Genentech: Publications

January 1, 2015

Induction dosing of peginterferon Alfa-2a (40KD) and/or high-dose ribavirin in genotype 1 CHC patients with difficult-to-treat characteristics: Pharmacokinetic and viral kinetic (PK/VK) assessment from progress

Hepato-Gastroenterology, ISSN: 01726390

Peter N. Morcos; Ruby Leong; James A. Thommes; Jean De Pamphilis; Joseph F. Grippo; Barbara J. Brennan

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January 1, 2015

Potential mechanisms for thrombocytopenia development with trastuzumab emtansine (T-DM1)

Clinical Cancer Research, ISSN: 15573265 10780432

Hirdesh Uppal; Estelle Doudement; Kaushiki Mahapatra; Darbonne; Daniela Bumbaca; Shen; Xiaoyan Du; Ola M. Saad; Kristin Harden; Steve Olsen; Gail L. Phillips; Dylan P. Hartley; Mark X. Sliwkowski; Sandhya Girish; Donna M. Dambach; Vanitha Ramakrishnan

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January 1, 2015

New stent leaves no polymer behind

Managed Care, ISSN: 10623388

Thomas Morrow

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January 1, 2015

Hamster phospholipase B-like 2 (PLBL2): A host-cell protein impurity in therapeutic monoclonal antibodies derived from chinese hamster ovary cells

BioProcess International, ISSN: 15426319

Vanderlaan; Wendy N. Sandoval; Peter S. Liu; Julie C. Nishihara; George Tsui; Margaret Lin; Feny Gunawan; Sara Parker; Robert Ming Wong; Justin Low; Xiangdan Wang; Yang; Karthik Veeravalli; McKay; X. Christopher Yu; O'Connell; Benjamin Tran; Rajesh Vij; Chris Fong; Kathleen Francissen; Judith Zhu-Shimoni; Quarmby; Denise C. Krawitz

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January 1, 2015

Sequence variants and sequence variant analysis in biotherapeutic proteins

ACS Symposium Series, ISSN: 19475918 00976156

Oleg V. Borisov; Melissa Alvarez; James A. Carroll; Paul W. Brown

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January 1, 2015

Predicting response to HER2 kinase inhibition

Oncotarget, ISSN: 19492553

Jeffrey Settleman

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January 1, 2015

MEK inhibitors beyond monotherapy: Current and future development

Current Opinion in Pharmacology, ISSN: 14714973 14714892

Ian E. Templeton; Luna Musib

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January 1, 2015

Dual B cell immunotherapy is superior to individual Anti-CD20 depletion or baff blockade in murine models of spontaneous or accelerated lupus

Arthritis and Rheumatology, ISSN: 23265205 23265191

Wei Yu Lin; Dhaya Seshasayee; Wyne P. Lee; Patrick Caplazi; Sami McVay; Eric Suto; Allen Nguyen; Zhonghua Lin; Yonglian Sun; Laura DeForge; Mercedesz Balazs; Flavius Martin; Ali A. Zarrin

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January 1, 2015

Antibody isotype switching in vertebrates

Results and Problems in Cell Differentiation, ISSN: 18610412 00801844

Kate Senger; Jason A. Hackney; Jian Payandeh; Ali A. Zarrin

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January 1, 2015

Mericitabine and ritonavir-boosted danoprevir with or without ribavirin in treatment-naive HCV genotype 1 patients: INFORM-SVR study

Liver International, ISSN: 14783231 14783223

Edward J. Gane; Pockros; Stefan Zeuzem; Marcellin; Anna Shikhman; Coen A. Bernaards; Julian Zhou; Ellen S. Yetzer; Rosa Ballester; Cindy Dwyer; Xiao Tong; Nájera; Anne Bertasso; Janet Hammond; Amy Kindrick; Peter N. Morcos; Patrick F. Smith; Saray Stancic; Nancy Shulman

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January 1, 2015

Reply

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Aidan Long; Kenneth J. Rothman; Hubert Chen; Gillis Carrigan; Stanley J. Szefler

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January 1, 2015

Functional and structural abnormalities in deferoxamine retinopathy: A review of the literature

BioMed Research International, ISSN: 23146141 23146133

Maura Di Nicola; Giulio Barteselli; Laura Dell'Arti; Roberto Ratiglia; Francesco Viola

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January 1, 2015

CMC considerations when a drug development project is assigned breakthrough therapy status

Pharmaceutical Engineering, ISSN: 02738139

Earl S. Dye; John Groskoph; Kelley; George Millili; Moheb Nasr; Christopher J. Potter; Eric Thostesen; Hans Vermeersch

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January 1, 2015

Imaging the distribution of an antibody-drug conjugate constituent targeting mesothelin with 89Zr and IRDye 800CW in mice bearing human pancreatic tumor xenografts

Oncotarget, ISSN: 19492553

Eva J. ter Weele; Anton G.T. Terwisscha van Scheltinga; Jos G.W. Kosterink; Linda Pot; Silke R. Vedelaar; Laetitia E. Lamberts; Simon P. Williams; Marjolijn N. Lub-de Hooge; Elisabeth G. E. De Vries

