476

Sophia Doll; Anatoly Urisman; Juan A. Oses-Prieto; David Arnott; Alma Burlingame

January 1, 2017

Tumour-infiltrating lymphocytes in advanced HER2-positive breast cancer treated with pertuzumab or placebo in addition to trastuzumab and docetaxel: a retrospective analysis of the CLEOPATRA study

The Lancet Oncology, ISSN: 14745488 14702045

Stephen J Luen; Roberto Salgado; Stephen B. Fox; Peter Savas; Jennifer Eng-Wong; Emma Clark; Astrid Kiermaier; Sandra M. Swain; Baselga; Stefan Michiels; Sherene Loi

January 1, 2017

Efficacy and Safety of Onartuzumab in Combination With First-Line Bevacizumab- or Pemetrexed-Based Chemotherapy Regimens in Advanced Non-Squamous Non–Small-Cell Lung Cancer

Clinical Lung Cancer, ISSN: 19380690 15257304

Heather A. Wakelee; Zanete Zvirbule; Filippo De Braud; C. Daniel Kingsley; Tarek Mekhail; Thomas Lowe; Wolfgang Schütte; Hervé Lena; William Lawler; Fadi S. Braiteh; Thomas Cosgriff; Diego Kaen; Michelle Boyer; Jessie Hsu; See Phan; Silvia Novello

January 1, 2017

Effect of pirfenidone on mortality: pooled analyses and meta-analyses of clinical trials in idiopathic pulmonary fibrosis

The Lancet Respiratory Medicine, ISSN: 22132619 22132600

Steven D Nathan; Carlo Albera; Williamson Bradford; Ulrich Costabel; Ian Glaspole; Marilyn K Glassberg; David Kardatzke; Monica Daigl; Klaus-Uwe Kirchgaessler; Lisa H Lancaster; David J Lederer; Carlos A Pereira; Jeffrey J. Swigris; Dominique Valeyre; Paul W. Noble

January 1, 2017

Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma

Gastroenterology, ISSN: 15280012 00165085

Yiwei Wang; Dan Huang; Kai-Yuan Chen; Min Cui; Weihuan Wang; Xiaoran Huang; Amad Awadellah; Qing Li; Ann Friedman; William Xin; Luca Di Martino; Fabio Cominelli; Alex Miron; Ricky Chan; James G. Fox; Yan Xu; Xiling Shen; Mathew F. Kalady; Sanford D. Markowitz; Ivan Maillard; John Lowe; Wei Xin; Lan Zhou

January 1, 2017

Bevacizumab plus paclitaxel versus placebo plus paclitaxel as first-line therapy for HER2-negative metastatic breast cancer (MERiDiAN): A double-blind placebo-controlled randomised phase III trial with prospective biomarker evaluation

European Journal of Cancer, ISSN: 18790852 09598049

David W. Miles; David Cameron; Igor Bondarenko; Lyudmila Manzyuk; Juan Carlos Alcedo; Roberto Ivan Lopez; Seock-Ah Im; Jean-Luc Canon; Yaroslav Shparyk; Denise A. Yardley; Norikazu Masuda; Jungsil Ro; Neelima Denduluri; Stanislas Hubeaux; Quah; Carlos Bais; O'Shaughnessy

January 1, 2017

Quantitative Systems Pharmacology: A Case for Disease Models

Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236

Musante; Ramanujan; Brian J. Schmidt; Ghobrial; Lu; Heatherington

January 1, 2017

TIGIT: A Key Inhibitor of the Cancer Immunity Cycle

Trends in Immunology, ISSN: 14714981 14714906

Nicholas A. Manieri; Eugene Y. Chiang; Jane L. Grogan

January 1, 2017

Photo-oxidation of IgG1 and Model Peptides: Detection and Analysis of Triply Oxidized His and Trp Side Chain Cleavage Products

Pharmaceutical Research, ISSN: 1573904X 07248741

Jessica Bane; Olivier Mozziconacci; Li Yi; Y. John Wang; Alavattam Sreedhara; Christian Schöneich

January 1, 2017

Specific Immune Response to Phospholipase B-Like 2 Protein, a Host Cell Impurity in Lebrikizumab Clinical Material

