Genentech: Publications

January 1, 2015

Expanded change protocols: Benefits, cost considerations, and regulatory views

BioProcess International, ISSN: 15426319

Nadine Ritter; Julia Edwards; Stefanie Pluschkell; Suzanne Stella; Rebekah Logan; Chana Fuchs; Wassim Nashabeh; Rohin Mahtre

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January 1, 2015

United States comparative costs and absenteeism of diabetic ophthalmic conditions

Postgraduate Medicine, ISSN: 19419260 00325481

Richard A. Brook; Nathan L. Kleinman; Sunil Patel; Jim E. Smeeding; Ian A. Beren; Adam Turpcu

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January 1, 2015

Enhancing efficiency of trace metals analysis using a validated generic ICP-OES method

American Pharmaceutical Review, ISSN: 10998012

Ila Patel; Venkatramani; Colin D. Medley; Kavita Mistry; Larry Wigman; Nik P. Chetwyn

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January 1, 2015

Creating a specialist protein resource network: A meeting report for the protein bioinformatics and community resources retreat

Database, ISSN: 17580463

Patricia C. Babbitt; Pantelis G. Bagos; Amos Bairoch; Alex Bateman; Arnaud Chatonnet; Mark J. Chen; David J. Craik; Robert D. Finn; David Gloriam; Daniel H. Haft; Bernard Henrissat; Gemma L. Holliday; Vignir Isberg; Quentin Kaas; David Landsman; Nicolas Lenfant; Gerard Manning; Nozomi Nagano; Narayanaswamy Srinivasan; Claire O'Donovan; Kim D. Pruitt; Ramanathan Sowdhamini; Neil D. Rawlings; Milton H. Saier Jr.; Joanna L. Sharman; Michael Spedding; Konstantinos D. Tsirigos; Ake Vastermark; Gerrit Vriend

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January 1, 2015

The authors explore and define common industry approaches and practices when applying GMPs in early development

Pharmaceutical Technology, ISSN: 21507376 15432521

Q. Chan Li; Jackson D. Pellett; Michael Szulc; Mark D. Trone; Kirby Wong-Moon

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January 1, 2015

A biopharmaceutical industry perspective on single-use sensors for biological process applications

BioPharm International, ISSN: 19391862 1542166X

Bradley H. Diehl; Mark A. Lapack; Tony Y. Wang; Robert E. Kottmeier; Stacey M. Kaneshiro; Michael C. Brandenstein; Yongchun Zhang; Yuk Chun Chiu; Seongkyu Yoon; Victor Saucedo

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January 1, 2015

Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: Addressing methodologic issues of plasma membrane isolation and expression-activity relationship

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Vineet Kumar; Bhagwat Prasad; Gabriela Patilea; Anshul Gupta; Laurent Salphati; Raymond Evers; Cornelis E. Hop; Jashvant D. Unadkat

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January 1, 2015

Development and implementation of a double-blind corticosteroid-tapering regimen for a clinical trial

International Journal of Rheumatology, ISSN: 16879279 16879260

Neil Collinson; Katie Tuckwell; Frank Habeck; Monique Chapman; Micki Klearman; John H. Stone

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January 1, 2015

First million-dollar syringe could be a sight for sore eyes

Managed Care, ISSN: 10623388

Thomas Morrow

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January 1, 2015

Predictors of early discontinuation of pegylated interferon for reasons other than lack of efficacy in United States veterans with chronic hepatitis c

Gastroenterology Nursing, ISSN: 15389766 1042895X

Joanne Lafleur; Hoop; Korner; Scott L. Duvall; Timothy Morgan; Prashant K. Pandya; Jian Han; Kristin Knippenberg; Richard E. Nelson

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January 1, 2015

Evaluation of detection sensitivity in comprehensive two-dimensional liquid chromatography separations of an active pharmaceutical ingredient and its degradants

Analytical and Bioanalytical Chemistry, ISSN: 16182650 16182642

Dwight R. Stoll; Eric S. Talus; David C. Harmes; Kelly Zhang

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January 1, 2015

Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells

Oncotarget, ISSN: 19492553

Nitu Bansal; Prasun J. Mishra; Mark Stein; Robert S. DiPaola; Joseph R. Bertino

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January 1, 2015

Anemia Predicts Sustained Virological Response in Cirrhotic and Noncirrhotic Patients with Chronic Hepatitis C Treated with Peginterferon Alfa-2a and Ribavirin