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January 1, 2015

Antibody engineering & therapeutics 2015: The antibody society’s annual meeting december 7–10, 2015, San Diego, CA

mAbs, ISSN: 19420870 19420862

Paul W. H. I. Parren; Dennis R. Burton; Andrew Bradbury; James S. Huston; Paul J. Carter; Trudi Veldman; Kerry A. Chester; James W. Larrick; Mark R. Alfenito; Jamie K. Scott; Louis M. Weiner; Gregory P. Adams; Janice M. Reichert

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January 1, 2015

Ocular angiogenesis: Vascular endothelial growth factor and other factors

Developments in Ophthalmology, ISSN: 16622790 02503751

Roman G. Rubio; Anthony P. Adamis

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January 1, 2015

100% Container closure integrity testing of lyophilized drug products by the oxygen head space analysis methodology

Pharmazeutische Industrie, ISSN: 0031711X

Tobias Posset; Misael Schleger; Fred Lim; Mumenthaler; Sebastian Schneider; Thomas Kaiser

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January 1, 2015

Prediction of Drug Distribution in Subcutaneous Xenografts of Human Tumor Cell Lines and Healthy Tissues in Mouse: Application of the Tissue Composition-Based Model to Antineoplastic Drugs

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Patrick Poulin; Yunghsiang Chen; Xiao Ding; Stephen Gould; Cornelis E. Hop; Kirsten Messick; Jason Oeh; Bianca M. Liederer

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January 1, 2015

Derivation of phase 3 dosing for peginterferon lambda-1a in chronic hepatitis C, Part 2: Exposure-response analyses for efficacy and safety variables

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Matthew Hruska; Xiaodong Wang; Phyllis Chan; Alaa Ahmad; Jeremy Freeman; Maria Arantxa Horga; Jan Hillson; Vikram Kansra; Juan-Carlos Lopez-Talavera

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January 1, 2015

Dusp5 negatively regulates IL-33-mediated eosinophil survival and function

EMBO Journal, ISSN: 14602075 02614189

Derek A. Holmes; Jung-Hua Yeh; Donghong Yan; Min Xu; Andrew A. Chan

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January 1, 2015

Randomized study of danoprevir/ritonavir-based therapy for HCV genotype 1 patients with prior partial or null responses to peginterferon/ribavirin

Journal of Hepatology, ISSN: 16000641 01688278

Jordan J. Feld; Ira M. Jacobson; Donald Jensen; Graham R. Foster; Stanislas Pol; Edward Tam; Maciej Jablkowski; Hanna Berak; John M. Vierling; Eric Yoshida; Héctor R. Perez-Gomez; Astrid Scalori; Gregory J. Hooper; Jorge A. Tavel; Mercidita T. Navarro; Saba Shahdad; Rohit Kulkarni; Sophie Le Pogam; Nájera; Simon Eng; Chin Yin Lim; Nancy Shulman; Ellen S. Yetzer

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January 1, 2015

Tocilizumab in rheumatoid arthritis: A case study of safety evaluations of a large postmarketing data set from multiple data sources

Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172

Jeffrey R. Curtis; Susana Perez-Gutthann; Samy Suissa; Pavel Napalkov; Natasha Singh; Liz Thompson; Benjamin Porter-Brown

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January 1, 2015

Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinoma

Genes and Cancer, ISSN: 19476027 19476019

Chen; James Lee; Noelyn Kljavin; Benjamin Haley; Anneleen Daemen; Leisa Johnson; Yuxin Liang

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January 1, 2015

The VEGF receptor family

Receptor Tyrosine Kinases: Family and Subfamilies,

Guanglei Zhuang; Napoleone Ferrara

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January 1, 2015

Caspase-3 deficiency results in disrupted synaptic homeostasis and impaired attention control

Journal of Neuroscience, ISSN: 15292401 02706474

Shih-Ching Lo; Yuanyuan Wang; Martin Weber; Jessica L. Larson; Kimberly Scearce-Levie; Morgan Sheng

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January 1, 2015

Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis

Thorax, ISSN: 14683296 00406376

Daryle J. DePianto; Sanjay Chandriani; Abbas Alexander; Guiquan Jia; Elsa N. N'Diaye; Patrick Caplazi; Steven E. Kauder; Sabyasachi Biswas; Satyajit K. Karnik; Connie Ha; Zora Modrusan; Michael A. Matthay; Kukreja; Harold R. Collard; Jackson G. Egen; Paul J. Wolters; Joseph R. Arron

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January 1, 2015

Neoadjuvant breast cancer treatment as a sensitive setting for trastuzumab biosimilar development and extrapolation

Future Oncology, ISSN: 17448301 14796694

Christian Jackisch; Frank A. Scappaticci; Dominik Heinzmann; Fabio Bisordi; Thomas Schreitmüller; Gunter Von Minckwitz; Javier Cortés

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January 1, 2015

Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI?