AAPS Journal, ISSN: 15507416

Saloumeh Kadkhodayan Fischer; Melissa Cheu; Kun Peng; John Lowe; James Araujo; Elaine R. Murray; Mcclintock; Matthews; Patricia Siguenza; An Song

January 1, 2017

Degradation Mechanisms of Polysorbate 20 Differentiated by 18O-labeling and Mass Spectrometry

Pharmaceutical Research, ISSN: 1573904X 07248741

Lin Zhang; Sandeep Yadav; Barthélemy Demeule; Y. John Wang; Olivier Mozziconacci; Christian Schöneich

January 1, 2017

Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics

AAPS Journal, ISSN: 15507416

Siddharth Sukumaran; Crystal Zhang; Douglas Leipold; Ola M. Saad; Keyang Xu; Kapil Gadkar; Divya Samineni; Wang; Marija Milojic-Blair; Montserrat Carrasco-Triguero; Bonnee Rubinfeld; Fielder; Kedan Lin; Ramanujan

January 1, 2017

Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death

Cell Death and Differentiation, ISSN: 14765403 13509047

Maria Cristina De Almagro; Tatiana Goncharov; Anita Izrael-Tomasevic; Stefanie Duttler; Matthias Kist; Eugene Varfolomeev; Xiumin Wu; Wyne P. Lee; Jeremy Murray; Webster; Kebing Yu; Donald S. Kirkpatrick; Kim Newton; Domagoj Vucic

January 1, 2017

Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs

Xenobiotica, ISSN: 13665928 00498254

Ryan Takahashi; Shuguang Ma; Qin Yue; Heasook Kim-Kang; Yijun Yi; Justin Ly; Jason Boggs; Alec Fettes; Andrew McClory; Yuzhong Deng; Cornelis E. Hop; S. Cyrus Khojasteh; Edna F. Choo

December 28, 2016

Utilization of In Vitro Neurotoxicity Models in Pre-Clinical Toxicity Assessment

Stem Cells in Toxicology and Medicine,

Karin Staflin; Misner; Donna M. Dambach

December 22, 2016

IL-13 is a therapeutic target in radiation lung injury

Scientific Reports, ISSN: 20452322

Su I. Chung; Jason A. Horton; Thirumalai R. Ramalingam; Ayla O. White; Eun Joo Chung; Kathryn E. Hudak; Bradley T. Scroggins; Joseph R. Arron; Thomas A. Wynn; Deborah E. Citrin

December 20, 2016

Characterization of chain pairing variants of bispecific IgG Expressed in a single host cell by high-resolution native and denaturing mass spectrometry

Analytical Chemistry, ISSN: 15206882 00032700

Luis Schachner; Guanghui Han; Michael Dillon; Jianhui Zhou; Luke McCarty; Diego Ellerman; Yiyuan Yin; Christoph Spiess; Jennie R. Lill; Paul J. Carter; Wendy N. Sandoval

December 20, 2016

Structure of crenezumab complex with aβ shows loss of β-hairpin

Scientific Reports, ISSN: 20452322

Ultsch; Bing Li; Till Maurer; Mary Mathieu; Oskar Adolfsson; Andreas Muhs; Andrea Pfeifer; Maria Pihlgren; Travis W. Bainbridge; Mike Reichelt; James A. Ernst; Eigenbrot; Fuh; Jasvinder K. Atwal; Ryan J. Watts; Weiru Wang

December 16, 2016

Transition-Metal-Free Synthesis of Tertiary Aminocyclopropanes

Organic Letters, ISSN: 15237052 15237060

Patrick Cyr; Alexandre Côté-Raiche; Sarah M. Bronner

December 16, 2016

Rhodium(III)-Catalyzed C-H Functionalization of 1-(2H)-Phthalazinones at C8

Journal of Organic Chemistry, ISSN: 15206904 00223263

Malcolm P. Huestis

December 15, 2016

Impact of blood-brain barrier integrity on tumor growth and therapy response in brain metastases

Clinical Cancer Research, ISSN: 15573265 10780432

Matthias Osswald; Jonas Blaes; Yunxiang Liao; Gergely Solecki; Miriam Gömmel; Anna S. Berghoff; Laurent Salphati; Jeffery J. Wallin; Phillips; Wick; Frank Winkler