Current Hepatitis Reports, ISSN: 15410706 15403416

Reau; Korner; Jian Han; Donald Jensen

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January 1, 2015

Safety, virology and pharmacokinetics of oseltamivir in infants with laboratory-confirmed influenza: A Phase I/II, prospective, open-label, multicentre clinical trial

Antiviral Therapy, ISSN: 20402058 13596535

Barbara A. Rath; Jerzy Brzostek; Sara Guillén; Vis Niranjan; Colombe Chappey; Craig R. Rayner; Barry Clinch

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January 1, 2015

Validation of a method for the determination of thiocyanate in human plasma by UV/VIS spectrophotometry and application to a Phase I clinical trial of GDC-0425

Translational and Clinical Pharmacology, ISSN: 22890882

Young G. Shin; Henri Meijering; Fred H. van Heuveln; Jaap Wieling; Jason S Halladay; Srikumar Sahasranaman; Cornelis E. Hop

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January 1, 2015

The BioMart community portal: An innovative alternative to large, centralized data repositories

Nucleic Acids Research, ISSN: 13624962 03051048

Damian Smedley; Syed Haider; Durinck; Luca Pandini; Paolo Provero; James Allen; Olivier Arnaiz; Mohammad H.amza Awedh; Richard Baldock; Giulia Barbiera; Philippe Bardou; Tim Beck; Andrew Blake; Merideth Bonierbale; Anthony J. Brookes; Gabriele Bucci; Iwan Buetti; Sarah Burge; Cédric Cabau; Joseph W. Carlson; Claude Chelala; Charalambos Chrysostomou; Davide Cittaro; Olivier Collin; Raul Cordova; Rosalind J. Cutts; Erik Dassi; Alex Di Genova; Anis Djari; Anthony Esposito; Heather Estrella; Eduardo Eyras; Julio Fernandez-Banet; Simon Forbes; Robert C. Free; Takatomo Fujisawa; Emanuela Gadaleta; Jose M. Garcia-Manteiga; David Goodstein; Kristian Gray; José Afonso Guerra-Assunção; Bernard Haggarty; Dong-Jin Han; Byung Woo Han; Todd Harris; Jayson Harshbarger; Robert K. Hastings; Richard D. Hayes; Claire Hoede; Shen Hu; Zhi-Liang Hu; Lucie Hutchins; Zhengyan Kan; Hideya Kawaji; Aminah Keliet; Arnaud Kerhornou; Sunghoon Kim; Rhoda Kinsella; Christophe Klopp; Lei Kong; Daniel Lawson; Dejan Lazarevic; Ji-Hyun Lee; Thomas Letellier; Chuan-Yun Li; Pietro Lio; Chu-Jun Liu; Jie Luo; Alejandro Maass; Jerome Mariette; Thomas Maurel; Stefania Merella; Azza Mostafa Mohamed; Francois Moreews; Ibounyamine Nabihoudine; Nelson Ndegwa; Céline Noirot; Cristian Perez-Llamas; Michael Primig; Alessandro Quattrone; Hadi Quesneville; Davide Rambaldi; James Reecy; Michela Riba; Steven Rosanoff; Amna Ali Saddiq; Elisa Salas; Olivier Sallou; Rebecca Shepherd; Reinhard Simon; Linda Sperling; William Spooner; Daniel M. Staines; Delphine Steinbach; Kevin Stone; Elia Stupka; Jon W. Teague; Abu Z. Dayem Ullah; Jun Wang; Doreen Ware; Marie Wong-Erasmus; Ken Youens-Clark; Amonida Zadissa; Shi-Jian Zhang; Arek Kasprzyk

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January 1, 2015

Challenges and considerations for development of therapeutic proteins in pediatric patients

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Yi Zhang; Xiaohui Wei; Gaurav Bajaj; Jeffrey S. Barrett; Bernd Meibohm; Amita Joshi; Manish Gupta