Scientific World Journal, ISSN: 1537744X 23566140

Savita V. Dandapani; Ying Zhang; Richard Jennelle; Yvonne G. Lin

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January 1, 2015

Female bias in systemic lupus erythematosus is associated with the differential expression of X-linked toll-like receptor 8

Frontiers in Immunology, ISSN: 16643224

Gabrielle McDonald; Nicholas Cabal; Augustin Vannier; Benjamin Umiker; Raymund H. Yin; Arturo V. Orjalo; Hans E. Johansson; Jin-Hwan Han; Thereza Imanishi-Kari

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January 1, 2015

Toward an era of utilizing methionine overproducing hosts for recombinant protein production in Escherichia coli

Bioengineered, ISSN: 21655987 21655979

Karthik Veeravalli; Mike Laird

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January 1, 2015

Separation science in drug development, part 1: High-throughput purification

LC-GC Europe, ISSN: 14716577

Mengling Wong; Brent Murphy; Joseph H. Pease; Michael W. Dong

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January 1, 2015

Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma

Oncotarget, ISSN: 19492553

Lindi Chen; Raphaël F. Rousseau; Steven A. Middleton; Gwen L. Nichols; David R. Newell; John Lunec; Deborah A. Tweddle

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January 1, 2015

Analytical technologies for genotoxic impurities in pharmaceutical compounds

LCGC North America, ISSN: 15275949

Archana Kumar; Kelly Zhang; Larry Wigman

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January 1, 2015

Separation science in drug development, part I: High-throughput purification

LCGC North America, ISSN: 15275949

Joseph H. Pease; Brent Murphy; Mengling Wong; Michael W. Dong

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January 1, 2015

Separation science in drug development, part II: High-throughput characterization

LCGC North America, ISSN: 15275949

Baiwei Lin; Joseph H. Pease; Michael W. Dong

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January 1, 2015

Iridium(III)-catalyzed benzylic amine directed C-H sulfonamidation of arenes with sulfonyl azides

ChemCatChem, ISSN: 18673899 18673880

Heng Chen; Malcolm P. Huestis

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January 1, 2015

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

Nature Genetics, ISSN: 15461718 10614036

Durinck; Eric Stawiski; Andrea Pavía-Jiménez; Zora Modrusan; Payal Kapur; Bijay S. Jaiswal; Na Zhang; Vanina Toffessi-Tcheuyap; Thong T Nguyen; Kanika Bajaj Pahuja; Ying-Jiun J. Chen; Sadia Saleem; Subhra Chaudhuri; Sherry Heldens; Marlena Jackson; Samuel Peña-Llopis; Joseph Guillory; Toy; Connie Ha; Corissa J. Harris; Eboni Holloman; Haley M Hill; Stinson; Rivers; Vasantharajan Janakiraman; Weiru Wang; Lisa N. Kinch; Nick V Grishin; Matthias Peter; Bernard Chow; Julian S. Gehring; Jens Reeder; Gregoire Pau; Thomas D Wu; Vitaly Margulis; Yair Lotan; Arthur Sagalowsky; Ivan Pedrosa; Frederic J. De Sauvage; James Brugarolas; Somasekar Seshagiri

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January 1, 2015

Manufacturing of High-Concentration Monoclonal Antibody Formulations via Spray Drying-the Road to Manufacturing Scale

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Benson Gikanga; Robert Turok; Ada Hui; Mayumi Bowen; Oliver B. Stauch; Maa

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January 1, 2015

Cognitive deficits, changes in synaptic function, and brain pathology in a mouse model of normal aging

eNeuro, ISSN: 23732822

Martin Weber; Tiffany Wu; Jesse E. Hanson; Nazia M. Alam; Hilda Solanoy; Hai Ngu; Benjamin E. Lauffer; Han H. Lin; Sara L. Dominguez; Jens Reeder; Jennifer A. Tom; Pascal Steiner; Oded Foreman; Glen T. Prusky; Kimberly Scearce-Levie

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January 1, 2015

Comparison of Healthcare Costs Between Rheumatoid Arthritis Patients Treated with Infused Biologics After Switching from Another Biologic

Drugs - Real World Outcomes, ISSN: 21989788 21991154

Stephen S. Johnston; Donna McMorrow; Amanda M. Farr; Paul Juneau; Sarika Ogale

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January 1, 2015

Exploring protein-protein interactions using peptide libraries displayed on phage

Phage Display in Biotechnology and Drug Discovery, Second Edition,

Deshayes; Jacob E. Corn

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January 1, 2015

Antibody humanization and affinity maturation using phage display

Phage Display in Biotechnology and Drug Discovery, Second Edition,

Jonathan S. Marvin; Henry B. Lowman

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January 1, 2015

Viral clearance of traditional unit operations: virus-retentive filtration

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124

Qi Chen; Dayue Chen

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January 1, 2015

Molecular assessment of monoclonal antibody-based therapeutics enabling lead selection for clinical development