December 15, 2016

Phase Ib study of duligotuzumab (MEHD7945A) plus cisplatin/5-fluorouracil or carboplatin/paclitaxel for first-line treatment of recurrent/metastatic squamous cell carcinoma of the head and neck

Cancer, ISSN: 10970142 0008543X

Antonio Jimeno; Jean-Pascal Machiels; Lori Wirth; Pol Specenier; Tanguy Y. Seiwert; Feby Mardjuadi; Xiaodong Wang; Amy V. Kapp; Stephanie Royer-Joo; Elicia M. Penuel; Bruce Mccall; Andrea Pirzkall; Paul M. Clement

December 15, 2016

Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoter

Oncogene, ISSN: 14765594 09509232

Xueping Qu; Thomas Sandmann; Frierson; Ling Fu; Eloisa Fuentes; Kimberly Walter; Kwame Okrah; Rumpel; Moskaluk; Shan Lu; Wang; Richard Bourgon; Elicia M. Penuel; Andrea Pirzkall; Lukas Amler; Lackner; Tabernero; Garret M. Hampton; Omar Kabbarah

December 14, 2016

The molecular landscape of high-risk early breast cancer: Comprehensive biomarker analysis of a phase III adjuvant population

npj Breast Cancer, ISSN: 23744677

Wilson; Yu; Xuyang Lu; Jill M. Spoerke; Yuanyuan Xiao; Carol O’brien; Heidi Savage; Huw; Wei Zou; Koeppen; William F. Forrest; Jane Fridlyand; Ling Fu; Rachel Tam; Erica Schleifman; Teiko Sumiyoshi; Luciana L. Molinero; Garret M. Hampton; O'Shaughnessy; Lackner

December 13, 2016

Communicating laboratory test results for rheumatoid factor: What do patients and physicians want?

Patient Preference and Adherence, ISSN: 1177889X

Ariella Kelman; Caroline O. Robinson; Elisenda Cochin; Nina J. Ahluwalia; Julia Braverman; Emil Chiauzzi; Kristina Simacek

December 9, 2016

ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models

Molecular Neurodegeneration, ISSN: 17501326

Mitchell S. Wold; Junghyun Lim; Véronik Lachance; Zhiqiang Deng; Zhenyu Yue

December 8, 2016

Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Terry Crawford; F. Anthony Romero; Kwong Wah Lai; Vickie Tsui; Alexander M. Taylor; Gladys De Leon Boenig; Cameron Noland; Jeremy Murray; Justin Ly; Edna F. Choo; Thomas Hunsaker; Emily Chan; Mark Merchant; Samir Kharbanda; Karen Gascoigne; Susan Kaufman; Beresini; Jiangpeng Liao; Wenfeng Liu; Kevin Chen; Zhongguo Chen; Andrew R. Conery; Alexandre Côté; Hariharan Jayaram; Ying Jiang; James R. Kiefer; Tracy L. Kleinheinz; Yingjie Li; Jonathan M. Maher; Eneida Pardo; Florence Poy; Kerry L. Spillane; Fei Wang; Jian Wang; Xiaocang Wei; Zhaowu Xu; Zhongya Xu; Ivana Yen; Laura E. Zawadzke; Xiaoyu Zhu; Steve Bellon; Richard T Cummings; Andrea G Cochran; Brian K Albrecht; Steven Magnuson

December 6, 2016

Automated affinity capture and on-tip digestion to accurately quantitate in vivo deamidation of therapeutic antibodies

Analytical Chemistry, ISSN: 15206882 00032700

John C. Tran; Daniel Tran; Amy Hilderbrand; Nisana Andersen; Tao Huang; Karin Reif; Isidro Hötzel; Stefanich; Yichin Liu; Jianyong Wang

December 6, 2016

Custom-designed affinity capture LC-MS F(ab′)2 assay for biotransformation assessment of site-specific antibody drug conjugates

Analytical Chemistry, ISSN: 15206882 00032700

Dian Su; Carl Ng; Mehraban Khosraviani; Shang-Fan Yu; Ely Cosino; Surinder Kaur; Keyang Xu

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