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January 1, 2015

Oxidative degradation of polysorbate surfactants studied by liquid chromatography-mass spectrometry

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Oleg V. Borisov; Junyan A. Ji; Y. John Wang

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January 1, 2015

Sensitive and direct determination of lithium by mixed-mode chromatography and charged aerosol detection

Journal of Chromatography A, ISSN: 18733778 00219673

Lulu Dai; Larry Wigman; Kelly Zhang

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January 1, 2015

Effect of individual fc methionine oxidation on FcRn binding: Met252 oxidation impairs fcrn binding more profoundly than Met428 oxidation

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Xuan Gao; Junyan A. Ji; Karthik Veeravalli; Y. John Wang; Taylor Zhang; William Mcgreevy; Kai Zheng; Robert F. Kelley; Mike Laird; Jun Liu; Cromwell

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January 1, 2015

Derivation of phase 3 dosing for peginterferon lambda-1a in chronic hepatitis C, Part 1: Modeling optimal treatment duration and sustained virologic response rates

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Xiaodong Wang; Matthew Hruska; Phyllis Chan; Alaa Ahmad; Jeremy Freeman; Maria Arantxa Horga; Jan Hillson; Vikram Kansra; Juan-Carlos Lopez-Talavera

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January 1, 2015

Erlotinib therapy after initial platinum doublet therapy in patients with EGFR wild type non-small cell lung cancer: Results of a combined patient-level analysis of the NCIC CTG BR.21 and SATURN trials

Translational Lung Cancer Research, ISSN: 22264477 22186751

Raymond U. Osarogiagbon; Federico Cappuzzo; Tudor Ciuleanu; Larry Leon; Barbara Klughammer

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January 1, 2015

89Zr-Bevacizumab PET visualizes heterogeneous tracer accumulation in tumor lesions of renal cell carcinoma patients and differential effects of antiangiogenic treatment

Journal of Nuclear Medicine, ISSN: 01615505

Sjoukje F. Oosting; Adrienne H. Brouwers; Suzanne C. Van Es; Wouter B. Nagengast; Thijs H. Oude Munnink; Marjolijn N. Lub-de Hooge; Harry Hollema; Johan R. De Jong; Igle J. De Jong; Sanne De Haas; Stefan J. Scherer; Wim J. Sluiter; Rudi A. Dierckx; Alfons H.H. Bongaerts; Jourik A. Gietema; Elisabeth G. E. De Vries

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January 1, 2015

Nanomedicine based on nucleic acids: Pharmacokinetic and pharmacodynamic perspectives

Current Pharmaceutical Biotechnology, ISSN: 18734316 13892010

Chenguang Zhou; Zhaogang Yang; Lesheng Teng

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January 1, 2015

Biophysical techniques for characterizing the higher order structure and interactions of monoclonal antibodies

ACS Symposium Series, ISSN: 19475918 00976156

Yatin Gokarn; Sanjeev Agarwal; Kelly Arthur; Alexander Bepperling; Eric S. Day; Dana I. Filoti; Daniel G. Greene; David Hayes; Rachel Kroe-Barrett; Thomas M. Laue; Jasper C. Lin; Brian McGarry; Vladimir Razinkov; Sanjaya Singh; Rosalynn Taing; Sathyadevi Venkataramani; William Weiss; Danlin Yang; Isidro E. Zarraga

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January 1, 2015

Design and pharmacokinetic characterization of novel antibody formats for ocular therapeutics

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Kapil Gadkar; Cinthia V Pastuskovas; Jennifer Le Couter; J. Michael Elliott; Jianhuan Zhang; Chingwei V. Lee; Sarah Sanowar; Fuh; Hok Seon Kim; T. Noelle Lombana; Christoph Spiess; Makia Nakamura; Hass; Whitney Shatz; Meng; Justin M. Scheer

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January 1, 2015

Adventitious Agent Testing of Biologicals: Changing to a New Frontier of Technology, Cell-Based to Nucleic Acid-Based Detection

ACS Symposium Series, ISSN: 19475918 00976156

Ivar Kljavin; Kevin McCarthy; Dieter Schmalzing

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January 1, 2015

Trastuzumab emtansine (T-DM1) versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer and central nervous system metastases: A retrospective, exploratory analysis in EMILIA

Annals of Oncology, ISSN: 15698041 09237534

Ian E. Krop; Lin; Kimberly Blackwell; Ellie Guardino; Huober; Michael W. Lu; David W. Miles; Meghna Samant; Manfred Welslau; Diéras

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January 1, 2015

Sorbitol crystallization-induced aggregation in frozen mAb formulations

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Deirdre Murphy Piedmonte; Alison Hair; Priti Baker; Lejla Brych; Karthik Nagapudi; Hong Lin; Wenjin Cao; Susan Hershenson; Gayathri Ratnaswamy

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January 1, 2015

Gas-wall partitioning of oxygenated organic compounds: Measurements, structure-activity relationships, and correlation with gas chromatographic retention factor

Aerosol Science and Technology, ISSN: 15217388 02786826

Geoffrey K. Yeh; Paul J. Ziemann

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January 1, 2015

Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who remain symptomatic on h 1 antihistamines: A randomized, placebo-controlled study

Journal of Investigative Dermatology, ISSN: 15231747 0022202X

Sarbjit S. Saini; Carsten Bindslev-Jensen; Marcus Maurer; Jean-Jacques Grob; Emel Bülbül Baskan; Mary S. Bradley; Janice Canvin; Abdelkader Rahmaoui; Panayiotis Georgiou; Oral Alpan; Sheldon Spector; Karin Rosén

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January 1, 2015

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

Cell Death and Disease, ISSN: 20414889

Joel D. Leverson; Haichao Zhang; Jun Chen; Stephen K. Tahir; Darren C. Phillips; John Xue; Paul M. Nimmer; Sha Jin; Morey L. Smith; Yu Xiao; Peter J. Kovar; Tanaka; Bruncko; Sheppard; Le Wang; Sarah Gierke; Kategaya; Daniel J Anderson; Wong; Jeffrey Eastham-Anderson; Ludlam; Deepak Sampath; Wayne J. Fairbrother; Ingrid E. Wertz; Saul H. Rosenberg; Chris Tse; Steven W. Elmore; Andrew J. Souers

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January 1, 2015

Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Melissa Junttila; Vidusha Devasthali; Jason H. Cheng; Joseph Castillo; Ciara Metcalfe; Anne C. Clermont; Doug Den Otter; Emily Chan; Hani Bou-Reslan; Tim C. Cao; William F. Forrest; Michelle Nannini; French; Richard A. D. Carano; Mark Merchant; Klaus P. Hoeflich; Mallika Singh

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January 1, 2015

Clinical outcomes and medication adherence in acute coronary syndrome patients with and without type 2 diabetes mellitus: A longitudinal analysis 2006-2011

Journal of Managed Care Pharmacy, ISSN: 10834087

Mark J. Cziraky; Vanessa S. Reddy; Rakesh Luthra; Yaping Xu; Kenneth Wilhelm; Thomas P. Power; Maxine D. Fisher

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January 1, 2015

HSP105 recruits protein phosphatase 2A To dephosphorylate ß-catenin

Molecular and Cellular Biology, ISSN: 10985549 02707306

Nancy Yu; Michael Kakunda; Victoria Pham; Jennie R. Lill; Pan Du; Matthew Wongchenko; Yibing Yan; Ron Firestein; Xiaodong Huang

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January 1, 2015

Retinal ganglion cells thinning in eyes with nonproliferative idiopathic macular telangiectasia type 2A

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Jay Chhablani; Abhilash Goud; Ganesh Babu Jonnadulla

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January 1, 2015

Neurodegeneration in type 2 diabetes: Evidence from spectral-domain optical coherence tomography

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Jay Chhablani; Apoorva Sharma; Abhilash Goud; Hari Kumar Peguda; Harsha L. Rao; Viquar Unnisa Begum; Giulio Barteselli

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January 1, 2015

Strain engineering to prevent norleucine incorporation during recombinant protein production in Escherichia coli

Biotechnology Progress, ISSN: 15206033 87567938

Karthik Veeravalli; Mike Laird; Mark Fedesco; Yu Zhang; X. Christopher Yu

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January 1, 2015

IL-13 mediates IL-33-dependent mast cell and type 2 innate lymphoid cell effects on bronchial epithelial cells

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Deepti R. Nagarkar; Vladimir Ramirez-Carrozzi; David F. Choy; Kevin Lee; Robert Soriano; Guiquan Jia; Abbas Alexander; Zora Modrusan; Rajita Pappu; Joseph R. Arron

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January 1, 2015

Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for Antibody-Drug Conjugates

Clinical Pharmacokinetics, ISSN: 11791926 03125963

Yuan Chen; Divya Samineni; Sophie Mukadam; Harvey Wong; Shen; Dan Lu; Sandhya Girish; Cornelis E. Hop; Jin Y. Jin; Chunze Li

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January 1, 2015

Creating a unique, multi-stakeholder Paediatric Oncology Platform to improve drug development for children and adolescents with cancer

European Journal of Cancer, ISSN: 18790852 09598049

Gilles Vassal; Raphaël F. Rousseau; Patricia Blanc; Lucas Moreno; Gerlind Bode; Stefan Schwoch; Martin Schrappe; Jeffrey Skolnik; Bergmann; Mary Brigid Bradley-Garelik; Vaskar Saha; Andy Pearson; Heinz Zwierzina

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January 1, 2015

Clinical and economic burden of commercially insured patients with acromegaly in the United States: A retrospective analysis

Journal of Managed Care Pharmacy, ISSN: 10834087

Hilary Placzek; Yaping Xu; Yunming Mu; Susan M. Begelman; Maxine D. Fisher

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January 1, 2015

Excess of heme induces tissue factor-dependent activation of coagulation in mice

Haematologica, ISSN: 15928721 03906078

Erica Sparkenbaugh; Pichika Chantrathammachart; Shaobin Wang; Will Jonas; Daniel Kirchhofer; David Gailani; Andras Gruber; Raj Kasthuri; Nigel S. Key; Nigel Mackman; Rafal Pawlinski

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January 1, 2015

Performance bounds for particle filters using the optimal proposal

Monthly Weather Review, ISSN: 15200493 00270644

Chris Snyder; Thomas Bengtsson; Mathias Morzfeld

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January 1, 2015

Using lysine-reactive fluorescent dye for surface characterization of a mAb

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Ming Lei; Kao; Christian Schöneich

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January 1, 2015

Onartuzumab with or without bevacizumab in combination with weekly paclitaxel does not prolong QTc or adversely affect other ECG parameters in patients with locally recurrent or metastatic triple-negative breast cancer

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Marie T. Borin; Meng Chen; Mocci; Igor Rubets; Jason Chittenden; Wassim Aldairy; Mark Stroh

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January 1, 2015

Semiconductor-based sequencing of formalin-fixed, paraffin-embedded colorectal cancer samples

Oncologist, ISSN: 1549490X 10837159

Shidong Jia; Liangxuan Zhang; Gary J. Latham

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January 1, 2015

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Sharada Labadie; Peter Dragovich; Jinhua Chen; Benjamin P. Fauber; Jason Boggs; Laura B. Corson; Charles Z. Ding; Eigenbrot; Hongxiu Ge; Qunh Ho; Kwong Wah Lai; Shuguang Ma; Shiva Malek; David Peterson; Hans E. Purkey; Kirk D. Robarge; Laurent Salphati; Steve Sideris; Ultsch; Erica Vanderporten; Binqing Wei; Qing Xu; Ivana Yen; Qin Yue; Huihui Zhang; Xuying Zhang; Aihe Zhou

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January 1, 2015

Cell-specific aptamer characterization

Aptamers Selected by Cell-SELEX for Theranostics,

Tao Chen; Cuichen Wu; Weihong Tan

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January 1, 2015

Clinical impact of chemotherapy-related adverse events in patients with metastatic breast cancer in an integrated health care system

Journal of Managed Care Pharmacy, ISSN: 10834087

Nazia Rashid; Han A. Koh; Hilda C. Baca; Zhaoliang Li; Susan Malecha; Oyewale Abidoye; Anthony Masaquel

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